SL651498: An anxioselective compound with functional selectivity for α2- and α3-containing γ-aminobutyric acidA (GABAA) receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 753-768

  Griebel, Guy ^a   Perrault, Ghislaine ^a   Simiand, Jacques ^a   Cohen, Caroline ^a   Granger, Patrick ^a   Decobert, Michel ^a   Françon, Dominique ^a   Avenet, Patrick ^a   Depoortere, Henri ^a   Tan, Suon ^a   Oblin, André ^a   Schoemaker, Hans ^a   Evanno, Yannick ^a   Sevrin, Mireille ^a   George, Pascal ^a   Scatton, Bernard ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; 6 FLUORO 2,9 DIHYDRO 9 METHYL 2 PHENYL 4 (1 PYRROLIDINYLCARBONYL) 1H PYRIDO[3,4 B]INDOL 1 ONE; 6 FLUORO 9 METHYL 2 PHENYL 4 (PYRROLIDIN 1YLCARBONYL) 2,9 DIHYDRO 1H PYRIDO[3,4 B]INDOL 1 ONE; ALCOHOL; ANTICONVULSIVE AGENT; ANXIOLYTIC AGENT; CHLORDIAZEPOXIDE; DIAZEPAM; FLUMAZENIL; ISONIAZID; PENTETRAZOLE; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; ATAXIA; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; DISCRIMINATIVE STIMULUS; DRUG ALCOHOL INTERACTION; DRUG DEPENDENCE; DRUG DISCRIMINATION; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG TOLERABILITY; ELECTRIC SHOCK; ELECTROCORTICOGRAPHY; GRIP STRENGTH; HUMAN; HUMAN CELL; MALE; MAZE TEST; MOUSE; MUSCLE WEAKNESS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SEDATION; SLEEP WAKING CYCLE; SPINAL GANGLION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; ANXIETY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISCRIMINATION (PSYCHOLOGY); DRUG INTERACTIONS; DRUG TOLERANCE; ETHANOL; INDOLES; MALE; MEMBRANE POTENTIALS; MICE; MOTOR ACTIVITY; PATCH-CLAMP TECHNIQUES; PSYCHOMOTOR PERFORMANCE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, GABA-A; SUBSTANCE-RELATED DISORDERS;

EID: 0034920547     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. A receptors: Classification on the basis of subunit structure and receptor function
2. A receptors
3. A new method for the rapid screening of minor tranquillizers in mice
4. Multiple benzodiazepine receptors
5. 3H)diazepam binding
6. Pyrazoloquinolines: Second generation benzodiazepine receptor ligands have heterogeneous effects
7. Mechanism of action of the hypnotic zolpidem in vivo
8. Zolpidem, a novel non-benzodiazepine hypnotic: I. Neuropharmacological and behavioral effects
9. A receptors
10. A model of 'antipredator' defense in Swiss-Webster mice: Effects of benzodiazepine receptor ligands with different intrinsic activities
11. New evidence that the pharmacological effects of benzodiazepine receptor ligands can be associated with activities at different BZ (ω) receptor subtypes
12. Comparison of the pharmacological properties of classical and novel BZ-ω receptor ligands
13. Alcohol, the chloride ionophore and endogenous ligands for benzodiazepine receptors
14. A simplified method of evaluating dose-effect experiments
15. Molecular and neuronal substrate for the selective attenuation of anxiety
16. A receptor subunit mRNAs in rat spinal cord and dorsal root ganglia
17. Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam
18. Ro 16-6028: A novel anxiolytic acting as a partial agonist at the benzodiazepine receptor
19. A method for the routine assessment of fore- and hindlimb grip strength of rats and mice
20. Behavioural validation of a light/dark choice procedure for testing anti-anxiety agents
21. Benzodiazepine receptor: Demonstration in the central nervous system
22. Bi-directional changes in the levels of messenger RNAs encoding gamma-aminobutyric acidA receptor alpha subunits after flurazepam treatment
23. Validation of open: Closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
24. Differences in pharmacological profiles of a new generation of benzodiazepine and non-benzodiazepine hypnotics
25. Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem
26. Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence
27. A receptor subtypes
28. A/benzodiazepine receptor complex in the rat nervous system
29. A receptor subtypes
30. The behavioural effects of novel benzodiazepine (ω) receptor agonists and partial agonists: Increases in punished responding and antagonism of the pentylenetetrazole cue
31. A receptors: Differential profiles and receptor selectivity
32. Behavioral effects of nonbenzodiazepine anxiolytic drugs: A comparison of CGS 9896 and zopiclone with chlordiazepoxide
33. Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem
34. The discriminative stimulus properties of zolpidem, a novel imidazopyridine hypnotic
35. Neurochemical characteristics of amisulpride, an atypical dopamine D-2/D-3 receptor antagonist with both presynaptic and limbic selectivity
36. 5-containing omega/benzodiazepine receptor subtype in rat brain
37. Anticonvulsant action of the β-carboline abecarnil: Studies in rodents and baboon, Papio papio
38. A simple and reliable conflict procedure for testing anti-anxiety agents
39. A rapid screening method for the assessment of benzodiazepine receptor-related physical dependence in mice. Evaluation of benzodiazepine-related agonists and partial agonists
40. The pharmacological properties of Y-23684, a benzodiazepine receptor partial agonist
41. Receptor subtype-selective drugs: A new generation of anxiolytics and hypnotics