Induction of p53 without increase in p21WAF1 in betulinic acid-mediated cell death is preferential for human metastatic melanoma

DNA and Cell Biology

Volumn 17, Issue 5, 1998, Pages 399-406

  Rieber, Manuel ^a  

^a INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

BETULIC ACID; BROXURIDINE; PROTEIN P21; PROTEIN P53;

ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHROMOSOME 6; DNA DAMAGE; ENZYME ACTIVITY; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; MELANOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; SKIN METASTASIS; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 0031780114     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.1998.17.399     Document Type: Article

References (5)

1. BATES, G., PARRY, D., BONETTA, L., VOUSDEN, K., DICKSON, C., and PETERS, G. (1994). Absence of cyclin/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9, 1633-1640.
2. BERNHARD, E.J., GRUBER, S.B., and MUSCHEL, R.J. (1994). Direct evidence linking expression of matrix metalloproteinase 9 (92 kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc. Natl. Acad. Sci. USA 91,4293-4297.
3. r 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells. Cancer Res. 50, 3872-3877.
4. CAELLES, HELBERG, A., and KARIN, M. (1994). p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370, 220-223.
5. EL DEIRY, W.S., TOKINO, T., VELCULESCU, V.E., LEVY, D.B., PARSONS, R., TRENT, J.M., LIND, D., MERCER, W.E., KINZLER, K.W., and VOGELSTEIN, B.(1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.