Removal of amphipathic epitopes from genetically engineered antibodies: Production of modified immunoglobulins with reduced immunogenicity

Hybridoma

Volumn 19, Issue 6, 2000, Pages 463-471

  Mateo, C ^a   Lombardero, J ^a   Moreno, E ^a   Morales, A ^a   Bombino, G ^a   Coloma, J ^b   Wims, L ^b   Morrison, S L ^b   Perez R ^a  

^a CENTER OF MOLECULAR IMMUNOLOGY   (Cuba)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITOPE; IMMUNOGLOBULIN; PEPTIDE; R3 ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIGEN RECOGNITION; ARTICLE; COMPUTER PROGRAM; DATA BASE; GENETIC ENGINEERING; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; LYMPHOCYTE; MONKEY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ALGORITHMS; ANIMALS; ANTIBODIES; ANTIBODY SPECIFICITY; CERCOPITHECUS AETHIOPS; COMPLEMENTARITY DETERMINING REGIONS; EPITOPES; HUMANS; IMMUNIZATION; MICE; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

MURINAE;

EID: 0034532441     PISSN: 0272457X     EISSN: None     Source Type: Journal    
DOI: 10.1089/027245700750053959     Document Type: Article

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