SCOPUS 정보 검색 플랫폼

Molecular Informatics

Volumn 29, Issue 5, 2010, Pages 366-385

Bioisosteric replacement and scaffold hopping in lead generation and optimization

(3) Langdon, Sarah R a Ertl, Peter a Brown, Nathan b

a INSTITUTE OF CANCER RESEARCH (United Kingdom)

b NOVARTIS PHARMA AG (Switzerland)

Author keywords

Bioisostere; Chemotype; Drug design; Hopping; Isostere; Scaffold

Indexed keywords

DESIGN; MOLECULES;

BIOISOSTERES; CHEMICAL SPACE; CHEMOTYPES; DRUG DESIGN; HOPPING; ISOSTERE; LEAD GENERATION; LEAD OPTIMIZATION; PROPERTY; SCAFFOLD HOPPING;

SCAFFOLDS;

ANALYTIC METHOD; BINDING AFFINITY; BIOINFORMATICS; CHEMICAL BINDING; CHEMICAL REACTION; CHEMICAL STRUCTURE; DATA BASE; ENTROPY; HYDROGEN BOND; HYDROPHOBICITY; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MEDICAL RESEARCH; PHARMACOPHORE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVIEW;

HUMULUS;

EID: 77952732009 PISSN: 18681743 EISSN: 18681751 Source Type: Journal
DOI: 10.1002/minf.201000019 Document Type: Review

Times cited : (182)

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