Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 10, 2005, Pages 3447-3454

  Kvasnica, Miroslav ^a   Sarek, Jan ^a   Klinotova, Eva ^a   Dzubak, Petr ^b   Hajduch, Marian ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Betulin; Cytotoxicity; Phthalate; Triterpenes

Indexed keywords

BETULIC ACID; BETULIN; PHTHALAZINE DERIVATIVE;

ACYLATION; ARTICLE; CANCER CELL CULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NITROBLUE TETRAZOLIUM TEST;

EID: 17444420293     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.006     Document Type: Article

References (15)

1. E. Pisha, H. Chai, I.S. Lee, T.E. Chagwedera, N.R. Farnsworth, G.A. Cordell, C.W.W. Beecher, H.H.S. Fong, A.D. Kinghorn, D.M. Brown, M.C. Want, M.E. Wall, T.J. Hieken, T.K.D. Gupta, and J.M. Pezzuto Nat. Med. 1 1995 1046 1051
2. R.H. Cichewicz, and S.A. Kouzi Med. Res. Rev. 24 2004 90 114
3. V. Zuco, R. Supino, S.C. Righetti, L. Cleris, E. Marchesi, C. Gambacorti-Passerini, and F. Formelli Cancer Lett. 175 2002 17 25
4. D.S.H.L. Kim, J.M. Pezzuto, and E. Pisha Bioorg. Med. Chem. Lett. 8 1998 1707 1712
5. M. Urban, J. Sarek, J. Klinot, G. Korinkova, and M. Hajduch J. Nat. Prod. 67 2004 1100 1105
6. R. Mukherjee, M. Jaggi, P. Rajedran, M.J.A. Siddiqui, S.K. Srivastara, A. Vardhan, and A.C. Burman Bioorg. Med. Chem. Lett. 14 2004 2181 2184
7. S. Fulda, I. Jeremias, and K.M. Debatin Oncogene 23 2004 7611 7620
8. Hajduch, M.; Sarek, J.: Triterpenoid derivatives. PCT Int. Patent Appl. WO0190046, 23 May 2001
9. J.Y. Kim, H.M. Koo, and D.S.H.L. Kim Bioorg. Med. Chem. Lett. 11 2001 2405 2408
10. F. Hashimoto, Y. Kashiwada, L.M. Cosentino, C.-H. Chen, P.E. Garrett, and K.-H. Lee Bioorg. Med. Chem. 5 1997 2133 2143
11. J. Šarek, J. Klinot, S. Bražinová, P. Džubák, E. Klinotová, V. Nosková, V. Křeček, G. Kořínková, J.O. Thomson, A. Janošt'áková, S. Wang, S. Parsons, P.M. Fischer, N.Z. Zhelev, and M. Hajdúch J. Med. Chem. 46 2003 5402 5415
12. T.-S. Li, J.-X. Wang, and X.-J. Zheng J. Chem. Soc., Perkin Trans. 1 1998 3957 3965
13. L.F. Tietze, H. Heinzen, P. Moyna, M. Rischer, and H. Neunaber Liebigs Ann. Chem. 1991 1245 1249
14. A.M. Felix, E.P. Heimer, T.J. Lambros, C. Tzougraki, and J. Meienhofer J. Org. Chem. 43 1978 4194 4196
15. V. Noskova, P. Dzubak, G. Kuzmina, A. Ludkova, D. Stehlik, R. Trojanec, A. Janostakova, G. Korinkova, V. Mihal, and M. Hajduch Neoplasma 49 2002 418 425