Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules

Human Immunology

Volumn 45, Issue 2, 1996, Pages 79-93

  Sidney, John ^a   Grey, Howard M ^b   Southwood, Scott ^a   Celis, Esteban ^a   Wentworth, Peggy A ^a   Del Guercio, Marie France ^a   Kubo, Ralph T ^a   Chesnut, Robert W ^a   Sette, Alessandro ^a  

^a CYTEL CORPORATION   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; BINDING AFFINITY; CALCULATION; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; HLA SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PEPTIDE SYNTHESIS; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN PURIFICATION; STRUCTURE ANALYSIS;

EID: 0029933388     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/0198-8859(95)00173-5     Document Type: Article

References (65)

1. Townsend A, Bodmer H: Antigen recognition by class I-restricted T lymphocytes. Annu Rev Immunol 7:601, 1989.
2. Rötzschke O, Falk K, Deres K, Schild H, Norda M, Metzger J, Jung G, Rammensee H-G: Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature 348:252, 1990.
3. Falk K, Rötzschke O, Stevanovic S, Jung G, Rammensee H-G: Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290, 1991.
4. Engelhard VH: Structure of peptides associated with MHC class I molecules. Curr Opin Immunol 6:13, 1994.
5. Elliott T, Smith M, Driscoll P, McMichael A: Peptide selection by class I molecules of the major histocompatibility complex. Curr Biol 3:854, 1993.
6. Falk K, Rötzschke O: Consensus motifs and peptide ligands of MHC class I molecules. Sem Immunol 5:81, 1993.
7. Bjorkman PJ, Parham P: Structure, function, and diversity of class I major histocompatibility complex molecules. Annu Rev Biochem 59:253, 1990.
8. Zinkernagel RM, Dohety PC: Restriction of in vitro T cell mediated cytotoxicity in lymphocytic choriomeningitis with a syngeneic or semiallogeneic system. Nature 248: 701, 1974.
9. Zinkernagel RM, Dohety PC: MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T cell restriction specificity, function and responsiveness. Adv Immunol 27:52, 1979.
10. Kubo RT, Sette A, Grey HM, Appella E, Sakaguchi K, Zhu N-Z, Arnott D, Sherman N, Shabanowitz J, Michel H, Bodnar WM, Davis TA, Hunt DF: Definition of specific peptide motifs for four major HLA-A alleles. J Immunol 152:3913, 1994.
11. Kast WM, Brandt RMP, Sidney J, Drijfhout J-W, Kubo RT, Grey HM, Melief CJM, Sette A: The role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins. J Immunol 152:3904, 1994.
12. del Guercio M-F, Sidney J, Hermanson G, Perez C, Grey HM, Kubo RT, Sette A: Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype. J Immunol 154:685, 1995.
13. Sidney J, del Guercio MF, Southwood S, Engelhard VH, Appella E, Rammensee H-G, Falk K, Rötzschke O, Takiguchi M, Kubo RT, Grey HM, Sette A: Several HLA alleles share overlapping peptide specificities. J Immunol 154:247, 1995.
14. Barber LD, Gillece-Castro B, Percival L, Li X, Clayberger C, Parham P: Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes. Curr Biol 5:179, 1995.
15. Imanishi T, Akaza T, Kimura A, Tokunaga K, Gojobori T: Allele and haplotype frequencies for HLA and complement loci in various ethnic groups. In Tsuji K, Aizaqa M, Sasazuki T (eds): HLA 1991: Proceedings of the Eleventh International Histocompatibility Workshop and Conference, vol 1. Tokyo, Oxford University Press, 1992.
16. Hill AVS, Elvin J, Willis AC, Aidoo M, Allsopp CEM, Gotch FM, Gao XM, Takiguchi M, Greenwood BM, Townsend ARM, McMichael AJ, Whittle HC: Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360:434, 1992.
17. Guo HC, Jardetzky TS, Garret TPJ, Lane WS, Strominger JL, Wiley DC: Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature 360:364, 1992.
18. Falk K, Rötzschke O, Takiguchi M, Grahovac B, Gnau V, Stevanovic S, Jung G, Rammensee H-G: Peptide motifs of HLA-A1, -A11, -A31, and -A33 molecules. Immunogenetics 40:238, 1994.
19. Dibrino M, Tsuchida T, Turner RV, Parker KC, Coligan JE, Biddison WE: HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs. J Immunol 151:5930, 1993.
20. DiBrino M, Parker KC, Shiloach J, Knierman M, Lukszo J, Turner RV, Biddison WE, Coligan JE: Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides. Proc Natl Acad Sci USA 90:1508, 1993.
21. Zhang Q-J, Gavioli R, Klein G, Masucci MG: An HLA-A11-specific motif in nonamer peptides derived from viral and cellular proteins. Proc Natl Acad Sci USA 90:2217, 1993.
22. Sette A, Sidney J, del Guercio M-F, Southwood S, Ruppert J, Dahlberg C, Grey HM, Kubo RT: Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays. Mol Immunol 31: 813, 1994.
23. Tanigaki N, Fruci D, Chersi A, Falasca G, Tosi R, Butler RH: HLA-A2-binding peptides cross-react not only within the A2 subgroup but also with other HLA-A-locus allelic products. Hum Immunol 39:155, 1994.
24. Storkus WJ, Zeh HJ III, Maeruer MJ, Salter RD, Lotze MT: Identification of human melanoma peptides recognized by class I restricted tumor infiltrating T lymphocytes. J Immunol 151:3719, 1993.
25. Rammensee H-G, Friede T, Stevanovic S: MHC ligands and peptide motifs: first listing. Immunogenetics 41:178, 1995.
26. Fernandez-Viña MA, Falco M, Sun Y, Stastny P: DNA typing for HLA class I alleles: I. Subsets of HLA-A2 and of-A28. Hum Immunol 33:163, 1992.
27. Bodmer JG, Marsh SGE, Albert ED, Bodmer WF, Bontrop RE, Charron D, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T, Schreuder GMT, Strominger JL, Svejgaard A, Terasaki PI: Nomenclature for factors of the HLA system, 1995. Hum Immunol 43:149, 1995.
28. Rebai N, Malissen B: Structural and genetic analyses of HLA class I molecules using monoclonal xenoantibodies. Tissue Antigens 22:107, 1983.
29. Barnstable CJ, Bodmer WF, Brown G, Galfre G, Milstein C, Williams AF, Biegler A: Production of monoclonal antibodies to group A erythrocytes, HLA, and other human cell surface antigens: new tools for genetic analysis. Cell 14:9, 1978.
30. Ruppert J, Sidney J, Celis E, Kubo RT, Grey HM, Sette A: Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules. Cell 74:929, 1993.
31. Greenwood F, Hunter W, Glover J: The preparation of 131I-labeled human growth hormone of high specific radioactivity. Biochem J 89:114, 1963.
32. Missale G, Redeker A, Person J, Fowler P, Guilhot S, Schlicht HJ, Ferrari C, Chisari FV: HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis. J Exp Med 177:751, 1993.
33. Tiwari JL, Terasaki PI: The HLA complex. In: HLA and Disease Associations. New York, Springer-Verlag, 1985.
34. Madden DR, Garboczi DN, Wiley DC: The antigenic identity of peptide/MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75:693, 1993.
35. Saper MA, Bjorkman PJ, Wiley DC: Refined structure of the human histocompatibility antigen HLA-A2 at 26 Å resolution. J Mol Biol 219:277, 1991.
36. DiBrino M, Parker KC, Shiloach J, Turner RV, Tsuchida T, Garfield M, Biddison WE, Coligan JE: Endogenous peptides with distinct amino acid anchor residue motifs bind HLA-A1 and HLA-B8. J Immunol 152:620, 1994.
37. Jardetzky TS, Lane WS, Robinson RA, Madden DR, Wiley DC: Identification of self peptides bound to purified HLA-B27. Nature 353:326, 1991.
38. Rötzschke O, Falk K, Stevanovic S, Gnau V, Jung G, Rammensee H-G: Dominant aromatic/aliphatic C-terminal anchor in HLA-B*2702 and -B*2705 peptide motifs. Immunogenetics 39:74, 1994.
39. Falk K, Rötzschke O, Grahovac B, Schendel D, Stevanovic S, Jung, Rammensee H-G: Peptide motifs of HLA-B35 and -B37 molecules. Immunogenetics 38:161, 1993.
40. Huczko EL, Bodnar WM, Benjamin D, Sakaguchi K, Zhu NZ, Shabanowitz J, Henderson RA, Appella E, Hunt DF, Engelhard VH: Characteristics of endogenous peptides eluted from the class I MHC molecule HLA-B7 determined by mass spectrometry and computer modeling. J Immunol 151:2572, 1993.
41. Sutton J, Rowland-Jones S, Rosenberg W, Nixon D, Gotch F, Gao X-M, Murrary N, Spoonas A, Driscoll P, Smith M, Willis A, McMichael A: A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA-B8 revealed by analysis of epitopes and eluted peptides. Eur J Immunol 23:447, 1993.
42. Parham P, Adams EJ, Arnett KL: The origins of HLA-A, B, C polymorphism. Immunol Rev 143:141, 1995.
43. Fleischhauer K, Avila D, Vilbois F, Traversari C, Bordignon C: Characterization of natural peptide ligands for HLA-B*4402 and -B*4403: implications for peptide involvement in allorecognition of a single amino acid change in the HLA-B44 heavy chain. Tissue Antigens 44:311, 1994.
44. Rötzschke O, Falk K, Stevanovic S, Jung G, Rammensee H-G: Peptide motifs of closely related HLA class I molecules encompass substantial differences. Eur J Immunol 22:2453, 1992.
45. Koenig S, Fuerst TR, Wood LV, Woods RM, Suzich JA, Jones GM, de la Cruz VF, Davey RT Jr, Venkatesan S, Moss B, Biddison WE, Fauci AS: Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein. J Immunol 145:127, 1990.
46. Culmann B, Gomard E, Kiény M-P, Guy B, Dreyfus F, Saimot A-G, Sereni D, Sicard D, Lévy JP: Six epitopes reacting with human cytotoxic CD8+ T cells in the central region of the HIV-1 nef protein. J Immunol 146: 1560, 1991.
47. Wentworth PA, Celis E, Crimi C, Stitely S, Hale L, Tsai V, Serra HM, del Guercio M-F, Livingston B, Alazard D, Fikes J, Kubo RT, Grey HM, Chesnut RW, Chisari FV, Sette A: In vitro induction of primary, antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides. Mol Immunol 32: 603, 1995.
48. Ishikawa Y, Tokunaga K, Lin L, Imanishi T, Saitou S, Kimura A, Kashiwase K, Akaza T, Tadokoro K, Juji T: Sequences of four splits of HLA-A10 group: implications for serologic cross-reactivities and their evolution. Hum Immunol 39:220, 1994.
49. Firgaira FA, Male D, Morley AA: The ancestral HLA-A lineage split is delineated by an intron 3 insertion/ deletion polymorphism. Immunogenetics 40:445, 1994.
50. Kato K, Trapani JA, Allopenna J, Dupont B, Yang SY: Molecular analysis of the serologically defined HLA-Aw19 antigens: a genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30. J Immunol 143:3371, 1989.
51. Lawlor DA, Zemmour J, Ennis PD, Parham P: Evolution of class I MHC genes and proteins: from natural selection to thymic selection. Annu Rev Immunol 8:23, 1990.
52. Androlewicz MJ, Anderson KS, Cresswell P: Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc Natl Acad Sci USA 90:9130, 1993.
53. Androlewicz MJ, Cresswell P: Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity 1:7, 1994.
54. van Endert PM, Tampe R, Meyer TH, Tisch R, Bach J-F, McDevitt HO: A sequential model for peptide binding and transport by the transporters associated with antigen processing. Immunity 1:491, 1994.
55. Heemels MT, Ploegh HL: Substrate specificity of allelic variants of the TAP peptide transporter. Immunity 1:775, 1994.
56. Momburg F, Neefjes JJ, Hämmerling GJ: Peptide selection by MHC-encoded TAP transporters. Curr Opin Immunol 6:32, 1994.
57. Neefjes JJ, Momburg F, Hämmerling GJ: Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 261:769, 1993.
58. Harris PE, Colovai A, Liu Z, Dalla Pavera R, Suciu-Foca N: Naturally processed HLA class I bound peptides from c-myc-transfected cells reveal allele-specific motifs. J Immunol 151:5966, 1993.
59. Thorpe CJ, Travers PJ: Prediction of an HLA-B44 binding motif by the alignment of known epitopes and molecular modeling of the antigen binding cleft. Immunogenetics 40:303, 1994.
60. Falk K, Rötzschke O, Takiguchi M, Gnau V, Stevanovic S, Jung G, Rammensee H-G: Peptide motifs of HLA-B38 and B39 molecules. Immunogenetics 41:162, 1994.
61. Falk K, Rötzschke O, Takiguchi M, Gnau V, Stevanovic S, Jung G, Rammensee H-G: Peptides motifs of HLA-B58, B60, B61, and B62 molecules. Immunogenetics 41: 165, 1994.
62. Panina-Bordignon P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A: Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol 19:2237, 1989.
63. O'Sullivan D, Sidney J, Appella E, Walker L, Phillips L, Colón S, Miles C, Chesnut RW, Sette A: Characterization of the specificity of peptide binding to four DR haplotypes. J Immunol 145:1799, 1990.
64. Busch R, Strang G, Howland K, Rothbard JB: Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell surfaces. Int Immunol 2:443, 1990.
65. Vitiello A, Ishioka G, Grey HM, Rose R, Farness P, La-Fond R, Yuan L, Chisari FV, Furze J, Bartholomeuz R, Chesnut RW: Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection: I. Induction of a primary CTL response in man. J Clin Invest 95:341, 1995.