메뉴 건너뛰기




Volumn 13, Issue 3, 2006, Pages 163-170

Hyperketonemia (ketosis), oxidative stress and type 1 diabetes

Author keywords

Acetoacetate; Diabetes; Hyperketonemia; Ketosis; Oxygen radicals

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; GLUTATHIONE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; KETONE BODY; OXYGEN RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

EID: 33745685302     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pathophys.2006.05.005     Document Type: Review
Times cited : (72)

References (75)
  • 1
    • 0034687430 scopus 로고    scopus 로고
    • Inflammatory markers of coronary risk
    • Rader D.J. Inflammatory markers of coronary risk. N. Engl. J. Med. 343 (2000) 1179-1182
    • (2000) N. Engl. J. Med. , vol.343 , pp. 1179-1182
    • Rader, D.J.1
  • 2
    • 0034230589 scopus 로고    scopus 로고
    • Antioxidants and vitamins to reduce cardiovascular disease
    • Devaraj S., and Jialal I. Antioxidants and vitamins to reduce cardiovascular disease. Curr. Atheroscler. Rep. 2 (2000) 342-351
    • (2000) Curr. Atheroscler. Rep. , vol.2 , pp. 342-351
    • Devaraj, S.1    Jialal, I.2
  • 3
    • 0031860340 scopus 로고    scopus 로고
    • Protein kinase C activation and the development of diabetic complications
    • Koya D., and King G.L. Protein kinase C activation and the development of diabetic complications. Diabetes 47 (1998) 859-866
    • (1998) Diabetes , vol.47 , pp. 859-866
    • Koya, D.1    King, G.L.2
  • 5
    • 0036046384 scopus 로고    scopus 로고
    • Diabetic ketosis activates lymphomonocyte-inducible nitric oxide synthase
    • Iori E., Calo L., Valbusa D., et al. Diabetic ketosis activates lymphomonocyte-inducible nitric oxide synthase. Diab. Med. 19 (2002) 777-783
    • (2002) Diab. Med. , vol.19 , pp. 777-783
    • Iori, E.1    Calo, L.2    Valbusa, D.3
  • 6
    • 0032832864 scopus 로고    scopus 로고
    • Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients
    • Jain S.K., and McVie R. Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients. Diabetes 48 (1999) 555-1850
    • (1999) Diabetes , vol.48 , pp. 555-1850
    • Jain, S.K.1    McVie, R.2
  • 7
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus. N. Engl. J. Med. 329 (1993) 977-986
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
  • 8
    • 0030048496 scopus 로고    scopus 로고
    • Oxidative stress and diabetic vascular complications
    • Giugliano D., Ceriollo A., and Paolisso G. Oxidative stress and diabetic vascular complications. Diab. Care 19 (1996) 257-267
    • (1996) Diab. Care , vol.19 , pp. 257-267
    • Giugliano, D.1    Ceriollo, A.2    Paolisso, G.3
  • 9
    • 0031708582 scopus 로고    scopus 로고
    • Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents
    • Dominguez C., Rutz E., Gussinye M., and Carrascosa A. Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diab. Care 21 (1998) 1736-1742
    • (1998) Diab. Care , vol.21 , pp. 1736-1742
    • Dominguez, C.1    Rutz, E.2    Gussinye, M.3    Carrascosa, A.4
  • 10
    • 0024408737 scopus 로고
    • Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes
    • Jain S.K., McVie R., Duett J., and Herbst J.J. Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 38 (1989) 1539-1543
    • (1989) Diabetes , vol.38 , pp. 1539-1543
    • Jain, S.K.1    McVie, R.2    Duett, J.3    Herbst, J.J.4
  • 13
    • 0024803840 scopus 로고
    • Hyperglycemia can cause membrane lipid peroxidation and osmotic fragiliy in human red blood cells
    • Jain S.K. Hyperglycemia can cause membrane lipid peroxidation and osmotic fragiliy in human red blood cells. J. Biol. Chem. 264 (1989) 21340-21345
    • (1989) J. Biol. Chem. , vol.264 , pp. 21340-21345
    • Jain, S.K.1
  • 14
    • 0026004879 scopus 로고
    • Glucose induces lipid peroxidation and inactivation of membrane associated iron transport enzymes in human erythrocytes in vivo and in vitro
    • Rajeswari P., Natarajan R., Nadler J.L., and Kumar D. Glucose induces lipid peroxidation and inactivation of membrane associated iron transport enzymes in human erythrocytes in vivo and in vitro. J. Cell. Physiol. 149 (1991) 100-109
    • (1991) J. Cell. Physiol. , vol.149 , pp. 100-109
    • Rajeswari, P.1    Natarajan, R.2    Nadler, J.L.3    Kumar, D.4
  • 15
    • 0000690720 scopus 로고
    • Diabetic ketoacidosis and hyperglycaemic non-ketotic coma
    • Alberti K.G.M.M., DeFronzo R.A., Keen H., and Zimmet P. (Eds), John Wiley and Sons, New York
    • Marshall S.M., Walker M., and Alberti K.G.M.M. Diabetic ketoacidosis and hyperglycaemic non-ketotic coma. In: Alberti K.G.M.M., DeFronzo R.A., Keen H., and Zimmet P. (Eds). International Textbook of Diabetes Mellitus (1992), John Wiley and Sons, New York 1151-1166
    • (1992) International Textbook of Diabetes Mellitus , pp. 1151-1166
    • Marshall, S.M.1    Walker, M.2    Alberti, K.G.M.M.3
  • 17
    • 0015090949 scopus 로고
    • Relationship of blood acetoacetate and 3-hydroxybutyrate in diabetes
    • Stephens J.M., Sulway M.J., and Watkins P.J. Relationship of blood acetoacetate and 3-hydroxybutyrate in diabetes. Diabetes 20 (1971) 485-489
    • (1971) Diabetes , vol.20 , pp. 485-489
    • Stephens, J.M.1    Sulway, M.J.2    Watkins, P.J.3
  • 18
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes
    • Laffel L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diab. Metab. Res. Rev. 15 (1999) 412-426
    • (1999) Diab. Metab. Res. Rev. , vol.15 , pp. 412-426
    • Laffel, L.1
  • 19
    • 0028970171 scopus 로고
    • Decreased erythrocyte membrane fluidity in poorly controlled IDDM. Influence of ketone bodies
    • Candiloros H., Muller S., Zeghari N., Donner M., Drouin P., and Ziegler O. Decreased erythrocyte membrane fluidity in poorly controlled IDDM. Influence of ketone bodies. Diab. Care 18 (1995) 549-551
    • (1995) Diab. Care , vol.18 , pp. 549-551
    • Candiloros, H.1    Muller, S.2    Zeghari, N.3    Donner, M.4    Drouin, P.5    Ziegler, O.6
  • 20
    • 0023220366 scopus 로고
    • Diabetic ketoacidosis
    • Krane E.J. Diabetic ketoacidosis. Pediatr. Clin. N. Am. 34 (1987) 935-960
    • (1987) Pediatr. Clin. N. Am. , vol.34 , pp. 935-960
    • Krane, E.J.1
  • 21
    • 33745734096 scopus 로고    scopus 로고
    • Management of hyperglycemic emergencies
    • Brenner Z.R. Management of hyperglycemic emergencies. AACN Clin. Issues 17 (2006) 56-65
    • (2006) AACN Clin. Issues , vol.17 , pp. 56-65
    • Brenner, Z.R.1
  • 22
    • 1942537025 scopus 로고    scopus 로고
    • Ketoacidosis and hyperosmolar hyperglycemic state in adult diabetic patients
    • Yared Z., and Chiasson J.I. Ketoacidosis and hyperosmolar hyperglycemic state in adult diabetic patients. Minerva Med. 94 (2003) 909-913
    • (2003) Minerva Med. , vol.94 , pp. 909-913
    • Yared, Z.1    Chiasson, J.I.2
  • 23
    • 4644255471 scopus 로고    scopus 로고
    • Diabetic ketoacidosis in type 1 and type 2 diabetes mellitus
    • Newton C.A., and Raskin P. Diabetic ketoacidosis in type 1 and type 2 diabetes mellitus. Arch. Intern. Med. 164 (2004) 1925-1931
    • (2004) Arch. Intern. Med. , vol.164 , pp. 1925-1931
    • Newton, C.A.1    Raskin, P.2
  • 24
    • 0042859988 scopus 로고    scopus 로고
    • Diabetic ketoacidosis: risk factors and management
    • Umpierrez G.E., and Kitabchi A.E. Diabetic ketoacidosis: risk factors and management. Treat. Endocrinol. 3 (2003) 95-108
    • (2003) Treat. Endocrinol. , vol.3 , pp. 95-108
    • Umpierrez, G.E.1    Kitabchi, A.E.2
  • 26
    • 0025026316 scopus 로고
    • Hollier B: elevated lipid peroxidation levels in red blood cells of streptozotocin-treated diabetic rats
    • Jain S.K., Levine S.N., and Duett J. Hollier B: elevated lipid peroxidation levels in red blood cells of streptozotocin-treated diabetic rats. Metabolism 39 (1989) 971-975
    • (1989) Metabolism , vol.39 , pp. 971-975
    • Jain, S.K.1    Levine, S.N.2    Duett, J.3
  • 27
    • 0025540553 scopus 로고
    • Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes
    • Mullarkey C.J., Eldstein D., and Brownlee M. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem. Biophys. Res. Commun. 173 (1990) 932-939
    • (1990) Biochem. Biophys. Res. Commun. , vol.173 , pp. 932-939
    • Mullarkey, C.J.1    Eldstein, D.2    Brownlee, M.3
  • 28
    • 33745706067 scopus 로고    scopus 로고
    • A. van Campenhout, C. van Campenhout, A.R. Lagrou, et al., Impact of diabetes mellitus on the relationship between iron-, inflammatory and oxidative stress, Diab. Metab. Res. Rev., in press.
  • 29
    • 0035668462 scopus 로고    scopus 로고
    • The AGE-receptor in the pathogenesis of diabetic complications
    • Vlassara H. The AGE-receptor in the pathogenesis of diabetic complications. Diab. Metab. Res. Rev. 17 (2001) 436-443
    • (2001) Diab. Metab. Res. Rev. , vol.17 , pp. 436-443
    • Vlassara, H.1
  • 30
    • 0037038819 scopus 로고    scopus 로고
    • Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings
    • Stern D., Yan S.D., Yan S.F., and Schmidt A.M. Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings. Adv. Drug Deliv. Rev. 54 (2002) 1615-1625
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1615-1625
    • Stern, D.1    Yan, S.D.2    Yan, S.F.3    Schmidt, A.M.4
  • 31
    • 0023582040 scopus 로고
    • Glycation and inactivation of human Cu-Zn-superoxide dismutase. Identification of the in vitro glycated sites
    • Arai K., Maguchi S., Fuji S., Ishibash H., Oikawa K., and Taniguchi N. Glycation and inactivation of human Cu-Zn-superoxide dismutase. Identification of the in vitro glycated sites. J. Biol. Chem. 262 (1987) 16969-16972
    • (1987) J. Biol. Chem. , vol.262 , pp. 16969-16972
    • Arai, K.1    Maguchi, S.2    Fuji, S.3    Ishibash, H.4    Oikawa, K.5    Taniguchi, N.6
  • 32
    • 0036160759 scopus 로고    scopus 로고
    • Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model
    • Natarajan R., Gerrity R.G., Gu J.L., Lanting L., Thomas L., and Nadler J.L. Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model. Diabetologia 45 (2002) 125-133
    • (2002) Diabetologia , vol.45 , pp. 125-133
    • Natarajan, R.1    Gerrity, R.G.2    Gu, J.L.3    Lanting, L.4    Thomas, L.5    Nadler, J.L.6
  • 33
    • 0036157629 scopus 로고    scopus 로고
    • Autoantibodies to oxidized low-density lipoprotein in patients with type 2 diabetes mellitus
    • Hsu R.M., Devaraj S., and Jialal I. Autoantibodies to oxidized low-density lipoprotein in patients with type 2 diabetes mellitus. Clin. Chim. Acta 317 (2002) 145-150
    • (2002) Clin. Chim. Acta , vol.317 , pp. 145-150
    • Hsu, R.M.1    Devaraj, S.2    Jialal, I.3
  • 35
    • 0026759488 scopus 로고
    • Free radicals mediate endothelial cell dysfunction caused by elevated glucose
    • Tesfamariam B., and Cohen R.A. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am. J. Physiol. 262 (1992) H321-H326
    • (1992) Am. J. Physiol. , vol.262
    • Tesfamariam, B.1    Cohen, R.A.2
  • 36
  • 37
    • 0031962668 scopus 로고    scopus 로고
    • Hyperketonemia (acetoacetate) increases the oxidizability of LDL + VLDL in type-i diabetic patients
    • Jain S.K., McVie R., and Jaramillo J.J. Hyperketonemia (acetoacetate) increases the oxidizability of LDL + VLDL in type-i diabetic patients. Free Radic. Biol. Med. 24 (1998) 175-181
    • (1998) Free Radic. Biol. Med. , vol.24 , pp. 175-181
    • Jain, S.K.1    McVie, R.2    Jaramillo, J.J.3
  • 38
    • 0033051632 scopus 로고    scopus 로고
    • Effect of hyperketonemia on lipid peroxidation levels of plasma in diabetic patients
    • Jain S.K., McVie R., Jackson R., Levine S.N., and Lim G. Effect of hyperketonemia on lipid peroxidation levels of plasma in diabetic patients. Diab. Care 22 (1999) 1171-1175
    • (1999) Diab. Care , vol.22 , pp. 1171-1175
    • Jain, S.K.1    McVie, R.2    Jackson, R.3    Levine, S.N.4    Lim, G.5
  • 39
    • 0842264588 scopus 로고    scopus 로고
    • Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes
    • Jain S.K., Kannan K., Lim G., Matthew-Greer J., McVie R., and Bocchini J.A. Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes. Diab. Care 26 (2003) 2139-2143
    • (2003) Diab. Care , vol.26 , pp. 2139-2143
    • Jain, S.K.1    Kannan, K.2    Lim, G.3    Matthew-Greer, J.4    McVie, R.5    Bocchini, J.A.6
  • 40
    • 0032832864 scopus 로고    scopus 로고
    • Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type-1 diabetic patients
    • Jain S.K., and McVie R. Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type-1 diabetic patients. Diabetes 48 (1999) 1850
    • (1999) Diabetes , vol.48 , pp. 1850
    • Jain, S.K.1    McVie, R.2
  • 41
    • 0032401572 scopus 로고    scopus 로고
    • Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells
    • Jain S.K., Kannan K., and Lim G. Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells. Free Radic. Biol. Med. 25 (1998) 1083-1088
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 1083-1088
    • Jain, S.K.1    Kannan, K.2    Lim, G.3
  • 42
    • 0033140341 scopus 로고    scopus 로고
    • Effect of hyperketonemia on blood monocyttes in type-1 diabetic patients and apoptosis in cultured U937 monocytes
    • Jain S.K., Kannan K., and McVie R. Effect of hyperketonemia on blood monocyttes in type-1 diabetic patients and apoptosis in cultured U937 monocytes. Antioxid. Redox Signal. 1 (1999) 211
    • (1999) Antioxid. Redox Signal. , vol.1 , pp. 211
    • Jain, S.K.1    Kannan, K.2    McVie, R.3
  • 43
    • 0010322092 scopus 로고
    • Making sense of free radicals and their effects on the body
    • Kelly J. Making sense of free radicals and their effects on the body. Nurs. Times 90 (1994) 34-36
    • (1994) Nurs. Times , vol.90 , pp. 34-36
    • Kelly, J.1
  • 44
    • 0021324990 scopus 로고
    • The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes
    • Jain S.K. The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes. J. Biol. Chem. 259 (1984) 3391
    • (1984) J. Biol. Chem. , vol.259 , pp. 3391
    • Jain, S.K.1
  • 45
    • 0022390631 scopus 로고
    • In vivo externalization of phosphatidylserine and phosphatidylethanolamine in the membrane bilayer and hypercoagulability by the lipid peroxidation of erythrocytes in rats
    • Jain S.K. In vivo externalization of phosphatidylserine and phosphatidylethanolamine in the membrane bilayer and hypercoagulability by the lipid peroxidation of erythrocytes in rats. J. Clin. Invest. 76 (1985) 281
    • (1985) J. Clin. Invest. , vol.76 , pp. 281
    • Jain, S.K.1
  • 46
    • 0030846867 scopus 로고    scopus 로고
    • Oxidant stress-induced transendothelial migration of monocytes is linked to phosphorylation of PECAM-1
    • Rattan V., Sultana C., Shen Y., and Kalra V.K. Oxidant stress-induced transendothelial migration of monocytes is linked to phosphorylation of PECAM-1. Am. J. Physiol. 273 (1997) E453
    • (1997) Am. J. Physiol. , vol.273
    • Rattan, V.1    Sultana, C.2    Shen, Y.3    Kalra, V.K.4
  • 47
    • 0020692228 scopus 로고
    • The effect of malonyldialdehyde, a product of lipid peroxidation, on the deformability, dehydration, and 51Cr-survival of erythrocytes
    • Jain S.K., Mohandas N., Clark M.R., and Shohet S.B. The effect of malonyldialdehyde, a product of lipid peroxidation, on the deformability, dehydration, and 51Cr-survival of erythrocytes. Br. J. Haematol. 53 (1983) 247
    • (1983) Br. J. Haematol. , vol.53 , pp. 247
    • Jain, S.K.1    Mohandas, N.2    Clark, M.R.3    Shohet, S.B.4
  • 48
    • 0029811042 scopus 로고    scopus 로고
    • Effect of elevated glucose concentrations on cellular lipid peroxidation and growth of cultured human kidney proximal tubule cells
    • Jain S.K., Morshed K.M., Kannan K., McMartin K.E., and Bocchini J.A. Effect of elevated glucose concentrations on cellular lipid peroxidation and growth of cultured human kidney proximal tubule cells. Mol. Cell. Biochem. 162 (1996) 11
    • (1996) Mol. Cell. Biochem. , vol.162 , pp. 11
    • Jain, S.K.1    Morshed, K.M.2    Kannan, K.3    McMartin, K.E.4    Bocchini, J.A.5
  • 49
    • 0030832182 scopus 로고    scopus 로고
    • Diabetic RBC-induced oxidant stress leads to transendothelial migration of monocyte-like HL60 cells
    • Rattan V., Shen Y., Sultana C., Kumar D., and Kalra V.K. Diabetic RBC-induced oxidant stress leads to transendothelial migration of monocyte-like HL60 cells. Am. J. Physiol. 273 (1997) E369
    • (1997) Am. J. Physiol. , vol.273
    • Rattan, V.1    Shen, Y.2    Sultana, C.3    Kumar, D.4    Kalra, V.K.5
  • 50
    • 0023612927 scopus 로고
    • Increased adherence of oxidanttreated human and bovine erythrocytes to cultured endothelial cells
    • Wali R.K., Jafe S., Kumar D., Sorgenete N., and Kalra V.K. Increased adherence of oxidanttreated human and bovine erythrocytes to cultured endothelial cells. J. Cell. Physiol. 133 (1987) 25
    • (1987) J. Cell. Physiol. , vol.133 , pp. 25
    • Wali, R.K.1    Jafe, S.2    Kumar, D.3    Sorgenete, N.4    Kalra, V.K.5
  • 51
    • 0033083310 scopus 로고    scopus 로고
    • Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently form activation of caspases in fas signalling
    • Banki R., Hutter E., Gonchoroff N.J., and Perl A. Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently form activation of caspases in fas signalling. J. Immunol. 162 (1999) 1466
    • (1999) J. Immunol. , vol.162 , pp. 1466
    • Banki, R.1    Hutter, E.2    Gonchoroff, N.J.3    Perl, A.4
  • 52
    • 0025046403 scopus 로고
    • The effect of malonyldialdehyde on viscosity of normal and sickle red blood cells
    • Jain S.K., Ross J.D., and Levy G. The effect of malonyldialdehyde on viscosity of normal and sickle red blood cells. Biochem. Med. Metab. Biol. 44 (1990) 37-41
    • (1990) Biochem. Med. Metab. Biol. , vol.44 , pp. 37-41
    • Jain, S.K.1    Ross, J.D.2    Levy, G.3
  • 53
    • 0033163393 scopus 로고    scopus 로고
    • Is NF-kB the sensor of oxidative stress
    • Li N., and Karin M. Is NF-kB the sensor of oxidative stress. FASEB J. 13 (1999) 1137-1143
    • (1999) FASEB J. , vol.13 , pp. 1137-1143
    • Li, N.1    Karin, M.2
  • 55
    • 0037073574 scopus 로고    scopus 로고
    • Acetoacetate increases expression of intracellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells
    • Hoffman W.H., Cheng C., Passmore G.G., Carroll J.E., and Hess D. Acetoacetate increases expression of intracellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells. Neurosci. Lett. 334 (2002) 71
    • (2002) Neurosci. Lett. , vol.334 , pp. 71
    • Hoffman, W.H.1    Cheng, C.2    Passmore, G.G.3    Carroll, J.E.4    Hess, D.5
  • 56
    • 0036789676 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1
    • Uehara Y., Engel T., Li Z., et al. Polyunsaturated fatty acids and acetoacetate downregulate the expression of the ATP-binding cassette transporter A1. Diabetes 51 (2002) 2922-2928
    • (2002) Diabetes , vol.51 , pp. 2922-2928
    • Uehara, Y.1    Engel, T.2    Li, Z.3
  • 57
    • 0037371610 scopus 로고    scopus 로고
    • Distinct effect of ketones bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells
    • Yokoo, et al. Distinct effect of ketones bodies on down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation in adrenal chromaffin cells. J. Pharmacol. Exp. Ther. 304 (2003) 995-1002
    • (2003) J. Pharmacol. Exp. Ther. , vol.304 , pp. 995-1002
    • Yokoo1
  • 59
    • 0017348934 scopus 로고
    • Mitochondrial production of superoxide radical and hydrogen peroxide
    • Boveris A. Mitochondrial production of superoxide radical and hydrogen peroxide. Adv. Exp. Biol. Med. 78 (1977) 67-82
    • (1977) Adv. Exp. Biol. Med. , vol.78 , pp. 67-82
    • Boveris, A.1
  • 60
    • 0034625372 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor necrosis factor a gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and -independent pathways
    • Guha M., Bai W., Nadler J.L., and Natarajan R. Molecular mechanisms of tumor necrosis factor a gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and -independent pathways. J. Biol. Chem. 275 (2000) 17728-17739
    • (2000) J. Biol. Chem. , vol.275 , pp. 17728-17739
    • Guha, M.1    Bai, W.2    Nadler, J.L.3    Natarajan, R.4
  • 61
    • 3242797399 scopus 로고    scopus 로고
    • Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises
    • Stenz F.B., Umpierrez G.E., Cuervo R., and Kitabachi A.E. Proinflammatory cytokines, markers of cardiovascular risks, oxidative stress, and lipid peroxidation in patients with hyperglycemic crises. Diabetes 53 (2004) 2079-2086
    • (2004) Diabetes , vol.53 , pp. 2079-2086
    • Stenz, F.B.1    Umpierrez, G.E.2    Cuervo, R.3    Kitabachi, A.E.4
  • 62
    • 0033037930 scopus 로고    scopus 로고
    • Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells
    • Yerneni K.K., Bai W., Khan B.V., Medford R.M., and Natarajan R. Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells. Diabetes 48 (1999) 855-864
    • (1999) Diabetes , vol.48 , pp. 855-864
    • Yerneni, K.K.1    Bai, W.2    Khan, B.V.3    Medford, R.M.4    Natarajan, R.5
  • 63
    • 0037155879 scopus 로고    scopus 로고
    • The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II effects
    • Reddy M.A., Thimmalapura P.R., Lanting L., Nadler J.L., Fatima S., and Natarajan R. The oxidized lipid and lipoxygenase product 12(S)-hydroxyeicosatetraenoic acid induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38 MAPK and cAMP response element-binding protein activation. Mediation of angiotensin II effects. J. Biol. Chem. 277 (2002) 9920-9928
    • (2002) J. Biol. Chem. , vol.277 , pp. 9920-9928
    • Reddy, M.A.1    Thimmalapura, P.R.2    Lanting, L.3    Nadler, J.L.4    Fatima, S.5    Natarajan, R.6
  • 64
    • 0026672590 scopus 로고
    • Vascular smooth muscle cells exhibit increased growth in response to elevated glucose
    • Natarajan R., Gonzales N., Xu L., and Nadler J.L. Vascular smooth muscle cells exhibit increased growth in response to elevated glucose. Biochem. Biophys. Res. Commun. 187 (1992) 552-560
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 552-560
    • Natarajan, R.1    Gonzales, N.2    Xu, L.3    Nadler, J.L.4
  • 65
    • 0035572857 scopus 로고    scopus 로고
    • Signaling mechanisms of nuclear factor-kappab-mediated activation of inflammatory genes by 13-hydroperoxyoctadecadienoic acid in cultured vascular smooth muscle cells
    • Natarajan R., Reddy M.A., Malik K.U., Fatima S., and Khan B.V. Signaling mechanisms of nuclear factor-kappab-mediated activation of inflammatory genes by 13-hydroperoxyoctadecadienoic acid in cultured vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 21 (2001) 1408-1413
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1408-1413
    • Natarajan, R.1    Reddy, M.A.2    Malik, K.U.3    Fatima, S.4    Khan, B.V.5
  • 66
    • 0036709174 scopus 로고    scopus 로고
    • Nuclear factor-kappa B and cancer: its role in the prevention and therapy
    • Bharti A.C., and Aggrawal B.B. Nuclear factor-kappa B and cancer: its role in the prevention and therapy. Biochem. Pharmacol. 64 (2002) 883-888
    • (2002) Biochem. Pharmacol. , vol.64 , pp. 883-888
    • Bharti, A.C.1    Aggrawal, B.B.2
  • 67
    • 1442325581 scopus 로고    scopus 로고
    • Molecular mechanisms of high glucose-induced cyclooxygenase-2 expression in monocytes
    • Shanmugam N., Gaw Gonzalo I.T., and Natarajan R. Molecular mechanisms of high glucose-induced cyclooxygenase-2 expression in monocytes. Diabetes 53 (2004) 795-802
    • (2004) Diabetes , vol.53 , pp. 795-802
    • Shanmugam, N.1    Gaw Gonzalo, I.T.2    Natarajan, R.3
  • 68
    • 0036305669 scopus 로고    scopus 로고
    • Hyperketonemia increases TNF-α secretion in cultured U937 monocytes and type-1 diabetic patients
    • Jain S.K., Kannan K., Lim G., McVie R., and Bocchini J.A. Hyperketonemia increases TNF-α secretion in cultured U937 monocytes and type-1 diabetic patients. Diabetes 51 (2002) 2287-2293
    • (2002) Diabetes , vol.51 , pp. 2287-2293
    • Jain, S.K.1    Kannan, K.2    Lim, G.3    McVie, R.4    Bocchini, J.A.5
  • 71
    • 3342967630 scopus 로고    scopus 로고
    • Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress
    • Abdelmegeed M.A., Kim S.K., Woodcroft K.J., and Novak R.F. Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress. J. Pharmacol. Exp. Ther. 310 (2004) 728-736
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 728-736
    • Abdelmegeed, M.A.1    Kim, S.K.2    Woodcroft, K.J.3    Novak, R.F.4
  • 72
    • 23744441515 scopus 로고    scopus 로고
    • Insulin resistance and inflammation in the early phase of type 2 diabetes: potential for therapeutic intervention
    • Schernthaner G.H., and Schernthaner G. Insulin resistance and inflammation in the early phase of type 2 diabetes: potential for therapeutic intervention. Scand. J. Clin. Lab. Invest. (Suppl.) 240 (2005) 30-40
    • (2005) Scand. J. Clin. Lab. Invest. (Suppl.) , vol.240 , pp. 30-40
    • Schernthaner, G.H.1    Schernthaner, G.2
  • 73
    • 0027935267 scopus 로고
    • Evidence that glucose increases monocyte binding to human aortic endothelial cells
    • Kim J.A., Berliner J.A., Natarajan R.D., and Nadler J.L. Evidence that glucose increases monocyte binding to human aortic endothelial cells. Diabetes 43 (1994) 1103-1107
    • (1994) Diabetes , vol.43 , pp. 1103-1107
    • Kim, J.A.1    Berliner, J.A.2    Natarajan, R.D.3    Nadler, J.L.4
  • 74
    • 0023091309 scopus 로고
    • Tumor necrosis factor-álpha is chemotactic for monocytes and polymorphonuclear leukocytes
    • Ming W.F., Bersani L., and Mantovani A. Tumor necrosis factor-álpha is chemotactic for monocytes and polymorphonuclear leukocytes. J. Immunol. 138 (1987) 1469-1474
    • (1987) J. Immunol. , vol.138 , pp. 1469-1474
    • Ming, W.F.1    Bersani, L.2    Mantovani, A.3
  • 75
    • 2342460463 scopus 로고    scopus 로고
    • Modulation of inflammatory response in cardiovascular disease
    • Granger D.N., Vowinkel T., and Petnehazy T. Modulation of inflammatory response in cardiovascular disease. Hypertension 43 (2004) 924-931
    • (2004) Hypertension , vol.43 , pp. 924-931
    • Granger, D.N.1    Vowinkel, T.2    Petnehazy, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.