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Volumn 35, Issue 7, 2010, Pages 986-993

Effect of combination treatment of rapamycin and isoflavones on mtor pathway in human glioblastoma (U87) cells

Author keywords

Glioblastoma; Isoflavones; MTOR; Rapamycin

Indexed keywords

BIOCHANIN A; GENISTEIN; INITIATION FACTOR 4E; ISOFLAVONE DERIVATIVE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; RAPAMYCIN;

EID: 77953230474     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0142-2     Document Type: Article
Times cited : (31)

References (66)
  • 4
    • 44449112209 scopus 로고    scopus 로고
    • Regulation of glioblastoma cell invasion by PKCι and RhoB
    • DOI 10.1038/sj.onc.1211027, PII 1211027
    • RM Baldwin DA Parolin IA Lorimer 2008 Regulation of glioblastoma cell invasion by PKC iota and RhoB Oncogene 27 25 3587 3595 10.1038/sj.onc.1211027 1:CAS:528:DC%2BD1cXmslWlsrg%3D 18212741 (Pubitemid 351793806)
    • (2008) Oncogene , vol.27 , Issue.25 , pp. 3587-3595
    • Baldwin, R.M.1    Parolin, D.A.E.2    Lorimer, I.A.J.3
  • 5
    • 0347659463 scopus 로고    scopus 로고
    • Advances in molecular therapies in patients with brain tumors
    • 12712007
    • IW Tremont-Lukats MR Gilbert 2003 Advances in molecular therapies in patients with brain tumors Cancer Control 10 2 125 137 12712007
    • (2003) Cancer Control , vol.10 , Issue.2 , pp. 125-137
    • Tremont-Lukats, I.W.1    Gilbert, M.R.2
  • 6
    • 34447343798 scopus 로고    scopus 로고
    • Lessons learned in the development of targeted therapy for malignant gliomas
    • DOI 10.1158/1535-7163.MCT-07-0047
    • AM Omuro S Faivre E Raymond 2007 Lessons learned in the development of targeted therapy for malignant gliomas Mol Cancer Ther 6 7 1909 1919 10.1158/1535-7163.MCT-07-0047 1:CAS:528:DC%2BD2sXnsVyqu7k%3D 17620423 (Pubitemid 47052481)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.7 , pp. 1909-1919
    • Omuro, A.M.P.1    Faivre, S.2    Raymond, E.3
  • 7
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • 10.1038/nrc839 1:CAS:528:DC%2BD38XkvFKltLs%3D 12094235
    • I Vivanco CL Sawyers 2002 The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 489 501 10.1038/nrc839 1:CAS:528: DC%2BD38XkvFKltLs%3D 12094235
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 8
    • 0023429079 scopus 로고
    • Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification
    • 10.1073/pnas.84.19.6899 1:CAS:528:DyaL1cXktVyq 3477813
    • AJ Wong SH Bigner DD Bigner, et al. 1987 Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification Proc Natl Acad Sci 84 6899 6903 10.1073/pnas.84.19.6899 1:CAS:528:DyaL1cXktVyq 3477813
    • (1987) Proc Natl Acad Sci , vol.84 , pp. 6899-6903
    • Wong, A.J.1    Bigner, S.H.2    Bigner, D.D.3
  • 9
    • 16444368462 scopus 로고    scopus 로고
    • Genetic pathways to glioblastomas
    • DOI 10.1111/j.1440-1789.2004.00600.x
    • H Ohgaki 2005 Genetic pathways to glioblastomas Neuropathology 25 1 1 7 10.1111/j.1440-1789.2004.00600.x 15822813 (Pubitemid 40477707)
    • (2005) Neuropathology , vol.25 , Issue.1 , pp. 1-7
    • Ohgaki, H.1
  • 10
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3-kinase signaling pathway in glioblastoma patients in vivo
    • 1:CAS:528:DC%2BD3sXkt1aju7w%3D 12782577
    • G Choe S Horvath TF Cloughesy, et al. 2003 Analysis of the phosphatidylinositol 3-kinase signaling pathway in glioblastoma patients in vivo Cancer Res 63 2742 2746 1:CAS:528:DC%2BD3sXkt1aju7w%3D 12782577
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3
  • 12
    • 0010138067 scopus 로고    scopus 로고
    • AKT signal transduction pathway in oncogenesis
    • Springer, Berlin
    • Cheng JQ, Nicosia SV (2001) AKT signal transduction pathway in oncogenesis. Encylopedia reference of cancer. Springer, Berlin, pp 35-37
    • (2001) Encylopedia Reference of Cancer , pp. 35-37
    • Cheng, J.Q.1    Nicosia, S.V.2
  • 13
    • 33645473862 scopus 로고    scopus 로고
    • Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma
    • 10.1158/1535-7163.MCT-05-0453 1:CAS:528:DC%2BD28Xitl2ltLY%3D
    • D Koul R Shen S Bergh, et al. 2006 Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma Mol Can Therap 5 3 637 644 10.1158/1535-7163.MCT-05-0453 1:CAS:528:DC%2BD28Xitl2ltLY%3D
    • (2006) Mol Can Therap , vol.5 , Issue.3 , pp. 637-644
    • Koul, D.1    Shen, R.2    Bergh, S.3
  • 14
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • DOI 10.1101/gad.1212704
    • N Hay N Sonenberg 2004 Upstream and downstream of mTOR Genes Dev 18 1926 1945 10.1101/gad.1212704 1:CAS:528:DC%2BD2cXmvFKqsLk%3D 15314020 (Pubitemid 39071573)
    • (2004) Genes and Development , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 15
    • 32944456143 scopus 로고    scopus 로고
    • Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions
    • DOI 10.1158/0008-5472.CAN-05-3375
    • F Kaper N Dornhoefer AJ Giaccia 2006 Mutation in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions Cancer Res 66 3 1561 1569 10.1158/0008-5472.CAN-05-3375 1:CAS:528:DC%2BD28XpsVensw%3D%3D 16452213 (Pubitemid 43259938)
    • (2006) Cancer Research , vol.66 , Issue.3 , pp. 1561-1569
    • Kaper, F.1    Dornhoefer, N.2    Giaccia, A.J.3
  • 16
    • 2342559981 scopus 로고    scopus 로고
    • The TOR pathway: A target of cancer therapy
    • 10.1038/nrc1362 1:CAS:528:DC%2BD2cXjsFSlu7Y%3D 15122205
    • MA Bjornsti PJ Houghton 2004 The TOR pathway: a target of cancer therapy Nat Rev Cancer 4 335 348 10.1038/nrc1362 1:CAS:528:DC%2BD2cXjsFSlu7Y%3D 15122205
    • (2004) Nat Rev Cancer , vol.4 , pp. 335-348
    • Bjornsti, M.A.1    Houghton, P.J.2
  • 17
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • DOI 10.1038/sj.onc.1204091
    • M Hidalgo EK Rowinsky 2000 The rapamycin-sensitive signal transduction pathway as a target for cancer therapy Oncogene 19 6680 6686 10.1038/sj.onc.1204091 1:CAS:528:DC%2BD3MXhsF2rs7w%3D 11426655 (Pubitemid 32197708)
    • (2000) Oncogene , vol.19 , Issue.56 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 19
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • DOI 10.1101/gad.887201
    • AC Gingras B Raught N Sonenberg 2001 Regulation of translation initiation by FRAP/mTOR Genes Dev 15 807 826 10.1101/gad.887201 1:CAS:528: DC%2BD3MXivVams7k%3D 11297505 (Pubitemid 32295062)
    • (2001) Genes and Development , vol.15 , Issue.7 , pp. 807-826
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 20
    • 0036225178 scopus 로고    scopus 로고
    • Inhibitors of mammalian target of rapamycin as novel antitumor agents: From bench to clinic
    • 1:CAS:528:DC%2BD38Xmt1WqsLs%3D
    • S Huang PJ Houghton 2002 Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic Curr Opinion Invest Drugs 3 295 304 1:CAS:528:DC%2BD38Xmt1WqsLs%3D
    • (2002) Curr Opinion Invest Drugs , vol.3 , pp. 295-304
    • Huang, S.1    Houghton, P.J.2
  • 21
    • 0034901515 scopus 로고    scopus 로고
    • Biochemical correlates of mTOR inhibition by the rapamycin ester CC1-779 and tumor growth inhibition
    • 1:CAS:528:DC%2BD3MXltV2hsL4%3D 11410517
    • L Dudkin MB Dilling PJ Cheshire, et al. 2001 Biochemical correlates of mTOR inhibition by the rapamycin ester CC1-779 and tumor growth inhibition Clin Cancer Res 7 1758 1764 1:CAS:528:DC%2BD3MXltV2hsL4%3D 11410517
    • (2001) Clin Cancer Res , vol.7 , pp. 1758-1764
    • Dudkin, L.1    Dilling, M.B.2    Cheshire, P.J.3
  • 22
    • 0036776168 scopus 로고    scopus 로고
    • A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling
    • 10.1016/S0006-2952(02)01263-7
    • J Chen Y Fang 2004 A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling Biochem Pharmacol 64 1071 1077 10.1016/S0006-2952(02) 01263-7
    • (2004) Biochem Pharmacol , vol.64 , pp. 1071-1077
    • Chen, J.1    Fang, Y.2
  • 23
    • 50349083186 scopus 로고    scopus 로고
    • Changes in tumor metabolism as readout for mammalian target of rapamycin kinase inhibition by rapamycin in glioblastoma
    • 10.1158/1078-0432.CCR-07-1824 1:CAS:528:DC%2BD1cXmslygsbs%3D 18519772
    • LH Wei H Su IJ Hildebrandt, et al. 2008 Changes in tumor metabolism as readout for mammalian target of rapamycin kinase inhibition by rapamycin in glioblastoma Clin Cancer Res 14 11 3416 3426 10.1158/1078-0432.CCR-07-1824 1:CAS:528:DC%2BD1cXmslygsbs%3D 18519772
    • (2008) Clin Cancer Res , vol.14 , Issue.11 , pp. 3416-3426
    • Wei, L.H.1    Su, H.2    Hildebrandt, I.J.3
  • 24
    • 75049084471 scopus 로고    scopus 로고
    • Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
    • 10.1007/s11060-009-9950-0 1:CAS:528:DC%2BC3cXpsVSjtA%3D%3D 19562254
    • DA Reardon A Desjardins JJ Vredenburgh, et al. 2010 Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma J Neurooncol 96 2 219 230 10.1007/s11060-009-9950-0 1:CAS:528:DC%2BC3cXpsVSjtA%3D%3D 19562254
    • (2010) J Neurooncol , vol.96 , Issue.2 , pp. 219-230
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 25
    • 0034790016 scopus 로고    scopus 로고
    • MTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • DOI 10.1677/erc.0.0080249
    • K Yu L Toral-Barza C Discafani, et al. 2001 mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer Endocr Relat Cancer 8 249 258 10.1677/erc.0.0080249 11566616 (Pubitemid 32947647)
    • (2001) Endocrine-Related Cancer , vol.8 , Issue.3 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3    Zhang, W.-G.4    Skotnicki, J.5    Frost, P.6    Gibbons, J.J.7
  • 26
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • DOI 10.1016/j.bbrc.2003.09.132
    • N Gao Z Zhang BH Jiang, et al. 2003 Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer Biochem Biophys Res Commun 310 4 1124 1132 10.1016/j.bbrc.2003.09.132 1:CAS:528:DC%2BD3sXotVCisL4%3D 14559232 (Pubitemid 37237653)
    • (2003) Biochemical and Biophysical Research Communications , vol.310 , Issue.4 , pp. 1124-1132
    • Gao, N.1    Zhang, Z.2    Jiang, B.-H.3    Shi, X.4
  • 28
    • 7144223432 scopus 로고    scopus 로고
    • PTEN mutations in gliomas and glioneuronal tumors
    • 10.1038/sj.onc.1201756 1:CAS:528:DyaK1cXjtFegtbw%3D 9619835
    • EM Duerr B Rollbrocker Y Hayashi, et al. 1998 PTEN mutations in gliomas and glioneuronal tumors Oncogene 16 17 2259 2264 10.1038/sj.onc.1201756 1:CAS:528:DyaK1cXjtFegtbw%3D 9619835
    • (1998) Oncogene , vol.16 , Issue.17 , pp. 2259-2264
    • Duerr, E.M.1    Rollbrocker, B.2    Hayashi, Y.3
  • 30
    • 0035694808 scopus 로고    scopus 로고
    • Resistance to rapamycin: A novel anticancer drug
    • DOI 10.1023/A:1013167315885
    • S Huang PJ Houghton 2001 Resistance to rapamycin: a novel anticancer drug Cancer Metastasis Rev 20 1-2 69 78 10.1023/A:1013167315885 11831650 (Pubitemid 34074681)
    • (2001) Cancer and Metastasis Reviews , vol.20 , Issue.1-2 , pp. 69-78
    • Huang, S.1    Houghton, P.J.2
  • 31
    • 0035744033 scopus 로고    scopus 로고
    • Mechanisms of resistance to rapamycins
    • DOI 10.1054/drup.2002.0227
    • S Huang PJ Houghton 2001 Mechanisms of resistance to rapamycins Drug Resist Updat 4 6 378 391 10.1054/drup.2002.0227 1:CAS:528:DC%2BD38Xlsl2hsbc%3D 12030785 (Pubitemid 34746872)
    • (2001) Drug Resistance Updates , vol.4 , Issue.6 , pp. 378-391
    • Huang, S.1    Houghton, P.J.2
  • 33
    • 33644877965 scopus 로고    scopus 로고
    • Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells
    • 10.1593/neo.05361 1:CAS:528:DC%2BD2MXhtlClurvP 16242075
    • RD Rao AC Mladek JD Lamont, et al. 2005 Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells Neoplasia 7 10 921 929 10.1593/neo.05361 1:CAS:528:DC%2BD2MXhtlClurvP 16242075
    • (2005) Neoplasia , vol.7 , Issue.10 , pp. 921-929
    • Rao, R.D.1    Mladek, A.C.2    Lamont, J.D.3
  • 34
    • 13944269599 scopus 로고    scopus 로고
    • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition
    • 1:CAS:528:DC%2BD2MXksFyqsA%3D%3D 15657358
    • RK Goudar Q Shi MD Hjelmeland, et al. 2005 Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition Mol Cancer Ther 4 1 101 112 1:CAS:528:DC%2BD2MXksFyqsA%3D%3D 15657358
    • (2005) Mol Cancer Ther , vol.4 , Issue.1 , pp. 101-112
    • Goudar, R.K.1    Shi, Q.2    Hjelmeland, M.D.3
  • 35
    • 33746807790 scopus 로고    scopus 로고
    • Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
    • DOI 10.1212/01.wnl.0000223844.77636.29, PII 0000611420060711000038
    • L Doherty DC Gigas S Kesari, et al. 2006 Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas Neurology 67 1 156 158 10.1212/01.wnl.0000223844.77636.29 1:CAS:528:DC%2BD28XlvFylu7c%3D 16832099 (Pubitemid 44305484)
    • (2006) Neurology , vol.67 , Issue.1 , pp. 156-158
    • Doherty, L.1    Gigas, D.C.2    Kesari, S.3    Drappatz, J.4    Kim, R.5    Zimmerman, J.6    Ostrowsky, L.7    Wen, P.Y.8
  • 36
    • 59349089499 scopus 로고    scopus 로고
    • A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM)
    • 10.1007/s11060-008-9741-z 1:CAS:528:DC%2BD1MXhtVGjtLY%3D 19018475
    • TN Kreisl AB Lassman PS Mischel, et al. 2009 A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM) J Neurooncol 92 1 99 105 10.1007/s11060-008-9741-z 1:CAS:528:DC%2BD1MXhtVGjtLY%3D 19018475
    • (2009) J Neurooncol , vol.92 , Issue.1 , pp. 99-105
    • Kreisl, T.N.1    Lassman, A.B.2    Mischel, P.S.3
  • 37
    • 66349086978 scopus 로고    scopus 로고
    • Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation
    • 10.1158/0008-5472.CAN-08-3260 1:CAS:528:DC%2BD1MXmsFGltLY%3D 19458076
    • S Paternot PP Roger 2009 Combined inhibition of MEK and mammalian target of rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their proliferation Cancer Res 69 11 4577 4581 10.1158/0008-5472.CAN-08-3260 1:CAS:528:DC%2BD1MXmsFGltLY%3D 19458076
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4577-4581
    • Paternot, S.1    Roger, P.P.2
  • 38
    • 33947266995 scopus 로고    scopus 로고
    • Upstream signaling inhibition enhances rapamycin effect on growth of kidney cancer cells
    • DOI 10.1016/j.urology.2007.01.053, PII S0090429507001173
    • LJ Costa RM Gemmill HA Drabkin 2007 Upstream signaling inhibition enhances rapamycin effect on growth of kidney cancer cells Urology 69 3 596 602 10.1016/j.urology.2007.01.053 17382186 (Pubitemid 46428416)
    • (2007) Urology , vol.69 , Issue.3 , pp. 596-602
    • Costa, L.J.1    Gemmill, R.M.2    Drabkin, H.A.3
  • 39
    • 0028804581 scopus 로고
    • Epidemiology of soy and cancer: Perspectives and directions
    • 1:CAS:528:DyaK2MXktFGlsrw%3D 7884555
    • V Persky L Van Horn 1995 Epidemiology of soy and cancer: perspectives and directions J Nutr 125 3 709S 712S 1:CAS:528:DyaK2MXktFGlsrw%3D 7884555
    • (1995) J Nutr , vol.125 , Issue.3
    • Persky, V.1    Van Horn, L.2
  • 40
    • 0028910254 scopus 로고
    • Biochemical targets of the isoflavone genistein in tumor cell lines
    • 1:CAS:528:DyaK2MXivFehtLY%3D 7892283
    • S Barnes TG Peterson 1995 Biochemical targets of the isoflavone genistein in tumor cell lines Proc Soc Exp Biol Med 208 1 103 108 1:CAS:528: DyaK2MXivFehtLY%3D 7892283
    • (1995) Proc Soc Exp Biol Med , vol.208 , Issue.1 , pp. 103-108
    • Barnes, S.1    Peterson, T.G.2
  • 41
    • 0027464720 scopus 로고
    • Genistein, a dietary-derived inhibitor of in vitro angiogenesis
    • 10.1073/pnas.90.7.2690 1:CAS:528:DyaK3sXit1Ggsrw%3D 7681986
    • T Fotsis M Pepper H Adlercreutz, et al. 1993 Genistein, a dietary-derived inhibitor of in vitro angiogenesis Proc Natl Acad Sci USA 90 7 2690 2694 10.1073/pnas.90.7.2690 1:CAS:528:DyaK3sXit1Ggsrw%3D 7681986
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.7 , pp. 2690-2694
    • Fotsis, T.1    Pepper, M.2    Adlercreutz, H.3
  • 42
    • 0023664272 scopus 로고
    • Genistein, a specific inhibitor of tyrosine-specific protein kinases
    • 1:CAS:528:DyaL2sXktF2rurk%3D 3106339
    • T Akiyama J Ishida S Nakagawa, et al. 1987 Genistein, a specific inhibitor of tyrosine-specific protein kinases J Biol Chem 262 12 5592 5595 1:CAS:528:DyaL2sXktF2rurk%3D 3106339
    • (1987) J Biol Chem , vol.262 , Issue.12 , pp. 5592-5595
    • Akiyama, T.1    Ishida, J.2    Nakagawa, S.3
  • 43
    • 0026361965 scopus 로고
    • Inhibitory effects of biochanin A on mouse lung tumor induced by benzo(a)pyrene
    • 1:CAS:528:DyaK3sXks1amtLg%3D 1844641
    • YS Lee JS Seo HT Chung, et al. 1991 Inhibitory effects of biochanin A on mouse lung tumor induced by benzo(a)pyrene J Korean Med Sci 6 4 325 328 1:CAS:528:DyaK3sXks1amtLg%3D 1844641
    • (1991) J Korean Med Sci , vol.6 , Issue.4 , pp. 325-328
    • Lee, Y.S.1    Seo, J.S.2    Chung, H.T.3
  • 44
    • 0031752105 scopus 로고    scopus 로고
    • Growth inhibition of prostate cell lines in vitro by phyto-oestrogens
    • 1:CAS:528:DyaK1cXnsVWrurw%3D 9806188
    • J Hempstock JP Kavanagh NJ George 1998 Growth inhibition of prostate cell lines in vitro by phyto-oestrogens Br J Urol 82 4 560 563 1:CAS:528: DyaK1cXnsVWrurw%3D 9806188
    • (1998) Br J Urol , vol.82 , Issue.4 , pp. 560-563
    • Hempstock, J.1    Kavanagh, J.P.2    George, N.J.3
  • 45
    • 0036680526 scopus 로고    scopus 로고
    • Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts
    • DOI 10.1002/pros.10100
    • L Rice VG Samedi TA Medrano, et al. 2002 Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts Prostate 52 3 201 212 10.1002/pros.10100 1:CAS:528:DC%2BD38XmsVWqtbo%3D 12111696 (Pubitemid 34791222)
    • (2002) Prostate , vol.52 , Issue.3 , pp. 201-212
    • Rice, L.1    Samedi, V.G.2    Medrano, T.A.3    Sweeney, C.A.4    Baker, H.V.5    Stenstrom, A.6    Furman, J.7    Shiverick, K.T.8
  • 46
    • 0031016446 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain
    • DOI 10.1097/00006123-199701000-00032
    • PL Penar S Khoshyomn A Bhushan, et al. 1997 Inhibition of epidermal growth factor receptor-associated tyrosine kinase blocks glioblastoma invasion of the brain Neurosurgery 40 1 141 151 10.1097/00006123-199701000-00032 1:STN:280:DyaK2s7is12lug%3D%3D 8971836 (Pubitemid 26425661)
    • (1997) Neurosurgery , vol.40 , Issue.1 , pp. 141-151
    • Penar, P.L.1    Khoshyomn, S.2    Bhushan, A.3    Tritton, T.R.4
  • 47
    • 0031955049 scopus 로고    scopus 로고
    • Inhibition of glioma invasion of fetal brain aggregates
    • 1:CAS:528:DyaK1cXis1Kktbs%3D 9575429
    • PL Penar S Khoshyomn A Bhushan, et al. 1998 Inhibition of glioma invasion of fetal brain aggregates In Vivo 12 1 75 84 1:CAS:528:DyaK1cXis1Kktbs%3D 9575429
    • (1998) In Vivo , vol.12 , Issue.1 , pp. 75-84
    • Penar, P.L.1    Khoshyomn, S.2    Bhushan, A.3
  • 48
    • 77749271163 scopus 로고    scopus 로고
    • Biochanin A modulates cell viability, invasion and growth promoting signaling pathways in HER-2-positive breast cancer cells
    • Press
    • Sehdev V, Lai JC, Bhushan A (2009) Biochanin A modulates cell viability, invasion and growth promoting signaling pathways in HER-2-positive breast cancer cells. J Oncol (In Press)
    • (2009) J Oncol
    • Sehdev, V.1    Lai, J.C.2    Bhushan, A.3
  • 49
    • 33748453503 scopus 로고    scopus 로고
    • Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones
    • DOI 10.1007/s11060-006-9126-0
    • S Puli A Bhushan JC Lai 2006 Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones J Neurooncol 79 2 135 142 10.1007/s11060-006-9126-0 1:CAS:528:DC%2BD28XhtFemtLvL 16598420 (Pubitemid 44349940)
    • (2006) Journal of Neuro-Oncology , vol.79 , Issue.2 , pp. 135-142
    • Puli, S.1    Lai, J.C.K.2    Bhushan, A.3
  • 50
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • DOI 10.1158/0008-5472.CAN-05-0917
    • SY Sun LM Rosenberg X Wang, et al. 2005 Activation of Akt and eIF4E survival pathways by rapamycin mediated mammalian target of rapamycin inhibition Cancer Res 65 16 7052 7058 10.1158/0008-5472.CAN-05-0917 1:CAS:528: DC%2BD2MXns1Wrt7c%3D 16103051 (Pubitemid 41161231)
    • (2005) Cancer Research , vol.65 , Issue.16 , pp. 7052-7058
    • Sun, S.-Y.1    Rosenberg, L.M.2    Wang, X.3    Zhou, Z.4    Yue, P.5    Fu, H.6    Khuri, F.R.7
  • 51
    • 18644377225 scopus 로고    scopus 로고
    • MTOR promotes survival and astrocytic characteristics induced by Pten/Akt signaling in glioblastoma
    • DOI 10.1593/neo.04595
    • X Hu PP Pandolfi Y Li, et al. 2005 mTOR promotes survival and astrocytic characteristics induced by Pten/Akt signaling in glioblastoma Neoplasia 7 4 356 368 10.1593/neo.04595 1:CAS:528:DC%2BD2MXkvFeqtLs%3D 15967113 (Pubitemid 40664225)
    • (2005) Neoplasia , vol.7 , Issue.4 , pp. 356-368
    • Hu, X.1    Pandolfi, P.P.2    Li, Y.3    Koutcher, J.A.4    Rosenblum, M.5    Holland, E.C.6
  • 52
    • 0028328655 scopus 로고
    • Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type i insulin-like growth factor receptor
    • 1:CAS:528:DyaK2cXitVyju74%3D 7508822
    • MB Dilling P Dias DN Shapiro, et al. 1994 Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor Cancer Res 54 4 903 907 1:CAS:528:DyaK2cXitVyju74%3D 7508822
    • (1994) Cancer Res , vol.54 , Issue.4 , pp. 903-907
    • Dilling, M.B.1    Dias, P.2    Shapiro, D.N.3
  • 53
    • 0031755688 scopus 로고    scopus 로고
    • Studies on the mechanism of resistance to rapamycin in human cancer cells
    • 1:CAS:528:DyaK1cXntlOntLg%3D 9804616
    • H Hosoi MB Dilling LN Liu, et al. 1998 Studies on the mechanism of resistance to rapamycin in human cancer cells Mol Pharmacol 54 815 824 1:CAS:528:DyaK1cXntlOntLg%3D 9804616
    • (1998) Mol Pharmacol , vol.54 , pp. 815-824
    • Hosoi, H.1    Dilling, M.B.2    Liu, L.N.3
  • 54
    • 0037115523 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy
    • 1:CAS:528:DC%2BD3sXhtV2jsA%3D%3D 12499272
    • JS Eshleman BL Carlson AC Mladek, et al. 2002 Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy Cancer Res 62 7291 7297 1:CAS:528:DC%2BD3sXhtV2jsA%3D%3D 12499272
    • (2002) Cancer Res , vol.62 , pp. 7291-7297
    • Eshleman, J.S.1    Carlson, B.L.2    Mladek, A.C.3
  • 56
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • DOI 10.1210/me.14.6.783
    • T Haruta T Uno J Kawahara, et al. 2000 A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1 Mol Endocrinol 14 6 783 789 10.1210/me.14.6.783 1:CAS:528:DC%2BD3cXlt1Wgtr8%3D 10847581 (Pubitemid 32260492)
    • (2000) Molecular Endocrinology , vol.14 , Issue.6 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6    Olefsky, J.M.7    Kobayashi, M.8
  • 57
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • DOI 10.1016/S0092-8674(02)00808-5
    • DH Kim DD Sarbassov SM Ali, et al. 2002 mTOR interacts with raptor to form nutrient-sensitive complex that signals to the cell growth machinery Cell 110 163 175 10.1016/S0092-8674(02)00808-5 1:CAS:528:DC%2BD38XlvV2htr4%3D 12150925 (Pubitemid 34876545)
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 58
    • 1942487890 scopus 로고    scopus 로고
    • Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
    • DOI 10.1111/j.1356-9597.2004.00727.x
    • N Oshiro K Yoshino S Hidayat, et al. 2004 Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function Genes Cells 9 359 366 10.1111/j.1356-9597.2004.00727.x 1:CAS:528:DC%2BD2cXjsVGqu7o%3D 15066126 (Pubitemid 38514871)
    • (2004) Genes to Cells , vol.9 , Issue.4 , pp. 359-366
    • Oshiro, N.1    Yoshino, K.-I.2    Hidayat, S.3    Tokunaga, C.4    Hara, K.5    Eguchi, S.6    Avruch, J.7    Yonezawa, K.8
  • 59
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • DOI 10.1126/science.1106148
    • DD Sarbassov DA Guertin SM Ali, et al. 2005 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex Science 307 5712 1098 1101 10.1126/science.1106148 1:CAS:528:DC%2BD2MXhtlSrtbY%3D 15718470 (Pubitemid 40262113)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 60
    • 67649958571 scopus 로고    scopus 로고
    • Current status and challenges associated with targeting mTOR for cancer therapy
    • 1:CAS:528:DC%2BD1MXovFSnsbo%3D
    • RJ Dowling M Pollak N Sonenberg 2009 Current status and challenges associated with targeting mTOR for cancer therapy Bio Drugs 23 2 77 91 1:CAS:528:DC%2BD1MXovFSnsbo%3D
    • (2009) Bio Drugs , vol.23 , Issue.2 , pp. 77-91
    • Dowling, R.J.1    Pollak, M.2    Sonenberg, N.3
  • 61
    • 70449457461 scopus 로고    scopus 로고
    • Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility
    • 1:CAS:528:DC%2BD1MXht1Wju7nP 19724909
    • N Gulati M Karsy L Albert, et al. 2009 Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility Int J Oncol 35 4 731 740 1:CAS:528:DC%2BD1MXht1Wju7nP 19724909
    • (2009) Int J Oncol , vol.35 , Issue.4 , pp. 731-740
    • Gulati, N.1    Karsy, M.2    Albert, L.3
  • 62
    • 62849111751 scopus 로고    scopus 로고
    • Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: Competition with rapamycin
    • 10.1128/MCB.00782-08 1:CAS:528:DC%2BD1MXjt1Wls7o%3D 19114562
    • A Toschi E Lee L Xu, et al. 2009 Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin Mol Cell Biol 29 6 1411 1420 10.1128/MCB.00782-08 1:CAS:528:DC%2BD1MXjt1Wls7o%3D 19114562
    • (2009) Mol Cell Biol , vol.29 , Issue.6 , pp. 1411-1420
    • Toschi, A.1    Lee, E.2    Xu, L.3
  • 63
    • 37549048521 scopus 로고    scopus 로고
    • MTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
    • 10.1158/0008-5472.CAN-07-2223 1:CAS:528:DC%2BD2sXhsVCjs7vJ 18089801
    • J Masri A Bernath J Martin, et al. 2007 mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor Cancer Res 67 24 11712 11720 10.1158/0008-5472.CAN-07-2223 1:CAS:528: DC%2BD2sXhsVCjs7vJ 18089801
    • (2007) Cancer Res , vol.67 , Issue.24 , pp. 11712-11720
    • Masri, J.1    Bernath, A.2    Martin, J.3
  • 64
    • 64849116285 scopus 로고    scopus 로고
    • Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002
    • 10.1111/j.1365-2133.2008.08991.x 1:CAS:528:DC%2BD1MXlvFOisrg%3D 19120326
    • J Werzowa D Cejka T Fuereder, et al. 2009 Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002 Br J Dermatol 160 5 955 964 10.1111/j.1365-2133.2008. 08991.x 1:CAS:528:DC%2BD1MXlvFOisrg%3D 19120326
    • (2009) Br J Dermatol , vol.160 , Issue.5 , pp. 955-964
    • Werzowa, J.1    Cejka, D.2    Fuereder, T.3


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