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Volumn 11, Issue 6, 2010, Pages 404-413

When pathways collide: Collaboration and connivance among signalling proteins in development

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; WNT PROTEIN;

EID: 77952954695     PISSN: 14710072     EISSN: 14710080     Source Type: Journal    
DOI: 10.1038/nrm2902     Document Type: Review
Times cited : (122)

References (93)
  • 1
    • 0019982538 scopus 로고
    • The role of protein phosphorylation in neural and hormonal control of cellular activity
    • Cohen, P. The role of protein phosphorylation in neural and hormonal control of cellular activity. Nature 296, 613-620 (1982).
    • (1982) Nature , vol.296 , pp. 613-620
    • Cohen, P.1
  • 2
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • van Amerongen, R. & Nusse, R. Towards an integrated view of Wnt signaling in development. Development 136, 3205-3214 (2009).
    • (2009) Development , vol.136 , pp. 3205-3214
    • Van Amerongen, R.1    Nusse, R.2
  • 3
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling: Components, mechanisms, and diseases
    • MacDonald, B. T., Tamai, K. & He, X. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17, 9-26 (2009).
    • (2009) Dev. Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 4
    • 57049097531 scopus 로고    scopus 로고
    • The Hippo-YAP pathway: New connections between regulation of organ size and cancer
    • Zhao, B., Lei, Q. Y. & Guan, K. L. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Curr. Opin. Cell Biol. 20, 638-646 (2008).
    • (2008) Curr. Opin. Cell Biol. , vol.20 , pp. 638-646
    • Zhao, B.1    Lei, Q.Y.2    Guan, K.L.3
  • 5
    • 39849097306 scopus 로고    scopus 로고
    • The emerging role of the Hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals
    • Zeng, Q. & Hong, W. The emerging role of the Hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 13, 188-192 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 188-192
    • Zeng, Q.1    Hong, W.2
  • 6
    • 0028568147 scopus 로고
    • Signaling by wingless in drosophila
    • Klingensmith, J. & Nusse, R. Signaling by Wingless in Drosophila. Dev. Biol. 166, 396-414 (1994).
    • (1994) Dev. Biol. , vol.166 , pp. 396-414
    • Klingensmith, J.1    Nusse, R.2
  • 7
    • 34249061491 scopus 로고    scopus 로고
    • Wilms tumor suppressor WTX negatively regulates WNT/β-catenin signaling
    • Major, M. B. et al. Wilms tumor suppressor WTX negatively regulates WNT/β-catenin signaling. Science 316, 1043-1046 (2007).
    • (2007) Science , vol.316 , pp. 1043-1046
    • Major, M.B.1
  • 8
    • 73149084197 scopus 로고    scopus 로고
    • Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway
    • Miller, B. W. et al. Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Mol. Syst. Biol. 5, 315 (2009).
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 315
    • Miller, B.W.1
  • 9
    • 62849106337 scopus 로고    scopus 로고
    • β-catenin hits chromatin: Regulation of Wnt target gene activation
    • Mosimann, C., Hausmann, G. & Basler, K. β-catenin hits chromatin: regulation of Wnt target gene activation. Nature Rev. Mol. Cell Biol. 10, 276-286 (2009).
    • (2009) Nature Rev. Mol. Cell Biol. , vol.10 , pp. 276-286
    • Mosimann, C.1    Hausmann, G.2    Basler, K.3
  • 10
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/β-catenin/TCF signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    • Jho, E. H. et al. Wnt/β-catenin/TCF signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell. Biol. 22, 1172-1183 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1172-1183
    • Jho, E.H.1
  • 11
    • 4243067196 scopus 로고    scopus 로고
    • The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
    • Lee, E., Salic, A., Kruger, R., Heinrich, R. & Kirschner, M. W. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 1, E10 (2003).
    • (2003) PLoS Biol. , vol.1
    • Lee, E.1    Salic, A.2    Kruger, R.3    Heinrich, R.4    Kirschner, M.W.5
  • 12
    • 42149131539 scopus 로고    scopus 로고
    • Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen
    • Benchabane, H., Hughes, E. G., Takacs, C. M., Baird, J. R. & Ahmed, Y. Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen. Development 135, 963-971 (2008).
    • (2008) Development , vol.135 , pp. 963-971
    • Benchabane, H.1    Hughes, E.G.2    Takacs, C.M.3    Baird, J.R.4    Ahmed, Y.5
  • 13
    • 33846193290 scopus 로고    scopus 로고
    • The many ways of Wnt in cancer
    • Polakis, P. The many ways of Wnt in cancer. Curr. Opin. Genet. Dev. 17, 45-51 (2007).
    • (2007) Curr. Opin. Genet. Dev. , vol.17 , pp. 45-51
    • Polakis, P.1
  • 14
    • 34249311572 scopus 로고    scopus 로고
    • Functional redundancy of GSK-3a and GSK-3(3 in Wnt/p-catenin signaling shown by using an allelic series of embryonic stem cell lines
    • Doble, B. W, Patel, S., Wood, G. A., Kockeritz, L. K. & Woodgett, J. R. Functional redundancy of GSK-3a and GSK-3(3 in Wnt/p-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev. Cell 12, 957-971 (2007).
    • (2007) Dev. Cell , vol.12 , pp. 957-971
    • Doble, B.W.1    Patel, S.2    Wood, G.A.3    Kockeritz, L.K.4    Woodgett, J.R.5
  • 16
    • 28644444440 scopus 로고    scopus 로고
    • Casein kinase 1 y couples Wnt receptor activation to cytoplasmic signal transduction
    • Davidson, G. et al. Casein kinase 1 y couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438, 867-872 (2005).
    • (2005) Nature , vol.438 , pp. 867-872
    • Davidson, G.1
  • 17
    • 28644439005 scopus 로고    scopus 로고
    • A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
    • Zeng, X. et al. A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature 438, 873-877 (2005).
    • (2005) Nature , vol.438 , pp. 873-877
    • Zeng, X.1
  • 18
    • 38949194936 scopus 로고    scopus 로고
    • Initiation of Wnt signaling: Control of Wnt coreceptor LRP6 phosphorylation/activation via Frizzled Dishevelled and Axin functions
    • Zeng, X. et al. Initiation of Wnt signaling: control of Wnt coreceptor LRP6 phosphorylation/activation via Frizzled, Dishevelled and Axin functions. Development 135, 367-375 (2008).
    • (2008) Development , vol.135 , pp. 367-375
    • Zeng, X.1
  • 19
    • 38349083255 scopus 로고    scopus 로고
    • Dual positive and negative regulation of Wingless signaling by Adenomatous polyposis coli
    • Takacs, C. M. et al. Dual positive and negative regulation of Wingless signaling by Adenomatous polyposis coli. Science 319, 333-336 (2008).
    • (2008) Science , vol.319 , pp. 333-336
    • Takacs, C.M.1
  • 20
    • 18444399216 scopus 로고    scopus 로고
    • Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
    • McManus, E. J. et al. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J. 24, 1571-1583 (2005).
    • (2005) EMBO J. , vol.24 , pp. 1571-1583
    • McManus, E.J.1
  • 21
    • 72149109797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling does not activate the Wnt cascade
    • Ng, S. S. et al. Phosphatidylinositol 3-kinase signaling does not activate the Wnt cascade. J. Biol. Chem. 284, 35308-35313 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 35308-35313
    • Ng, S.S.1
  • 22
    • 0029768676 scopus 로고    scopus 로고
    • An in vivo structure-function study of Armadillo, the β-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signaling
    • Orsulic, S. & Peifer, M. An in vivo structure-function study of Armadillo, the β-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signaling. J. Cell Biol. 134, 1283-1300 (1996).
    • (1996) J. Cell Biol. , vol.134 , pp. 1283-1300
    • Orsulic, S.1    Peifer, M.2
  • 23
    • 58149185543 scopus 로고    scopus 로고
    • Planar cell polarity signaling: From fly development to human disease
    • Simons, M. & Mlodzik, M. Planar cell polarity signaling: from fly development to human disease. Annu. Rev. Genet. 42, 517-540 (2008).
    • (2008) Annu. Rev. Genet. , vol.42 , pp. 517-540
    • Simons, M.1    Mlodzik, M.2
  • 24
    • 44649101853 scopus 로고    scopus 로고
    • Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling
    • Chen, W. S. et al. Asymmetric homotypic interactions of the atypical cadherin Flamingo mediate intercellular polarity signaling. Cell 133, 1093-1105 (2008).
    • (2008) Cell , vol.133 , pp. 1093-1105
    • Chen, W.S.1
  • 25
    • 0036333367 scopus 로고    scopus 로고
    • Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen
    • Lawrence, P. A., Casal, J. & Struhl, G. Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. Development 129, 2749-2760 (2002).
    • (2002) Development , vol.129 , pp. 2749-2760
    • Lawrence, P.A.1    Casal, J.2    Struhl, G.3
  • 26
    • 0037162283 scopus 로고    scopus 로고
    • Developmental compartments and planar polarity in Drosophila
    • Casal, J., Struhl, G. & Lawrence, P. A. Developmental compartments and planar polarity in Drosophila. Curr. Biol. 12, 1189-1198 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 1189-1198
    • Casal, J.1    Struhl, G.2    Lawrence, P.A.3
  • 27
    • 0037172663 scopus 로고    scopus 로고
    • The cadherins Fat and Dachsous regulate dorsal/ventral signaling in the Drosophila eye
    • Rawls, A. S., Guinto, J. B. & Wolff, T. The cadherins Fat and Dachsous regulate dorsal/ventral signaling in the Drosophila eye. Curr. Biol. 12, 1021-1026 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 1021-1026
    • Rawls, A.S.1    Guinto, J.B.2    Wolff, T.3
  • 28
    • 0037040407 scopus 로고    scopus 로고
    • Regulation of Frizzled by Fat-like cadherins during planar polarity signaling in the Drosophila compound eye
    • Yang, C. H., Axelrod, J. D. & Simon, M. A. Regulation of Frizzled by Fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell 108, 675-688 (2002).
    • (2002) Cell , vol.108 , pp. 675-688
    • Yang, C.H.1    Axelrod, J.D.2    Simon, M.A.3
  • 29
    • 48349125616 scopus 로고    scopus 로고
    • Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
    • Saburi, S. et al. Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease. Nature Genet. 40, 1010-1015 (2008).
    • (2008) Nature Genet. , vol.40 , pp. 1010-1015
    • Saburi, S.1
  • 30
    • 33845288905 scopus 로고    scopus 로고
    • Tw o separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
    • Casal, J., Lawrence, P. A. & Struhl, G. Tw o separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development 133, 4561-4572 (2006).
    • (2006) Development , vol.133 , pp. 4561-4572
    • Casal, J.1    Lawrence, P.A.2    Struhl, G.3
  • 31
    • 70349338886 scopus 로고    scopus 로고
    • The skinny on Fat: An enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity
    • Sopko, R. & McNeill, H. The skinny on Fat: an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity. Curr. Opin. Cell Biol. 21, 717-723 (2009).
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 717-723
    • Sopko, R.1    McNeill, H.2
  • 32
    • 0037324628 scopus 로고    scopus 로고
    • The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor
    • Fanto, M. et al. The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor. Development 130, 763-774 (2003).
    • (2003) Development , vol.130 , pp. 763-774
    • Fanto, M.1
  • 33
    • 4444240972 scopus 로고    scopus 로고
    • Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    • Matakatsu, H. & Blair, S. S. Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. Development 131, 3785-3794 (2004).
    • (2004) Development , vol.131 , pp. 3785-3794
    • Matakatsu, H.1    Blair, S.S.2
  • 34
    • 12344251185 scopus 로고    scopus 로고
    • Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression
    • Simon, M. A. Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression. Development 131, 6175-6184 (2004).
    • (2004) Development , vol.131 , pp. 6175-6184
    • Simon, M.A.1
  • 35
    • 69749095888 scopus 로고    scopus 로고
    • Convergence and extension movements during vertebrate gastrulation
    • Yin, C., Ciruna, B. & Solnica-Krezel, L. Convergence and extension movements during vertebrate gastrulation. Curr. Top. Dev. Biol. 89, 163-192 (2009).
    • (2009) Curr. Top. Dev. Biol. , vol.89 , pp. 163-192
    • Yin, C.1    Ciruna, B.2    Solnica-Krezel, L.3
  • 36
    • 0028929367 scopus 로고
    • Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos
    • Du, S. J., Purcell, S. M., Christian, J. L., McGrew, L. L. & Moon, R. T. Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol. Cell. Biol. 15, 2625-2634 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2625-2634
    • Du, S.J.1    Purcell, S.M.2    Christian, J.L.3    McGrew, L.L.4    Moon, R.T.5
  • 37
    • 0027965236 scopus 로고
    • Differential transformation of mammary epithelial cells by Wnt genes
    • Wong, G. T., Gavin, B. J. & McMahon, A. P. Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 14, 6278-6286 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6278-6286
    • Wong, G.T.1    Gavin, B.J.2    McMahon, A.P.3
  • 38
    • 67649470380 scopus 로고    scopus 로고
    • Proximal events in Wnt signal transduction
    • Angers, S. & Moon, R. T. Proximal events in Wnt signal transduction. Nature Rev. Mol. Cell Biol. 10, 468-477 (2009).
    • (2009) Nature Rev. Mol. Cell Biol. , vol.10 , pp. 468-477
    • Angers, S.1    Moon, R.T.2
  • 39
    • 0029939701 scopus 로고    scopus 로고
    • Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development
    • Torres, M. A. et al. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J. Cell Biol. 133, 1123-1137 (1996).
    • (1996) J. Cell Biol. , vol.133 , pp. 1123-1137
    • Torres, M.A.1
  • 40
    • 0033600239 scopus 로고    scopus 로고
    • The TAK1-NLK-MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
    • Ishitani, T. et al. The TAK1-NLK-MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF. Nature 399, 798-802 (1999).
    • (1999) Nature , vol.399 , pp. 798-802
    • Ishitani, T.1
  • 41
    • 0033600227 scopus 로고    scopus 로고
    • MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
    • Meneghini, M. D. et al. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature 399, 793-797 (1999).
    • (1999) Nature , vol.399 , pp. 793-797
    • Meneghini, M.D.1
  • 42
    • 0035869002 scopus 로고    scopus 로고
    • Naked cuticle targets Dishevelled to antagonize Wnt signal transduction
    • Rousset, R. et al. Naked cuticle targets Dishevelled to antagonize Wnt signal transduction. Genes Dev. 15, 658-671 (2001).
    • (2001) Genes Dev. , vol.15 , pp. 658-671
    • Rousset, R.1
  • 43
    • 0035957382 scopus 로고    scopus 로고
    • Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd
    • Yan, D. et al. Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc. Natl Acad. Sci. USA 98, 3802-3807 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3802-3807
    • Yan, D.1
  • 44
    • 74749106487 scopus 로고    scopus 로고
    • RORα attenuates Wnt/β-catenin signaling by PKCα-dependent phosphorylation in colon cancer
    • Lee, J. M. et al. RORα attenuates Wnt/β-catenin signaling by PKCα-dependent phosphorylation in colon cancer. Mol. Cell 37, 183-195 (2010).
    • (2010) Mol. Cell , vol.37 , pp. 183-195
    • Lee, J.M.1
  • 45
    • 73949156925 scopus 로고    scopus 로고
    • Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
    • Minami, Y., Oishi, I., Endo, M. & Nishita, M. Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev. Dyn. 239, 1-15 (2010).
    • (2010) Dev. Dyn. , vol.239 , pp. 1-15
    • Minami, Y.1    Oishi, I.2    Endo, M.3    Nishita, M.4
  • 46
    • 75649084593 scopus 로고    scopus 로고
    • Wnt5a regulates distinct signalling pathways by binding to Frizzled2
    • Sato, A., Yamamoto, H., Sakane, H., Koyama, H. & Kikuchi, A. Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J. 29, 41-54 (2010).
    • (2010) EMBO J. , vol.29 , pp. 41-54
    • Sato, A.1    Yamamoto, H.2    Sakane, H.3    Koyama, H.4    Kikuchi, A.5
  • 47
    • 77950526433 scopus 로고    scopus 로고
    • Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells
    • Matsumoto, S., Fumoto, K., Okamoto, T., Kaibuchi, K. & Kikuchi, A. Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells. EMBO J. 29, 1192-1204 (2010).
    • (2010) EMBO J. , vol.29 , pp. 1192-1204
    • Matsumoto, S.1    Fumoto, K.2    Okamoto, T.3    Kaibuchi, K.4    Kikuchi, A.5
  • 48
    • 44649182871 scopus 로고    scopus 로고
    • Original CIN: Reviewing roles for APC in chromosome instability
    • Rusan, N. M. & Peifer, M. Original CIN: reviewing roles for APC in chromosome instability. J. Cell Biol. 181, 719-726 (2008).
    • (2008) J. Cell Biol. , vol.181 , pp. 719-726
    • Rusan, N.M.1    Peifer, M.2
  • 49
    • 73849123750 scopus 로고    scopus 로고
    • The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
    • O'Connell, M. P. et al. The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma. Oncogene 29, 34-44 (2010).
    • (2010) Oncogene , vol.29 , pp. 34-44
    • O'Connell, M.P.1
  • 50
    • 36448970568 scopus 로고    scopus 로고
    • WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia
    • Roman-Gomez, J. et al. WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia. Eur. J. Cancer 43, 2736-2746 (2007).
    • (2007) Eur. J. Cancer , vol.43 , pp. 2736-2746
    • Roman-Gomez, J.1
  • 51
    • 10744219743 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway
    • Oishi, I. et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8, 645-654 (2003).
    • (2003) Genes Cells , vol.8 , pp. 645-654
    • Oishi, I.1
  • 52
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context
    • Mikels, A. J. & Nusse, R. Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context. PLoS Biol. 4, e115 (2006).
    • (2006) PLoS Biol. , vol.4
    • Mikels, A.J.1    Nusse, R.2
  • 53
    • 0030941498 scopus 로고    scopus 로고
    • A member of the Frizzled protein family mediating axis induction by Wnt-5A
    • He, X. et al. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275, 1652-1654 (1997).
    • (1997) Science , vol.275 , pp. 1652-1654
    • He, X.1
  • 54
    • 54249099446 scopus 로고    scopus 로고
    • Ror receptor tyrosine kinases: Orphans no more
    • Green, J. L., Kuntz, S. G. & Sternberg, P. W. Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol. 18, 536-544 (2008).
    • (2008) Trends Cell Biol. , vol.18 , pp. 536-544
    • Green, J.L.1    Kuntz, S.G.2    Sternberg, P.W.3
  • 55
    • 46049083566 scopus 로고    scopus 로고
    • Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex
    • Yamamoto, S. et al. Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15, 23-36 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 23-36
    • Yamamoto, S.1
  • 56
    • 2642583350 scopus 로고    scopus 로고
    • Wnt signaling: Ig-norrin the dogma
    • Clevers, H. Wnt signaling: Ig-norrin the dogma. Curr. Biol. 14, R436-R437 (2004).
    • (2004) Curr. Biol. , vol.14
    • Clevers, H.1
  • 57
    • 61749089153 scopus 로고    scopus 로고
    • The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    • Badouel, C. et al. The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev. Cell 16, 411-420 (2009).
    • (2009) Dev. Cell , vol.16 , pp. 411-420
    • Badouel, C.1
  • 58
    • 40849086201 scopus 로고    scopus 로고
    • Scalloped interacts with Yorkie, the nuclear effector of the Hippo tumor-suppressor pathway in Drosophila
    • Goulev, Y. et al. Scalloped interacts with Yorkie, the nuclear effector of the Hippo tumor-suppressor pathway in Drosophila. Curr. Biol. 18, 435-441 (2008).
    • (2008) Curr. Biol. , vol.18 , pp. 435-441
    • Goulev, Y.1
  • 59
    • 42049116586 scopus 로고    scopus 로고
    • The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway
    • Wu, S., Liu, Y., Zheng, Y., Dong, J. & Pan, D. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev. Cell 14, 388-398 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 388-398
    • Wu, S.1    Liu, Y.2    Zheng, Y.3    Dong, J.4    Pan, D.5
  • 60
    • 42049120338 scopus 로고    scopus 로고
    • The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    • Zhang, L. et al. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev. Cell 14, 377-387 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 377-387
    • Zhang, L.1
  • 61
    • 33750611115 scopus 로고    scopus 로고
    • Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
    • Bennett, F. C. & Harvey, K. F. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr. Biol. 16, 2101-2110 (2006).
    • (2006) Curr. Biol. , vol.16 , pp. 2101-2110
    • Bennett, F.C.1    Harvey, K.F.2
  • 62
    • 33749125438 scopus 로고    scopus 로고
    • Delineation of a Fat tumor suppressor pathway
    • Cho, E. et al. Delineation of a Fat tumor suppressor pathway. Nature Genet. 38, 1142-1150 (2006).
    • (2006) Nature Genet. , vol.38 , pp. 1142-1150
    • Cho, E.1
  • 63
    • 33750624298 scopus 로고    scopus 로고
    • The tumor-suppressor gene fat controls tissue growth upstream of Expanded in the Hippo signaling pathway
    • Silva, E., Tsatskis, Y., Gardano, L., Tapon, N. & McNeill, H. The tumor-suppressor gene fat controls tissue growth upstream of Expanded in the Hippo signaling pathway. Curr. Biol. 16, 2081-2089 (2006).
    • (2006) Curr. Biol. , vol.16 , pp. 2081-2089
    • Silva, E.1    Tsatskis, Y.2    Gardano, L.3    Tapon, N.4    McNeill, H.5
  • 64
    • 33750614445 scopus 로고    scopus 로고
    • The Fat cadherin acts through the Hippo tumor-suppressor pathway to regulate tissue size
    • Willecke, M. et al. The Fat cadherin acts through the Hippo tumor-suppressor pathway to regulate tissue size. Curr. Biol. 16, 2090-2100 (2006).
    • (2006) Curr. Biol. , vol.16 , pp. 2090-2100
    • Willecke, M.1
  • 65
    • 46149099112 scopus 로고    scopus 로고
    • The Hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity
    • Yu, J., Poulton, J., Huang, Y. C. & Deng, W. M. The Hippo pathway promotes Notch signaling in regulation of cell differentiation, proliferation, and oocyte polarity. PLoS One 3, e1761 (2008).
    • (2008) PLoS One , vol.3
    • Yu, J.1    Poulton, J.2    Huang, Y.C.3    Deng, W.M.4
  • 66
    • 35548970323 scopus 로고    scopus 로고
    • The Salvador-Warts-Hippo pathway is required for epithelial proliferation and axis specification in Drosophila
    • Meignin, C., Alvarez-Garcia, I., Davis, I. & Palacios, I. M. The Salvador-Warts-Hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr. Biol. 17, 1871-1878 (2007).
    • (2007) Curr. Biol. , vol.17 , pp. 1871-1878
    • Meignin, C.1    Alvarez-Garcia, I.2    Davis, I.3    Palacios, I.M.4
  • 67
    • 35548957838 scopus 로고    scopus 로고
    • Salvador-Warts-Hippo signaling promotes Drosophila posterior follicle cell maturation downstream of Notch
    • Polesello, C. & Tapon, N. Salvador-Warts-Hippo signaling promotes Drosophila posterior follicle cell maturation downstream of Notch. Curr. Biol. 17, 1864-1870 (2007).
    • (2007) Curr. Biol. , vol.17 , pp. 1864-1870
    • Polesello, C.1    Tapon, N.2
  • 68
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu, F. et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nature Cell Biol. 8, 27-36 (2006).
    • (2006) Nature Cell Biol. , vol.8 , pp. 27-36
    • Hamaratoglu, F.1
  • 69
    • 67649842389 scopus 로고    scopus 로고
    • Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase Discs overgrown
    • Sopko, R. et al. Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase Discs overgrown. Curr. Biol. 19, 1112-1117 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 1112-1117
    • Sopko, R.1
  • 70
    • 67749093511 scopus 로고    scopus 로고
    • Processing and phosphorylation of the Fat receptor
    • Feng, Y. & Irvine, K. D. Processing and phosphorylation of the Fat receptor. Proc. Natl Acad. Sci. USA 106, 11989-11994 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 11989-11994
    • Feng, Y.1    Irvine, K.D.2
  • 71
    • 76249109900 scopus 로고    scopus 로고
    • Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded
    • Yu, J. et al. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev. Cell 18, 288-299 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 288-299
    • Yu, J.1
  • 72
    • 76249125346 scopus 로고    scopus 로고
    • The WW domain protein Kibra acts upstream of Hippo in Drosophila
    • Baumgartner, R., Poernbacher, I., Buser, N., Hafen, E. & Stocker, H. The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev. Cell 18, 309-316 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 309-316
    • Baumgartner, R.1    Poernbacher, I.2    Buser, N.3    Hafen, E.4    Stocker, H.5
  • 73
    • 76249093838 scopus 로고    scopus 로고
    • Kibra is a regulator of the Salvador/Warts/Hippo signaling network
    • Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J. & Tapon, N. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev. Cell 18, 300-308 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 300-308
    • Genevet, A.1    Wehr, M.C.2    Brain, R.3    Thompson, B.J.4    Tapon, N.5
  • 74
    • 70349786516 scopus 로고    scopus 로고
    • Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling
    • Oh, H., Reddy, B. V. & Irvine, K. D. Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling. Dev. Biol. 335, 188-197 (2009).
    • (2009) Dev. Biol. , vol.335 , pp. 188-197
    • Oh, H.1    Reddy, B.V.2    Irvine, K.D.3
  • 75
    • 48749101754 scopus 로고    scopus 로고
    • Morphogen control of wing growth through the Fat signaling pathway
    • Rogulja, D., Rauskolb, C. & Irvine, K. D. Morphogen control of wing growth through the Fat signaling pathway. Dev. Cell 15, 309-321 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 309-321
    • Rogulja, D.1    Rauskolb, C.2    Irvine, K.D.3
  • 76
    • 47749136645 scopus 로고    scopus 로고
    • The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating Dally and Dally-like
    • Baena-Lopez, L. A., Rodriguez, I. & Baonza, A. The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating Dally and Dally-like. Proc. Natl Acad. Sci. USA 105, 9645-9650 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9645-9650
    • Baena-Lopez, L.A.1    Rodriguez, I.2    Baonza, A.3
  • 77
    • 55849112207 scopus 로고    scopus 로고
    • Signalling molecules, growth regulators and cell cycle control in Drosophila
    • Herranz, H. & Milan, M. Signalling molecules, growth regulators and cell cycle control in Drosophila. Cell Cycle 7, 3335-3337 (2008).
    • (2008) Cell Cycle , vol.7 , pp. 3335-3337
    • Herranz, H.1    Milan, M.2
  • 78
    • 70349624119 scopus 로고    scopus 로고
    • Transcription factor choice in the Hippo signaling pathway: Homothorax and Yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    • Peng, H. W., Slattery, M. & Mann, R. S. Transcription factor choice in the Hippo signaling pathway: Homothorax and Yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc. Genes Dev. 23, 2307-2319 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 2307-2319
    • Peng, H.W.1    Slattery, M.2    Mann, R.S.3
  • 79
    • 70350780570 scopus 로고    scopus 로고
    • Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways
    • Alarcon, C. et al. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways. Cell 139, 757-769 (2009).
    • (2009) Cell , vol.139 , pp. 757-769
    • Alarcon, C.1
  • 80
    • 72549090299 scopus 로고    scopus 로고
    • YAP1 is amplified and up-regulated in Hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
    • Fernandez, L. A. et al. YAP1 is amplified and up-regulated in Hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 23, 2729-2741 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 2729-2741
    • Fernandez, L.A.1
  • 81
    • 77951915105 scopus 로고    scopus 로고
    • The Hippo pathway regulates Wnt/β-catenin signalling
    • Varelas, X. et al. The Hippo pathway regulates Wnt/β-catenin signalling. Dev. Cell 18, 579-591 (2010).
    • (2010) Dev. Cell , vol.18 , pp. 579-591
    • Varelas, X.1
  • 82
    • 77950470207 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120
    • Yuan, Z. et al. Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J. Biol. Chem. 285, 3815-3824 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 3815-3824
    • Yuan, Z.1
  • 83
    • 73349128777 scopus 로고    scopus 로고
    • YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
    • Zhang, J. et al. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nature Cell Biol. 11, 1444-1450 (2009).
    • (2009) Nature Cell Biol. , vol.11 , pp. 1444-1450
    • Zhang, J.1
  • 84
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • Zhou, D. et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16, 425-438 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1
  • 85
    • 34248595035 scopus 로고    scopus 로고
    • Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
    • Owens, D. M. & Keyse, S. M. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26, 3203-3213 (2007).
    • (2007) Oncogene , vol.26 , pp. 3203-3213
    • Owens, D.M.1    Keyse, S.M.2
  • 86
    • 70349695861 scopus 로고    scopus 로고
    • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
    • Huang, S. M. et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461, 614-620 (2009).
    • (2009) Nature , vol.461 , pp. 614-620
    • Huang, S.M.1
  • 87
    • 41549132691 scopus 로고    scopus 로고
    • Quantitative analysis of pathways controlling extrinsic apoptosis in single cells
    • Albeck, J. G. et al. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol. Cell 30, 11-25 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 11-25
    • Albeck, J.G.1
  • 88
    • 62049085035 scopus 로고    scopus 로고
    • The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
    • Arnold, H. K. et al. The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc. EMBO J. 28, 500-512 (2009).
    • (2009) EMBO J. , vol.28 , pp. 500-512
    • Arnold, H.K.1
  • 89
    • 71149092489 scopus 로고    scopus 로고
    • Evidence that fold-change, and not absolute level, of β-catenin dictates Wnt signaling
    • Goentoro, L. & Kirschner, M. W. Evidence that fold-change, and not absolute level, of β-catenin dictates Wnt signaling. Mol. Cell 36, 872-884 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 872-884
    • Goentoro, L.1    Kirschner, M.W.2
  • 90
    • 76749147440 scopus 로고    scopus 로고
    • Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo
    • Buchert, M. et al. Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo. PLoS Genet. 6, e1000816 (2010).
    • (2010) PLoS Genet. , vol.6
    • Buchert, M.1
  • 91
    • 58149239950 scopus 로고    scopus 로고
    • The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex
    • Yokota, Y. et al. The adenomatous polyposis coli protein is an essential regulator of radial glial polarity and construction of the cerebral cortex. Neuron 61, 42-56 (2009).
    • (2009) Neuron , vol.61 , pp. 42-56
    • Yokota, Y.1
  • 92
    • 71149099313 scopus 로고    scopus 로고
    • The incoherent feedforward loop can provide fold-change detection in gene regulation
    • Goentoro, L., Shoval, O., Kirschner, M. W. & Alon, U. The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol. Cell 36, 894-899 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 894-899
    • Goentoro, L.1    Shoval, O.2    Kirschner, M.W.3    Alon, U.4
  • 93
    • 80051806451 scopus 로고    scopus 로고
    • GSK-3 is a master regulator of neural progenitor homeostasis
    • Kim, W. Y. et al. GSK-3 is a master regulator of neural progenitor homeostasis. Nature Neurosci. 12, 1390-1397 (2009).
    • (2009) Nature Neurosci. , vol.12 , pp. 1390-1397
    • Kim, W.Y.1


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