Contribution of the α1-GABAA receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists

Neuropharmacology

Volumn 43, Issue 4, 2002, Pages 679-684

  Crestani, F ^a   Assandri, R ^a   Tauber M ^a   Martin, J R ^b   Rudolph, U ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

DMCM; GABAA receptors; Inverse agonism; Knock in mice; Recombinant; Ro 15 4513

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; AZIDE; BENZODIAZEPINE DERIVATIVE; CARBOLINE DERIVATIVE; CHLORIDE CHANNEL; CONVULSANT AGENT; METHYL 6,7-DIMETHOXY-4-ETHYL-BETA-CARBOLINE-3-CARBOXYLATE; PENTETRAZOLE; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BETA CARBOLINE; LIGAND;

ANIMAL; ARTICLE; CELL LINE; DRUG EFFECT; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; HUMAN; MOTOR ACTIVITY; MOUSE; POINT MUTATION; RAT; TRANSGENIC MOUSE; ALLOSTERISM; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; BEHAVIOR; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG TARGETING; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; SEDATION; STIMULUS RESPONSE; WILD TYPE;

ANIMALS; AZIDES; BENZODIAZEPINES; CARBOLINES; CELL LINE; CHLORIDE CHANNELS; CONVULSANTS; ELECTROPHYSIOLOGY; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; PENTYLENETETRAZOLE; POINT MUTATION; RATS; TRANSFECTION;

EID: 0036707590     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00159-4     Document Type: Article

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