Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

Journal of Medicinal Chemistry

Volumn 48, Issue 22, 2005, Pages 7084-7088

  Barreca, Maria Letizia ^a   Ferro, Stefania ^a   Rao, Angela ^a   De Luca, Laura ^a   Zappalà, Maria ^a   Monforte, Anna Maria ^a   Debyser, Zeger ^b   Witvrouw, Myriam ^b   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 (4 FLUOROBENZYL) 2 FURYL] 3 (1,2,4 TRIAZOL 3 YL) 1,3 PROPANEDIONE; ANTIRETROVIRUS AGENT; BENZYLINDOLE DERIVATIVE; INTEGRASE INHIBITOR; N (4 FLUOROBENZYL) 8 HYDROXY 5 (TETRAHYDRO 2H 1,2 THIAZIN 2 YL) 1,6 NAPHTHYRIDINE 7 CARBOXAMIDE S,S DIOXIDE; UNCLASSIFIED DRUG;

ALGORITHM; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; HYDROPHOBICITY; MICROWAVE RADIATION; MOLECULAR MODEL; PHARMACOPHORE; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS;

ANTI-HIV AGENTS; BINDING SITES; CELL LINE; CYTOPATHOGENIC EFFECT, VIRAL; DRUG DESIGN; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HUMANS; KETO ACIDS; LYMPHOCYTES; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27444447888     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050549e     Document Type: Article

References (24)

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