메뉴 건너뛰기




Volumn 6, Issue 6, 2010, Pages 689-699

Altered drug metabolism during pregnancy: Hormonal regulation of drug-metabolizing enzymes

Author keywords

CYP; Drug metabolism; Hormones; Pregnancy

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ATENOLOL; CONSTITUTIVE ANDROSTANE RECEPTOR; CORTICOTROPIN RELEASING FACTOR; DRUG METABOLIZING ENZYME; ESTETROL; ESTRADIOL; ESTRIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTRONE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A4; GROWTH HORMONE; HEPATOCYTE NUCLEAR FACTOR; HUMAN PLACENTA LACTOGEN; HYDROCORTISONE; LABETALOL; LAMOTRIGINE; MORPHINE; NICOTINE; PLACENTAL GROWTH HORMONE; PREGNANE X RECEPTOR; PROGESTERONE; PROLACTIN; STAT5B PROTEIN; TRANSCORTIN; UNCLASSIFIED DRUG; VALPROIC ACID; DRUG; HORMONE;

EID: 77952572759     PISSN: 17425255     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425251003677755     Document Type: Review
Times cited : (134)

References (98)
  • 2
    • 0038743344 scopus 로고    scopus 로고
    • Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population
    • Glover DD, Amonkar M, Rybeck BF, et al. Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population. Am J Obstet Gynecol 2003;188(4):1039-45
    • (2003) Am. J. Obstet. Gynecol. , vol.188 , Issue.4 , pp. 1039-1045
    • Glover, D.D.1    Amonkar, M.2    Rybeck, B.F.3
  • 3
    • 0942287304 scopus 로고    scopus 로고
    • Updates on the treatment of epilepsy in women
    • Tatum WO, Liporace J, Benbadis SR, et al. Updates on the treatment of epilepsy in women. Arch Intern Med 2004;164(2):137-45
    • (2004) Arch. Intern. Med. , vol.164 , Issue.2 , pp. 137-145
    • Tatum, W.O.1    Liporace, J.2    Benbadis, S.R.3
  • 4
    • 33646814764 scopus 로고    scopus 로고
    • Antibiotic use in pregnancy and lactation: What is and is not known about teratogenic and toxic risks
    • Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol 2006;107(5):1120-38
    • (2006) Obstet. Gynecol. , vol.107 , Issue.5 , pp. 1120-1138
    • Nahum, G.G.1    Uhl, K.2    Kennedy, D.L.3
  • 5
    • 40749096515 scopus 로고    scopus 로고
    • ACOG practice bulletin: Clinical management guidelines for obstetrician gynecologists number 90, February 2008: Asthma in pregnancy
    • Dombrowski MP, Schatz M. ACOG practice bulletin: clinical management guidelines for obstetrician gynecologists number 90, February 2008: asthma in pregnancy. Obstet Gynecol 2008;111(2 Pt 1):457-64
    • (2008) Obstet. Gynecol. , vol.111 , Issue.1-2 PT , pp. 457-464
    • Dombrowski, M.P.1    Schatz, M.2
  • 6
    • 28844472592 scopus 로고    scopus 로고
    • Manifestations of chronic disease during pregnancy
    • Kaaja RJ, Greer IA. Manifestations of chronic disease during pregnancy. JAMA 2005;294(21):2751-7
    • (2005) JAMA , vol.294 , Issue.21 , pp. 2751-2757
    • Kaaja, R.J.1    Greer, I.A.2
  • 7
    • 25144516296 scopus 로고    scopus 로고
    • Pregnancy-induced changes in pharmacokinetics: A mechanistic-based approach
    • • Review of altered drug disposition during pregnancy
    • Anderson GD. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 2005;44(10):989-1008 • Review of altered drug disposition during pregnancy.
    • (2005) Clin. Pharmacokinet , vol.44 , Issue.10 , pp. 989-1008
    • Anderson, G.D.1
  • 9
    • 85047683695 scopus 로고    scopus 로고
    • Alterations in drug disposition during pregnancy: Implications for drug therapy
    • • Review of altered drug disposition during pregnancy
    • Hodge LS, Tracy TS. Alterations in drug disposition during pregnancy: implications for drug therapy. Expert Opin Drug Metab Toxicol 2007;3(4):557-71 • Review of altered drug disposition during pregnancy.
    • (2007) Expert Opin. Drug. Metab. Toxicol. , vol.3 , Issue.4 , pp. 557-571
    • Hodge, L.S.1    Tracy, T.S.2
  • 10
    • 33645391801 scopus 로고    scopus 로고
    • Impact of pregnancy on abacavir pharmacokinetics
    • Best BM, Mirochnick M, Capparelli EV, et al. Impact of pregnancy on abacavir pharmacokinetics. AIDS 2006;20(4):553-60
    • (2006) AIDS , vol.20 , Issue.4 , pp. 553-560
    • Best, B.M.1    Mirochnick, M.2    Capparelli, E.V.3
  • 11
    • 0025139714 scopus 로고
    • Plasma protein binding of drugs in pregnancy and in neonates
    • Notarianni LJ. Plasma protein binding of drugs in pregnancy and in neonates. Clin Pharmacokinet 1990;18(1):20-36
    • (1990) Clin. Pharmacokinet , vol.18 , Issue.1 , pp. 20-36
    • Notarianni, L.J.1
  • 12
    • 0034894719 scopus 로고    scopus 로고
    • Human alpha-1-glycoprotein and its interactions with drugs
    • Israili ZH, Dayton PG. Human alpha-1-glycoprotein and its interactions with drugs. Drug Metab Rev 2001;33(2):161-235
    • (2001) Drug. Metab. Rev. , vol.33 , Issue.2 , pp. 161-235
    • Israili, Z.H.1    Dayton, P.G.2
  • 13
    • 0020183865 scopus 로고
    • Glomerular ultrafiltration in the pseudopregnant rat
    • Baylis C. Glomerular ultrafiltration in the pseudopregnant rat. Am J Physiol 1982;243(3):F300-5
    • (1982) Am. J. Physiol. , vol.243 , Issue.3
    • Baylis, C.1
  • 14
    • 0030806572 scopus 로고    scopus 로고
    • Pharmacokinetic changes during pregnancy and their clinical relevance
    • Loebstein R, Lalkin A, Koren G. Pharmacokinetic changes during pregnancy and their clinical relevance. Clin Pharmacokinet 1997;33(5):328-43
    • (1997) Clin. Pharmacokinet , vol.33 , Issue.5 , pp. 328-343
    • Loebstein, R.1    Lalkin, A.2    Koren, G.3
  • 15
    • 0032922072 scopus 로고    scopus 로고
    • Pharmacokinetics during pregnancy: Evidence-based maternal dose formulation
    • Little BB. Pharmacokinetics during pregnancy: evidence-based maternal dose formulation. Obstet Gynecol 1999;93(5 Pt 2):858-68
    • (1999) Obstet. Gynecol. , vol.93 , Issue.2-5 PT , pp. 858-868
    • Little, B.B.1
  • 16
    • 16644402527 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartum
    • Hebert MF, Carr DB, Anderson GD, et al. Pharmacokinetics and pharmacodynamics of atenolol during pregnancy and postpartum. J Clin Pharmacol 2005;45(1):25-33
    • (2005) J. Clin. Pharmacol. , vol.45 , Issue.1 , pp. 25-33
    • Hebert, M.F.1    Carr, D.B.2    Anderson, G.D.3
  • 18
    • 0036932917 scopus 로고    scopus 로고
    • Assessment of the hepatic arterial and portal venous blood flows during pregnancy with Doppler ultrasonography
    • Nakai A, Sekiya I, Oya A, et al. Assessment of the hepatic arterial and portal venous blood flows during pregnancy with Doppler ultrasonography. Arch Gynecol Obstet 2002;266(1):25-9
    • (2002) Arch. Gynecol. Obstet. , vol.266 , Issue.1 , pp. 25-29
    • Nakai, A.1    Sekiya, I.2    Oya, A.3
  • 19
    • 0036231675 scopus 로고    scopus 로고
    • Accelerated metabolism of nicotine and cotinine in pregnant smokers
    • Dempsey D, Jacob P III, Benowitz NL. Accelerated metabolism of nicotine and cotinine in pregnant smokers. J Pharmacol Exp Ther 2002;301(2):594-8
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , Issue.2 , pp. 594-598
    • Dempsey, D.1    Jacob III, P.2    Benowitz, N.L.3
  • 20
    • 0025651512 scopus 로고
    • Maternal kinetics of morphine during labour
    • Gerdin E, Salmonson T, Lindberg B, et al. Maternal kinetics of morphine during labour. J Perinat Med 1990;18(6):479-87
    • (1990) J. Perinat Med. , vol.18 , Issue.6 , pp. 479-487
    • Gerdin, E.1    Salmonson, T.2    Lindberg, B.3
  • 21
    • 0141542598 scopus 로고    scopus 로고
    • Antiepileptic drug pharmacokinetics during pregnancy and lactation
    • Pennell PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 2003;61(6 Suppl 2):S35-42
    • (2003) Neurology , vol.61 , Issue.2-6 SUPPL.
    • Pennell, P.B.1
  • 22
    • 14644407562 scopus 로고    scopus 로고
    • Sex and racial differences in pharmacological response: Where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics
    • Anderson GD. Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics. J Womens Health (Larchmt) 2005;14(1):19-29
    • (2005) J. Womens Health (Larchmt) , vol.14 , Issue.1 , pp. 19-29
    • Anderson, G.D.1
  • 23
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994;270(1):414-23
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , Issue.1 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3
  • 24
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: Metabolism, expression, and disease
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 2000;40:581-616
    • (2000) Annu Rev. Pharmacol. Toxicol. , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 25
    • 0036226707 scopus 로고    scopus 로고
    • Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes
    • Hollenberg PF. Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes. Drug Metab Rev 2002;34(1-2):17-35
    • (2002) Drug. Metab. Rev. , vol.34 , Issue.1-2 , pp. 17-35
    • Hollenberg, P.F.1
  • 26
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 (CYP) genes by nuclear receptors
    • Honkakoski P, Negishi M. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 2000;347(Pt 2):321-37
    • (2000) Biochem. J. , vol.347 , Issue.2 PT , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 27
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs
    • Urquhart BL, Tirona RG, Kim RB. Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs. J Clin Pharmacol 2007;47(5):566-78
    • (2007) J. Clin. Pharmacol. , vol.47 , Issue.5 , pp. 566-578
    • Urquhart, B.L.1    Tirona, R.G.2    Kim, R.B.3
  • 28
    • 0031682988 scopus 로고    scopus 로고
    • The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
    • Honkakoski P, Zelko I, Sueyoshi T, et al. The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 1998;18(10):5652-8
    • (1998) Mol. Cell. Biol. , vol.18 , Issue.10 , pp. 5652-5658
    • Honkakoski, P.1    Zelko, I.2    Sueyoshi, T.3
  • 29
    • 69749083669 scopus 로고    scopus 로고
    • Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects
    • di Masi A, Marinis ED, Ascenzi P, et al. Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects. Mol Aspects Med 2009;30(5):297-343
    • (2009) Mol. Aspects Med. , vol.30 , Issue.5 , pp. 297-343
    • Di Masi, A.1    Marinis, E.D.2    Ascenzi, P.3
  • 31
    • 0003908489 scopus 로고    scopus 로고
    • 21st edition. McGraw-Hill Medical Publishing Division, New York
    • Cunningham FG. Williams obstetrics. 21st edition. McGraw-Hill Medical Publishing Division, New York; 2001
    • (2001) Williams Obstetrics
    • Cunningham, F.G.1
  • 33
    • 37549060373 scopus 로고    scopus 로고
    • Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination
    • Jeong H, Choi S, Song JW, et al. Regulation of UDP- glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination. Xenobiotica 2008;38(1):62-75
    • (2008) Xenobiotica , vol.38 , Issue.1 , pp. 62-75
    • Jeong, H.1    Choi, S.2    Song, J.W.3
  • 34
    • 70349142306 scopus 로고    scopus 로고
    • Upregulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17{beta}-Estradiol: A potential mechanism of increased lamotrigine elimination in pregnancy
    • Chen H, Yang K, Choi S, et al. Upregulation of UDP- glucuronosyltransferase (UGT) 1A4 by 17{beta}-Estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy. Drug Metab Dispos 2009;37(9):1841-7
    • (2009) Drug. Metab. Dispos , vol.37 , Issue.9 , pp. 1841-1847
    • Chen, H.1    Yang, K.2    Choi, S.3
  • 35
    • 78649288679 scopus 로고    scopus 로고
    • Effects of 17beta-estradiol (E2) on expression of CYP enzymes in human hepatocytes
    • Koh K, Jeong H. Effects of 17beta-estradiol (E2) on expression of CYP enzymes in human hepatocytes. Drug Metab Rev 2009;41(Suppl 3):49
    • (2009) Drug. Metab. Rev. , vol.41-49 , Issue.3 SUPPL.
    • Koh, K.1    Jeong, H.2
  • 36
    • 34748881453 scopus 로고    scopus 로고
    • Human CYP2A6 is induced by estrogen via estrogen receptor
    • Higashi E, Fukami T, Itoh M, et al. Human CYP2A6 is induced by estrogen via estrogen receptor. Drug Metab Dispos 2007;35(10):1935-41
    • (2007) Drug. Metab. Dispos , vol.35 , Issue.10 , pp. 1935-1941
    • Higashi, E.1    Fukami, T.2    Itoh, M.3
  • 37
    • 0033652116 scopus 로고    scopus 로고
    • Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene
    • Kawamoto T, Kakizaki S, Yoshinari K, et al. Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene. Mol Endocrinol 2000;14(11):1897-905
    • (2000) Mol. Endocrinol. , vol.14 , Issue.11 , pp. 1897-1905
    • Kawamoto, T.1    Kakizaki, S.2    Yoshinari, K.3
  • 38
    • 85069249849 scopus 로고    scopus 로고
    • CAR (constitutive androstane/active receptor) -mediated up-regulation of CYP2B6 expression by 17 b-estradiol
    • Yang K, Koh K, Choi S, et al. CAR (constitutive androstane/active receptor) -mediated up-regulation of CYP2B6 expression by 17 b-estradiol. Drug Metab Rev 2009;41(Suppl 3):89
    • (2009) Drug. Metab. Rev. , vol.41-89 , Issue.3 SUPPL.
    • Yang, K.1    Koh, K.2    Choi, S.3
  • 39
    • 0014465905 scopus 로고
    • Comparative binding affinity of estrogens and its relation to estrogenic potency
    • Korenman SG. Comparative binding affinity of estrogens and its relation to estrogenic potency. Steroids 1969;13(2):163-77
    • (1969) Steroids , vol.13 , Issue.2 , pp. 163-177
    • Korenman, S.G.1
  • 40
    • 0017230798 scopus 로고
    • Uterine estrogen receptor binding of catecholestrogens and of estetrol (1, 3, 5 (10) -estratriene-3, 15alpha, 16alpha, 17beta-tetrol)
    • Martucci C, Fishman J. Uterine estrogen receptor binding of catecholestrogens and of estetrol (1, 3, 5 (10) -estratriene-3, 15alpha, 16alpha, 17beta-tetrol). Steroids 1976;27(3):325-33
    • (1976) Steroids , vol.27 , Issue.3 , pp. 325-333
    • Martucci, C.1    Fishman, J.2
  • 42
    • 51349112216 scopus 로고    scopus 로고
    • Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferation
    • Watson CS, Jeng YJ, Kochukov MY. Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferation. FASEB J 2008;22(9):3328-36
    • (2008) FASEB J. , vol.22 , Issue.9 , pp. 3328-3336
    • Watson, C.S.1    Jeng, Y.J.2    Kochukov, M.Y.3
  • 43
    • 0031974628 scopus 로고    scopus 로고
    • Determinants of ligand specificity of estrogen receptor-alpha: Estrogen versus androgen discrimination
    • Ekena K, Katzenellenbogen JA, Katzenellenbogen BS. Determinants of ligand specificity of estrogen receptor-alpha: estrogen versus androgen discrimination. J Biol Chem 1998;273(2):693-9
    • (1998) J. Biol. Chem. , vol.273 , Issue.2 , pp. 693-699
    • Ekena, K.1    Katzenellenbogen, J.A.2    Katzenellenbogen, B.S.3
  • 44
    • 0034038026 scopus 로고    scopus 로고
    • Involvement of estrogen receptors alpha and beta in the regulation of cervical permeability
    • Gorodeski GI, Pal D. Involvement of estrogen receptors alpha and beta in the regulation of cervical permeability. Am J Physiol Cell Physiol 2000;278(4):C689-96
    • (2000) Am. J. Physiol. Cell. Physiol. , vol.278 , Issue.4
    • Gorodeski, G.I.1    Pal, D.2
  • 45
    • 34147142831 scopus 로고    scopus 로고
    • Physiologically high concentrations of 17beta-estradiol enhance NF-kappaB activity in human T cells
    • Hirano S, Furutama D, Hanafusa T. Physiologically high concentrations of 17beta-estradiol enhance NF-kappaB activity in human T cells. Am J Physiol Regul Integr Comp Physiol 2007;292(4):R1465-71
    • (2007) Am. J. Physiol. Regul Integr Comp. Physiol. , vol.292 , Issue.4
    • Hirano, S.1    Furutama, D.2    Hanafusa, T.3
  • 46
    • 36448934175 scopus 로고    scopus 로고
    • Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins
    • e1-7
    • Attardi BJ, Zeleznik A, Simhan H, et al. Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate, and related progestins. Am J Obstet Gynecol 2007;197(6):599 e1-7
    • (2007) Am. J. Obstet. Gynecol. , vol.197 , Issue.6 , pp. 599
    • Attardi, B.J.1    Zeleznik, A.2    Simhan, H.3
  • 47
    • 0031599561 scopus 로고    scopus 로고
    • Pregnancy and menstrual hormone levels in mothers of twins compared to mothers of singletons
    • Thomas HV, Murphy MF, Key TJ, et al. Pregnancy and menstrual hormone levels in mothers of twins compared to mothers of singletons. Ann Hum Biol 1998;25(1):69-75
    • (1998) Ann. Hum Biol. , vol.25 , Issue.1 , pp. 69-75
    • Thomas, H.V.1    Murphy, M.F.2    Key, T.J.3
  • 48
    • 20444401545 scopus 로고    scopus 로고
    • Pregnancy hormone concentrations across ethnic groups: Implications for later cancer risk
    • Potischman N, Troisi R, Thadhani R, et al. Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk. Cancer Epidemiol Biomarkers Prev 2005;14(6):1514-20
    • (2005) Cancer Epidemiol. Biomarkers Prev. , vol.14 , Issue.6 , pp. 1514-1520
    • Potischman, N.1    Troisi, R.2    Thadhani, R.3
  • 49
    • 33845309148 scopus 로고    scopus 로고
    • Effects of parity on pregnancy hormonal profiles across ethnic groups with a diverse incidence of breast cancer
    • Arslan AA, Zeleniuch-Jacquotte A, Lukanova A, et al. Effects of parity on pregnancy hormonal profiles across ethnic groups with a diverse incidence of breast cancer. Cancer Epidemiol Biomarkers Prev 2006;15(11):2123-30
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , Issue.11 , pp. 2123-2130
    • Arslan, A.A.1    Zeleniuch-Jacquotte, A.2    Lukanova, A.3
  • 50
    • 0036141071 scopus 로고    scopus 로고
    • Impact of progestins on estrogen-induced neuroprotection: Synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
    • Nilsen J, Brinton RD. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 2002;143(1):205-12
    • (2002) Endocrinology , vol.143 , Issue.1 , pp. 205-212
    • Nilsen, J.1    Brinton, R.D.2
  • 51
    • 0031853941 scopus 로고    scopus 로고
    • The effects of progesterone and progestins on endometrial proliferation
    • Moyer DL, Felix JC. The effects of progesterone and progestins on endometrial proliferation. Contraception 1998;57(6):399-403
    • (1998) Contraception , vol.57 , Issue.6 , pp. 399-403
    • Moyer, D.L.1    Felix, J.C.2
  • 52
    • 53249086413 scopus 로고    scopus 로고
    • Gender differences in pharmacological response
    • Anderson GD. Gender differences in pharmacological response. Int Rev Neurobiol 2008;83:1-10
    • (2008) Int. Rev. Neurobiol. , vol.83 , pp. 1-10
    • Anderson, G.D.1
  • 53
    • 33749849449 scopus 로고    scopus 로고
    • Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women
    • O'Connell MB, Frye RF, Matzke GR, et al. Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women. J Clin Pharmacol 2006;46(11):1299-307
    • (2006) J. Clin. Pharmacol. , vol.46 , Issue.11 , pp. 1299-1307
    • O'Connell, M.B.1    Frye, R.F.2    Matzke, G.R.3
  • 54
    • 10744221053 scopus 로고    scopus 로고
    • Hepatic CYP2B6 expression: Gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression
    • Lamba V, Lamba J, Yasuda K, et al. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther 2003;307(3):906-22
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , Issue.3 , pp. 906-922
    • Lamba, V.1    Lamba, J.2    Yasuda, K.3
  • 55
    • 50449088026 scopus 로고    scopus 로고
    • Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: Mechanisms, tissue specificity, and time course
    • • Review of sex differences in DME expression
    • Zhang H, Wu X, Wang H, et al. Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course. Mol Pharmacol 2008;74(3):714-23 • Review of sex differences in DME expression.
    • (2008) Mol. Pharmacol. , vol.74 , Issue.3 , pp. 714-723
    • Zhang, H.1    Wu, X.2    Wang, H.3
  • 56
    • 33646758222 scopus 로고    scopus 로고
    • Aspects of placental growth hormone physiology
    • Fuglsang J, Ovesen P. Aspects of placental growth hormone physiology. Growth Horm IGF Res 2006;16(2):67-85
    • (2006) Growth Horm IGF Res. , vol.16 , Issue.2 , pp. 67-85
    • Fuglsang, J.1    Ovesen, P.2
  • 57
    • 33744456856 scopus 로고    scopus 로고
    • Growth hormone regulation of sex-dependent liver gene expression
    • Waxman DJ, O'Connor C. Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 2006;20(11):2613-29
    • (2006) Mol. Endocrinol. , vol.20 , Issue.11 , pp. 2613-2629
    • Waxman, D.J.1    O'Connor, C.2
  • 58
    • 67650841094 scopus 로고    scopus 로고
    • Centennial perspective: Sex differences in the expression of hepatic drug metabolizing enzymes
    • Waxman DJ, Holloway MG. Centennial perspective: sex differences in the expression of hepatic drug metabolizing enzymes. Mol Pharmacol 2009;76(2):215-28
    • (2009) Mol. Pharmacol. , vol.76 , Issue.2 , pp. 215-228
    • Waxman, D.J.1    Holloway, M.G.2
  • 59
    • 2942644170 scopus 로고    scopus 로고
    • Intrinsic sex differences determine expression of growth hormone-regulated female cytochrome P450s
    • Thangavel C, Garcia MC, Shapiro BH. Intrinsic sex differences determine expression of growth hormone-regulated female cytochrome P450s. Mol Cell Endocrinol 2004;220(1-2):31-9
    • (2004) Mol. Cell. Endocrinol. , vol.220 , Issue.1-2 , pp. 31-39
    • Thangavel, C.1    Garcia, M.C.2    Shapiro, B.H.3
  • 60
    • 43049101096 scopus 로고    scopus 로고
    • Liver-specific hepatocyte nuclear factor-4alpha deficiency: Greater impact on gene expression in male than in female mouse liver
    • Holloway MG, Miles GD, Dombkowski AA, et al. Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver. Mol Endocrinol 2008;22(5):1274-86
    • (2008) Mol. Endocrinol. , vol.22 , Issue.5 , pp. 1274-1286
    • Holloway, M.G.1    Miles, G.D.2    Dombkowski, A.A.3
  • 61
    • 29244466095 scopus 로고    scopus 로고
    • Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone
    • Dhir RN, Dworakowski W, Thangavel C, et al. Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone. J Pharmacol Exp Ther 2006;316(1):87-94
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , Issue.1 , pp. 87-94
    • Dhir, R.N.1    Dworakowski, W.2    Thangavel, C.3
  • 62
    • 0031785886 scopus 로고    scopus 로고
    • Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes
    • Liddle C, Goodwin BJ, George J, et al. Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. J Clin Endocrinol Metab 1998;83(7):2411-6
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , Issue.7 , pp. 2411-2416
    • Liddle, C.1    Goodwin, B.J.2    George, J.3
  • 63
    • 8744269315 scopus 로고    scopus 로고
    • Effects of growth hormone deficiency and rhGH replacement therapy on the 6beta-hydroxycortisol/free cortisol ratio, a marker of CYP3A activity, in growth hormone-deficient children
    • Sinues B, Mayayo E, Fanlo A, et al. Effects of growth hormone deficiency and rhGH replacement therapy on the 6beta-hydroxycortisol/free cortisol ratio, a marker of CYP3A activity, in growth hormone-deficient children. Eur J Clin Pharmacol 2004;60(8):559-64
    • (2004) Eur. J. Clin. Pharmacol. , vol.60 , Issue.8 , pp. 559-564
    • Sinues, B.1    Mayayo, E.2    Fanlo, A.3
  • 64
    • 0029927697 scopus 로고    scopus 로고
    • Growth hormone treatment increases cytochrome P450-mediated antipyrine clearance in man
    • Cheung NW, Liddle C, Coverdale S, et al. Growth hormone treatment increases cytochrome P450-mediated antipyrine clearance in man. J Clin Endocrinol Metab 1996;81(5):1999-2001
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , Issue.5 , pp. 1999-2001
    • Cheung, N.W.1    Liddle, C.2    Coverdale, S.3
  • 65
    • 0036838944 scopus 로고    scopus 로고
    • Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans
    • • Clinical examination of the effects of GH pulsatility on CYP expression
    • Jaffe CA, Turgeon DK, Lown K, et al. Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans. Am J Physiol Endocrinol Metab 2002;283(5):E1008-15 • Clinical examination of the effects of GH pulsatility on CYP expression.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283 , Issue.5
    • Jaffe, C.A.1    Turgeon, D.K.2    Lown, K.3
  • 66
    • 0036218060 scopus 로고    scopus 로고
    • Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men
    • Jurgens G, Lange KH, Reuther LO, et al. Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men. Clin Pharmacol Ther 2002;71(3):162-8
    • (2002) Clin. Pharmacol. Ther. , vol.71 , Issue.3 , pp. 162-168
    • Jurgens, G.1    Lange, K.H.2    Reuther, L.O.3
  • 67
    • 1642619546 scopus 로고    scopus 로고
    • Growth hormone and prolactin-molecular and functional evolution
    • Forsyth IA, Wallis M. Growth hormone and prolactin-molecular and functional evolution. J Mammary Gland Biol Neoplasia 2002;7(3):291-312
    • (2002) J. Mammary Gland Biol. Neoplasia , vol.7 , Issue.3 , pp. 291-312
    • Forsyth, I.A.1    Wallis, M.2
  • 69
    • 0033043369 scopus 로고    scopus 로고
    • Prolactin increases the hepatic content of mu-class subunits of glutathione S-transferase in the rat
    • Luquita MG, Catania VA, Sanchez-Pozzi EJ, et al. Prolactin increases the hepatic content of mu-class subunits of glutathione S-transferase in the rat. Drug Metab Dispos 1999;27(1):122-4
    • (1999) Drug. Metab. Dispos , vol.27 , Issue.1 , pp. 122-124
    • Luquita, M.G.1    Catania, V.A.2    Sanchez-Pozzi, E.J.3
  • 70
    • 0028329186 scopus 로고
    • Analysis of p-nitrophenol glucuronidation in hepatic microsomes from lactating rats
    • Luquita MG, Sanchez Pozzi EJ, Catania VA, et al. Analysis of p-nitrophenol glucuronidation in hepatic microsomes from lactating rats. Biochem Pharmacol 1994;47(7):1179-85
    • (1994) Biochem. Pharmacol. , vol.47 , Issue.7 , pp. 1179-1185
    • Luquita, M.G.1    Pozzi, E.J.S.2    Catania, V.A.3
  • 71
    • 0030426847 scopus 로고    scopus 로고
    • Ovine prolactin increases hepatic UDP-glucuronosyltransferase activity in ovariectomized rats
    • Luquita MG, Catania VA, Sanchez-Pozzi EJ, et al. Ovine prolactin increases hepatic UDP-glucuronosyltransferase activity in ovariectomized rats. J Pharmacol Exp Ther 1996;278(2):921-5
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , Issue.2 , pp. 921-925
    • Luquita, M.G.1    Catania, V.A.2    Sanchez-Pozzi, E.J.3
  • 72
    • 0034968394 scopus 로고    scopus 로고
    • Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver
    • Luquita MG, Catania VA, Pozzi EJ, et al. Molecular basis of perinatal changes in UDP-glucuronosyltransferase activity in maternal rat liver. J Pharmacol Exp Ther 2001;298(1):49-56
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , Issue.1 , pp. 49-56
    • Luquita, M.G.1    Catania, V.A.2    Pozzi, E.J.3
  • 73
    • 0030994363 scopus 로고    scopus 로고
    • Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5
    • Ganguly TC, O'Brien ML, Karpen SJ, et al. Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5. J Clin Invest 1997;99(12):2906-14
    • (1997) J. Clin. Invest. , vol.99 , Issue.12 , pp. 2906-2914
    • Ganguly, T.C.1    O'Brien, M.L.2    Karpen, S.J.3
  • 74
    • 0034807523 scopus 로고    scopus 로고
    • PRL, placental lactogen, and GH induce NA (+)/taurocholate-cotransporting polypeptide gene expression by activating signal transducer and activator of transcription-5 in liver cells
    • Cao J, Gowri PM, Ganguly TC, et al. PRL, placental lactogen, and GH induce NA (+)/taurocholate-cotransporting polypeptide gene expression by activating signal transducer and activator of transcription-5 in liver cells. Endocrinology 2001;142(10):4212-22
    • (2001) Endocrinology , vol.142 , Issue.10 , pp. 4212-4222
    • Cao, J.1    Gowri, P.M.2    Ganguly, T.C.3
  • 75
    • 0026635655 scopus 로고
    • Prolactin regulates maternal bile secretory function post partum
    • Liu Y, Hyde JF, Vore M. Prolactin regulates maternal bile secretory function post partum. J Pharmacol Exp Ther 1992;261(2):560-6
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , Issue.2 , pp. 560-566
    • Liu, Y.1    Hyde, J.F.2    Vore, M.3
  • 78
    • 24944536730 scopus 로고    scopus 로고
    • Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry
    • Soldin OP, Guo T, Weiderpass E, et al. Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry. Fertil Steril 2005;84(3):701-10
    • (2005) Fertil Steril , vol.84 , Issue.3 , pp. 701-710
    • Soldin, O.P.1    Guo, T.2    Weiderpass, E.3
  • 79
    • 0037450436 scopus 로고    scopus 로고
    • The expression of CYP2B6, CYP2C9 and CYP3A4 genes: A tangle of networks of nuclear and steroid receptors
    • Pascussi JM, Gerbal-Chaloin S, Drocourt L, et al. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Biochim Biophys Acta 2003;1619(3):243-53
    • (2003) Biochim Biophys. Acta , vol.1619 , Issue.3 , pp. 243-253
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Drocourt, L.3
  • 80
    • 0033655573 scopus 로고    scopus 로고
    • Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes
    • LeCluyse E, Madan A, Hamilton G, et al. Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J Biochem Mol Toxicol 2000;14(4):177-88
    • (2000) J. Biochem. Mol. Toxicol. , vol.14 , Issue.4 , pp. 177-188
    • LeCluyse, E.1    Madan, A.2    Hamilton, G.3
  • 81
    • 0035659943 scopus 로고    scopus 로고
    • Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor
    • Pascussi JM, Drocourt L, Gerbal-Chaloin S, et al. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor. Eur J Biochem 2001;268(24):6346-58
    • (2001) Eur. J. Biochem. , vol.268 , Issue.24 , pp. 6346-6358
    • Pascussi, J.M.1    Drocourt, L.2    Gerbal-Chaloin, S.3
  • 82
    • 0033664347 scopus 로고    scopus 로고
    • Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: Consequences on cytochrome P450 gene regulation
    • Pascussi JM, Gerbal-Chaloin S, Fabre JM, et al. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol Pharmacol 2000;58(6):1441-50
    • (2000) Mol. Pharmacol. , vol.58 , Issue.6 , pp. 1441-1450
    • Pascussi, J.M.1    Gerbal-Chaloin, S.2    Fabre, J.M.3
  • 83
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi JM, Drocourt L, Fabre JM, et al. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 2000;58(2):361-72
    • (2000) Mol. Pharmacol. , vol.58 , Issue.2 , pp. 361-372
    • Pascussi, J.M.1    Drocourt, L.2    Fabre, J.M.3
  • 84
    • 14944341677 scopus 로고    scopus 로고
    • Transcriptional regulation of human UGT1A1 gene expression: Activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1
    • Sugatani J, Nishitani S, Yamakawa K, et al. Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. Mol Pharmacol 2005;67(3):845-55
    • (2005) Mol. Pharmacol. , vol.67 , Issue.3 , pp. 845-855
    • Sugatani, J.1    Nishitani, S.2    Yamakawa, K.3
  • 85
    • 0027255565 scopus 로고
    • Alterations in rat hepatic drug metabolism during pregnancy and lactation
    • Borlakoglu JT, Scott A, Henderson CJ, et al. Alterations in rat hepatic drug metabolism during pregnancy and lactation. Biochem Pharmacol 1993;46(1):29-36
    • (1993) Biochem. Pharmacol. , vol.46 , Issue.1 , pp. 29-36
    • Borlakoglu, J.T.1    Scott, A.2    Henderson, C.J.3
  • 86
    • 0019503298 scopus 로고
    • Drug metabolism, cytochrome P450 spin state, and phospholipid changes during pregnancy in the rat
    • Turcan RG, Tamburini PP, Gibson GG, et al. Drug metabolism, cytochrome P450 spin state, and phospholipid changes during pregnancy in the rat. Biochem Pharmacol 1981;30(11):1223-5
    • (1981) Biochem. Pharmacol. , vol.30 , Issue.11 , pp. 1223-1225
    • Turcan, R.G.1    Tamburini, P.P.2    Gibson, G.G.3
  • 87
    • 0015808273 scopus 로고
    • Effects of pregnancy on the metabolism of drugs in the rat and rabbit
    • Neale MG, Parke DV. Effects of pregnancy on the metabolism of drugs in the rat and rabbit. Biochem Pharmacol 1973;22(12):1451-61
    • (1973) Biochem. Pharmacol. , vol.22 , Issue.12 , pp. 1451-1461
    • Neale, M.G.1    Parke, D.V.2
  • 88
    • 0018709998 scopus 로고
    • Hepatic estrone and estradiol glucuronyltransferase activity in pregnancy. Induction by pretreatment with 3-methylcholanthrene and phenobarbital
    • Vore M, Soliven E. Hepatic estrone and estradiol glucuronyltransferase activity in pregnancy. Induction by pretreatment with 3-methylcholanthrene and phenobarbital. Drug Metab Dispos 1979;7(5):247-51
    • (1979) Drug. Metab. Dispos , vol.7 , Issue.5 , pp. 247-251
    • Vore, M.1    Soliven, E.2
  • 89
    • 36048976637 scopus 로고    scopus 로고
    • Gene expression profiles of drugmetabolizing enzymes (DMEs) in rat liver during pregnancy and lactation
    • He XJ, Yamauchi H, Suzuki K, et al. Gene expression profiles of drugmetabolizing enzymes (DMEs) in rat liver during pregnancy and lactation. Exp Mol Pathol 2007;83(3):428-34
    • (2007) Exp. Mol. Pathol. , vol.83 , Issue.3 , pp. 428-434
    • He, X.J.1    Yamauchi, H.2    Suzuki, K.3
  • 90
    • 0035857453 scopus 로고    scopus 로고
    • The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse
    • Masuyama H, Hiramatsu Y, Mizutani Y, et al. The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse. Mol Cell Endocrinol 2001;172(1-2):47-56
    • (2001) Mol. Cell. Endocrinol. , vol.172 , Issue.1-2 , pp. 47-56
    • Masuyama, H.1    Hiramatsu, Y.2    Mizutani, Y.3
  • 91
    • 0022550918 scopus 로고
    • Effect of tumor promoting contraceptive steroids on growth and drug metabolizing enzymes in rat liver
    • Ochs H, Dusterberg B, Gunzel P, et al. Effect of tumor promoting contraceptive steroids on growth and drug metabolizing enzymes in rat liver. Cancer Res 1986;46(3):1224-32
    • (1986) Cancer Res. , vol.46 , Issue.3 , pp. 1224-1232
    • Ochs, H.1    Dusterberg, B.2    Gunzel, P.3
  • 92
    • 85069245227 scopus 로고
    • First principles of gastroenterology: the basis of disease and an approach to management. 2nd edition. Ottawa, Ontario, Canada: Canadian Public Health Association
    • First principles of gastroenterology: the basis of disease and an approach to management. 2nd edition. Ottawa, Ontario, Canada: Canadian Public Health Association; 1992
    • (1992)
  • 93
    • 0015193545 scopus 로고
    • Estrone and estradiol levels in the ovarian venous blood from rats during the estrous cycle and pregnancy
    • Shaikh AA. Estrone and estradiol levels in the ovarian venous blood from rats during the estrous cycle and pregnancy. Biol Reprod 1971;5(3):297-307
    • (1971) Biol. Reprod. , vol.5 , Issue.3 , pp. 297-307
    • Shaikh, A.A.1
  • 94
    • 0016752325 scopus 로고
    • Hepatic microsomal metabolism of drugs during pregnancy in the rat
    • Dean ME, Stock BH. Hepatic microsomal metabolism of drugs during pregnancy in the rat. Drug Metab Dispos 1975;3(5):325-31
    • (1975) Drug. Metab. Dispos , vol.3 , Issue.5 , pp. 325-331
    • Dean, M.E.1    Stock, B.H.2
  • 95
    • 56749175044 scopus 로고    scopus 로고
    • Induction of drug metabolism: Species differences and toxicological relevance
    • Graham MJ, Lake BG. Induction of drug metabolism: species differences and toxicological relevance. Toxicology 2008;254(3):184-91
    • (2008) Toxicology , vol.254 , Issue.3 , pp. 184-191
    • Graham, M.J.1    Lake, B.G.2
  • 97
    • 0036676378 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity
    • Yallampalli C, Chauhan M, Thota CS, et al. Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. Trends Endocrinol Metab 2002;13(6):263-9
    • (2002) Trends Endocrinol. Metab. , vol.13 , Issue.6 , pp. 263-269
    • Yallampalli, C.1    Chauhan, M.2    Thota, C.S.3
  • 98
    • 0023233913 scopus 로고
    • Effects of pregnancy on the cytochrome P-450 system in mice
    • Lambert GH, Lietz HW, Kotake AN. Effects of pregnancy on the cytochrome P-450 system in mice. Biochem Pharmacol 1987;36(12):1965-71
    • (1987) Biochem. Pharmacol. , vol.36 , Issue.12 , pp. 1965-1971
    • Lambert, G.H.1    Lietz, H.W.2    Kotake, A.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.