Scaffold rearrangement of dihydroxypyrimidine inhibitors of HIV integrase: Docking model revisited

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3275-3279

  Tang, Jing ^a   Maddali, Kasthuraiah ^b   Pommier, Yves ^b   Sham, Yuk Y ^a   Wang, Zhengqiang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Binding mechanism; Docking model; HIV; Inhibitor design; Integrase

Indexed keywords

ANTIVIRUS AGENT; DIHYDROXYPYRIMIDINE INHIBITOR; ELVITEGRAVIR; INTEGRASE; RALTEGRAVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CRYSTAL STRUCTURE; DRUG DESIGN; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; SPUMA VIRUS; SYNTHESIS;

HIV INTEGRASE INHIBITORS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PYRIMIDINES;

HUMAN SPUMARETROVIRUS;

EID: 77953293159     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.048     Document Type: Article

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