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Thirty years of investigating the autoimmune basis for type 1 diabetes: Why can't we prevent or reverse this disease?
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Staeva-Vieira T, Peakman M, Von Herrath M. Translational mini-review series on type 1 diabetes: immune-based therapeutic approaches for type 1 diabetes. Clin Exp Immunol 2007; 148:17-31. This excellent review provides an in-depth discussion of nearly every current immunotherapy in clinical trial for T1D.
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Staeva-Vieira T, Peakman M, Von Herrath M. Translational mini-review series on type 1 diabetes: immune-based therapeutic approaches for type 1 diabetes. Clin Exp Immunol 2007; 148:17-31. This excellent review provides an in-depth discussion of nearly every current immunotherapy in clinical trial for T1D.
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Type 1 diabetes mellitus: Etiology, presentation, and management
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Haller MJ, Atkinson MA, Schatz D. Type 1 diabetes mellitus: etiology, presentation, and management. Pediatr Clin North Am 2005; 52:1553-1578.
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Type 1 diabetes: New perspectives on disease pathogenesis and treatment
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Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus
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Cyclosporin and childhood diabetes: Preliminary findings of the Saint Vincent de Paul trial]
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Cyclosporine delays but does not prevent clinical onset in glucose intolerant pretype 1 diabetic children
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Carel JC, Boitard C, Eisenbarth G, et al. Cyclosporine delays but does not prevent clinical onset in glucose intolerant pretype 1 diabetic children. J Autoimmun 1996; 9:739-745.
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Antithymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus
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European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes
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Gale EAM. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004; 363:925-931.
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Linear loss of insulin secretory capacity during the last six months preceding IDDM. No effect of antiedematous therapy with ketotifen
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Bohmer KP, Kolb H, Kuglin B, et al. Linear loss of insulin secretory capacity during the last six months preceding IDDM. No effect of antiedematous therapy with ketotifen. Diabetes Care 1994; 17:138-141.
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Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial - Type 1
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Skyler JS, Krischer JP, Wolfsdorf J, et al. Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial - Type 1. Diabetes Care 2005; 28:1068-1076.
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Skyler, J.S.1
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Intranasally administered insulin intended for prevention of type 1 diabetes - a safety study in healthy adults
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Kupila A, Sipila J, Keskinen P, et al. Intranasally administered insulin intended for prevention of type 1 diabetes - a safety study in healthy adults. Diabetes Metab Res Rev 2003; 19:415-420.
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Kupila, A.1
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Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
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Harrison LC, Honeyman MC, Steele CE, et al. Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care 2004; 27:2348-2355.
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Harrison, L.C.1
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Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes
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Agardh CD, Cilio CM, Lethagen A, et al. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications 2005; 19:238-246.
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Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
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Raz I, Elias D, Avron A, et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 2001; 358:1749-1753.
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Elias D, Avron A, Tamir M, Raz I. DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes. Ann N Y Acad Sci 2006; 1079:340-344. This paper documents the potential of DiaPep227 as an immunomodulatory therapy for T1D.
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Elias D, Avron A, Tamir M, Raz I. DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes. Ann N Y Acad Sci 2006; 1079:340-344. This paper documents the potential of DiaPep227 as an immunomodulatory therapy for T1D.
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18
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Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: A randomised, double-blind phase II study
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Lazar L, Ofan R, Weintrob N, et al. Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study. Diabetes Metab Res Rev 2006; 23:286-291.
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Lazar, L.1
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Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
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Keymeulen B, Vandemeulebroucke E, Ziegler AG, et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005; 352:2598-2608.
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Haller MJ, Schatz DA. CD3-antibody therapy in new-onset type 1 diabetes mellitus. N Engl J Med 2005; 353:2086-2087; author reply 2086-2087.
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Haller MJ, Schatz DA. CD3-antibody therapy in new-onset type 1 diabetes mellitus. N Engl J Med 2005; 353:2086-2087; author reply 2086-2087.
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