Interleukin-13 regulates secretion of the tumor growth factor - β superfamily cytokine activin A in allergic airway inflammation

American Journal of Respiratory Cell and Molecular Biology

Volumn 42, Issue 6, 2010, Pages 667-675

  Hardy, Charles L ^a,b,c   LeMasurier, Jeanne S ^a,b,c   Olsson, Fredrik ^a   Dang, Thanh ^a,b,c   Yao, Jun ^a,b,c   Yang, Ming ^d   Plebanski, Magdalena ^a,c   Phillips, David J ^a   Mollard, Richard ^a   Rolland, Jennifer M ^a,b,c   O'Hehir, Robyn E ^a,b,c  

^a MONASH UNIVERSITY   (Australia)

^b ALFRED HOSPITAL   (Australia)

^c CRC for Asthma and Airways   (Australia)

^d UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Activin A; IL 13; Inflammation; Knockout mice; Lung

Indexed keywords

ACTIVIN; ACTIVIN A; ACTIVIN BETA A; ACTIVIN RECEPTOR 1; INTERLEUKIN 13; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ACTIVIN RECEPTOR; INHIBIN; INHIBIN BETA A SUBUNIT; INTERLEUKIN 5; OVALBUMIN; RECOMBINANT PROTEIN;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; EOSINOPHIL; FEMALE; FIBROGENESIS; IMMUNOMODULATION; IMMUNOREACTIVITY; LUNG LAVAGE; LYMPH NODE; METAPLASIA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; TH2 CELL; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; DISEASE MODEL; EPITHELIUM CELL; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PNEUMONIA; RESPIRATORY TRACT MUCOSA; SIGNAL TRANSDUCTION; TIME;

MURINAE; MUS;

ACTIVIN RECEPTORS; ACTIVINS; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EOSINOPHILS; EPITHELIAL CELLS; FEMALE; HUMANS; INHIBIN-BETA SUBUNITS; INTERLEUKIN-13; INTERLEUKIN-5; METAPLASIA; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OVALBUMIN; PNEUMONIA; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 77953261745     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2008-0429OC     Document Type: Article

References (35)

1. Phillips DJ, Jones KL, Scheerlinck JY, Hedger MP, de Kretser DM. Evidence for activin A and follistatin involvement in the systemic inflammatory response. Mol Cell Endocrinol 2001;180:155-162.
2. Schmidt-Weber CB, Blaser K. Regulation and role of transforming growth factor-beta in immune tolerance induction and inflammation. Curr Opin Immunol 2004;16:709-716. (Pubitemid 39423658)
3. Hardy CL, O'Connor AE, Yao J, Sebire K, de Kretser DM, Rolland JM, Anderson GP, Phillips DJ, O'Hehir RE. Follistatin is a candidate endogenous negative regulator of activin A in experimental allergic asthma. Clin Exp Allergy 2006;36:941-950. (Pubitemid 43972961)
4. Karagiannidis C, Hense G, Martin C, Epstein M, Ruckert B, Mantel PY, Menz G, Uhlig S, Blaser K, Schmidt-Weber CB. Activin A is an acute allergen-responsive cytokine and provides a link to TGF-beta-mediated airway remodeling in asthma. J Allergy Clin Immunol 2006;117: 111-118. (Pubitemid 43017148)
5. Rosendahl A, Checchin D, Fehniger TE, ten Dijke P, Heldin CH, Sideras P. Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation. Am J Respir Cell Mol Biol 2001;25:60-68.
6. Aoki F, Kurabayashi M, Hasegawa Y, Kojima I. Attenuation of bleomycin-induced pulmonary fibrosis by follistatin. Am J Respir Crit Care Med 2005;172:713-720. (Pubitemid 41324226)
7. Cho SH, Yao Z, Wang SW, Alban RF, Barbers RG, French SW, Oh CK. Regulation of activin A expression in mast cells and asthma: its effect on the proliferation of human airway smooth muscle cells. J Immunol 2003;170:4045-4052. (Pubitemid 36428166)
8. Le AV, Cho JY, Miller M, McElwain S, Golgotiu K, Broide DH. Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice. J Immunol 2007;178:7310-7316. (Pubitemid 46847458)
9. Phillips DJ. The activin/inhibin family. In: Thomson A, Lotze MT, editors. The cytokine handbook, 4th ed. London: Academic Press; 2003. pp. 1153-1177.
10. Jones KL, De Kretser DM, Clarke IJ, Scheerlinck JP, Phillips DJ. Characterisation of the rapid release of activin a following acute lipopolysaccharide challenge in the ewe. J Endocrinol 2004;182:69-80.
11. Jones KL, Mansell A, Patella S, Scott BJ, Hedger MP, de Kretser DM, Phillips DJ. Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc Natl Acad Sci USA 2007;104:16239-16244. (Pubitemid 350099391)
12. Dohi T, Ejima C, Kato R, Kawamura YI, Kawashima R, Mizutani N, Tabuchi Y, Kojima I. Therapeutic potential of follistatin for colonic inflammation in mice. Gastroenterology 2005;128:411-423. (Pubitemid 40431093)
13. Abe M, Shintani Y, Eto Y, Harada K, Fujinaka Y, Kosaka M, Matsumoto T. Interleukin-1 beta enhances and interferon-gamma suppresses activin A actions by reciprocally regulating activin A and follistatin secretion from bone marrow stromal fibroblasts. Clin Exp Immunol 2001;126:64-68. (Pubitemid 32989493)
14. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 1998;282:2261-2263. (Pubitemid 29004075)
15. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-2261. (Pubitemid 29004074)
16. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002;8:885-889.
17. Wen FQ, Kohyama T, Liu X, Zhu YK, Wang H, Kim HJ, Kobayashi T, Abe S, Spurzem JR, Rennard SI. Interleukin-4- and interleukin-13- enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma. Am J Respir Cell Mol Biol 2002;26:484-490.
18. Richter A, Puddicombe SM, Lordan JL, Bucchieri F, Wilson SJ, Djukanovic R, Dent G, Holgate ST, Davies DE. The contribution of interleukin (IL)-4 and IL-13 to the epithelial-mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol 2001;25:385-391. (Pubitemid 32918922)
19. Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, Shipley JM, Gotwals P, Noble P, Chen Q, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001;194:809-821.
20. Hardy CL, Kenins L, Drew AC, Rolland JM, O'Hehir RE. Characterization of a mouse model of allergy to a major occupational latex glove allergen Hev b 5. Am J Respir Crit Care Med 2003;167:1393-1399.
21. O'Connor AE, McFarlane JR, Hayward S, Yohkaichiya T, Groome NP, de Kretser DM. Serum activin a and follistatin concentrations during human pregnancy: a cross-sectional and longitudinal study. Hum Reprod 1999;14:827-832.
22. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
23. McKenzie GJ, Emson CL, Bell SE, Anderson S, Fallon P, Zurawski G, Murray R, Grencis R, McKenzie AN. Impaired development of Th2 cells in IL-13-deficient mice. Immunity 1998;9:423-432.
24. Yang M, Hogan SP, Henry PJ, Matthaei KI, McKenzie AN, Young IG, Rothenberg ME, Foster PS. Interleukin-13 mediates airways hyper-reactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol 2001;25: 522-530.
25. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, McElwain K, McElwain S, Friedman S, Broide DH. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 2004;113:551-560.
26. Kobayashi T, Iijima K, Kita H. Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice. J Immunol 2003;170:5756-5763.
27. Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, et al. A critical role for eosinophils in allergic airways remodeling. Science 2004;305:1776-1779.
28. Mattes J, Yang M, Mahalingam S, Kuehr J, Webb DC, Simson L, Hogan SP, Koskinen A, McKenzie AN, Dent LA, et al. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyper-reactivity in experimental asthma. J Exp Med 2002;195:1433-1444.
29. Magnan A, Retornaz F, Tsicopoulos A, Brisse J, Van Pee D, Gosset P, Chamlian A, Tonnel AB, Vervloet D. Altered compartmentalization of transforming growth factor-beta in asthmatic airways. Clin Exp Allergy 1997;27:389-395.
30. Redington AE, Madden J, Frew AJ, Djukanovic R, Roche WR, Holgate ST, Howarth PH. Transforming growth factor-beta 1 in asthma: measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 1997;156:642-647.
31. McMillan SJ, Lloyd CM. Prolonged allergen challenge in mice leads to persistent airway remodelling. Clin Exp Allergy 2004;34:497-507.
32. Alcorn JF, Rinaldi LM, Jaffe EF, van Loon M, Bates JH, Janssen- Heininger YM, Irvin CG. Transforming growth factor-beta1 suppresses airway hyperresponsiveness in allergic airway disease. Am J Respir Crit Care Med 2007;176:974-982.
33. Robson NC, Phillips DJ, McAlpine T, Shin A, Svobodova S, Toy T, Pillay V, Kirkpatrick N, Zanker D, Wilson K, et al. Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production. Blood 2008;111:2733-2743.
34. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
35. Nusing RM, Barsig J. Induction of prostanoid, nitric oxide, and cytokine formation in rat bone marrow derived macrophages by activin A. Br J Pharmacol 1999;127:919-926.