Synthesis and pharmacological activity of betulin dinicotinate

Russian Journal of Bioorganic Chemistry

Volumn 28, Issue 6, 2002, Pages 494-500

  Flekhter, O B ^a   Karachurina, L T ^a   Nigmatullina, L R ^a   Sapozhnikova, T A ^a   Baltina, L A ^a   Zarudii, F S ^a   Galin, F Z ^a   Spirikhin, L V ^a   Tolstikov, G A ^a   Plyasunova, O A ^b   Pokrovskii, A G ^b  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

Author keywords

Anti HIV activities; Antiulcer; Betulin dinicotinate; Hepatoprotective; Immunomodulatory; Lupane triterpenoids

Indexed keywords

3O,28O DINICOTINOYLBETULIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIINFLAMMATORY AGENT; BETULIN; BETULIN DINICOTINATE; HYDROXYMETHYLURACIL; ORTOPHENUM; SUCRALFATE; TRITERPENOID; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ACYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ERYTHROCYTE; HEPATITIS; IMMUNOMODULATION; LIVER PROTECTION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; SHEEP; SKIN INJURY; ULCER;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; OVIS ARIES;

EID: 0036445754     PISSN: 10681620     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1021297600187     Document Type: Article

References (34)

1. Fujioka, T., Kashiwada, Y., Kilkuskie, R.E., Cosentino, L.M., Ballas, L.M., Jiang, J.B., Janzen, W.P., Chen, I.-S., and Lee, K.-H., J. Nat. Prod., 1994, vol. 57, pp. 243-247.
2. Pisha, E., Chai, H., Lee, I., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Beecher, C.W.W., Fong, H.H.S., Kinghorn, A.D., Brown, D.M., Wani, M.C., Wall, M.E., Hicken, T.J., Das Gupta, T.K., and Pezzuto, J.M., Nat. Med., 1995, vol. 1, pp. 1046-1051.
3. Recio, M.C., Giner, R.M., Manez, S., Gueno, S., Julien, H.R., Hostettmann, K., and Rios, J.L., Planta Med., 1995, vol. 61, pp. 9-12.
4. Fulda, S., Jeremias, I., Steiner, H.H., Pietsch, T., and Debatin, K.-M., Int. J. Cancer, 1999, vol. 82, pp. 435-441.
5. Carlson, R.M., Krasutsky, P.A., and Karim, R.-U., US Patent 5 750 578, 1998.
6. Lugemwa, F.N., Huang, F.Y., Bentley, M.D., Mendel, M.J., and Alford, A.R., J. Agric. Food Chem., 1990, vol. 38, pp. 493-496.
7. Huang, F.-Y., Chung, B.Y., Bentley, M.D., and Alford, A.R., J. Agric. Food Chem., 1995, vol. 43, pp. 2513-2516.
8. Nemilov, V.E., Nachinkin, O.I., and Tsarev, G.I., Fiz. Khim. Polimerov, 1996, vol. 2, pp. 124-127.
9. Jaaskelainen, P., Pap. Ja Puu, 1981, vol. 10, pp. 599-603.
10. Flekhter, O.B., Karachurina, L.T., Poroikov, V.V., Nigmatullina, L.R., Baltina, L.A., Zarudii, FS., Davydova, V.A., Spirikhin, L.V., Baikova, I.P., Galin, F.Z., and Tolstikov, G.A., Bioorg. Khim., 2000, vol. 26, pp. 215-223.
11. Flekhter, O.B., Karachurina, L.T., Nigmatullina, L.R., Baltina, L.A., Zarudii, F.S., Davydova, V.A., Spirikhin, L.V., Baikova, I.P., Galin, F.Z., and Tolstikov, G.A., Khim.-Farm. Zh., 2000, vol. 34, pp. 3-5.
12. Flekhter, O.B., Nigmatullina, L.R., Karachurina, L.T., Baltina, L.A., Zarudii, F.S., Davydova, V.A., Galin, F.Z., and Tolstikov, G.A., Khim.-Farm. Zh., 2000, vol. 34, pp. 17-20.
13. Tolstikov, G.A., Baltina, L.A., Shul'ts, E.E., and Pokrovskii, A.G., Bioorg. Khim., 1997, vol. 23, pp. 691-709.
14. Pokrovskii, A.G., Plyasunova, O.A., Tolstikov, G.A., and Murinov, Yu.I., USSR Inventor's Certificate no. 1804848, Byul. Izobret., 1993, no. 12.
15. Pokrovskii, A.G., Belanov, E.F., Volkov, G.V., Plyasunova, O.A., and Tolstikov, G.A., Dokl. Ross. Akad. Nauk, 1995, vol. 344, pp. 709-711.
16. Druzhinina, N.A., Special Features of the Diseases of the Upper Part of Digestive Tract in Scholars from the Regions with High Pollution of Atmosphere and Approaches to Their Pharmacotherapy, Cand. Sci. (Med.) Dissertation, Chelyabinsk, 1996.
17. Mamon, M.A., A Clinical and Pathological Study of Homeostasis and Excretory Function of Kidney in the Patients Suffering from the Hemorrhagic Fever with Nephritic Syndrome under the Conditions of Complex Therapy with the Use of Niglizin, Cand. Sci. (Med.) Dissertation, Moscow, 1998.
18. Sun, I.-C., Wang, H.-K., Kashiwada, Y., Shen, J.-K., Cosentino, L.M., Chen, C.-H., Yang, L.-M., and Lee, K.-H., J. Med. Chem., 1998, vol. 41, pp. 4648-4657.
19. Chatterjee, P., Pezzuto, J.M., and Kouzi, S.A., J. Nat. Prod., 1999, vol. 62, pp. 761-763.
20. Nikolaev, S.M., Rastitel' nye lekarstvennye preparaty pri povrezhdeniyakh gepatobiliarnoi sistemy (Plant Medicines at the Damages of Hepatobiliary System), Novosibirsk: Nauka, 1992.
21. Alekseeva, I.N., Bryzgin, T.M., Pavlovich, S.I., and Il'chevich, N.V., Pechen' i immunologicheskaya reaktivnost' (Liver and Immunological Reactivity), Kiev: Naukova Dumka, 1991.
22. Kamilov, F.Kh., Lazareva, D.N., and Plechev, V.V., Pirimidiny i ikh primenenie v meditsine, (Pyrimidines and Their Use in Medicine), Ufa: Bashk. Gos. Med. Inst., 1992.
23. Plyasunova, O.A., Egoricheva, I.N., Fedyuk, N.V., Pokrovskii, A.G., Baltina, L.A., Murinov, Yu.I., and Tolstikov, G.A., Vopr. Virusol., 1992, nos. 5-6, pp. 235-238.
24. Naumova, B.S., Chekmareva, I.B., Zhdanovich, E.S., and Preobrazhenskii, N.A., Khim.-Farm. Zh., 1969, vol. 3, pp. 11-12.
25. Belen'kii. M.L. Elementy kolichestvennoi otsenki farmakologicheskogo effekta (Components of the Quantitative Assessment of Pharmacological Effect), Leningrad: Medgiz, 1963.
26. Skakun, N.P. and Koval'chuk, S.F., Farmakol. Toksikol., 1987, vol. 50, pp. 97-99.
27. Kolb, V.G. and Kamyshnikov, V.S., Klinicheskaya biokhimiya (Clinical Biochemistry), Minsk: Belarus', 1976.
28. Stal'naya, I.D. and Garishvili, T.G., Sovremennye metody v biokhimii (Contemporary Methods in Biochemistry), Orekhovich, V.N., Ed., Moscow: Meditsyna, 1977, pp. 66-69.
29. Cunningham, A.J. and Gzenberg, A., Immunology, 1968, vol. 2, pp. 599-600.
30. Immunologicheskie, tsitokhimicheskie i biokhimicheskie metody issledovaniya fagotsitiruyushchikh kletok: Metodicheskie rekomendatsii (Immunological, Cytochemical, and Biochemical Methods in the Study of Phagocyting Cells), Ufa: Bashk. Gos. Med. Inst., 1996.
31. Anichkov, S.V. and Zavodskaya, I.S., Farmakoterapiya yazvennoi bolezni (Pharmacotherapy of Ulcer Disease), Leningrad: Meditsyna, 1965.
32. Kuz'mitskii, B.B., Mizulo, M.A., Romanova, V.N., and Malaeva, L.P., Eksper. Klin. Farmakol., 1992, vol. 55, pp. 27-28.
33. Vertelkin, V.A., Golofeevskii, V.Yu, Ctefanyuk, N.F., and Saltykov, A.A., Pat. Fiziol., 1987, no. 2, pp. 77-78.
34. Trinus, F.P., Mokhort, N.A., and Klebanov, B.M., Nesteroidnye protivovospalitel'nye sredstva (Nonsteroid Antiinflammatory Remedies), Kiev: Zdorov'ya, 1975.