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Volumn 86, Issue 5, 2010, Pages 1243-1255

Metabolic flux distributions: Genetic information, computational predictions, and experimental validation

Author keywords

13C metabolic flux analysis; Flux balance analysis; Industrial biotechnology; Metabolic engineering; Metabolic network analysis; Synthetic biology

Indexed keywords

FLUX BALANCE ANALYSIS; INDUSTRIAL BIOTECHNOLOGY; METABOLIC ENGINEERING; METABOLIC FLUX ANALYSIS; METABOLIC NETWORK ANALYSIS; SYNTHETIC BIOLOGY;

EID: 77952891125     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-010-2506-6     Document Type: Short Survey
Times cited : (29)

References (108)
  • 1
    • 0037133671 scopus 로고    scopus 로고
    • Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis
    • H Akashi T Gojobori 2002 Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis Proc Natl Acad Sci USA 99 3695 3700
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3695-3700
    • Akashi, H.1    Gojobori, T.2
  • 2
    • 6044265058 scopus 로고    scopus 로고
    • Integration of gene expression data into genome-scale metabolic models
    • M Akesson J Forster J Nielsen 2004 Integration of gene expression data into genome-scale metabolic models Metab Eng 6 285 293
    • (2004) Metab Eng , vol.6 , pp. 285-293
    • Akesson, M.1    Forster, J.2    Nielsen, J.3
  • 3
    • 0036286631 scopus 로고    scopus 로고
    • Energy balance for analysis of complex metabolic networks
    • DA Beard SD Liang H Qian 2002 Energy balance for analysis of complex metabolic networks Biophys J 83 79 86
    • (2002) Biophys J , vol.83 , pp. 79-86
    • Beard, D.A.1    Liang, S.D.2    Qian, H.3
  • 4
    • 27744506402 scopus 로고    scopus 로고
    • Amplified expression of fructose 1, 6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources
    • J Becker C Klopprogge O Zelder E Heinzle C Wittmann 2005 Amplified expression of fructose 1, 6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources Appl Environ Microbiol 71 8587 8596
    • (2005) Appl Environ Microbiol , vol.71 , pp. 8587-8596
    • Becker, J.1    Klopprogge, C.2    Zelder, O.3    Heinzle, E.4    Wittmann, C.5
  • 5
    • 73249151004 scopus 로고    scopus 로고
    • Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum
    • J Becker C Klopprogge H Schroder C Wittmann 2009 Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum Appl Environ Microbiol 75 7866 7869
    • (2009) Appl Environ Microbiol , vol.75 , pp. 7866-7869
    • Becker, J.1    Klopprogge, C.2    Schroder, H.3    Wittmann, C.4
  • 6
    • 25444467580 scopus 로고    scopus 로고
    • 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast
    • 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast Genome Biol 6 R49
    • (2005) Genome Biol , vol.6 , pp. 49
    • Blank, L.M.1    Kuepfer, L.2    Sauer, U.3
  • 7
    • 48649109598 scopus 로고    scopus 로고
    • Metabolic capacity estimation of Escherichia coli as a platform for redox biocatalysis: Constraint-based modeling and experimental verification
    • LM Blank BE Ebert B Bühler A Schmid 2008 Metabolic capacity estimation of Escherichia coli as a platform for redox biocatalysis: constraint-based modeling and experimental verification Biotechnol Bioeng 100 1050 1065
    • (2008) Biotechnol Bioeng , vol.100 , pp. 1050-1065
    • Blank, L.M.1    Ebert, B.E.2    Bühler, B.3    Schmid, A.4
  • 8
    • 34249942028 scopus 로고    scopus 로고
    • Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genes
    • JG Bragg A Wagner 2007 Protein carbon content evolves in response to carbon availability and may influence the fate of duplicated genes Proc Biol Sci 274 1063 1070
    • (2007) Proc Biol Sci , vol.274 , pp. 1063-1070
    • Bragg, J.G.1    Wagner, A.2
  • 9
    • 58149354386 scopus 로고    scopus 로고
    • Protein material costs: Single atoms can make an evolutionary difference
    • JG Bragg A Wagner 2009 Protein material costs: single atoms can make an evolutionary difference Trends Genet 25 5 8
    • (2009) Trends Genet , vol.25 , pp. 5-8
    • Bragg, J.G.1    Wagner, A.2
  • 10
    • 1242274402 scopus 로고    scopus 로고
    • Flux coupling analysis of genome-scale metabolic network reconstructions
    • AP Burgard EV Nikolaev CH Schilling CD Maranas 2004 Flux coupling analysis of genome-scale metabolic network reconstructions Genome Res 14 301 312
    • (2004) Genome Res , vol.14 , pp. 301-312
    • Burgard, A.P.1    Nikolaev, E.V.2    Schilling, C.H.3    Maranas, C.D.4
  • 11
    • 0037142769 scopus 로고    scopus 로고
    • Metabolic pathway analysis of a recombinant yeast for rational strain development
    • R Carlson D Fell F Srienc 2002 Metabolic pathway analysis of a recombinant yeast for rational strain development Biotechnol Bioeng 79 121 134
    • (2002) Biotechnol Bioeng , vol.79 , pp. 121-134
    • Carlson, R.1    Fell, D.2    Srienc, F.3
  • 13
    • 34247254436 scopus 로고    scopus 로고
    • Incorporating metabolic flux ratios into constraint-based flux analysis by using artificial metabolites and converging ratio determinants
    • HS Choi TY Kim DY Lee SY Lee 2007 Incorporating metabolic flux ratios into constraint-based flux analysis by using artificial metabolites and converging ratio determinants J Biotechnol 129 696 705
    • (2007) J Biotechnol , vol.129 , pp. 696-705
    • Choi, H.S.1    Kim, T.Y.2    Lee, D.Y.3    Lee, S.Y.4
  • 14
    • 0037008673 scopus 로고    scopus 로고
    • Transcriptional regulation in constraints-based metabolic models of Escherichia coli
    • MW Covert BO Palsson 2002 Transcriptional regulation in constraints-based metabolic models of Escherichia coli J Biol Chem 277 28058 28064
    • (2002) J Biol Chem , vol.277 , pp. 28058-28064
    • Covert, M.W.1    Palsson, B.O.2
  • 15
    • 0032087026 scopus 로고    scopus 로고
    • Selection costs of amino acid substitutions in ColE1 and ColIa gene clusters harbored by Escherichia coli
    • CL Craig RS Weber 1998 Selection costs of amino acid substitutions in ColE1 and ColIa gene clusters harbored by Escherichia coli Mol Biol Evol 15 774 776
    • (1998) Mol Biol Evol , vol.15 , pp. 774-776
    • Craig, C.L.1    Weber, R.S.2
  • 17
    • 67349280647 scopus 로고    scopus 로고
    • Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast
    • BL de Bivort EO Perlstein S Kunes SL Schreiber 2009 Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast J Mol Evol 68 490 497
    • (2009) J Mol Evol , vol.68 , pp. 490-497
    • De Bivort, B.L.1    Perlstein, E.O.2    Kunes, S.3    Schreiber, S.L.4
  • 18
    • 33749250188 scopus 로고    scopus 로고
    • Rapid metabolism of glucose detected with FRET glucose nanosensors in epidermal cells and intact roots of Arabidopsis RNA-silencing mutants
    • K Deuschle B Chaudhuri S Okumoto I Lager S Lalonde WB Frommer 2006 Rapid metabolism of glucose detected with FRET glucose nanosensors in epidermal cells and intact roots of Arabidopsis RNA-silencing mutants Plant Cell 18 2314 2325
    • (2006) Plant Cell , vol.18 , pp. 2314-2325
    • Deuschle, K.1    Chaudhuri, B.2    Okumoto, S.3    Lager, I.4    Lalonde, S.5    Frommer, W.B.6
  • 19
  • 20
    • 35648967032 scopus 로고    scopus 로고
    • Microtiter plates as mini-bioreactors: Miniaturization of fermentation methods
    • WA Duetz 2007 Microtiter plates as mini-bioreactors: miniaturization of fermentation methods Trends Microbiol 15 469 475
    • (2007) Trends Microbiol , vol.15 , pp. 469-475
    • Duetz, W.A.1
  • 21
    • 0035424201 scopus 로고    scopus 로고
    • Using proteins in their natural environment: Potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis
    • WA Duetz JB van Beilen B Witholt 2001 Using proteins in their natural environment: potential and limitations of microbial whole-cell hydroxylations in applied biocatalysis Curr Opin Biotechnol 12 419 425
    • (2001) Curr Opin Biotechnol , vol.12 , pp. 419-425
    • Duetz, W.A.1    Van Beilen, J.B.2    Witholt, B.3
  • 22
    • 0034625143 scopus 로고    scopus 로고
    • The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
    • JS Edwards BO Palsson 2000 The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities Proc Natl Acad Sci U S A 97 5528 5533
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5528-5533
    • Edwards, J.S.1    Palsson, B.O.2
  • 23
    • 0035125986 scopus 로고    scopus 로고
    • In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
    • JS Edwards RU Ibarra BO Palsson 2001 In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data Nat Biotechnol 19 125 130
    • (2001) Nat Biotechnol , vol.19 , pp. 125-130
    • Edwards, J.S.1    Ibarra, R.U.2    Palsson, B.O.3
  • 25
    • 14244256095 scopus 로고    scopus 로고
    • Experimental identification and quantification of glucose metabolism in seven bacterial species
    • T Fuhrer E Fischer U Sauer 2005 Experimental identification and quantification of glucose metabolism in seven bacterial species J Bacteriol 187 1581 1590
    • (2005) J Bacteriol , vol.187 , pp. 1581-1590
    • Fuhrer, T.1    Fischer, E.2    Sauer, U.3
  • 26
    • 24044432264 scopus 로고    scopus 로고
    • Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose: Roles of malic enzyme and fructose-1, 6-bisphosphatase
    • T Georgi D Rittmann VF Wendisch 2005 Lysine and glutamate production by Corynebacterium glutamicum on glucose, fructose and sucrose: roles of malic enzyme and fructose-1, 6-bisphosphatase Metab Eng 7 291 301
    • (2005) Metab Eng , vol.7 , pp. 291-301
    • Georgi, T.1    Rittmann, D.2    Wendisch, V.F.3
  • 27
    • 70350029519 scopus 로고    scopus 로고
    • FBA-SimVis: Interactive visualization of constraint-based metabolic models
    • E Grafahrend-Belau C Klukas BH Junker F Schreiber 2009 FBA-SimVis: interactive visualization of constraint-based metabolic models Bioinformatics 25 2755 2757
    • (2009) Bioinformatics , vol.25 , pp. 2755-2757
    • Grafahrend-Belau, E.1    Klukas, C.2    Junker, B.H.3    Schreiber, F.4
  • 28
    • 0020486135 scopus 로고
    • A role for mRNA secondary structure in the control of translation initiation
    • MN Hall J Gabay M Debarbouille M Schwartz 1982 A role for mRNA secondary structure in the control of translation initiation Nature 295 616 618
    • (1982) Nature , vol.295 , pp. 616-618
    • Hall, M.N.1    Gabay, J.2    Debarbouille, M.3    Schwartz, M.4
  • 29
    • 0015989446 scopus 로고
    • A linear steady-state treatment of enzymatic chains. General properties, control and effector strength
    • Heinrich R, Rapoport TA (1974) A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem 42(1):89-95
    • (1974) Eur J Biochem , vol.42 , Issue.1 , pp. 89-95
    • Heinrich, R.1    Rapoport, T.A.2
  • 30
    • 3242795003 scopus 로고    scopus 로고
    • The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks
    • HG Holzhutter 2004 The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks Eur J Biochem 271 2905 2922
    • (2004) Eur J Biochem , vol.271 , pp. 2905-2922
    • Holzhutter, H.G.1
  • 31
    • 0037079023 scopus 로고    scopus 로고
    • Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
    • RU Ibarra JS Edwards BO Palsson 2002 Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth Nature 420 186 189
    • (2002) Nature , vol.420 , pp. 186-189
    • Ibarra, R.U.1    Edwards, J.S.2    Palsson, B.O.3
  • 32
    • 33745013345 scopus 로고    scopus 로고
    • A genome-based approach to create a minimally mutated Corynebacterium glutamicum strain for efficient L-lysine production
    • M Ikeda J Ohnishi M Hayashi S Mitsuhashi 2006 A genome-based approach to create a minimally mutated Corynebacterium glutamicum strain for efficient L-lysine production J Ind Microbiol Biotech 33 610 615
    • (2006) J Ind Microbiol Biotech , vol.33 , pp. 610-615
    • Ikeda, M.1    Ohnishi, J.2    Hayashi, M.3    Mitsuhashi, S.4
  • 33
    • 34247584154 scopus 로고    scopus 로고
    • Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation
    • A Kabus T Georgi VF Wendisch M Bott 2007 Expression of the Escherichia coli pntAB genes encoding a membrane-bound transhydrogenase in Corynebacterium glutamicum improves L-lysine formation Appl Microbiol Biotechnol 75 47 53
    • (2007) Appl Microbiol Biotechnol , vol.75 , pp. 47-53
    • Kabus, A.1    Georgi, T.2    Wendisch, V.F.3    Bott, M.4
  • 34
    • 0027301842 scopus 로고
    • A universal method for achieving increases in metabolite production
    • H Kacser L Acerenza 1993 A universal method for achieving increases in metabolite production Eur J Biochem 216 361 367
    • (1993) Eur J Biochem , vol.216 , pp. 361-367
    • Kacser, H.1    Acerenza, L.2
  • 37
    • 0033816775 scopus 로고    scopus 로고
    • Predicted highly expressed genes of diverse prokaryotic genomes
    • S Karlin J Mrazek 2000 Predicted highly expressed genes of diverse prokaryotic genomes J Bacteriol 182 5238 5250
    • (2000) J Bacteriol , vol.182 , pp. 5238-5250
    • Karlin, S.1    Mrazek, J.2
  • 38
    • 0034888743 scopus 로고    scopus 로고
    • Characterizations of highly expressed genes of four fast-growing bacteria
    • S Karlin J Mrazek A Campbell D Kaiser 2001 Characterizations of highly expressed genes of four fast-growing bacteria J Bacteriol 183 5025 5040
    • (2001) J Bacteriol , vol.183 , pp. 5025-5040
    • Karlin, S.1    Mrazek, J.2    Campbell, A.3    Kaiser, D.4
  • 39
    • 58249089508 scopus 로고    scopus 로고
    • In silico genome-scale reconstruction and validation of the Corynebacterium glutamicum metabolic network
    • KR Kjeldsen J Nielsen 2009 In silico genome-scale reconstruction and validation of the Corynebacterium glutamicum metabolic network Biotechnol Bioeng 102 583 597
    • (2009) Biotechnol Bioeng , vol.102 , pp. 583-597
    • Kjeldsen, K.R.1    Nielsen, J.2
  • 40
    • 0037197159 scopus 로고    scopus 로고
    • Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria
    • S Klamt S Schuster ED Gilles 2002 Calculability analysis in underdetermined metabolic networks illustrated by a model of the central metabolism in purple nonsulfur bacteria Biotechnol Bioeng 77 734 751
    • (2002) Biotechnol Bioeng , vol.77 , pp. 734-751
    • Klamt, S.1    Schuster, S.2    Gilles, E.D.3
  • 41
    • 0037316342 scopus 로고    scopus 로고
    • FluxAnalyzer: Exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps
    • S Klamt J Stelling M Ginkel ED Gilles 2003 FluxAnalyzer: exploring structure, pathways, and flux distributions in metabolic networks on interactive flux maps Bioinformatics 19 261 269
    • (2003) Bioinformatics , vol.19 , pp. 261-269
    • Klamt, S.1    Stelling, J.2    Ginkel, M.3    Gilles, E.D.4
  • 42
    • 33847307148 scopus 로고    scopus 로고
    • Bayesian-based selection of metabolic objective functions
    • AL Knorr R Jain R Srivastava 2007 Bayesian-based selection of metabolic objective functions Bioinformatics 23 351 357
    • (2007) Bioinformatics , vol.23 , pp. 351-357
    • Knorr, A.L.1    Jain, R.2    Srivastava, R.3
  • 43
    • 0038514074 scopus 로고    scopus 로고
    • Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression
    • MA Koffas GY Jung G Stephanopoulos 2003 Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression Metab Eng 5 32 41
    • (2003) Metab Eng , vol.5 , pp. 32-41
    • Koffas, M.A.1    Jung, G.Y.2    Stephanopoulos, G.3
  • 44
    • 64849114915 scopus 로고    scopus 로고
    • Coding-sequence determinants of gene expression in Escherichia coli
    • G Kudla AW Murray D Tollervey JB Plotkin 2009 Coding-sequence determinants of gene expression in Escherichia coli Science 324 255 258
    • (2009) Science , vol.324 , pp. 255-258
    • Kudla, G.1    Murray, A.W.2    Tollervey, D.3    Plotkin, J.B.4
  • 45
    • 25844463806 scopus 로고    scopus 로고
    • Metabolic functions of duplicate genes in Saccharomyces cerevisiae
    • L Kuepfer U Sauer LM Blank 2005 Metabolic functions of duplicate genes in Saccharomyces cerevisiae Genome Res 15 1421 1430
    • (2005) Genome Res , vol.15 , pp. 1421-1430
    • Kuepfer, L.1    Sauer, U.2    Blank, L.M.3
  • 46
    • 33745433792 scopus 로고    scopus 로고
    • Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data
    • 0034
    • Kummel A, Panke S, Heinemann M (2006a) Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data. Mol Syst Biol 2:2006.0034
    • (2006) Mol Syst Biol , vol.2 , pp. 2006
    • Kummel, A.1    Panke, S.2    Heinemann, M.3
  • 47
    • 33845238737 scopus 로고    scopus 로고
    • Systematic assignment of thermodynamic constraints in metabolic network models
    • A Kummel S Panke M Heinemann 2006 Systematic assignment of thermodynamic constraints in metabolic network models BMC Bioinformatics 7 512
    • (2006) BMC Bioinformatics , vol.7 , pp. 512
    • Kummel, A.1    Panke, S.2    Heinemann, M.3
  • 48
    • 0034661295 scopus 로고    scopus 로고
    • Recursive MILP model for finding all the alternate optima in LP models for metabolic networks
    • S Lee C Phalakornkule MM Domach IE Grossmann 2000 Recursive MILP model for finding all the alternate optima in LP models for metabolic networks Comput Chem Eng 24 711 716
    • (2000) Comput Chem Eng , vol.24 , pp. 711-716
    • Lee, S.1    Phalakornkule, C.2    Domach, M.M.3    Grossmann, I.E.4
  • 49
    • 29144484729 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation
    • SJ Lee DY Lee TY Kim BH Kim J Lee SY Lee 2005 Metabolic engineering of Escherichia coli for enhanced production of succinic acid, based on genome comparison and in silico gene knockout simulation Appl Environ Microbiol 71 7880 7887
    • (2005) Appl Environ Microbiol , vol.71 , pp. 7880-7887
    • Lee, S.J.1    Lee, D.Y.2    Kim, T.Y.3    Kim, B.H.4    Lee, J.5    Lee, S.Y.6
  • 50
    • 42149149798 scopus 로고    scopus 로고
    • From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens
    • SY Lee JM Kim H Song JW Lee TY Kim YS Jang 2008 From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens Appl Microbiol Biotechnol 79 11 22
    • (2008) Appl Microbiol Biotechnol , vol.79 , pp. 11-22
    • Lee, S.Y.1    Kim, J.M.2    Song, H.3    Lee, J.W.4    Kim, T.Y.5    Jang, Y.S.6
  • 51
    • 62949232967 scopus 로고    scopus 로고
    • Low contents of carbon and nitrogen in highly abundant proteins: Evidence of selection for the economy of atomic composition
    • N Li J Lv DK Niu 2009 Low contents of carbon and nitrogen in highly abundant proteins: evidence of selection for the economy of atomic composition J Mol Evol 68 248 255
    • (2009) J Mol Evol , vol.68 , pp. 248-255
    • Li, N.1    Lv, J.2    Niu, D.K.3
  • 52
    • 15344340751 scopus 로고    scopus 로고
    • Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield
    • H Lin GN Bennett KY San 2005 Metabolic engineering of aerobic succinate production systems in Escherichia coli to improve process productivity and achieve the maximum theoretical succinate yield Metab Eng 7 116 127
    • (2005) Metab Eng , vol.7 , pp. 116-127
    • Lin, H.1    Bennett, G.N.2    San, K.Y.3
  • 53
    • 0036786891 scopus 로고    scopus 로고
    • Correlations between Shine-Dalgarno sequences and gene features such as predicted expression levels and operon structures
    • J Ma A Campbell S Karlin 2002 Correlations between Shine-Dalgarno sequences and gene features such as predicted expression levels and operon structures J Bacteriol 184 5733 5745
    • (2002) J Bacteriol , vol.184 , pp. 5733-5745
    • Ma, J.1    Campbell, A.2    Karlin, S.3
  • 54
    • 67349177730 scopus 로고    scopus 로고
    • Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry
    • S Maddula LM Blank A Schmid JI Baumbach 2009 Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry Anal Bioanal Chem 394 791 800
    • (2009) Anal Bioanal Chem , vol.394 , pp. 791-800
    • Maddula, S.1    Blank, L.M.2    Schmid, A.3    Baumbach, J.I.4
  • 55
    • 1642457253 scopus 로고    scopus 로고
    • The effects of alternate optimal solutions in constraint-based genome-scale metabolic models
    • R Mahadevan CH Schilling 2003 The effects of alternate optimal solutions in constraint-based genome-scale metabolic models Metab Eng 5 264 276
    • (2003) Metab Eng , vol.5 , pp. 264-276
    • Mahadevan, R.1    Schilling, C.H.2
  • 56
    • 0025405421 scopus 로고
    • Simple constrained-optimization view of acetate overflow in E. coli
    • RA Majewski MM Domach 1990 Simple constrained-optimization view of acetate overflow in E. coli Biotechnol Bioeng 35 732 738
    • (1990) Biotechnol Bioeng , vol.35 , pp. 732-738
    • Majewski, R.A.1    Domach, M.M.2
  • 57
    • 68549090718 scopus 로고    scopus 로고
    • High throughput in biotechnology: From shake-flasks to fully instrumented microfermentors
    • MP Marques JM Cabral P Fernandes 2009 High throughput in biotechnology: from shake-flasks to fully instrumented microfermentors Recent Pat Biotechnol 3 124 140
    • (2009) Recent Pat Biotechnol , vol.3 , pp. 124-140
    • Marques, M.P.1    Cabral, J.M.2    Fernandes, P.3
  • 58
    • 0030050268 scopus 로고    scopus 로고
    • Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing
    • A Marx AA de Graaf W Wiechert L Eggeling H Sahm 1996 Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing Biotechnol Bioeng 49 111 129
    • (1996) Biotechnol Bioeng , vol.49 , pp. 111-129
    • Marx, A.1    De Graaf, A.A.2    Wiechert, W.3    Eggeling, L.4    Sahm, H.5
  • 59
    • 0022350091 scopus 로고
    • The game of the pentose phosphate cycle
    • E Melendez-Hevia A Isidoro 1985 The game of the pentose phosphate cycle J Theor Biol 117 251 263
    • (1985) J Theor Biol , vol.117 , pp. 251-263
    • Melendez-Hevia, E.1    Isidoro, A.2
  • 60
    • 33751394915 scopus 로고    scopus 로고
    • Disruption of malate:quinone oxidoreductase increases L-lysine production by Corynebacterium glutamicum
    • DOI 10.1271/bbb.60298
    • S Mitsuhashi M Hayashi J Ohnishi M Ikeda 2006 Disruption of malate:quinone oxidoreductase increases L-lysine production by Corynebacterium glutamicum Biosci Biotechnol Biochem 70 2803 2806 (Pubitemid 44819862)
    • (2006) Bioscience, Biotechnology and Biochemistry , vol.70 , Issue.11 , pp. 2803-2806
    • Mitsuhashi, S.1    Hayashi, M.2    Ohnishi, J.3    Ikeda, M.4
  • 63
    • 73949135027 scopus 로고    scopus 로고
    • Comparison of quantitative metabolite imaging tools and carbon-13 techniques for fluxomics
    • T Niittylae B Chaudhuri U Sauer WB Frommer 2009 Comparison of quantitative metabolite imaging tools and carbon-13 techniques for fluxomics Methods Mol Biol 553 355 372
    • (2009) Methods Mol Biol , vol.553 , pp. 355-372
    • Niittylae, T.1    Chaudhuri, B.2    Sauer, U.3    Frommer, W.B.4
  • 64
    • 38749100629 scopus 로고    scopus 로고
    • Visualizing regulatory interactions in metabolic networks
    • S Noack A Wahl E Qeli W Wiechert 2007 Visualizing regulatory interactions in metabolic networks BMC Biol 5 46
    • (2007) BMC Biol , vol.5 , pp. 46
    • Noack, S.1    Wahl, A.2    Qeli, E.3    Wiechert, W.4
  • 66
    • 0036161274 scopus 로고    scopus 로고
    • A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant
    • J Ohnishi S Mitsuhashi M Hayashi S Ando H Yokoi K Ochiai M Ikeda 2002 A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant Appl Microbiol Biotechnol 58 217 223
    • (2002) Appl Microbiol Biotechnol , vol.58 , pp. 217-223
    • Ohnishi, J.1    Mitsuhashi, S.2    Hayashi, M.3    Ando, S.4    Yokoi, H.5    Ochiai, K.6    Ikeda, M.7
  • 67
    • 11144261828 scopus 로고    scopus 로고
    • A novel gnd mutation leading to increased L-lysine production in Corynebacterium glutamicum
    • J Ohnishi R Katahira S Mitsuhashi S Kakita M Ikeda 2005 A novel gnd mutation leading to increased L-lysine production in Corynebacterium glutamicum FEMS Microbiol Lett 242 265 274
    • (2005) FEMS Microbiol Lett , vol.242 , pp. 265-274
    • Ohnishi, J.1    Katahira, R.2    Mitsuhashi, S.3    Kakita, S.4    Ikeda, M.5
  • 68
    • 23944440242 scopus 로고    scopus 로고
    • Modeling Lactococcus lactis using a genome-scale flux model
    • AP Oliveira J Nielsen J Forster 2005 Modeling Lactococcus lactis using a genome-scale flux model BMC Microbiology 5 39
    • (2005) BMC Microbiology , vol.5 , pp. 39
    • Oliveira, A.P.1    Nielsen, J.2    Forster, J.3
  • 69
    • 62149111135 scopus 로고    scopus 로고
    • FORG3D: Force-directed 3D graph editor for visualization of integrated genome scale data
    • J Paananen G Wong 2009 FORG3D: force-directed 3D graph editor for visualization of integrated genome scale data BMC Syst Biol 3 26
    • (2009) BMC Syst Biol , vol.3 , pp. 26
    • Paananen, J.1    Wong, G.2
  • 71
    • 2942624207 scopus 로고    scopus 로고
    • Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
    • B Papp C Pal LD Hurst 2004 Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast Nature 429 661 664
    • (2004) Nature , vol.429 , pp. 661-664
    • Papp, B.1    Pal, C.2    Hurst, L.D.3
  • 72
    • 0034680782 scopus 로고    scopus 로고
    • In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum
    • S Petersen AA de Graaf L Eggeling M Mollney W Wiechert H Sahm 2000 In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum J Biol Chem 275 35932 35941
    • (2000) J Biol Chem , vol.275 , pp. 35932-35941
    • Petersen, S.1    De Graaf, A.A.2    Eggeling, L.3    Mollney, M.4    Wiechert, W.5    Sahm, H.6
  • 75
    • 25444464110 scopus 로고    scopus 로고
    • Correlation and prediction of gene expression level from amino acid and dipeptide composition of its protein
    • GP Raghava JH Han 2005 Correlation and prediction of gene expression level from amino acid and dipeptide composition of its protein BMC Bioinformatics 6 59
    • (2005) BMC Bioinformatics , vol.6 , pp. 59
    • Raghava, G.P.1    Han, J.H.2
  • 77
    • 0035017810 scopus 로고    scopus 로고
    • Flux-balance analysis of mitochondrial energy metabolism: Consequences of systemic stoichiometric constraints
    • R Ramakrishna JS Edwards A McCulloch BO Palsson 2001 Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints Am J Physiol-Reg I 280 R695 R704
    • (2001) Am J Physiol-Reg i , vol.280
    • Ramakrishna, R.1    Edwards, J.S.2    McCulloch, A.3    Palsson, B.O.4
  • 78
    • 4644220226 scopus 로고    scopus 로고
    • Genome-scale in silico models of E. coli have multiple equivalent phenotypic states: Assessment of correlated reaction subsets that comprise network states
    • JL Reed BO Palsson 2004 Genome-scale in silico models of E. coli have multiple equivalent phenotypic states: assessment of correlated reaction subsets that comprise network states Genome Res 14 1797 1805
    • (2004) Genome Res , vol.14 , pp. 1797-1805
    • Reed, J.L.1    Palsson, B.O.2
  • 79
    • 33747369422 scopus 로고    scopus 로고
    • Batch culture characterization and metabolic flux analysis of succinate-producing Escherichia coli strains
    • AM Sanchez GN Bennett KY San 2006 Batch culture characterization and metabolic flux analysis of succinate-producing Escherichia coli strains Metab Eng 8 209 226
    • (2006) Metab Eng , vol.8 , pp. 209-226
    • Sanchez, A.M.1    Bennett, G.N.2    San, K.Y.3
  • 80
    • 33846061120 scopus 로고    scopus 로고
    • 13C-based flux analysis
    • 13C-based flux analysis Mol Syst Biol 2 62
    • (2006) Mol Syst Biol , vol.2 , pp. 62
    • Sauer, U.1
  • 83
    • 34447523907 scopus 로고    scopus 로고
    • Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
    • R Schuetz L Kuepfer U Sauer 2007 Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli Mol Syst Biol 3 119
    • (2007) Mol Syst Biol , vol.3 , pp. 119
    • Schuetz, R.1    Kuepfer, L.2    Sauer, U.3
  • 85
    • 0037069467 scopus 로고    scopus 로고
    • Analysis of optimality in natural and perturbed metabolic networks
    • D Segre D Vitkup GM Church 2002 Analysis of optimality in natural and perturbed metabolic networks Proc Natl Acad Sci USA 99 15112 15117
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15112-15117
    • Segre, D.1    Vitkup, D.2    Church, G.M.3
  • 86
    • 19644386033 scopus 로고    scopus 로고
    • Regulatory on/off minimization of metabolic flux changes after genetic perturbations
    • T Shlomi O Berkman E Ruppin 2005 Regulatory on/off minimization of metabolic flux changes after genetic perturbations Proc Natl Acad Sci USA 102 7695 7700
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7695-7700
    • Shlomi, T.1    Berkman, O.2    Ruppin, E.3
  • 88
    • 34548043216 scopus 로고    scopus 로고
    • Improving lysine production by Corynebacterium glutamicum through DNA microarray-based identification of novel target genes
    • G Sindelar VF Wendisch 2007 Improving lysine production by Corynebacterium glutamicum through DNA microarray-based identification of novel target genes Appl Microbiol Biotechnol 76 677 689
    • (2007) Appl Microbiol Biotechnol , vol.76 , pp. 677-689
    • Sindelar, G.1    Wendisch, V.F.2
  • 89
    • 52949098408 scopus 로고    scopus 로고
    • Large-scale computation of elementary flux modes with bit pattern trees
    • M Terzer J Stelling 2008 Large-scale computation of elementary flux modes with bit pattern trees Bioinformatics 24 2229 2235
    • (2008) Bioinformatics , vol.24 , pp. 2229-2235
    • Terzer, M.1    Stelling, J.2
  • 90
    • 27944487902 scopus 로고    scopus 로고
    • Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes
    • BP Tu A Kudlicki M Rowicka SL McKnight 2005 Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes Science 310 1152 1158
    • (2005) Science , vol.310 , pp. 1152-1158
    • Tu, B.P.1    Kudlicki, A.2    Rowicka, M.3    McKnight, S.L.4
  • 92
    • 0028764687 scopus 로고
    • Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates
    • RT van der Heijden JJ Heijnen C Hellinga B Romein KC Luyben 1994 Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates Biotechnol Bioeng 43 3 10
    • (1994) Biotechnol Bioeng , vol.43 , pp. 3-10
    • Van Der Heijden, R.T.1    Heijnen, J.J.2    Hellinga, C.3    Romein, B.4    Luyben, K.C.5
  • 93
    • 0028973161 scopus 로고
    • A metabolic network stoichiometry analysis of microbia growth and product formation
    • WM van Gulik JJ Heijnen 1995 A metabolic network stoichiometry analysis of microbia growth and product formation Biotechnol Bioeng 48 681 698
    • (1995) Biotechnol Bioeng , vol.48 , pp. 681-698
    • Van Gulik, W.M.1    Heijnen, J.J.2
  • 94
    • 15044347498 scopus 로고    scopus 로고
    • Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of (13)C-labeled primary metabolites
    • WA van Winden JC van Dam C Ras RJ Kleijn JL Vinke WM van Gulik JJ Heijnen 2005 Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of (13)C-labeled primary metabolites FEMS Yeast Res 5 559 568
    • (2005) FEMS Yeast Res , vol.5 , pp. 559-568
    • Van Winden, W.A.1    Van Dam, J.C.2    Ras, C.3    Kleijn, R.J.4    Vinke, J.L.5    Van Gulik, W.M.6    Heijnen, J.J.7
  • 95
    • 0028146781 scopus 로고
    • Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110
    • A Varma BO Palsson 1994 Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110 Appl Environ Microbiol 60 3724 3731
    • (1994) Appl Environ Microbiol , vol.60 , pp. 3724-3731
    • Varma, A.1    Palsson, B.O.2
  • 96
    • 0036210809 scopus 로고    scopus 로고
    • Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli
    • GN Vemuri MA Eiteman E Altman 2002 Effects of growth mode and pyruvate carboxylase on succinic acid production by metabolically engineered strains of Escherichia coli Appl Environ Microbiol 68 1715 1727
    • (2002) Appl Environ Microbiol , vol.68 , pp. 1715-1727
    • Vemuri, G.N.1    Eiteman, M.A.2    Altman, E.3
  • 97
    • 0036309458 scopus 로고    scopus 로고
    • Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions
    • GN Vemuri MA Eiteman E Altman 2002 Succinate production in dual-phase Escherichia coli fermentations depends on the time of transition from aerobic to anaerobic conditions J Ind Microbiol Biotechnol 28 325 232
    • (2002) J Ind Microbiol Biotechnol , vol.28 , pp. 325-232
    • Vemuri, G.N.1    Eiteman, M.A.2    Altman, E.3
  • 98
    • 33751545659 scopus 로고    scopus 로고
    • Genome-scale in silico aided metabolic analysis and flux comparisons of Escherichia coli to improve succinate production
    • Q Wang X Chen Y Yang X Zhao 2006 Genome-scale in silico aided metabolic analysis and flux comparisons of Escherichia coli to improve succinate production Appl Microbiol Biotechnol 73 887 894
    • (2006) Appl Microbiol Biotechnol , vol.73 , pp. 887-894
    • Wang, Q.1    Chen, X.2    Yang, Y.3    Zhao, X.4
  • 100
    • 0034741983 scopus 로고    scopus 로고
    • 13C metabolic flux analysis
    • 13C metabolic flux analysis Metab Eng 3 195 206
    • (2001) Metab Eng , vol.3 , pp. 195-206
    • Wiechert, W.1
  • 102
    • 17144387903 scopus 로고    scopus 로고
    • From stationary to instationary metabolic flux analysis
    • W Wiechert K Noh 2005 From stationary to instationary metabolic flux analysis Adv Biochem Eng Biotechnol 92 145 172
    • (2005) Adv Biochem Eng Biotechnol , vol.92 , pp. 145-172
    • Wiechert, W.1    Noh, K.2
  • 104
    • 0036956758 scopus 로고    scopus 로고
    • Genealogy profiling through strain improvement by using metabolic network analysis: Metabolic flux genealogy of several generations of lysine-producing corynebacteria
    • C Wittmann E Heinzle 2002 Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria Appl Environ Microbiol 68 5843 5859
    • (2002) Appl Environ Microbiol , vol.68 , pp. 5843-5859
    • Wittmann, C.1    Heinzle, E.2
  • 105
    • 16344378267 scopus 로고    scopus 로고
    • 13C-metabolic flux analysis with sole quantification of carbon dioxide labeling
    • 13C-metabolic flux analysis with sole quantification of carbon dioxide labeling Comput Biol Chem 29 121 133
    • (2005) Comput Biol Chem , vol.29 , pp. 121-133
    • Yang, T.H.1    Heinzle, E.2    Wittmann, C.3
  • 108
    • 67649218402 scopus 로고    scopus 로고
    • Genetic modification of flux for flux prediction of mutants
    • Q Zhao H Kurata 2009 Genetic modification of flux for flux prediction of mutants Bioinformatics 25 1702 1708
    • (2009) Bioinformatics , vol.25 , pp. 1702-1708
    • Zhao, Q.1    Kurata, H.2


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