Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis

Circulation Research

Volumn 104, Issue 7, 2009, Pages 896-904

  Li, Guo Hua ^a   Shi, Yu ^a   Chen, Yu ^a   Sun, Mei ^a   Sader, Sawsan ^a   Maekawa, Yuichiro ^a   Arab, Sara ^a   Dawood, Fayez ^a   Chen, Manyin ^a   De Couto, Geoffrey ^a   Liu, Youan ^a   Fukuoka, Masahiro ^a   Yang, Stanley ^b   Da Shi, Ming ^a   Kirshenbaum, Lorrie A ^c   McCulloch, Christopher A ^d   Liu, Peter ^a,d  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST BONIFACE GENERAL HOSPITAL RESEARCH CENTRE   (Canada)

^d TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Apoptosis; Cardiac remodeling; Deoxyribonuclease I; Gelsolin; Myocardial infarction

Indexed keywords

DEOXYRIBONUCLEASE I; GELSOLIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BCL 2; PROTEIN KINASE B; SERINE DERIVATIVE; CASPASE; HIF1A PROTEIN, RAT;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY LIGATION; ARTICLE; ASSAY; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROSING ALVEOLITIS; GEL; GENE EXPRESSION; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART INFARCTION; HEART INFARCTION SIZE; HEART VENTRICLE REMODELING; KNOCKOUT MOUSE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MORTALITY; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SHAM PROCEDURE; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DISEASE MODEL; ENZYMOLOGY; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; HUMAN; METABOLISM; MICROFILAMENT; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TIME; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASES; DEOXYRIBONUCLEASE I; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENZYME ACTIVATION; FIBROSIS; GELSOLIN; GENE EXPRESSION REGULATION; HEART FAILURE; HUMANS; HYPERTROPHY, LEFT VENTRICULAR; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENTS; MYOCARDIAL INFARCTION; MYOCARDIUM; PROMOTER REGIONS, GENETIC; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 65249166117     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.172882     Document Type: Article

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