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Volumn 29, Issue 1, 2010, Pages 1-19

Cellular and molecular mechanisms of venous leg ulcers development - The "puzzle" theory

Author keywords

Apoptosis; Iron overload; Leg; T lymphocytes; Ulcer; Varicose veins; Venous insufficiency

Indexed keywords

CASPASE; CELL ADHESION MOLECULE; CHEMOKINE; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; FAS LIGAND; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GAMMA INTERFERON RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON GAMMA RECEPTOR 2; IRON; UNCLASSIFIED DRUG;

EID: 77952519484     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (32)

References (113)
  • 2
    • 33747067953 scopus 로고    scopus 로고
    • The causes of skin damage and leg ulceration in chronic venous disease
    • DOI 10.1177/1534734606292429
    • Coleridge Smith PD. The causes of skin damage and leg ulceration in chronic venous disease. Int J Low Extrem Wounds 2006;5:160-168 (Pubitemid 44215097)
    • (2006) International Journal of Lower Extremity Wounds , vol.5 , Issue.3 , pp. 160-168
    • Smith, P.C.1
  • 3
    • 1942423221 scopus 로고    scopus 로고
    • The role of matrix metalloproteinases (MMPs) and their inhibitors in venous leg ulcer healing
    • Herouy Y. The role of matrix metalloproteinases (MMPs) and their inhibitors in venous leg ulcer healing. Phlebolymphology 2004;44:231-243 (Pubitemid 38508412)
    • (2004) Phlebolymphology , Issue.44 , pp. 231-243
    • Herouy, Y.1
  • 4
    • 44849104154 scopus 로고    scopus 로고
    • Mechanism of disease: The inflammatory chain in chronic venous disorders and genetic screening for prevention of venous leg ulcers
    • Lanzara S, Catozzi L, De Palma M, Federici F, Palazzo A, Tacconi G, et al. Mechanism of disease: the inflammatory chain in chronic venous disorders and genetic screening for prevention of venous leg ulcers. Acta Phlebol 2006;7:39-44.
    • (2006) Acta Phlebol , vol.7 , pp. 39-44
    • Lanzara, S.1    Catozzi, L.2    De Palma, M.3    Federici, F.4    Palazzo, A.5    Tacconi, G.6
  • 5
    • 33745273002 scopus 로고    scopus 로고
    • A potential role of interferon-γ in the pathogenesis of venous leg ulcers
    • DOI 10.1016/j.mehy.2005.12.031, PII S0306987706000119
    • Simka M. A potential role of interferon-gamma in the pathogenesis of venous leg ulcers. Med Hypothes 2006;67:639-644 (Pubitemid 43928301)
    • (2006) Medical Hypotheses , vol.67 , Issue.3 , pp. 639-644
    • Simka, M.1
  • 6
    • 33845681129 scopus 로고    scopus 로고
    • Basic approach to inflammatory ulcers
    • Panuncialman, Falanga V. Basic approach to inflammatory ulcers. Dermatol Ther 2006;19:365-376
    • (2006) Dermatol Ther , vol.19 , pp. 365-376
    • Panuncialman, F.V.1
  • 7
    • 35348837991 scopus 로고    scopus 로고
    • T-cell receptor repertoire in pyoderma gangrenosum: Evidence for clonal expansions and trafficking
    • Brooklyn TN, Williams AM, Dunnill MG, Probert CS. T-cell receptor repertoire in pyoderma gangrenosum: evidence for clonal expansions and trafficking. Br J Dermatol 2007;15:,960-966
    • (2007) Br J Dermatol , vol.15 , pp. 960-966
    • Brooklyn, T.N.1    Williams, A.M.2    Dunnill, M.G.3    Probert, C.S.4
  • 8
    • 0034564878 scopus 로고    scopus 로고
    • Microcirculatory inflammation in chronic venous insufficiency: Current status and future directions
    • Durán W, Pappas PJ, Schmid-Schönbein GW. Microcirculatory inflammation in chronic venous insufficiency: current status and future directions. Microcirculation 2000;7:S49-S58.
    • (2000) Microcirculation , vol.7
    • Durán, W.1    Pappas, P.J.2    Schmid-Schönbein, G.W.3
  • 9
    • 33847020833 scopus 로고    scopus 로고
    • Inflammation in wound repair: Molecular and cellular mechanisms
    • DOI 10.1038/sj.jid.5700701
    • Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007;127:514-525 (Pubitemid 46271017)
    • (2007) Journal of Investigative Dermatology , vol.127 , Issue.3 , pp. 514-525
    • Eming, S.A.1    Krieg, T.2    Davidson, J.M.3
  • 11
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-Á: An overview of signals, mechanisms and functions
    • Schroder K, Hertzog PJ, Flavasi T, Hume DA. Interferon-Á: an overview of signals, mechanisms and functions. J Leukoc Biol 2004;75:163-188
    • (2004) J Leukoc Biol , vol.75 , pp. 163-188
    • Schroder, K.1    Hertzog, P.J.2    Flavasi, T.3    Hume, D.A.4
  • 12
    • 3442875521 scopus 로고    scopus 로고
    • IFN-γ inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis
    • DOI 10.1189/jlb.0503247
    • De Rose V, Cappello P, Sorbello V, Ceccarini B, Gani F, Bosticardo M, et al. IFN-Á inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis. J Leukoc Biol 2004;76:423-432 (Pubitemid 39006957)
    • (2004) Journal of Leukocyte Biology , vol.76 , Issue.2 , pp. 423-432
    • De Rose, V.1    Cappello, P.2    Sorbello, V.3    Ceccarini, B.4    Gani, F.5    Bosticardo, M.6    Fassio, S.7    Novelli, F.8
  • 14
    • 17144393009 scopus 로고    scopus 로고
    • The contribution of the Fas/FasL apoptotic pathway in ulcer formation during Leishmania mayor-induced cutaneous leishmaniasis
    • Eidsmo L, Nylen S, Khamesipour A, Hedblad MA, Chiodi F, Akuffo H. The contribution of the Fas/FasL apoptotic pathway in ulcer formation during Leishmania major-induced cutaneous leishmaniasis. Am J Pathol 2005;166:1099-1108 (Pubitemid 40524434)
    • (2005) American Journal of Pathology , vol.166 , Issue.4 , pp. 1099-1108
    • Eidsmo, L.1    Nylen, S.2    Khamesipour, A.3    Hedblad, M.-A.4    Chiodi, F.5    Akuffo, H.6
  • 16
    • 33644504480 scopus 로고    scopus 로고
    • Use of intravenous immunoglobulin in toxic epidermal necrolysis and Stevens-Johnson syndrome: Our current understanding
    • DOI 10.1016/j.intimp.2005.11.012, PII S1567576905003115, Use of Immune Globulin Intravenous in Dermatology
    • French LE, Trent JT, Kerdel FA. Use of intravenous immunoglobulin in toxic epidermal necrolysis and Stevens-Johnson syndrome: our current understanding. Int Immunopharmacol 2006;6:543-549 (Pubitemid 43295459)
    • (2006) International Immunopharmacology , vol.6 , Issue.4 , pp. 543-549
    • French, L.E.1    Trent, J.T.2    Kerdel, F.A.3
  • 17
    • 0030781073 scopus 로고    scopus 로고
    • Cutaneous inflammation limited to the region of the ulcer in chronic venous insufficiency
    • Hahn J, Jünger M, Friedrich B, Zuder D, Steins A, Hahn M, et al. Cutaneous inflammation limited to the region of the ulcer in chronic venous insufficiency. VASA 1997;26:277-281
    • (1997) VASA , vol.26 , pp. 277-281
    • Hahn, J.1    Jünger, M.2    Friedrich, B.3    Zuder, D.4    Steins, A.5    Hahn, M.6
  • 18
    • 77949386133 scopus 로고    scopus 로고
    • Inappropriate leukocyte activation in venous disease
    • Bergan JJ, editor, Academic Press
    • Coleridge Smith PD. Inappropriate leukocyte activation in venous disease. In: Bergan JJ, editor, The vein book. Academic Press 2006. p. 57-65.
    • (2006) The Vein Book , pp. 57-65
    • Coleridge Smith, P.D.1
  • 20
    • 12844257370 scopus 로고    scopus 로고
    • Keratinocyte and dermal vascular endothelial cell capacities remain unimpaired in the margin of chronic venous ulcer
    • DOI 10.1007/s00403-004-0521-0
    • Galkowska H, Olszewski WL, Wojewodzka U. Keratinocyte and dermal vascular endothelial cell capacities remain unimpaired in the margin of chronic venous ulcer. Arch Dermatol Res 2005;296:286-295 (Pubitemid 40169520)
    • (2005) Archives of Dermatological Research , vol.296 , Issue.7 , pp. 286-295
    • Galkowska, H.1    Olszewski, W.L.2    Wojewodzka, U.3
  • 21
    • 0033933205 scopus 로고    scopus 로고
    • Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions
    • DOI 10.1128/IAI.68.7.4303-4311.2000
    • Wang J, Fan X, Lindholm C, Bennett M, O'Connoll J, Shanahan F, et al. Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions. Infect Immunity 2000;68:4303-4311 (Pubitemid 30434587)
    • (2000) Infection and Immunity , vol.68 , Issue.7 , pp. 4303-4311
    • Wang, J.1    Fan, X.2    Lindholm, C.3    Bennett, M.4    O'Connoll, J.5    Shanahan, F.6    Brooks, E.G.7    Reyes, V.E.8    Ernst, P.B.9
  • 22
    • 33845317597 scopus 로고    scopus 로고
    • The big idea: Iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis
    • Zamboni P: The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J Roy Soc Med 2006;99:1-5.
    • (2006) J Roy Soc Med , vol.99 , pp. 1-5
    • Zamboni, P.1
  • 23
    • 76149119833 scopus 로고    scopus 로고
    • Seasonal variation of onset of venous leg ulcers
    • Simka M. Seasonal variation of onset of venous leg ulcers. EWMA Journal 2006;6:23-24
    • (2006) EWMA Journal , vol.6 , pp. 23-24
    • Simka, M.1
  • 24
    • 2942525459 scopus 로고    scopus 로고
    • Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): Randomised controlled trial
    • Barwell JR, Davies CE, Deacon J, Harvey K, Minor J, Sassano A, et al. Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial. Lancet. 2004;363:1854-1859
    • (2004) Lancet , vol.363 , pp. 1854-1859
    • Barwell, J.R.1    Davies, C.E.2    Deacon, J.3    Harvey, K.4    Minor, J.5    Sassano, A.6
  • 25
    • 34447640702 scopus 로고    scopus 로고
    • Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): Randomised controlled trial
    • Gohel MS, Barwell JR, Taylor M, Chant T, Foy C, Earnshaw JJ, et al. Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial. BMJ 2007;335:83-88
    • (2007) BMJ , vol.335 , pp. 83-88
    • Gohel, M.S.1    Barwell, J.R.2    Taylor, M.3    Chant, T.4    Foy, C.5    Earnshaw, J.J.6
  • 27
    • 0036118018 scopus 로고    scopus 로고
    • Variations in plasma free radicals in patients with venous hypertension with HR (Paroven, Venoruton; 0-(β-hydroxyethyl)-rutosides): A clinical, prospective, placebo- Controlled, randomized trial
    • Cesarone, MR, Incandela L, DeSanctis, MT, Belcaro,G, Dugall, M, Acerbi G. Variations in plasma free radicals in patients with venous hypertension with hr (Paroven, Venoruton; 0-(ß-hydroxyethyl)-rutosides): a clinical, prospective, placebo-controlled, randomized trial. J Cardiovasc Pharmacol Ther 2002;7:S25-8. (Pubitemid 34408832)
    • (2002) Journal of Cardiovascular Pharmacology and Therapeutics , vol.7 , Issue.SUPPL. 1
    • Cesarone, M.R.1    Incandela, L.2    Desanctis, M.T.3    Belcaro, G.4    Dugall, M.5    Acerbi, G.6
  • 28
    • 46749090667 scopus 로고    scopus 로고
    • Molecular basis of venous insufficiency
    • Bergan JJ, editor, The vein book. Academic Press
    • Schmid-Schönbein GW. Molecular basis of venous insufficiency. In: Bergan JJ, editor, The vein book. The vein book. Academic Press; 2006. p. 67-78.
    • (2006) The Vein Book , pp. 67-78
    • Schmid-Schönbein, G.W.1
  • 30
    • 34547767579 scopus 로고    scopus 로고
    • Calf muscle pump impairment and delayed healing of venous leg ulcers: Air plethysmographic findings
    • DOI 10.1111/j.1346-8138.2007.00327.x
    • Simka M. Calf muscle pump impairment and delayed healing of venous leg ulcers - Air-plethysmographic findings. J Dermatol 2007;34:537-544 (Pubitemid 47228529)
    • (2007) Journal of Dermatology , vol.34 , Issue.8 , pp. 537-544
    • Simka, M.1
  • 31
    • 34247590871 scopus 로고    scopus 로고
    • Molecular Mechanisms in Chronic Venous Insufficiency
    • DOI 10.1016/j.avsg.2007.03.011, PII S0890509607001628
    • Bergan JJ. Molecular mechanisms in chronic venous insufficiency. Ann Vasc Surg 2007;21:260-266 (Pubitemid 46678673)
    • (2007) Annals of Vascular Surgery , vol.21 , Issue.3 , pp. 260-266
    • Bergan, J.1
  • 32
    • 0018916872 scopus 로고
    • Ultrastructural changes of capillaries in chronic venous insufficiency
    • Wenner A, Leu HJ, Spvcher MA, Brunner U. Ultrastructural changes of capillaries in chronic venous insufficiency. Exp Cell Biol 1980;48:1-14.
    • (1980) Exp Cell Biol , vol.48 , pp. 1-14
    • Wenner, A.1    Leu, H.J.2    Spvcher, M.A.3    Brunner, U.4
  • 33
    • 33747147127 scopus 로고    scopus 로고
    • A review of the microcirculation in skin in patients with chronic venous insufficiency: The problem and the evidence available for therapeutic options
    • DOI 10.1177/1534734606291870
    • Wollina U, Abdel-Naser MB, Mani R. A review of the microcirculation in skin in patients with chronic venous insufficiency: the problem and the evidence available for therapeutic options. Int J Low Extrem Wounds 2006;5:169. (Pubitemid 44218592)
    • (2006) International Journal of Lower Extremity Wounds , vol.5 , Issue.3 , pp. 169-180
    • Wollina, U.1    Abdel-Naser, M.B.2    Mani, R.3
  • 34
    • 0030665415 scopus 로고    scopus 로고
    • Morphometric assessment of the dermal microcirculation in patients with chronic venous insufficiency
    • Pappas PJ, DeFouw DO, Venezio LM. Morphometric assessment of the dermal microcirculation in patients with chronic venous insufficiency. J Vasc Surg 1997;26:784-95.
    • (1997) J Vasc Surg , vol.26 , pp. 784-795
    • Pappas, P.J.1    DeFouw, D.O.2    Venezio, L.M.3
  • 35
    • 25644449640 scopus 로고    scopus 로고
    • Pathophysiological consequences of VEGF-induced vascular permeability
    • Weis SM, Cheresh DA. Pathophysiological consequences of VEGF-induced vascular permeability. Nature 2005;437:497-504.
    • (2005) Nature , vol.437 , pp. 497-504
    • Weis, S.M.1    Cheresh, D.A.2
  • 36
    • 34547859252 scopus 로고    scopus 로고
    • Regulation of vascular endothelial permeability by junctional adhesion molecules (JAM)
    • DOI 10.1160/TH07-03-0206
    • Orlova VV, Chavakis T. Regulation of vascular endothelial permeability by junctional adhesion molecules (JAM). Thromb Haemost 2007;98:327-332 (Pubitemid 47250235)
    • (2007) Thrombosis and Haemostasis , vol.98 , Issue.2 , pp. 327-332
    • Orlova, V.V.1    Chavakis, T.2
  • 37
    • 0034609968 scopus 로고    scopus 로고
    • T-cell function and migration. Two sides of the same coin
    • Andrian von UH, Mackay CR. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000;343:1020-1034
    • (2000) N Engl J Med , vol.343 , pp. 1020-1034
    • Andrian Von, U.H.1    Mackay, C.R.2
  • 39
    • 20444484851 scopus 로고    scopus 로고
    • Endothelial adhesion molecules contribution to leukocyte recruitment into inflamed tissues
    • DuÊ D, Paprocka M, Kieda C: Endothelial adhesion molecules contribution to leukocyte recruitment into inflamed tissues. Centr Eur J Immunol 2003;28:23-28 (Pubitemid 40825812)
    • (2003) Central-European Journal of Immunology , vol.28 , Issue.1 , pp. 23-28
    • Dus, D.1    Paprocka, M.2    Kieda, C.3
  • 41
    • 0034566739 scopus 로고    scopus 로고
    • Therapeutic management of chronic venous insufficiency: Microcirculation as a target
    • Bergan JJ, Schmid-Schönbein GW: Therapeutic management of chronic venous insufficiency: microcirculation as a target. Microcirculation 2000;7:S23-8.
    • (2000) Microcirculation , vol.7
    • Bergan, J.J.1    Schmid-Schönbein, G.W.2
  • 42
    • 0036625642 scopus 로고    scopus 로고
    • Deleterious effect of white cells in the course of skin damage in CVI
    • Coleridge Smith PD. Deleterious effect of white cells in the course of skin damage in CVI. Int Angiol 2002;21(suppl.1):26-32.
    • (2002) Int Angiol , vol.21 , Issue.SUPPL. 1 , pp. 26-32
    • Coleridge Smith, P.D.1
  • 43
    • 0032849078 scopus 로고    scopus 로고
    • Neutrophil activation and mediators of inflammation in chronic venous insufficiency
    • DOI 10.1159/000054071
    • Coleridge Smith PD. Neutrophil activation and mediators of inflammation in chronic venous insufficiency. J Vasc Res 1999;3 (suppl.1):24-36. (Pubitemid 29411272)
    • (1999) Journal of Vascular Research , vol.36 , Issue.SUPPL. 1 , pp. 24-36
    • Coleridge Smith, P.D.1
  • 44
    • 0034566561 scopus 로고    scopus 로고
    • Microcirculatory dysfunction in chronic venous insufficiency (CVI)
    • Jünger M, Steins A, Hahn M, Häfner HM. Microcirculatory dysfunction in chronic venous insufficiency (CVI). Microcirculation 2000;7:S3-S12.
    • (2000) Microcirculation , vol.7
    • Jünger, M.1    Steins, A.2    Hahn, M.3    Häfner, H.M.4
  • 45
    • 0034284237 scopus 로고    scopus 로고
    • Activation of human leukocytes reduces surface P-selectin glycoproteinligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro
    • Davenpeck KL, Brummet ME, Hudson SA, Mayer RJ, Bochner BS. Activation of human leukocytes reduces surface P-selectin glycoproteinligand-1 (PSGL-1, CD162) and adhesion to P-selectin in vitro. J Immunol 2000; 165:2764-72.
    • (2000) J Immunol , vol.165 , pp. 2764-2772
    • Davenpeck, K.L.1    Brummet, M.E.2    Hudson, S.A.3    Mayer, R.J.4    Bochner, B.S.5
  • 47
    • 33645087923 scopus 로고    scopus 로고
    • Molecular mechanisms involved in T cell migration across the blood-brain barrier
    • Engelhardt B. Molecular mechanisms involved in T cell migration across the blood-brain barrier. J Neural Transm 2006;113:477-485
    • (2006) J Neural Transm , vol.113 , pp. 477-485
    • Engelhardt, B.1
  • 48
    • 0035914708 scopus 로고    scopus 로고
    • CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin
    • DOI 10.1084/jem.194.10.1541
    • Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC: CC chemokine receptor (CCR)4 and CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med 2001;194:1541-1547 (Pubitemid 33081528)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.10 , pp. 1541-1547
    • Reiss, Y.1    Proudfoot, A.E.2    Power, C.A.3    Campbell, J.J.4    Butcher, E.C.5
  • 49
    • 0037372241 scopus 로고    scopus 로고
    • H lymphocyte trafficking
    • DOI 10.1182/blood-2002-07-2348
    • Soler D, Humphreys TL, Spinola SM, Campbell JJ. CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Blood 2003;101:1677-1683 (Pubitemid 36237558)
    • (2003) Blood , vol.101 , Issue.5 , pp. 1677-1683
    • Soler, D.1    Humphreys, T.L.2    Spinola, S.M.3    Campbell, J.J.4
  • 50
    • 0031740262 scopus 로고    scopus 로고
    • Chemokines IL-8, GRO-, MCP-I, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing
    • Engelhardt E, Toksoy A, Goebeler M, Debus S, Bröckner EB, Gillitzer R. Chemokines IL-8, GRO-, MCP-I, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. Am J Pathol 1998;153:1849-1860.
    • (1998) Am J Pathol , vol.153 , pp. 1849-1860
    • Engelhardt, E.1    Toksoy, A.2    Goebeler, M.3    Debus, S.4    Bröckner, E.B.5    Gillitzer, R.6
  • 51
    • 0036141219 scopus 로고    scopus 로고
    • Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes
    • Kunkel EJ, Boisvert J, Murphy K, Vierra MA, Genovese MC, Wardlaw AJ, et al. Expression of the chemokine receptors CCR4, CCR5, and CXCR3 by human tissue-infiltrating lymphocytes. Am J Pathol 2002;160:347-355
    • (2002) Am J Pathol , vol.160 , pp. 347-355
    • Kunkel, E.J.1    Boisvert, J.2    Murphy, K.3    Vierra, M.A.4    Genovese, M.C.5    Wardlaw, A.J.6
  • 52
    • 0034798403 scopus 로고    scopus 로고
    • A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases
    • Albanesi C, Scarponi C, Sebastini S, Cavani A, Federici M, Sozzani S, Girolomoni G. A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. J Leukocyte Biol 2001;70:617-623 (Pubitemid 32954773)
    • (2001) Journal of Leukocyte Biology , vol.70 , Issue.4 , pp. 617-623
    • Albanesi, C.1    Scarponi, C.2    Sebastiani, S.3    Cavani, A.4    Federici, M.5    Sozzani, S.6    Girolomoni, G.7
  • 53
    • 0038108805 scopus 로고    scopus 로고
    • A second step of chemotaxis after transendothelial migration: Keratinocytes undergoing apoptosis release IFN-γ-inducible protein 10, monokine induced by IFN-γ, and IFN-γ-inducible α- chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis
    • Klunker S, Trautmann A, Akdis M, Verhagen J, Schmid-Grendelmeier P, Blaser K, et al. A second step of Chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis relese INF-Á-inducible protein 10, monokine induced by INF-Ä, and INF-Á-inducible-chemoattactant for T cell Chemotaxis toward epidermis in atopic dermatitis. J Immunol 2003;171:1078-1084 (Pubitemid 36871425)
    • (2003) Journal of Immunology , vol.171 , Issue.2 , pp. 1078-1084
    • Klunker, S.1    Trautmann, A.2    Akdis, M.3    Verhagen, J.4    Schmid-Grendelmeier, P.5    Blaser, K.6    Akdis, C.A.7
  • 54
    • 33846019216 scopus 로고    scopus 로고
    • CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow derived-keratinocytes
    • Inokuma D, Abe R, Fujita Y Sasaki M, Shibaki A, Nakamura H, et al. CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow derived-keratinocytes. Stem Cells 2006;24:2810-2816
    • (2006) Stem Cells , vol.24 , pp. 2810-2816
    • Inokuma, D.1    Abe, R.2    Fujita, Y.3    Sasaki, M.4    Shibaki, A.5    Nakamura, H.6
  • 55
    • 34447266461 scopus 로고    scopus 로고
    • Delayed healing of chronic leg ulcers can result from impaired trafficking of bone marrow-derived precursors of keratinocytes to the skin
    • DOI 10.1016/j.mehy.2006.12.049, PII S0306987707000564
    • Simka M. Delayed healing of chronic leg ulcers can result from impaired trafficking of bone marrow-derived precursors of keratinocytes to the skin. Med Hypothes 2007;69:637-641 (Pubitemid 47043241)
    • (2007) Medical Hypotheses , vol.69 , Issue.3 , pp. 637-641
    • Simka, M.1
  • 56
    • 0035184161 scopus 로고    scopus 로고
    • Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-α plus interferon-γ does not reduce leukocyte transmigration under flow
    • Shaw SK, Perkins BN, Lim YC, Liu Y, Nusrat A, Schnell FJ, et al. Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor- plus interferon-Á does not reduce leukocyte transmigration under flow. Am J Pathol 2001;159:2281-2291 (Pubitemid 33104281)
    • (2001) American Journal of Pathology , vol.159 , Issue.6 , pp. 2281-2291
    • Shaw, S.K.1    Perkins, B.N.2    Lim, Y.-C.3    Liu, Y.4    Nusrat, A.5    Schnell, F.J.6    Parkos, C.A.7    Luscinskas, F.W.8
  • 59
    • 0032526580 scopus 로고    scopus 로고
    • Interferon enhances tumor necrosis factor-induced vascular cell adhesion molecule 1 (CD106) expression in human endothelial cells by an interferon- Related factor 1-dependent pathway
    • DOI 10.1084/jem.187.12.2023
    • Lechleitner S, Gille J, Johnson DR, Petzelbauer P: Interferon enhances tumor necrosis factor-induced vascular cell adhesion molecule 1 (CD 106) expression in human endothelial cells by an interferon-related factor 1-dependent pathway. J Exp Med 1998;187:2023-2030 (Pubitemid 28285571)
    • (1998) Journal of Experimental Medicine , vol.187 , Issue.12 , pp. 2023-2030
    • Lechleitner, S.1    Gille, J.2    Johnson, D.R.3    Petzelbauer, P.4
  • 60
    • 0036510590 scopus 로고    scopus 로고
    • Interferon-gamma induced epithelial ICAM-1 expression and monocytes adhesion. Involvement of protein kinase C-dependent c-Scr tyrosine kinase activation pathway
    • Chang YJ, Holtzman MJ, Chen CC. Interferon-gamma induced epithelial ICAM-1 expression and monocytes adhesion. Involvement of protein kinase C-dependent c-Scr tyrosine kinase activation pathway. J Biol Chem 2002;277:7118-7126
    • (2002) J Biol Chem , vol.277 , pp. 7118-7126
    • Chang, Y.J.1    Holtzman, M.J.2    Chen, C.C.3
  • 61
    • 0035184161 scopus 로고    scopus 로고
    • Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-α plus interferon-γ does not reduce leukocyte transmigration under flow
    • Shaw SK, Perkins BN, Lim YC, Liu Y, Nusrat A, Schnell FJ, et al. Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor- plus interferon-Á does not reduce leukocyte transmigration under flow. Am J Pathol 2001;159:2281-2291 (Pubitemid 33104281)
    • (2001) American Journal of Pathology , vol.159 , Issue.6 , pp. 2281-2291
    • Shaw, S.K.1    Perkins, B.N.2    Lim, Y.-C.3    Liu, Y.4    Nusrat, A.5    Schnell, F.J.6    Parkos, C.A.7    Luscinskas, F.W.8
  • 64
    • 33646155314 scopus 로고    scopus 로고
    • The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis
    • Zamboni P, Izzo M, Tognazzo S. The overlapping of local iron overload and HFE mutation in venous leg ulcer pathogenesis. Free Radic Biol Med 2006;40:1869-1873
    • (2006) Free Radic Biol Med , vol.40 , pp. 1869-1873
    • Zamboni, P.1    Izzo, M.2    Tognazzo, S.3
  • 66
    • 0036440671 scopus 로고    scopus 로고
    • Chronic leg ulceration in homozygous sickle cell disease: The role of venous incompetence
    • Clare A, FitzHenley M, Harris J, Hambleton I, Serjeant GR: Chronic leg ulceration in homozygous sickle cell disease: the role of venous incompetence.Br J Haematol. 2002;119, 567-571
    • (2002) Br J Haematol , vol.119 , pp. 567-571
    • Clare, A.1    FitzHenley, M.2    Harris, J.3    Hambleton, I.4    Serjeant, G.R.5
  • 67
    • 0023765047 scopus 로고
    • Overload of iron in the skin of patients with varicose ulcers. Possible contributing role of iron accumulation in progression of the disease
    • Ackerman Z, Seidenbaum M, Loewenthal E, Rubinow A. Overload of iron in the skin of patients with varicose ulcers. Possible contributing role of iron accumulation in progression of the disease. Arch Dermatol 1988;124:1376-1378
    • (1988) Arch Dermatol , vol.124 , pp. 1376-1378
    • Ackerman, Z.1    Seidenbaum, M.2    Loewenthal, E.3    Rubinow, A.4
  • 68
    • 22844447869 scopus 로고    scopus 로고
    • Serum iron and MMP-9 variation in limbs affected by chronic venous disease and venous leg ulcers
    • Zamboni P, Scapoli G, Lanzara V, Izzo M, Fortini P, Legnaro A. Serum iron and MMP-9 variation in limbs affected by chronic venous disease and venous leg ulcers. Dermatol Surg 2005;31:644-649
    • (2005) Dermatol Surg , vol.31 , pp. 644-649
    • Zamboni, P.1    Scapoli, G.2    Lanzara, V.3    Izzo, M.4    Fortini, P.5    Legnaro, A.6
  • 69
    • 0141921992 scopus 로고    scopus 로고
    • Iron and 8-Isoprostane Levels in Acute and Chronic Wounds
    • DOI 10.1046/j.1523-1747.2003.12471.x
    • Yeoh-Ellerton S, Stacey MC: Iron and 8-isoprostane levels in acute and chronic wounds. J Invest Dermatol 2003;121:918-925 (Pubitemid 37239139)
    • (2003) Journal of Investigative Dermatology , vol.121 , Issue.4 , pp. 918-925
    • Yeoh-Ellerton, S.1    Stacey, M.C.2
  • 70
    • 45649085636 scopus 로고    scopus 로고
    • Hypothetical molecular mechanisms by which local iron overload facilitates the development of venous leg ulcers and multiple sclerosis lesions
    • Simka M., Rybak Z. Hypothetical molecular mechanisms by which local iron overload facilitates the development of venous leg ulcers and multiple sclerosis lesions. Med Hypothes 2008;71:293-297
    • (2008) Med Hypothes , vol.71 , pp. 293-297
    • Simka, M.1    Rybak, Z.2
  • 74
    • 33646467929 scopus 로고    scopus 로고
    • Annexin V associates with the IFN-Á receptor and regulates IFN-Á signaling
    • Leon C, Nandan D, Lopez M, Moeenrezakhalou A, Reiner NE. Annexin V associates with the IFN-Á receptor and regulates IFN-Á signaling. J Immunol 2006;176:5934-5942
    • (2006) J Immunol , vol.176 , pp. 5934-5942
    • Leon, C.1    Nandan, D.2    Lopez, M.3    Moeenrezakhalou, A.4    Reiner, N.E.5
  • 75
    • 0141993007 scopus 로고    scopus 로고
    • IGF-1 down-regulates IFN-γR2 chain surface expression and desensitizes IFN-γ/STAT-1 signaling in human T lymphocytes
    • DOI 10.1182/blood-2003-01-0100
    • Bernabei P, Bosticardo M, Losana G, Regis G, Di Paola F, De Angelis S, et al IGF-1 down-regulates IFN-ÁR2 chain surface expression and desensitizes IFN-g/STAT-1 signaling in human T lymphocytes. Blood 2003;102:2933-2939 (Pubitemid 37248867)
    • (2003) Blood , vol.102 , Issue.8 , pp. 2933-2939
    • Bernabei, P.1    Bosticardo, M.2    Losana, G.3    Regis, G.4    Di Paola, F.5    De Angelis, S.6    Giovarelli, M.7    Novelli, F.8
  • 76
    • 0028986107 scopus 로고
    • Interferon-Á inhibits macrophage insulin-like growth factor-1 synthesis at the transcriptional level
    • Arkins S, Rebeiz N, Brunke-Reese DL, Birgyn A, Kelly KW. Interferon-Á inhibits macrophage insulin-like growth factor-1 synthesis at the transcriptional level. Mol Endocrinol 1995;9:350-360
    • (1995) Mol Endocrinol , vol.9 , pp. 350-360
    • Arkins, S.1    Rebeiz, N.2    Brunke-Reese, D.L.3    Birgyn, A.4    Kelly, K.W.5
  • 78
    • 0032828455 scopus 로고    scopus 로고
    • Nitric oxide suppresses human T lymphocyte proliferation through IFN-γ- Dependent and IFN-γ-independent induction of apoptosis
    • Allione A, Bernabei P, Bosticardo M, Ariotti S, Forni G, Novelli F. Nitric oxide suppresses human T lymphocyte proliferation through INF-Á-dependent and INF-Á-independent induction of apoptosis. J Immunol 1999;163:4182-4191 (Pubitemid 29474481)
    • (1999) Journal of Immunology , vol.163 , Issue.8 , pp. 4182-4191
    • Allione, A.1    Bernabei, P.2    Bosticardo, M.3    Ariotti, S.4    Forni, G.5    Novelli, F.6
  • 79
    • 0036797993 scopus 로고    scopus 로고
    • Analysis of the mechanisms of human cytotoxic T lymphocyte response inhibition by NO
    • Blesson S, Thiery J, Gaudin C, Stancou R, Kolb JP, Moreau JL, et al. Analysis of the mechanisms of human cytotoxic T lymphocyte response inhibition by NO. Int Immunol 2002;14:1169-1178
    • (2002) Int Immunol , vol.14 , pp. 1169-1178
    • Blesson, S.1    Thiery, J.2    Gaudin, C.3    Stancou, R.4    Kolb, J.P.5    Moreau, J.L.6
  • 81
    • 0034646693 scopus 로고    scopus 로고
    • Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition
    • Kim YM, Chung HT, Simmons RL, Billiar TR. Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J Biol Chem 2000;275:10954-10961
    • (2000) J Biol Chem , vol.275 , pp. 10954-10961
    • Kim, Y.M.1    Chung, H.T.2    Simmons, R.L.3    Billiar, T.R.4
  • 83
    • 21644445023 scopus 로고    scopus 로고
    • Interferon (IFN)-γ is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine IFN-γ and tumour necrosis factor-α production
    • DOI 10.1111/j.1365-2133.2005.06508.x
    • Konur A, Schulz U, Eissner G, Andreesen R, Holler E: Interferon (INF)-Á is a main mediator of keratinocyte (HaCaT) apoptosis and contributes to autocrine INF-gamma and tumour necrosis factor-a production. Br J Dermatol 2005;152:1134-1142 (Pubitemid 40933409)
    • (2005) British Journal of Dermatology , vol.152 , Issue.6 , pp. 1134-1142
    • Konur, A.1    Schulz, U.2    Eissner, G.3    Andreesen, R.4    Holler, E.5
  • 84
    • 0036915653 scopus 로고    scopus 로고
    • Substance P enhances the production of interferon-induced protein of 10 kDa by human keratinocytes in synergy with interferon-γ
    • DOI 10.1046/j.1523-1747.2002.19626.x
    • Kanda N, Watanabe S: Substance P enhances the production of interferon-induced protein of 10 kDa by human keratinocytes in synergy with interferon-Á. J Invest Dermatol 2002;119:1290-1297 (Pubitemid 36005611)
    • (2002) Journal of Investigative Dermatology , vol.119 , Issue.6 , pp. 1290-1297
    • Kanda, N.1    Watanabe, S.2
  • 88
    • 20544448597 scopus 로고    scopus 로고
    • Human keratinocytes respond to interleukin-18: Implication for the course of chronic inflammatory skin diseases
    • DOI 10.1111/j.0022-202X.2005.23715.x
    • Wittmann M, Purwar R, Hartmann C, Gutzmer R, Werfel T. Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases. J Invest Dermatol 2005;124:1225-1233 (Pubitemid 40847410)
    • (2005) Journal of Investigative Dermatology , vol.124 , Issue.6 , pp. 1225-1233
    • Wittmann, M.1    Purwar, R.2    Hartmann, C.3    Gutzmer, R.4    Werfel, T.5
  • 90
    • 77952466798 scopus 로고    scopus 로고
    • Welche Rolle spielt die Apoptose in der Haut von Patienten mit chronischen venösen Ulzerationen
    • abstract
    • Riedel F, Heising S, Jünger M, Ostrowitzki AL, Heitman M, Haase H, et al. Welche Rolle spielt die Apoptose in der Haut von Patienten mit chronischen venösen Ulzerationen (abstract). Phlebologie 2006;35:A39.
    • (2006) Phlebologie , vol.35
    • Riedel, F.1    Heising, S.2    Jünger, M.3    Ostrowitzki, A.L.4    Heitman, M.5    Haase, H.6
  • 91
    • 0041326643 scopus 로고    scopus 로고
    • Expression of apoptosis-and cell cycle-related proteins in epidermis of venous leg and diabetic foot ulcers
    • DOI 10.1067/msy.2003.223
    • Galkowska H, Olszewski WL, Wojewodzka U, Mijal J, Filipiuk E: Expression of apoptosis- and cell cycle-related proteins in epidermis or venous leg and diabetic foot ulcers. Surgery 2003;134:213-220 (Pubitemid 37070341)
    • (2003) Surgery , vol.134 , Issue.2 , pp. 213-220
    • Galkowska, H.1    Olszewski, W.L.2    Wojewodzka, U.3    Mijal, J.4    Filipiuk, E.5
  • 94
    • 33644644954 scopus 로고    scopus 로고
    • Keratinocyte apoptosis in epidermal development and disease
    • DOI 10.1038/sj.jid.5700008, PII 5700008
    • Raj D, Brash DE, Grossman D. Keratinocyte apoptosis in epidermal development and disease. J Invest Dermatol 2006;126:243-257 (Pubitemid 43323157)
    • (2006) Journal of Investigative Dermatology , vol.126 , Issue.2 , pp. 243-257
    • Raj, D.1    Brash, D.E.2    Grossman, D.3
  • 95
    • 16244362671 scopus 로고    scopus 로고
    • Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells
    • Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immunity 2005;73:1907-1916
    • (2005) Infect Immunity , vol.73 , pp. 1907-1916
    • Fink, S.L.1    Cookson, B.T.2
  • 97
    • 22144490885 scopus 로고    scopus 로고
    • Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors
    • DOI 10.1016/j.bbcan.2005.04.001, PII S0304419X05000089
    • Assefa Z, van Laethem A, Garmyn M, Agostinis P. Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors. Biochim Biophys Acta 2005;1755:90-106. (Pubitemid 40982560)
    • (2005) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1755 , Issue.2 , pp. 90-106
    • Assefa, Z.1    Van Laethem, A.2    Garmyn, M.3    Agostinis, P.4
  • 100
    • 0034740726 scopus 로고    scopus 로고
    • Role of NF-kappaB activity in apoptotic response of keratinocyte mediated by interferon-gamma, tumor necrosis factor-alfa, and tumor-necrosis-related apoptosis-inducing ligand
    • Qin JZ, Bacon P, Chaturvedi V, Nickloff BJ: Role of NF-kappaB activity in apoptotic response of keratinocyte mediated by interferon-gamma, tumor necrosis factor-alfa, and tumor-necrosis-related apoptosis-inducing ligand. J Invest Dermatol 2001;117:898-907.
    • (2001) J Invest Dermatol , vol.117 , pp. 898-907
    • Qin, J.Z.1    Bacon, P.2    Chaturvedi, V.3    Nickloff, B.J.4
  • 102
    • 0032867552 scopus 로고    scopus 로고
    • Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand- And CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis
    • DOI 10.1074/jbc.274.41.28916
    • Kothny-Wikes G, Kulms D, Luger TA, Kubin M, Schwarz T. Interleukin-1 protects transformed keratinocytes from tumor necrosis factor-related apoptosis-inducing ligand-and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. J Biol Chem 1999;274:28916-28921 (Pubitemid 29477045)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.41 , pp. 28916-28921
    • Kothny-Wilkes, G.1    Kulms, D.2    Luger, T.A.3    Kubin, M.4    Schwarz, T.5
  • 103
    • 0033564708 scopus 로고    scopus 로고
    • Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: Modulation by cytokines
    • Arnold R, Seifert M, Asadullah K, Volk HD. Crosstalk between keratinocytes and T lymphocytes via Fas/Fas ligand interaction: modulation by cytokines. J Immunol 1999;162:7140-7147 (Pubitemid 29277684)
    • (1999) Journal of Immunology , vol.162 , Issue.12 , pp. 7140-7147
    • Arnold, R.1    Seifert, M.2    Asadullah, K.3    Volk, H.D.4
  • 105
    • 85012514730 scopus 로고    scopus 로고
    • Role of Fas-FasL in inflammatory diseases
    • O'Connell J. Role of Fas-FasL in inflammatory diseases. Expert Rev Mol Med 2001;3:1-18.
    • (2001) Expert Rev Mol Med , vol.3 , pp. 1-18
    • O'Connell, J.1
  • 106
    • 0035172262 scopus 로고    scopus 로고
    • Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound fas ligand
    • Matsuno H, Yudoh K, Watanabe Y, Nakazawa F, Aono H, Kimura T. Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand. J Rheumatol 2001;28:22-28 (Pubitemid 32062020)
    • (2001) Journal of Rheumatology , vol.28 , Issue.1 , pp. 22-28
    • Matsuno, H.1    Yudoh, K.2    Watanabe, Y.3    Nakazawa, F.4    Aono, H.5    Kimura, T.6
  • 107
    • 0033576645 scopus 로고    scopus 로고
    • The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis
    • DOI 10.1016/S0960-9822(00)80113-X
    • Powell WC, Fingleton B, Wilson CL, Boothby M, Matrisian LM. The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis. Curr Biol 1999;9:1441-1447 (Pubitemid 30023478)
    • (1999) Current Biology , vol.9 , Issue.24 , pp. 1441-1447
    • Powell, W.C.1    Fingleton, B.2    Wilson, C.L.3    Boothby, M.4    Matrisian, L.M.5
  • 108
    • 34247276120 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends lire in a transgenic mouse model of amyotrophic lateral sclerosis
    • Kiaei M, Kipiani K, Calingasan NY, Wille E, Chen J, Heissig B, et al. Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends lire in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol 2007;205:74-81.
    • (2007) Exp Neurol , vol.205 , pp. 74-81
    • Kiaei, M.1    Kipiani, K.2    Calingasan, N.Y.3    Wille, E.4    Chen, J.5    Heissig, B.6
  • 111
    • 33845658332 scopus 로고    scopus 로고
    • Fas ligand exerts its pro-inflammatory effects via neutrophil recruitment but not activation
    • Dupont PJ, Warrens AN. Fas ligand exerts its pro-inflammatory effects via neutrophil recruitment but not activation. Immunology 2007;120:133-139.
    • (2007) Immunology , vol.120 , pp. 133-139
    • Dupont, P.J.1    Warrens, A.N.2
  • 113
    • 1642525667 scopus 로고    scopus 로고
    • The essential involvement of cross-talk between IFN-Á and TGF-, In the skin wound-healing process
    • Ishida Y, Kondo T, Takayasu T, Iwakura Y, Mukaida N. The essential involvement of cross-talk between IFN-Á and TGF-, In the skin wound-healing process. J Immunol 2004;172:1848-1855
    • (2004) J Immunol , vol.172 , pp. 1848-1855
    • Ishida, Y.1    Kondo, T.2    Takayasu, T.3    Iwakura, Y.4    Mukaida, N.5


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