The development of multi-epitope vaccines: Epitope identification, vaccine design and clinical evaluation

Biologicals

Volumn 29, Issue 3-4, 2001, Pages 271-276

  Sette, A ^a   Livingston, B ^a   McKinney, D ^a   Appella, E ^b   Fikes, J ^a   Sidney, J ^a   Newman, M ^a   Chesnut, R ^a  

^a Epimmune   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer; CTL; Epitope; HIV; HLA; HTL; Population coverage; Vaccines

Indexed keywords

CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; EPITOPE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; VIRUS VACCINE;

ANTIGEN BINDING; CANCER IMMUNOTHERAPY; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOASSAY; IMMUNOGENICITY; IN VITRO STUDY; MALARIA; NONHUMAN; PRIORITY JOURNAL; VACCINE PRODUCTION;

EID: 0035697665     PISSN: 10451056     EISSN: None     Source Type: Journal    
DOI: 10.1006/biol.2001.0297     Document Type: Conference Paper

References (16)

1. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and B polymorphism
2. Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis
3. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes
4. Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs
5. HLA supertypes and supermotifs: A functional perspective on HLA polymorphism
6. HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs
7. Several common HLA-DR types share a largely overlapping peptide binding repertoire
8. Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes
9. In vitro induction of primary antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides
10. Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis
11. Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles
12. The multi-epitope approach for immunotherapy for cancer: Identification of several CTL epitopes from various tumor-associated antigens expressed on solid epithelial tumors
13. Acute viral escape from cytotoxic T lymphocytes; Implications for HIV vaccine design
14. Definition of the Mamu A*01 peptide binding specificity: Application to the identification of wildtype and optimized ligands from simian immunodeficiency virus regulatory proteins
15. Differences and similarities in the A2.1-restricted cytotoxic T cells repertoire in humans and human leukocyte antigen transgenic mice
16. Optimization of epitope processing enhances immunogenicity of vaccines