Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death

Cancer Research

Volumn 67, Issue 24, 2007, Pages 11848-11858

  Ganguly, Agneyo ^a   Das, Benubrata ^b   Roy, Amit ^a   Sen, Nilkantha ^c   Dasgupta, Somdeb Bose ^a   Mukhopadhayay, Sibabrata ^a   Majumder, Hemanta K ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b NATIONAL CANCER INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETULIC ACID; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; GUANOSINE DERIVATIVE; OLIGONUCLEOTIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAUROSPORINE;

APOPTOSIS; ARTICLE; CANCER CELL; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; DRUG TARGETING; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DNA BINDING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DNA, NEOPLASM; ENZYME INHIBITORS; HUMANS; MALE; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; TRITERPENES;

EID: 37549036327     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1615     Document Type: Article

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