메뉴 건너뛰기




Volumn 68, Issue 7, 2000, Pages 4303-4311

Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033933205     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.7.4303-4311.2000     Document Type: Article
Times cited : (88)

References (53)
  • 1
    • 0028804157 scopus 로고
    • Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-α and ligation of Fas antigen
    • Abreu-Martin, M. T., A. Vidrich, D. H. Lynch, and S. R. Targan. 1995. Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-α and ligation of Fas antigen. J. Immunol. 155:4147-4154.
    • (1995) J. Immunol. , vol.155 , pp. 4147-4154
    • Abreu-Martin, M.T.1    Vidrich, A.2    Lynch, D.H.3    Targan, S.R.4
  • 4
    • 0030021024 scopus 로고    scopus 로고
    • Helicobacter pylori and cell proliferation of the gastric mucosa: Possible implications for gastric carcinogenesis
    • Bechi, P., M. Balzi, A. Becciolini, A. Maugeri, C. C. Raggi, A. Amorosi, and R. Dei. 1996. Helicobacter pylori and cell proliferation of the gastric mucosa: possible implications for gastric carcinogenesis. Am. J. Gastroenterol. 91: 271-276.
    • (1996) Am. J. Gastroenterol. , vol.91 , pp. 271-276
    • Bechi, P.1    Balzi, M.2    Becciolini, A.3    Maugeri, A.4    Raggi, C.C.5    Amorosi, A.6    Dei, R.7
  • 5
    • 0033006366 scopus 로고    scopus 로고
    • Is autoimmunity coming to a Fas(L) end?
    • Brunner, T., and C. Mueller. 1999. Is autoimmunity coming to a Fas(L) end? Nat. Med. 5:19-20.
    • (1999) Nat. Med. , vol.5 , pp. 19-20
    • Brunner, T.1    Mueller, C.2
  • 6
    • 0344258462 scopus 로고    scopus 로고
    • Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-I, IL-6, TNF-alpha, or IFN-gamma
    • Choi, C., J. Park, J. Lee, J. H. Lim, E. C. Shin, Y. S. Ahn, C. H. Kim, S. J. Kim, J. Kim, I. S. Choi, and K. L. Choi. 1999. Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-I, IL-6, TNF-alpha, or IFN-gamma. J. Immunol. 162:1889-1895.
    • (1999) J. Immunol. , vol.162 , pp. 1889-1895
    • Choi, C.1    Park, J.2    Lee, J.3    Lim, J.H.4    Shin, E.C.5    Ahn, Y.S.6    Kim, C.H.7    Kim, S.J.8    Kim, J.9    Choi, I.S.10    Choi, K.L.11
  • 7
    • 0031929816 scopus 로고    scopus 로고
    • Carcinogenesis, apoptosis and cell proliferation
    • Correa, P., and M. J. S. Miller. 1998. Carcinogenesis, apoptosis and cell proliferation. Br. Med. Bull. 54:151-162.
    • (1998) Br. Med. Bull. , vol.54 , pp. 151-162
    • Correa, P.1    Miller, M.J.S.2
  • 10
    • 0028200445 scopus 로고
    • Pathophysiology of Helicobacter pylori infection
    • Dixon, M. F. 1994. Pathophysiology of Helicobacter pylori infection. Scand. J. Gastroenterol. 29:7-10.
    • (1994) Scand. J. Gastroenterol. , vol.29 , pp. 7-10
    • Dixon, M.F.1
  • 12
    • 0028170496 scopus 로고
    • Gastric T lymphocyte response to Helicobacter pylori in patients with H. pylori colonisation
    • Fan, X. J., A. Chua, C. N. Shahi, J. McDevitt, P. W. N. Keeling, and D. Kelleher. 1994. Gastric T lymphocyte response to Helicobacter pylori in patients with H. pylori colonisation. Gut 35:1379-1384.
    • (1994) Gut , vol.35 , pp. 1379-1384
    • Fan, X.J.1    Chua, A.2    Shahi, C.N.3    McDevitt, J.4    Keeling, P.W.N.5    Kelleher, D.6
  • 13
    • 0032543222 scopus 로고    scopus 로고
    • The effect of class II MHC expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: A mechanism for Th1 cell-mediated damage
    • Fan, X. J., S. E. Crowe, S. Behar, H. Gunasena, G. Ye, H. Haeberle, N. Van Houten, W. K. Gourley, P. B. Ernst, and V. E. Reyes. 1998. The effect of class II MHC expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for Th1 cell-mediated damage. J. Exp. Med. 187:1659-1669.
    • (1998) J. Exp. Med. , vol.187 , pp. 1659-1669
    • Fan, X.J.1    Crowe, S.E.2    Behar, S.3    Gunasena, H.4    Ye, G.5    Haeberle, H.6    Van Houten, N.7    Gourley, W.K.8    Ernst, P.B.9    Reyes, V.E.10
  • 14
    • 0027603209 scopus 로고
    • Changes in the gastric mucosa following eradication of Helicobacter pylori
    • Genta, R. M., G. M. Lew, and D. Y. Graham. 1993. Changes in the gastric mucosa following eradication of Helicobacter pylori. Mod. Pathol. 6:281-289.
    • (1993) Mod. Pathol. , vol.6 , pp. 281-289
    • Genta, R.M.1    Lew, G.M.2    Graham, D.Y.3
  • 15
    • 0031899363 scopus 로고    scopus 로고
    • Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-κB activation
    • Glocker, E., C. Lange, A. Covacci, S. Bereswill, M. Kist, and H. L. Pahl. 1998. Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-κB activation. Infect. Immun. 66:2346-2348.
    • (1998) Infect. Immun. , vol.66 , pp. 2346-2348
    • Glocker, E.1    Lange, C.2    Covacci, A.3    Bereswill, S.4    Kist, M.5    Pahl, H.L.6
  • 16
    • 0031937067 scopus 로고    scopus 로고
    • Small bowel enteropathy: Role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal
    • Guy-Grand, D., J. P. DiSanto, P. Henchoz, M. Malassis-Seris, and P. Vassalli. 1998. Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal. Eur. J. Immunol. 28:730-744.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 730-744
    • Guy-Grand, D.1    DiSanto, J.P.2    Henchoz, P.3    Malassis-Seris, M.4    Vassalli, P.5
  • 17
    • 15144347037 scopus 로고    scopus 로고
    • Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa
    • Haeberle, H. A., M. Kubin, K. B. Bamford, R. Garofalo, D. Y. Graham, F. El-Zaatari, R. Karttunen, S. E. Crowe, V. E. Reyes, and P. B. Ernst. 1997. Differential stimulation of interleukin-12 (IL-12) and IL-10 by live and killed Helicobacter pylori in vitro and association of IL-12 production with gamma interferon-producing T cells in the human gastric mucosa. Infect. Immun. 65:4229-4235.
    • (1997) Infect. Immun. , vol.65 , pp. 4229-4235
    • Haeberle, H.A.1    Kubin, M.2    Bamford, K.B.3    Garofalo, R.4    Graham, D.Y.5    El-Zaatari, F.6    Karttunen, R.7    Crowe, S.E.8    Reyes, V.E.9    Ernst, P.B.10
  • 18
    • 0028990666 scopus 로고
    • Mechanism and biological significance of CD4-mediated cytotoxicity
    • Hahn, S., R. Gehri, and P. Erb. 1995. Mechanism and biological significance of CD4-mediated cytotoxicity. Immunol. Rev. 146:57-79.
    • (1995) Immunol. Rev. , vol.146 , pp. 57-79
    • Hahn, S.1    Gehri, R.2    Erb, P.3
  • 19
    • 0031045634 scopus 로고    scopus 로고
    • Expression of Fas antigen and its mediation of apoptosis in human gastric cancer cell lines
    • Hayashi, H., S. Tatebe, M. Osaki, A. Goto, Y. Suzuki, and H. Ito. 1997. Expression of Fas antigen and its mediation of apoptosis in human gastric cancer cell lines. Jpn. J. Cancer Res. 88:49-55.
    • (1997) Jpn. J. Cancer Res. , vol.88 , pp. 49-55
    • Hayashi, H.1    Tatebe, S.2    Osaki, M.3    Goto, A.4    Suzuki, Y.5    Ito, H.6
  • 20
    • 0029911619 scopus 로고    scopus 로고
    • Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: A review
    • Hopkins, R. J., L. S. Girardi, and E. A. Turney. 1996. Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review. Gastroenterology 110:1244-1252.
    • (1996) Gastroenterology , vol.110 , pp. 1244-1252
    • Hopkins, R.J.1    Girardi, L.S.2    Turney, E.A.3
  • 21
    • 0032987480 scopus 로고    scopus 로고
    • Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway
    • Houghton, J., R. M. Korah, M. R. Condon, and K. H. Kim. 1999. Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway. Dig. Dis. Sci. 44:465-478.
    • (1999) Dig. Dis. Sci. , vol.44 , pp. 465-478
    • Houghton, J.1    Korah, R.M.2    Condon, M.R.3    Kim, K.H.4
  • 22
    • 0033975683 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and interleukin 1β up-regulate gastric mucosal Fas antigen expression in Helicobacter pylori infection
    • Houghton, J., L. S. Macera-Bloch, L. Harrison, K. H. Kim, and R. M. Korah. 2000. Tumor necrosis factor alpha and interleukin 1β up-regulate gastric mucosal Fas antigen expression in Helicobacter pylori infection. Infect. Immun. 68:1189-1195.
    • (2000) Infect. Immun. , vol.68 , pp. 1189-1195
    • Houghton, J.1    Macera-Bloch, L.S.2    Harrison, L.3    Kim, K.H.4    Korah, R.M.5
  • 23
    • 0030697294 scopus 로고    scopus 로고
    • Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine
    • Inagaki-Ohara, K., H. Nishimura, T. Sakai, D. H. Lynch, and Y. Yoshikai. 1997. Potential for involvement of Fas antigen/Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine. Lab. Investig. 77:421-429.
    • (1997) Lab. Investig. , vol.77 , pp. 421-429
    • Inagaki-Ohara, K.1    Nishimura, H.2    Sakai, T.3    Lynch, D.H.4    Yoshikai, Y.5
  • 24
    • 0032783147 scopus 로고    scopus 로고
    • Helicobacter pylori induces gastric epithelial cell apoptosis in association with increased Fas receptor expression
    • Jones, N. L., A. S. Day, H. A. Jennings, and P. M. Sherman. 1999. Helicobacter pylori induces gastric epithelial cell apoptosis in association with increased Fas receptor expression. Infect. Immun. 67:4237-4242.
    • (1999) Infect. Immun. , vol.67 , pp. 4237-4242
    • Jones, N.L.1    Day, A.S.2    Jennings, H.A.3    Sherman, P.M.4
  • 25
    • 0030668211 scopus 로고    scopus 로고
    • Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection
    • Jones, N. L., P. T. Shannon, E. Cutz, H. Yeger, and P. M. Sherman. 1997. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am. J. Pathol. 151:1695-1703.
    • (1997) Am. J. Pathol. , vol.151 , pp. 1695-1703
    • Jones, N.L.1    Shannon, P.T.2    Cutz, E.3    Yeger, H.4    Sherman, P.M.5
  • 26
    • 0028913117 scopus 로고
    • Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis
    • Karttunen, R., T. Karttunen, H.-P. T. Ekre, and T. T. MacDonald. 1995. Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis. Gut 36:341-345.
    • (1995) Gut , vol.36 , pp. 341-345
    • Karttunen, R.1    Karttunen, T.2    Ekre, H.-P.T.3    MacDonald, T.T.4
  • 27
    • 0030772159 scopus 로고    scopus 로고
    • Helicobacter pylori activate NFκB in gastric epithelial cells
    • Keates, S., Y. S. Hitti, M. Upton, and C. P. Kelly. 1997. Helicobacter pylori activate NFκB in gastric epithelial cells. Gastroenterology 113:1099-1109.
    • (1997) Gastroenterology , vol.113 , pp. 1099-1109
    • Keates, S.1    Hitti, Y.S.2    Upton, M.3    Kelly, C.P.4
  • 28
    • 0032804501 scopus 로고    scopus 로고
    • Relationship between Fas-ligand expression on carcinoma cell and cytotoxic T-lymphocyte response in lymphoepithelioma-like cancer of the stomach
    • Kume, T., K. Oshima, Y. Yamashita, T. Shirakusa, and M. Kikuchi. 1999. Relationship between Fas-ligand expression on carcinoma cell and cytotoxic T-lymphocyte response in lymphoepithelioma-like cancer of the stomach. Int. J. Cancer 84:339-343.
    • (1999) Int. J. Cancer , vol.84 , pp. 339-343
    • Kume, T.1    Oshima, K.2    Yamashita, Y.3    Shirakusa, T.4    Kikuchi, M.5
  • 29
    • 0030919131 scopus 로고    scopus 로고
    • Inoculation of VacA- and CagA-Helicobacter pylori delays gastric ulcer healing in the rat
    • Li, H., B. Mellgard, and I. M. Helander. 1999. Inoculation of VacA- and CagA-Helicobacter pylori delays gastric ulcer healing in the rat. Scand. J. Gastroenterol. 32:439-444.
    • (1999) Scand. J. Gastroenterol. , vol.32 , pp. 439-444
    • Li, H.1    Mellgard, B.2    Helander, I.M.3
  • 30
    • 0032005020 scopus 로고    scopus 로고
    • Fas ligand-mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease
    • Lin, T., T. Brunner, B. Tietz, J. Madsen, E. Bonfoco, M. Reaves, M. Huflejt, and D. R. Green. 1998. Fas ligand-mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease. J. Clin. Investig. 101:570-577.
    • (1998) J. Clin. Investig. , vol.101 , pp. 570-577
    • Lin, T.1    Brunner, T.2    Tietz, B.3    Madsen, J.4    Bonfoco, E.5    Reaves, M.6    Huflejt, M.7    Green, D.R.8
  • 33
    • 0025792001 scopus 로고
    • The JAM test. a simple assay for DNA fragmentation and cell death
    • Matzinger, P. 1991. The JAM test. A simple assay for DNA fragmentation and cell death. I. Immunol. Methods 145:185-192.
    • (1991) I. Immunol. Methods , vol.145 , pp. 185-192
    • Matzinger, P.1
  • 34
    • 0343980065 scopus 로고    scopus 로고
    • Helicobacter pylori activates MAP kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun
    • in press
    • Meyer-Ter-Vehn, T., A. Covacci, M. Kist, and H. L. Pahl. Helicobacter pylori activates MAP kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun. J. Biol. Chem., in press.
    • J. Biol. Chem.
    • Meyer-Ter-Vehn, T.1    Covacci, A.2    Kist, M.3    Pahl, H.L.4
  • 35
    • 0029987967 scopus 로고    scopus 로고
    • Induction of gastric epithelial apoptosis by Helicobacter pylori
    • Moss, S. F., J. Calam, B. Agarwal, S. Wang, and P. G. Holt. 1996. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut 38:498-501.
    • (1996) Gut , vol.38 , pp. 498-501
    • Moss, S.F.1    Calam, J.2    Agarwal, B.3    Wang, S.4    Holt, P.G.5
  • 37
    • 0029808372 scopus 로고    scopus 로고
    • The Fas counter-attack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
    • O'Connell, J., G. C. O'Sullivan, J. K. Collins, and F. Shanahan. 1996. The Fas counter-attack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J. Exp. Med. 184:1075-1082.
    • (1996) J. Exp. Med. , vol.184 , pp. 1075-1082
    • O'Connell, J.1    O'Sullivan, G.C.2    Collins, J.K.3    Shanahan, F.4
  • 39
  • 40
    • 0028172588 scopus 로고
    • Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death
    • Ramsdell, F., M. S. Seaman, R. E. Miller, K. S. Picha, M. K. Kennedy, and D. H. Lynch. 1994. Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int. Immunol. 6:1545-1553.
    • (1994) Int. Immunol. , vol.6 , pp. 1545-1553
    • Ramsdell, F.1    Seaman, M.S.2    Miller, R.E.3    Picha, K.S.4    Kennedy, M.K.5    Lynch, D.H.6
  • 41
    • 0032532381 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis
    • Rudi, J., D. Kuck, S. Strand, A. Von Herbay, S. M. Mariani, P. H. Krammer, P. R. Galle, and W. Stremmel. 1998. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J. Clin. Investig. 102:1506-1514.
    • (1998) J. Clin. Investig. , vol.102 , pp. 1506-1514
    • Rudi, J.1    Kuck, D.2    Strand, S.3    Von Herbay, A.4    Mariani, S.M.5    Krammer, P.H.6    Galle, P.R.7    Stremmel, W.8
  • 42
    • 0030917133 scopus 로고    scopus 로고
    • Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during graft-versus-host disease in mice
    • Sakai, T., Y. Kimura, K. Inagaki-Ohara, K. Kusugami, D. H. Lynch, and Y. Yoshikai. 1997. Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during graft-versus-host disease in mice. Gastroenterology 113: 168-174.
    • (1997) Gastroenterology , vol.113 , pp. 168-174
    • Sakai, T.1    Kimura, Y.2    Inagaki-Ohara, K.3    Kusugami, K.4    Lynch, D.H.5    Yoshikai, Y.6
  • 43
    • 0032030668 scopus 로고    scopus 로고
    • Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells
    • Sharma, S. A., M. K. Tummuru, M. J. Blaser, and L. D. Kerr. 1998. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells. J. Immunol. 160:2401-2407.
    • (1998) J. Immunol. , vol.160 , pp. 2401-2407
    • Sharma, S.A.1    Tummuru, M.K.2    Blaser, M.J.3    Kerr, L.D.4
  • 45
    • 0032864191 scopus 로고    scopus 로고
    • Intestinal crypt cell apoptosis in murine acute graft versus host disease is mediated by tumour necrosis factor alpha and not by the FasL-Fas interaction: Effect of pentoxifylline on the development of mucosal atrophy
    • Stuber, E., A. Buschenfeld, A. von Freier, T. Arendt, and U. R. Folsch. 1999. Intestinal crypt cell apoptosis in murine acute graft versus host disease is mediated by tumour necrosis factor alpha and not by the FasL-Fas interaction: effect of pentoxifylline on the development of mucosal atrophy. Gut 45:229-235.
    • (1999) Gut , vol.45 , pp. 229-235
    • Stuber, E.1    Buschenfeld, A.2    Von Freier, A.3    Arendt, T.4    Folsch, U.R.5
  • 48
    • 0026737347 scopus 로고
    • Accelerated programmed cell death of MRL-lpr/lprT lymphocytes
    • Van Houten, N., and R. C. Budd. 1992. Accelerated programmed cell death of MRL-lpr/lprT lymphocytes. J. Immunol. 149:2513-2517.
    • (1992) J. Immunol. , vol.149 , pp. 2513-2517
    • Van Houten, N.1    Budd, R.C.2
  • 50
    • 0032125574 scopus 로고    scopus 로고
    • IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: Requirement of STAT1 protein for up-regulation of Fas and FasL expression
    • Xu, X., X. Y. Fu, J. Plate, and A. S. Chong. 1999. IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res. 58:2832-2837.
    • (1999) Cancer Res. , vol.58 , pp. 2832-2837
    • Xu, X.1    Fu, X.Y.2    Plate, J.3    Chong, A.S.4
  • 52
    • 0026526503 scopus 로고
    • Tumor necrosis factor α and interferon γ synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kappaB-like binding sites of the interleukin 8 gene
    • Yasumoto, K., S. Okamoto, N. Mukaida, S. Murakami, M. Mai, and K. Matsushima. 1992. Tumor necrosis factor α and interferon γ synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kappaB-like binding sites of the interleukin 8 gene. J. Biol. Chem. 267:22506-22511.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22506-22511
    • Yasumoto, K.1    Okamoto, S.2    Mukaida, N.3    Murakami, S.4    Mai, M.5    Matsushima, K.6
  • 53
    • 0030891986 scopus 로고    scopus 로고
    • Gastric epithelial cells express the costimulatory molecules B7.1 and B7.2 during infection with Helicobacter pylori and activate CD4 T cells
    • Ye, G., C. Barrera, X. J. Fan, S. E. Crowe, P. B. Ernst, and V. E. Reyes. 1997. Gastric epithelial cells express the costimulatory molecules B7.1 and B7.2 during infection with Helicobacter pylori and activate CD4 T cells. J. Clin. Investig. 99:1628-1636.
    • (1997) J. Clin. Investig. , vol.99 , pp. 1628-1636
    • Ye, G.1    Barrera, C.2    Fan, X.J.3    Crowe, S.E.4    Ernst, P.B.5    Reyes, V.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.