Structure and subunit composition of GABA(A) receptors

Neurochemistry International

Volumn 34, Issue 5, 1999, Pages 379-385

  Sieghart, W ^a   Fuchs, K ^a   Tretter, V ^a   Ebert, V ^a   Jechlinger, M ^a   Hoger H ^b   Adamiker, D ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Institute of Animal Breeding   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR;

ANIMAL CELL; BRAIN; CONFERENCE PAPER; ELECTROPHYSIOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; RECEPTOR BINDING; STOICHIOMETRY; THEORY;

ANIMALS; BRAIN CHEMISTRY; HUMANS; MACROMOLECULAR SUBSTANCES; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033004375     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(99)00045-5     Document Type: Conference Paper

References (71)

1. 2 S subunits produce unique ion channels with dissimilar single-channel properties. J. Neurosci. 13:1993;1429-1440.
2. A receptor deduced from mutation-induced rectification. NeuroReport. 5:1993;285-288.
3. Barnard E.A., Skolnick P., Olsen R.W., Möhler H., Sieghart W., Biggio G., Braestrup C., Bateson A.N., Langer S.Z. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50:1998;291-313.
4. A receptors containing α4 subunits do not contain γ or δ subunits, J. Biol. Chem. (in press).
5. A receptors display association of γ2-subunits with α1- and β2/3-subunits. J. Biol. Chem. 266:1991;4478-4483.
6. Bertrand D., Changeux J.P. Nicotinic receptor: an allosteric protein specialized for intercellular communication. Seminars Neurosci. 7:1995;75-90.
7. A receptor form ion channels with properties of the native receptor. Science. 242:1988;577-579.
8. 3H]GABA in the nerve terminals of rat cerebral cortex by electron microscopic autoradiography. Nature. 229:1971;628-630.
9. C receptors. Trends Neurosci. 11:1995;112-116.
10. A receptor subtypes: from pharmacology to molecular biology. FASEB J. 5:1991;2916-2923.
11. A receptor subunits in label-fracture replicas of cultured rat cerebellar granule cells. Recept. Channels. 2:1994;143-153.
12. A receptor. J. Neurosci. 16:1996;5415-5424.
13. Connolly C.N., Krishek B.J., McDonald B.J., Smart T.G., Moss S.J. Assembly and cell surface expression of heteromeric and homomeric γ-aminobutyric acid type A receptors. J. Biol. Chem. 271:1996;89-96.
14. Connolly C.N., Wooltorton J.R.A., Smart T.G., Moss S.J. Subcellular localization of γ-aminobutyric acid type A receptors is determined by receptor β subunits. Proc. Natl. Acad. Sci. USA. 93:1996;9899-9904.
15. Cooper S.J. Benzodiazepines and appetite: recent pre-clinical advances and their clinical implications. Human Psychopharmacol. 4:1989;81-89.
16. Cutting G.R., Lu L., O'Hara B.F., Kasch L.M., Montrose-Rafizadeh C., Donovan D.M., Shimada S., Antonarakis S.E., Guggino W.B., Uhl G.R., Kazazian H.H. Cloning of the γ-aminobutyric acid (GABA) ρ1 cDNA: a GABA receptor subunit highly expressed in the retina. Proc. Natl. Acad. Sci. USA. 88:1991;2673-2677.
17. A receptor subunit. Nature. 385:1997;820-823.
18. A receptors comprised of α1β3 and β3 subunits expressed in human embryonic kidney 293 cells. Br. J. Pharmacol. 120:1997;899-909.
19. A receptor α-subunit iso-oligomers. Demonstration of receptor populations containing α1α2, α1α3, and α2α3 subunit pairs. J. Biol. Chem. 266:1991;24778-24784.
20. A receptors by rapsyn. Neurochem. Internat. (MS# NCISV/98/85B(prov) Editorial reference NCISV/1998.00090 (NCI800).
21. C receptors. Vision Res. 38:1998;1431-1441.
22. C receptor ρ subunits are heterogeneously expressed in the human CNS and form homo- and hetero-oligomers with distinct physical properties. Eur. J. Neurosci. 11:1999;41-50.
23. ffrench-Constant R.H., Mortlock D.P., Shaffer C.D., MacIntyre R.J., Roush R.T. Molecular cloning and transformation of cyclodiene resistance in Drosophila: An invertebrate γ-aminobutyric acid subtype A receptor locus. Proc. Natl. Acad. Sci USA. 88:1991;7209-7213.
24. A receptors composed of single or multiple β subunit subtypes. Neuropharmacol. 36:1997;1601-1610.
25. Fritschy J.M., Benke D., Mertens S., Oertel W.H., Bachi T., Möhler H. Five subtypes of type A γ-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies. Proc. Natl. Acad. Sci. USA. 89:1992;6726-6730.
26. A-receptors in temporal lobe epilepsy. Neurochem. Inter. 34:1999;435-445.
27. Green W.N., Millar N.S. Ion-channel assembly. Trends Neurosci. 18:1995;280-287.
28. A receptor. FEBS Lett. 331:1993;211-216.
29. A receptor subunit in tissues of the reproductive system. J. Biol. Chem. 272:1997;15346-15350.
30. A receptor subunit requires a monomeric subunit of α6 or γ2. J. Biol. Chem. 270:1995;26063-26066.
31. A receptor modulation of memory: the role of endogenous benzodiazepines. Trends Pharmacol. Sci. 12:1991;260-265.
32. A receptors containing α6 subunits. J. Neurosci. 18:1998;2449-2457.
33. - ion flux measurements. Synapse. 13:1993;74-93.
34. A receptors isolated by selective immunoprecipitation from the cell surface. Neuropharmacol. 35:1996;1403-1411.
35. A/benzodiazepine receptor from rat cerebellum. J. Neurochem. 63:1994;371-374.
36. A receptors comprising the α3, β1 and γ2 subunits. Eur. J. Neurosci. 4:1992;1-9.
37. A receptor-ion channels: evalution of pharmacological and physiological properties. Mol. Pharmacol. 49:1996;494-504.
38. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci. 12:1992;1063-1076.
39. Li M., De Blas A.L. Coexistence of two β subunit isoforms in the same γ-aminobutyric acid type A receptor. J. Biol. Chem. 272:1997;16564-16569.
40. A/benzodiazepine receptor complex. J. Receptor Res. 11:1991;535-551.
41. A receptor channels. Ann. Rev. Neurosci. 17:1994;569-602.
42. A receptor populations with novel subunit combinations and drug-binding profiles identified in brain by α5- and δ-subunit specific immunopurification. J. Biol. Chem. 268:1993;5965-5973.
43. A receptors. J. Biol. Chem. 269:1994;25777-25782.
44. A receptor determined by electron microscope image analysis. J. Neurochem. 62:1994;815-818.
45. Nutt D.J., Glue P., Lawson C. The neurochemistry of anxiety: an update. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 14:1990;737-752.
46. Olsen R.W., Avoli M. GABA and epileptogenesis. Epilepsia. 38:1997;399-407.
47. A receptor subunits in the rat CNS. J. Comp. Neurol. 326:1992;193-216.
48. Pratt J.A. The neuroanatomical basis of anxiety. Pharmac. Ther. 55:1992;149-181.
49. A receptor subunits. Science. 242:1988;1306-1308.
50. Quirk K., Gillard N.P., Ragan C.I., Whiting P.J., McKernan R.M. γ-Aminobutyric acid type A receptors in the rat brain can contain both γ2 and γ3 subunits, but γ1 does not exist in combination with another γ-subunit. Mol. Pharmacol. 45:1994;1061-1070.
51. A receptors from rat brain. Eur. J. Pharmacol. 290:1995;175-181.
52. Sanna E., Garau F., Harris R.A. Novel properties of homomeric β1 γ-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital. Mol. Pharmacol. 47:1995;213-217.
53. Sarter M., Schneider H.H., Stephens D.N. Treatment strategies for senile dementia: antagonist β-carbolines. Trends Neurosci. 11:1988;13-16.
54. A receptor subunits: role of the δ subunit. J. Neurosci. 14:1994;7077-7086.
55. A receptor shows a ligand-gated receptor superfamily. Nature. 328:1987;221-227.
56. A receptor subunits exist in distinct neuronal subpopulations. Neuron. 3:1989;327-337.
57. A receptor subtypes. Pharmacol. Rev. 47:1995;181-234.
58. A receptor forms a picrotoxin-sensitive anion channel open in the absence of GABA. FEBS Lett. 257:1989;377-379.
59. A receptors on channel function. Neuron. 5:1990;703-711.
60. A receptors. Trends Pharmacol. Sci. 16:1995;162-168.
61. A receptor is concentrated in synaptic junctions containing the α1 and β2/3 subunits in hippocampus, cerebellum, and globus pallidus. Neuropharmacol. 35:1996;1425-1444.
62. A receptor subtype. J. Neurosci. 17:1997;2728-2737.
63. Turek F.W., Van Reeth O. Altering the mammalian circadian clock with the short-acting benzodiazepine triazolam. Trends Neurosci. 11:1988;535-541.
64. Verdoorn T.A. Formation of heteromeric γ-aminobutyric acid type A receptors containing two different α-subunits. Mol. Pharmacol. 45:1994;475-480.
65. A receptors depend upon subunit composition. Neuron. 4:1990;919-928.
66. A receptor subunit conferring atypical functional properties. J. Neurosci. 17:1997;5027-5037.
67. A receptor gene family: new targets for therapeutic intervention. Neurochem. Int. 34:1999;387-390.
68. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12:1992;1040-1062.
69. A receptors. Eur. J. Neurosci. 9:1997;2225-2235.
70. B receptors in mammalian brain: potential targets for drug development. Drug Dev. Res. 21:1990;161-167.
71. Abenzodiazepine receptors by immunoaffinity chromatography. FEBS Lett. 284:1991;15-18.