The Salvador-Warts-Hippo Pathway Is Required for Epithelial Proliferation and Axis Specification in Drosophila

Current Biology

Volumn 17, Issue 21, 2007, Pages 1871-1878

  Meignin, Carine ^a   Alvarez Garcia, Ines ^b   Davis, Ilan ^a   Palacios, Isabel M ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

DEVBIO

Indexed keywords

CELL CYCLE PROTEIN; DROSOPHILA PROTEIN; HPO PROTEIN, DROSOPHILA; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SALVADOR PROTEIN, DROSOPHILA; UNCLASSIFIED DRUG; WARTS PROTEIN, DROSOPHILA;

ANIMAL; ANIMAL EMBRYO; ARTICLE; CELL DIFFERENTIATION; CELL POLARITY; CELL PROLIFERATION; CYTOLOGY; DROSOPHILA MELANOGASTER; EPITHELIUM CELL; FEMALE; METABOLISM; OOCYTE; OOCYTE DEVELOPMENT; OVARY FOLLICLE; SIGNAL TRANSDUCTION;

ANIMALS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL POLARITY; CELL PROLIFERATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; EPITHELIAL CELLS; FEMALE; OOCYTES; OOGENESIS; OVARIAN FOLLICLE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 35548970323     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2007.09.062     Document Type: Article

References (40)

1. Lopez-Schier H. The polarisation of the anteroposterior axis in Drosophila. Bioessays 25 (2003) 781-791
2. Ruohola H., Bremer K.A., Baker D., Swedlow J.R., Jan L.Y., and Jan Y.N. Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila. Cell 66 (1991) 433-449
3. Gonzalez-Reyes A., and St Johnston D. Patterning of the follicle cell epithelium along the anterior-posterior axis during Drosophila oogenesis. Development 125 (1998) 2837-2846
4. Deng W.M., and Bownes M. Patterning and morphogenesis of the follicle cell epithelium during Drosophila oogenesis. Int. J. Dev. Biol. 42 (1998) 541-552
5. Sapir A., Schweitzer R., and Shilo B.Z. Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis. Development 125 (1998) 191-200
6. Gonzalez-Reyes A., Elliott H., and St Johnston D. Polarization of both major body axes in Drosophila by gurken-torpedo signalling. Nature 375 (1995) 654-658
7. Roth S., Neuman-Silberberg F.S., Barcelo G., and Schüpbach T. Cornichon and the EGF receptor signalling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila. Cell 81 (1995) 967-978
8. Deng W.M., and Ruohola-Baker H. Laminin A is required for follicle cell-oocyte signaling that leads to establishment of the anterior-posterior axis in Drosophila. Curr. Biol. 10 (2000) 683-686
9. Frydman H.M., and Spradling A.C. The receptor-like tyrosine phosphatase lar is required for epithelial planar polarity and for axis determination within drosophila ovarian follicles. Development 128 (2001) 3209-3220
10. MacDougall N., Lad Y., Wilkie G.S., Francis-Lang H., Sullivan W., and Davis I. Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyte. Development 128 (2001) 665-673
11. Hamaratoglu F., Willecke M., Kango-Singh M., Nolo R., Hyun E., Tao C., Jafar-Nejad H., and Halder G. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat. Cell Biol. 8 (2006) 27-36
12. Edgar B.A. From cell structure to transcription: Hippo forges a new path. Cell 124 (2006) 267-273
13. Hariharan I.K. Growth regulation: A beginning for the hippo pathway. Curr. Biol. 16 (2006) R1037-R1039
14. Hipfner D.R., and Cohen S.M. Connecting proliferation and apoptosis in development and disease. Nat. Rev. Mol. Cell Biol. 5 (2004) 805-815
15. Harvey K., and Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat. Rev. Cancer 7 (2007) 182-191
16. Harvey K.F., Pfleger C.M., and Hariharan I.K. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114 (2003) 457-467
17. Wu S., Huang J., Dong J., and Pan D. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114 (2003) 445-456
18. Huang J., Wu S., Barrera J., Matthews K., and Pan D. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122 (2005) 421-434
19. Deng W.M., Althauser C., and Ruohola-Baker H. Notch-Delta signaling induces a transition from mitotic cell cycle to endocycle in Drosophila follicle cells. Development 128 (2001) 4737-4746
20. Schaeffer V., Althauser C., Shcherbata H.R., Deng W.M., and Ruohola-Baker H. Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells. Curr. Biol. 14 (2004) 630-636
21. Fernandez-Minan A., Martin-Bermudo M.D., and Gonzalez-Reyes A. Integrin signaling regulates spindle orientation in Drosophila to preserve the follicular-epithelium monolayer. Curr. Biol. 17 (2007) 683-688
22. Edgar B.A., and Orr-Weaver T.L. Endoreplication cell cycles: More for less. Cell 105 (2001) 297-306
23. Lopez-Schier H., and St Johnston D. Delta signaling from the germ line controls the proliferation and differentiation of the somatic follicle cells during Drosophila oogenesis. Genes Dev. 15 (2001) 1393-1405
24. Bai J., and Montell D. Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis. Development 129 (2002) 5377-5388
25. Sun J., and Deng W.M. Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Dev. Cell 12 (2007) 431-442
26. Maitra S., Kulikauskas R.M., Gavilan H., and Fehon R.G. The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr. Biol. 16 (2006) 702-709
27. Poulton J.S., and Deng W.M. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc. Natl. Acad. Sci. USA 103 (2006) 12775-12780
28. Micklem D.R., Dasgupta R., Elliott H., Gergely F., Davidson C., Brand A., Gonzalez-Reyes A., and St Johnston D. The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila. Curr. Biol. 7 (1997) 468-478
29. Jia J., Zhang W., Wang B., Trinko R., and Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev. 17 (2003) 2514-2519
30. Xu T., Wang W., Zhang S., Stewart R.A., and Yu W. Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase. Development 121 (1995) 1053-1063
31. Boedigheimer M., and Laughon A. Expanded: A gene involved in the control of cell proliferation in imaginal discs. Development 118 (1993) 1291-1301
32. Bryant P.J., Huettner B., Held Jr. L.I., Ryerse J., and Szidonya J. Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila. Dev. Biol. 129 (1988) 541-554
33. Palacios I.M., and St Johnston D. Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte. Development 129 (2002) 5473-5485
34. Lee T., and Luo L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22 (1999) 451-461
35. D1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras. Development 119 (1993) 1359-1369
36. Chou T.B., and Perrimon N. The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics 144 (1996) 1673-1679
37. Xu T., and Rubin G.M. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117 (1993) 1223-1237
38. Wilkie G.S., Shermoen A.W., O'Farrell P.H., and Davis I. Transcribed genes are localized according to chromosomal position within polarized Drosophila embryonic nuclei. Curr. Biol. 9 (1999) 1263-1266
39. St Johnston D., Beuchle D., and Nusslein-Volhard C. Staufen, a gene required to localize maternal RNAs in the Drosophila egg. Cell 66 (1991) 51-63
40. Davis I. Visualising fluorescence in Drosophila-optimal detection in thick specimens. In: Allan V.J. (Ed). Protein Localisation by Fluorescence Microscopy: A Practical Approach (2000), Oxford University Press, Oxford 131-162