Naked cuticle targets dishevelled to antagonize Wnt signal transduction

Genes and Development

Volumn 15, Issue 6, 2001, Pages 658-671

  Rousset, Raphaël ^a   Mack, Judith A ^a,c   Wharton Jr , Keith A ^a,d   Axelrod, Jeffrey D ^a   Cadigan, Ken M ^a,b   Fish, Matthew P ^a   Nusse, Roel ^a   Scott, Matthew P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c DEPARTMENT OF COLORECTAL SURGERY   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Dishevelled; Drosophila; Naked cuticle; Segmentation; Wnt wingless; Zeste white 3

Indexed keywords

BETA CATENIN;

ANIMAL CELL; ARMADILLO; ARTICLE; CONTROLLED STUDY; CUTICLE; DNA FLANKING REGION; DROSOPHILA; EMBRYO DEATH; GENE EXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; YEAST;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ARMADILLO DOMAIN PROTEINS; BODY PATTERNING; COS CELLS; CROSSES, GENETIC; DROSOPHILA; DROSOPHILA PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPISTASIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; INSECT PROTEINS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MUTAGENESIS; MUTATION; PHENOTYPE; PHOSPHOPROTEINS; PHOTORECEPTORS, INVERTEBRATE; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES; WNT PROTEINS; ZEBRAFISH PROTEINS;

ANIMALIA; ARMADILLO; HEXAPODA;

EID: 0035869002     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.869201     Document Type: Article

References (61)

1. β-catenin is a target for the ubiquitin-proteasome pathway
2. Regulation of Armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development
3. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and wingless signaling pathways
4. Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos
5. A new member of the frizzled family from Drosophila functions as a wingless receptor
6. An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2 + subfamily
7. Dishevelled: At the crossroads of divergent intracellular signaling pathways
8. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
9. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the wingless signal in Drosophila
10. Wingless signaling in the Drosophila eye and embryonic epidermis
11. Wnt signaling: A common theme in animal development
12. Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments
13. Wingless repression of Drosophila frizzled 2 expression shapes the wingless morphogen gradient in the wing
14. Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila
15. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis
16. Drosophila wingless generates cell type diversity among engrailed expressing cells
17. Feedback control of intercellular signalling in development
18. A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster
19. Negative regulation of wingless signaling by D-axin, a Drosophila homolog of axin
20. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin
21. Role of the Drosophila patched gene in positional signalling
22. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. II. Zygotic loci on the third chromosome
23. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
24. Signaling by wingless in Drosophila
25. The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal
26. A single frizzled protein has a dual function in tissue polarity
27. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
28. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt- mediated regulation of LEF-1
29. Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo
30. Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
31. Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo
32. The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo
33. Dishevelled and Armadillo act in the wingless signalling pathway in Drosophila
34. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
35. Spitz and wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis
36. Negative regulation of Armadillo, a wingless effector in Drosophila
37. The segment polarity gene Armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin
38. Wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo
39. Multiple functions of segment polarity genes in Drosophila
40. Multiple functions of a Drosophila homeotic gene, zeste-white 3, during segmentation and neurogenesis
41. Negative feedback mechanisms and their roles during pattern formation
42. Casein kinase I transduces Wnt signals
43. Wnt signaling and cancer
44. Frizzled signaling and the developmental control of cell polarity
45. Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3
46. Wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate
47. Components of wingless signalling in Drosophila
48. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype
49. Antagonism between EGFR and wingless signalling in the larval cuticle of Drosophila
50. Dishevelled is required during wingless signaling to establish both cell polarity and cell identity
51. Decoding vectorial information from a gradient: Sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye
52. Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
53. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
54. Cell patterning in the Drosophila segment: Engrailed and wingless antigen distributions in segment polarity mutant embryos
55. The state of engrailed expression is not clonally transmitted during early Drosophila development
56. Dishevelled controls cell polarity during Xenopus gastrulation
57. Casein kinase 2 associates with and phosphorylates dishevelled
58. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
59. The dishevelled protein is modified by wingless signaling in Drosophila
60. The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
61. Naked cuticle encodes an inducible antagonist of Wnt signalling