In silico identification of bioisosteric functional groups

Current Opinion in Drug Discovery and Development

Volumn 10, Issue 3, 2007, Pages 281-288

  Ertl, Peter ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Bioisosteric design; Bioisosteric replacement; Functional group; Spacer; Substituent properties; Substituents

Indexed keywords

FUNCTIONAL GROUP; G PROTEIN COUPLED RECEPTOR; PHOSPHOTRANSFERASE INHIBITOR;

ATOM; BIOLOGICAL ACTIVITY; BIOMEDICINE; COMBINATORIAL CHEMISTRY; COMPUTER MODEL; CRYSTAL STRUCTURE; DATA BASE; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG TRANSPORT; ELECTRICITY; EXPERIMENTATION; GEOMETRY; HYDROGEN BOND; HYDROPHOBICITY; MEDICINE; METHODOLOGY; MOLECULAR WEIGHT; PATENT; PHARMACOPHORE; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; STEREOSPECIFICITY;

BINDING SITES; COMPUTER SIMULATION; DATABASES, FACTUAL; DRUG DESIGN; HYDROGEN BONDING; HYDROPHOBICITY; INFORMATICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TECHNOLOGY, PHARMACEUTICAL;

EID: 34249086830     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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