Deleterious effects of white cells in the course of skin damage in CVI

International Angiology

Volumn 21, Issue 2 SUPPL. 1, 2002, Pages 26-32

  Coleridge Smith, P D ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Microcirculation; Neutrophils; Varicose ulcer, therapy; Varicose veins, diagnosis; Varicose veins, therapy; Venous insufficiency

Indexed keywords

ACETYLSALICYLIC ACID; ELASTASE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IFETROBAN; ILOPROST; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; PENTOXIFYLLINE; PLACEBO; PROSTACYCLIN DERIVATIVE; PROSTAGLANDIN E1; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

CAPILLARY PROLIFERATION; CHRONIC INFLAMMATION; CHRONIC VEIN INSUFFICIENCY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HYPERTENSION; HYPOXEMIA; LEG BLOOD FLOW; LEG COMPRESSION; LEG ISCHEMIA; LEG ULCER; LEUKOCYTE ACTIVATION; LIPODERMATOSCLEROSIS; MICROCIRCULATION; NEUTROPHIL CHEMOTAXIS; PATHOPHYSIOLOGY; REPERFUSION INJURY; REVIEW; SKIN CAPILLARY; SKIN FIBROSIS; SKIN INFLAMMATION; SKIN ULCER; ULCER HEALING; ULCEROGENESIS; VEIN RECONSTRUCTION;

EID: 0036625642     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Browse NL, Burnand KG. The cause of venous ulceration. Lancet 1982; ii:243-5.
2. Coleridge-Smith PD, Thomas P, Scurr JH, Dormandy JA. Causes of venous ulceration: a new hypothesis. Br Med J 1988; 296:1726-7.
3. Moyses C, Cederholm-Williams SA, Michel CC. Haemoconcentration and the accumulation of white cells in the feet during venous stasis. Int J Microcirc Clin Exp 1987; 5:311-20.
4. Thomas PRS, Nash GB, Dormandy JA. White cell accumulation in dependent legs of patients with venous hypertension: a possible mechanism for trophic changes in the skin. Br Med J 1988; 296:1693-5.
5. Vanscheidt W, Kresse O, Hach-Wunderle V, Hasler K, Scharrer I, Wokalek H et al. Leg ulcer patients: no decreased fibrinolytic response but white cell trapping after venous occlusion of the upper limb. Phlebology 1992; 7:92-6.
6. Shields DA, Andaz S, Sarin S, Scurr JH, Coleridge-Smith PD. Neutrophil activation in experimental venous hypertension. Phlebologie 1993; 46:687-9.
7. Saharay M, Shields DA, Porter JB, Scurr JH, Coleridge-Smith PD. Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease. J Vasc Surg 1997; 26:265-73.
8. 2 levels and hematocrit in chronic venous hypertension. Rev Paul Med 1998; 116:1721-6.
9. Shields DA, Andaz SK, Sarin S, Scurr JH, Coleridge-Smith PD. Plasma elastase in venous disease. Br J Surg 1994; 81:1496-9.
10. Shields DA, Andaz S, Abeysinghe RD, Porter JB, Scurr JH, Coleridge-Smith PD. Plasma lactoferrin as a marker of white cell degranulation in venous disease. Phlebology 1994; 9:55-8.
11. Pappas PJ, Teehan EP, Fallek SR, Garcia A, Araki CT, Back TL et al. Diminished mononuclear cell function is associated with chronic venous insufficiency. J Vasc Surg 1995; 22:580-6.
12. Powell CC, Rohrer MJ, Barnard MR, Peyton BD, Furman MI, Michelson AD. Chronic venous insufficiency is associated with increased platelet and monocyte activation and aggregation. J Vasc Surg 1999; 30:844-51.
13. Layton AM, Ibbotson SH, Davies JA, Goodfield MJ. Randomised trial of oral aspirin for chronic venous leg ulcers. Lancet 1994; 344:164-5.
14. Lyon RT, Veith FJ, Bolton L, Machado F. Clinical benchmark for healing of chronic venous ulcers. Venous ulcer study collaborators. Am J Surg 1998; 176:172-5.
15. Burnand KG, Whimster I, Naidoo A, Browse NL. Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration. Br Med J 1982; 285:1071-2.
16. Wilkinson LS, Bunker C, Edwards JCW, Scurr JH, Coleridge-Smith PD. Leukocytes: their role in the etiopathogenesis of skin damage in venous disease. J Vasc Surg 1993; 17:669-75.
17. Hahn J, Junger M, Friedrich B, Zuder D, Steins A, Hahn M et al. Cutaneous inflammation limited to the region of the ulcer in chronic venous insufficiency. Vasa 1997; 26:277-81.
18. 1 gene expression and protein production. J Vasc Surg 1999; 30: 1129-45.
19. Chant A. The biomechanics of leg ulceration. Ann R Coll Surg Engl 1999; 81:80-5.
20. Shoab SS, Scurr JH, Coleridge-Smith PD. Increased plasma vascular endothelial growth factor among patients with chronic venous disease. J Vasc Surg 1998; 28:535-40.
21. Saharay M, Shields DA, Georgiannos SN, Porter JB, Scurr JH, Coleridge Smith PD. Endothelial activation in patients with chronic venous disease. Eur J Vasc Endovasc Surg 1998; 15:342-9.
22. Ciuffetti G, Lombardini R, Pasqualini L, Vaudo G, Lupattelli G. Circulating leukocyte adhesion molecules in chronic venous insufficiency. Vasa 1999; 28:156-9.
23. Sinzinger H, Virgolini I, Fitscha R. Pathomechanisms of atherosclerosis beneficially affected by prostaglandin E1 (PGE1) - an update. Vasa 1989; 28(Suppl):6-13.
24. Beitner H, Hamar H, Olsson AG, Thyresson N. Prostaglandin El treatment of leg ulcers caused by venous or arterial incompetence. Acta Derm Venereol (Stockholm) 1980; 60:425-30.
25. 1 in the treatment of venous ulcers - a double-blind, placebo-con-trolled trial. Vasa 1989; 28(Suppl):39-43.
26. 2) mimetics in severe peripheral vascular disease. Biomed Biochim Acta 1988; 47:S40-4.
27. Musial J, Wilczynska M, Sladek K, Ciernewski CS, Nizankowski R, Szczeklik A. Fibrinolytic activity of prostacyclin and iloprost in patients with peripheral arterial disease. Prostaglandins 1986; 31:61-70.
28. Belch JJF, Saniabadi A, Dickson R, Sturrock RD, Forbes CD. Effect of Iloprost (ZK 36374) on white cell behaviour. In: Gryglewski RJ, Stock G, editors. Prostacyclin and its stable analogue iloprost. Berlin: Springer-Verlag, 1987:97-102.
29. 1, indomethacin, forskolin, BW 755 C, sulotroban, hirudin, and thrombocytopenia. Eicosanoids 1988; 1:13-7.
30. Sturzebecher CS, Losert W. Effects of Iloprost on platelet activation in vitro. In: Gryglewski RJ, Stock G, editors. Prostacyclin and its stable analogue iloprost. Berlin: Springer-Verlag, 1987:39-45.
31. Werner-Schlenzka H, Kuhlmann RK. Treatment of venous leg ulcers with topical iloprost: a placebo controlled study. Vasa 1994; 23:145-50.
32. Roekkaerts F, Deleers L. Trental 400 in the treatment of intermittent claudication: results of long-term, placebo-controlled administration. Angiology 1984; 35:396-406.
33. Sullivan GW, Carper HT, Novick WJ Jr, Mandell GL. Inhibition of the inflammatory action of interleukin-1 and tumour necrosis factor (α) on neutrophil function by pentoxifylline. Infect Immunol 1988; 56: 1722-9.
34. Angelides NS, Weil von der Ahe CA. Effect of oral pentoxifylline theraapy on venous lower extremity ulcers due to deep venous incompetence. Angiology 1989; 40:752-63.
35. Colgan M-P, Dormandy JA, Jones PW, Schraibman IG, Shanik DG, Young RAL. Oxpentifylline treatment of venous ulcers of the leg. Br Med J 1990; 300:972-5.
36. Dale JJ, Ruckley CV, Harper DR, Gibson B, Nelson EA, Prescott RJ. A randomised, double-blind placebo controlled trial of oxpentifylline in the treatment of venous leg ulcers. In: Negus D, Jantet G, Coleridge-Smith PD, editors. Phlebology '95. Phlebology 1995; 2(Supp'l):917-8.