Estimating design space available for polyepitopes through consideration of major histocompatibility complex binding motifs

Biomedical Microdevices

Volumn 12, Issue 2, 2010, Pages 207-222

  Lee, Yvonne ^d   Ferrari, Giacomo ^e   Lee, Stephen Craig ^a,b,c  

^a The Ohio State University   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e Rice University   (United States)

Author keywords

Immune mitigation; Immunodominance reducing immunogenicity; Immunogenicity; MHC motifs; Polyepitope; Supertypes; T cell epitopes; Vaccines

Indexed keywords

BINDING MOTIF; CLASS I; CLASS II; CLASS II MHC; COMPUTER BASED TOOLS; DESIGN SPACES; IMMUNODOMINANCE; IMMUNOGENICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MHC MOTIFS; PEPTIDE BINDING; PRE-SELECTED; PROTEIN VARIANTS; ROBUST ADAPTIVE; T-CELL EPITOPES;

AMINO ACIDS; DESIGN; ORGANIC ACIDS; POLYPEPTIDES; PROTEINS;

VACCINES;

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VACCINE;

ADAPTIVE IMMUNITY; AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG DESIGN; DRUG RESEARCH; HELPER CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF;

ALGORITHMS; AMINO ACID MOTIFS; ANIMALS; EPITOPES; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; PROTEIN BINDING; VACCINES;

EID: 77952890617     PISSN: 13872176     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10544-009-9376-7     Document Type: Article

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