Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18918-18927

  Martin, Praxedis ^a,e   Pardo, Julián ^a,f   Schill, Natalie ^a,g   Jöckel, Lars ^a,h   Berg, Matthias ^b   Froelich, Christopher J ^c   Wallich, Reinhard ^d   Simon, Markus M ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b M Scan   (Germany)

^c NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e UNIVERSITY OF GENEVA   (Switzerland)

^f UNIVERSITY OF ZARAGOZA   (Spain)

^g Fisher Clinical Services   (Switzerland)

^h UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN CYTOSKELETON; ACTIN FILAMENT; CASPASE-3; CASPASES; CYTOSKELETONS; CYTOTOXIC; CYTOTOXIC ACTIVITIES; CYTOTOXIC T LYMPHOCYTES; EX-VIVO; GELSOLIN; GRANZYME B; HOST DEFENSE; IN-VITRO; IN-VIVO; INFLAMMATORY CYTOKINES; INTRACELLULAR PATHOGENS; INTRACELLULAR PROCESS; ISOLATED MOUSE; NATURAL KILLER CELLS; PERFORIN; T CELLS; TARGET CELLS;

PRESSURE EFFECTS; PROTEINS; TARGETS;

CELLS;

CASPASE 3; CASPASE 7; GELSOLIN; GRANZYME B;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXIC T LYMPHOCYTE; EMBRYO; ENZYME ACTIVATION; ENZYME RELEASE; EX VIVO STUDY; HOST RESISTANCE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; VIRUS IMMUNITY;

ANIMALS; APOPTOSIS; CASPASE 3; CD8-POSITIVE T-LYMPHOCYTES; CYTOSKELETON; FIBROBLASTS; GELSOLIN; GRANZYMES; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION, GENETIC;

EID: 77953308122     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.056028     Document Type: Article

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