T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens

European Journal of Immunology

Volumn 29, Issue 7, 1999, Pages 2197-2204

  Grufman, Per ^a   Wolpert, Elisabeth Z ^a   Sandberg, Johan K ^a   Kärre, Klas ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Dendritic cell; Immunodominance; Minor histocompatibility antigen; T cell competition

Indexed keywords

CD8 ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; IMMUNIZATION; IMMUNODOMINANT EPITOPES; LYMPHOCYTE ACTIVATION; MICE; MICE, CONGENIC; MICE, INBRED BALB C; MICE, INBRED C57BL; MINOR HISTOCOMPATIBILITY ANTIGENS; MODELS, BIOLOGICAL; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0032999203     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199907)29:07<2197::AID-IMMU2197>3.0.CO;2-B     Document Type: Article

References (45)

1. Bailey, D. W. and Mobraaten, L. E., Estimates of the number of loci contributing to the histoincompatibility between C57BL/6 and BALB/c strains of mice. Transplantation 1969. 7: 394-400.
2. Wolpert, E., Franksson, L. and Kärre, K., Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides. Int. Immunol. 1995. 7: 919-928.
3. Vijh, S. and Pamer, E. G., Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. 1997. 158: 3366-3371.
4. b-restricted cytotoxic T-lymphocyte epitopes within simian virus 40 T antigen. J. Virol. 1995. 69: 6665-6677.
5. Vitiello, A., Yuan, L., Chesnut, R. W., Sidney, J., Southwood, S., Farness, P., Jackson, M. R., Peterson, P. A. and Sette, A., Immunodominance analysis of CTL responses to influenza PR8 virus reveals two new dominant and subdominant Kb restricted epitopes. J. Immunol. 1996. 157: 5555-5562.
6. Oukka, M., Manuguerra, J. C., Livaditis, N., Tourdot, S., Riche, N., Vergnon, I., Cordopatis, P. and Kosmatopoulos, K., Protection against lethal viral infection by vaccination with nonimmunodominant peptides. J. Immunol. 1996. 157: 3039-3045.
7. Deng, Y., Yewdell, J. W., Eisenlohr, L. C. and Bennink, J. R., MHC affinity, peptide liberation, T-cell repertoire, and immunodominance all contribute to the paucity of MHC class I-restricted peptides recognized by antiviral CTL. J. Immunol. 1996. 158: 1507-1515.
8. Wettstein, P. J. and Balley, D. W., Immunodominance in the immune response to "multiple" histocompatibility antigens. Immunogenetics 1982. 16: 47-58.
9. Wettstein, P. J., Immunodominance in the T cell response to multiple non-H-2 histocompatibility antigens. III. Single histocompatibility antigens dominate the male antigen. J. Immunol. 1986. 137: 2073-2079.
10. Korngold, R. and Wettstein, P. J., Immunodominance in the graft-vs-host disease T cell response to minor histocompatibility antigens. J. Immunol. 1990. 145: 4079-4088.
11. Franksson, L., Petersson, M., Kiessling, R. and Kärre, K., Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells. Eur. J. Immunol. 1993. 23: 2606-2613.
12. Yin, L., Poirier, G., Neth, O., Hsuan, J. J., Totty, N. F. and Stauss, H. J., Few peptides dominante cytotoxic T lymphocyte responses to single and multiple minor histocompatibility antigens. Int. Immunol. 1993. 5: 1003-1009.
13. Goulmy, E., Schipper, R., Pool, J., Blokland, E., Falkenburg, J. H., Vossen, J., Grathwohl, A., Vogelsang, G. B., van Houwelingen, H. C. and van Rood, J. J., Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N. Engl. J. Med. 1996. 334: 281-285.
14. Chen, W., Khilko, S., Fecondo, J., Margulies, D. H. and McCluskey, J., Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by non-dominant anchor residues. J. Exp. Med. 1994. 180: 1471-1483.
15. b-restricted epitopes and reversal by dendritic cell-mediated antigen delivery. J. Immunol. 1998. 160: 3163-3169.
16. Dick, L. R., Aldrich, C., Jameson, S. C., Moomaw, C. R., Pramanik, B. C., Doyle, C. K., DeMartino, G. N., Bevan, M. J., Forman, J. M. and Slaughter, C. A., Proteolytic processing of ovalbumin and beta-galactosidase by the proteosome to a yield antigenic peptides. J. Immunol. 1994. 152: 3884-3894.
17. Niedermann, G., King, G., Butz, S., Birsner, U., Grimm, R., Shabanowitz, J., Hunt, D. F. and Eichmann, K., The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides. Proc. Natl. Acad. Sci. USA 1996. 93: 8572-8577.
18. Eggers, M., Boes-Fabian, B., Ruppert, T., Kloetzel, P. M. and Koszinowski, U. H., The cleavage preference of the proteosome governs the yield of antigenic peptides. J. Exp. Med. 1995. 182: 1865-1870.
19. Sette, A., Vitiello, A., Reherman, B., Fowler, P., Nayersina, R., Kast, W. M., Melief, C. J., Oseroff, C., Yuan, L. and Ruppert, J., The relationship between class I binding affinity and immunogenicity of potential cytotoxic Tcell epitopes. J. Immunol. 1994. 153: 5586-5592.
20. van der Most, R. G., Sette, S., Oseroff, C., Alexander, J., Murali-Krishna, K., Lau, L. L., Southwood, S., Sidney, J., Chesnut, R. W., Matloubian, M. and Ahmed, R., Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J. Immunol. 1996. 157: 5543-5554.
21. van der Burg, S. H., Visseren, M. J., Brandt, R. M., Kast, W. M. and Melief, C. J., Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability. J. Immunol. 1996. 156: 3308-3314.
22. Levitsky, V., Zhang, Q. J., Levitskaya, J. and Masucci, M. G., The life span of major histocompatibility complex-peptide complexes influences the efficiency of presentation and immunogenicity of two class I-restricted cytotoxic T lymphocyte epitopes in the Epstein-Barr virus nuclear antigen 4. J. Exp. Med. 1996. 183: 915-926.
23. Levitsky, V., Zhang, Q., Levitskaya, J., Kurilla, M. G. and Masucci, M. G., Natural variants of the immunodominant HLA-A11 restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to intracellular dissociation from the MHC class I: peptide complexes. J. Immunol. 1997. 159: 5383-5390.
24. Matsui, K., Boniface, J. J., Steffner, P., Reay, P. A. and Davis, M. M., Kinetics of T-cell receptor binding tp peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc. Natl. Acad. Sci. USA 1994. 91: 12862-12866.
25. Campos-Lima, P. O., Levitsky, V., Imreh, M. P., Gavioli, R. and Masucci, M. G., Epitope-dependent selection of highly restricted or diverse T cell receptor repertoires in response to persistent infection by Epstein-Barr virus. J. Exp. Med. 1997. 186: 83-89.
26. - strains. Proc. Natl. Acad. Sci. USA 1994. 91: 11482-11486.
27. Daly, K., Nguyen, P., Woodland, D. L. and Blackman, M. A., Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire. J. Virol. 1995. 69: 7416-7422.
28. + CTL response to an influenza hemagglutinin epitope reflects limited T cell availability. J. Immunol. 1996. 157: 505-511.
29. Oldstone, M. B. A., Lewicki, H., Borrow, P., Hudrisier, D. and Gairin, J. E., Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection. J. Virol. 1995. 69: 7423-7429.
30. Gegin, C. and Lehmann-Grube, F., Control of acute infection with lymphocytic choriomeningitis virus in mice that cannot present an immunodominant viral cytotoxic T lymphocyte epitope. J. Immunol. 1992. 149: 3331-3338.
31. Pion, S., Fontaine, P., Desaulniers, M., Jutras, J., Filep, J. G. and Perreault, C., On the mechanism of immunodominance in cytotoxic T lymphocyte responses to minor histocompatibility antigens. Eur. J. Immunol. 1997. 27: 421-430.
32. Wolpert, E. Z., Grufman, P., Sandberg, J. K., Tegnesjö, A. and Kärre, K., Immunodominance in the CTL response against minor histocompatibility antigens: interference between responding T cells rather then with antigen presentation. J. Immunol. 1998. 161: 4499-4505.
33. Wettstein, P. J., Immunodominance in the T-cell response to multiple non H-2 histocompatibility antigens. II. Observation of a hierarchy among dominant antigens. Immunogenetics 1986. 24: 24-31.
34. Gammon, G., Shastri, N., Cogswell, J., Wilbur, S., Sadegh-Nasseri, S., Krzych, U., Miller, A. and Sercarz, E., The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol. Rev. 1987. 98: 53-73.
35. Sercarz, E. E., Lehmann, P. V., Ametani, A., Benichou, G., Miller, A. and Moudgil, K., Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol. 1993. 11: 728-766.
36. Eberl, G., Kessler, B., Peduto Eberl, L, Brunda, M. J., Valmori, D. and Corradin, G., Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12. Eur. J. Immunol. 1996. 26: 2709-2716.
37. Taams, L. S., van Rensen, A. J. M., Poelen, M. C. M., van Els, C. A. C. M., Besseling, A. C., Wagenaar, J. P. A., van Eden, W. and Wauben, M. H. M., Anergic T cells actively suppress T cell responses via the antigen-presenting cell. Eur. J. Immunol. 1998. 28: 2902-2912.
38. Heufler, C., Koch, F., Stanzl, U., Topar, G., Wysocka, M., Trinchieri, G., Enk, A., Steinmann, R. M., Romani, N. and Sculer, G., Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur. J. Immunol. 1996. 26: 659-668.
39. Cella, M., Sheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
40. + cytolytic T lymphocytes. J. Exp. Med. 1996. 183: 791-800.
41. + T cells. J. Exp. Med. 1997. 185: 2133-2141.
42. McMichael, A. J., The original sin of killer T cells. Nature 1998. 394: 421-422.
43. Gapin, L., Bravo de Alba, Y., Casrouge, A., Cabaniols, J., Kourilsky, P. and Kanellopoulos, J., Antigen presentation by dendritic cells focuses T cell responses against immunodominant peptides: studies in the hen egg-white lysozyme (HEL) model. J. Immunol. 1998. 160: 1555-1564.
44. Butz, E. and Bevan, M. J., Differential presentation of the same MHC class I epitopes by fibroblasts and dendritic cells. J. Immunol. 1998. 160: 2139-2144.
45. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S. and Steinman, R. M., Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/ macrophage colony-stimulating factor. J. Exp. Med. 1992. 176: 1693-1702.