Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells

Gene Therapy

Volumn 17, Issue 5, 2010, Pages 653-661

  Toptan, T ^a,b   Ensser, A ^c   Fickenscher, H ^a,b  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

CD2; Herpesvirus saimiri; HTERT; IL 26; Rhadinovirus; Telomerase

Indexed keywords

CD2 ANTIGEN; HERPESVIRUS VECTOR; INTERLEUKIN 26; PROTEIN KINASE LYN; TELOMERASE REVERSE TRANSCRIPTASE; VIRUS VECTOR;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; ENZYME ACTIVITY; GENE AMPLIFICATION; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHADINOVIRUS; T LYMPHOCYTE; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS CELL TRANSFORMATION; VIRUS MUTANT;

ANTIGENS, CD2; CELL TRANSFORMATION, VIRAL; GENETIC VECTORS; HERPESVIRUS 2, SAIMIRIINE; HUMANS; INTERLEUKINS; PHOSPHOPROTEINS; SRC-FAMILY KINASES; T-LYMPHOCYTES; TELOMERASE; TRANSDUCTION, GENETIC; VIRAL PROTEINS;

BACTERIA (MICROORGANISMS); RHADINOVIRUS; SAIMIRIINE HERPESVIRUS 2;

EID: 77952430113     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.3     Document Type: Article

References (57)

1. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, Futcher AB et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992; 89: 10114-10118.
2. Blackburn EH. Telomerases. Annu Rev Biochem 1992; 61: 113-129.
3. Hodes RJ, Hathcock KS, Weng NP. Telomeres in T and B cells. Nat Rev Immunol 2002; 2: 699-706.
4. Weng NP, Hathcock KS, Hodes RJ. Regulation of telomere length and telomerase in T and B cells: a mechanism for maintaining replicative potential. Immunity 1998; 9: 151-157.
5. Luiten RM, Pene J, Yssel H, Spits H. Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood 2003; 101: 4512-4519.
6. Hooijberg E, Ruizendaal JJ, Snijders PJ, Kueter EW, Walboomers JM, Spits H. Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol 2000; 165: 4239-4245.
7. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-352.
8. Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998; 8: 279-282.
9. Yang J, Chang E, Cherry AM, Bangs CD, Oei Y, Bodnar A et al. Human endothelial cell life extension by telomerase expression. J Biol Chem 1999; 274: 26141-26148.
10. Kiyono T, Foster SA, Koop JI, McDougall JK, Galloway DA, Klingelhutz AJ. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 1998; 396: 84-88.
11. Ohara T, Koyama K, Kusunoki Y, Hayashi T, Tsuyama N, Kubo Y et al. Memory functions and death proneness in three CD4+CD45RO+ human T cell subsets. J Immunol 2002; 169: 39-48.
12. Akbar AN, Beverley PC, Salmon M. Will telomere erosion lead to a loss of T-cell memory? Nat Rev Immunol 2004; 4: 737-743.
13. Melendez LV, Hunt RD, Daniel MD, Garcia FG, Fraser CE. Herpesvirus saimiri. II. Experimentally induced malignant lymphoma in primates. Lab Anim Care 1969; 19: 378-386.
14. Fickenscher H, Fleckenstein B. Herpesvirus saimiri. Philos Trans R Soc Lond B Biol Sci 2001; 356: 545-567.
15. Fleckenstein B, Wolf H. Purification and properties of herpes-virus saimiri DNA. Virology 1974; 58: 55-64.
16. Biesinger B, Müller-Fleckenstein I, Simmer B, Lang G, Wittmann S, Platzer E et al. Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proc Natl Acad Sci USA 1992; 89: 3116-3119.
17. Jung JU, Trimble JJ, King NW, Biesinger B, Fleckenstein BW, Desrosiers RC. Identification of transforming genes of subgroup A and C strains of herpesvirus saimiri. Proc Natl Acad Sci USA 1991; 88: 7051-7055.
18. Biesinger B, Tsygankov AY, Fickenscher H, Emmrich F, Fleck-enstein B, Bolen JB et al. The product of the herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J Biol Chem 1995; 270: 4729-4734.
19. Fickenscher H, Biesinger B, Knappe A, Wittmann S, Fleckenstein B. Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes. J Virol 1996; 70: 6012-6019.
20. Knappe A, Hiller C, Thurau M, Wittmann S, Hofmann H, Fleckenstein B et al. The superantigen-homologous viral immediate-early gene ie14/vsag in herpesvirus saimiri-trans-formed human T cells. J Virol 1997; 71: 9124-9133.
21. Duboise SM, Guo J, Czajak S, Desrosiers RC, Jung JU. STP and Tip are essential for herpesvirus saimiri oncogenicity. J Virol 1998; 72: 1308-1313.
22. Harnack U, Lehmann C, Matthes E, Pecher G. Up-regulation of telomerase activity in herpesvirus saimiri immortalized human T-lymphocytes. Anticancer Res 2001; 21: 3969-3972.
23. Hiller C, Wittmann S, Slavin S, Fickenscher H. Functional long-term thymidine kinase suicide gene expression in human T cells using a herpesvirus saimiri vector. Gene Therapy 2000; 7: 664-674.
24. Stevenson AJ, Frolova-Jones E, Hall KT, Kinsey SE, Markham AF, Whitehouse A et al. A herpesvirus saimiri-based gene therapy vector with potential for use in cancer immunotherapy. Cancer Gene Ther 2000; 7: 1077-1085.
25. Frolova-Jones EA, Ensser A, Stevenson AJ, Kinsey SE, Meredith DM. Stable marker gene transfer into human bone marrow stromal cells and their progenitors using novel herpesvirus saimiri-based vectors. J Hematother Stem Cell Res 2000; 9: 573-581.
26. Knappe A, Feldmann G, Dittmer U, Meinl E, Nisslein T, Wittmann S et al. Herpesvirus saimiri-transformed macaque T cells are tolerated and do not cause lymphoma after autologous reinfusion. Blood 2000; 95: 3256-3261.
27. Stevenson AJ, Clarke D, Meredith DM, Kinsey SE, Whitehouse A, Bonifer C. Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro. Gene Therapy 2000; 7: 464-471.
28. Wieser C, Stumpf D, Grillhösl C, Lengenfelder D, Gay S, Fleckenstein B et al. Regulated and constitutive expression of anti-inflammatory cytokines by nontransforming herpesvirus saimiri vectors. Gene Therapy 2005; 12: 395-406.
29. Griffiths RA, Boyne JR, Whitehouse A. Herpesvirus saimiri-based gene delivery vectors. Curr Gene Ther 2006; 6: 1-15.
30. Macnab S, White R, Hiscox J, Whitehouse A. Production of an infectious herpesvirus saimiri-based episomally maintained amplicon system. J Biotechnol 2008; 134: 287-296.
31. Grassmann R, Dengler C, Müller-Fleckenstein I, Fleckenstein B, McGuire K, Dokhelar MC et al. Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a herpesvirus saimiri vector. Proc Natl Acad Sci USA 1989; 86: 3351-3355.
32. Court DL, Sawitzke JA, Thomason LC. Genetic engineering using homologous recombination. Annu Rev Genet 2002; 36: 361-388.
33. Mittrücker HW, Müller-Fleckenstein I, Fleckenstein B, Fleischer B. CD2-mediated autocrine growth of herpes virus saimiri-transformed human T lymphocytes. J Exp Med 1992; 176: 909-913.
34. Knappe A, Hör S, Wittmann S, Fickenscher H. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. J Virol 2000; 74: 3881-3887.
35. Wiese N, Tsygankov AY, Klauenberg U, Bolen JB, Fleischer B, Bröker BM. Selective activation of T cell kinase p56lck by Herpesvirus saimiri protein tip. J Biol Chem 1996; 271: 847-852.
36. Birkmann A, Mahr K, Ensser A, Yaguboglu S, Titgemeyer F, Fleckenstein B et al. Cell surface heparan sulfate is a receptor for human herpesvirus 8 and interacts with envelope glycoprotein K8.1. J Virol 2001; 75: 11583-11593.
37. Ensser A, Pfinder A, Müller-Fleckenstein I, Fleckenstein B. The URNA genes of herpesvirus saimiri (strain C488) are dispensable for transformation of human Tcells in vitro. J Virol 1999; 73: 10551-10555.
38. Tischer BK, von Einem J, Kaufer B, Osterrieder N. Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli. Biotechniques 2006; 40: 191-197.
39. Tischer BK, Smith G, Osterrieder N. En Passant Mutagenesis\A two step markerless Red recombination system. In: Braman J (ed.), In vitro Mutagenesis Protocols. Humana Press Inc.: New York, NY, USA, 2009, in press.
40. Fickenscher H, Fleckenstein B. Growth-transformation of human T cells. Methods Microbiol 2002; 32: 657-692.
41. Yamanashi Y, Mori S, Yoshida M, Kishimoto T, Inoue K, Yamamoto T et al. Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I. Proc Natl Acad Sci USA 1989; 86: 6538-6542.
42. Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, Jorcano JL et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratino-cytes. EMBO J 2001; 20: 2619-2630.
43. Dong CK, Masutomi K, Hahn WC. Telomerase: regulation, function and transformation. Crit Rev Oncol Hematol 2005; 54: 85-93.
44. Rufer N, Migliaccio M, Antonchuk J, Humphries RK, Roosnek E, Lansdorp PM. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 2001; 98: 597-603.
45. Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR et al. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 1999; 18: 1219-1226.
46. Ulaner GA, Hu JF, Vu TH, Giudice LC, Hoffman AR. Telomerase activity in human development is regulated by human telomer-ase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res 1998; 58: 4168-4172.
47. Weng NP. Regulation of telomerase expression in human lymphocytes. Springer Semin Immunopathol 2002; 24: 23-33.
48. Migliaccio M, Amacker M, Just T, Reichenbach P, Valmori D, Cerottini JC et al. Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization. J Immunol 2000; 165: 4978-4984.
49. Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW. Telomerase activity does not always imply telomere maintenance. Biochem Biophys Res Commun 1999; 254: 795-803.
50. Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM et al. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 1998; 95: 14723-14728.
51. Pawelec G. Hypothesis: loss of telomerase inducibility and subsequent replicative senescence in cultured human T cells is a result of altered costimulation. Mech Ageing Dev 2000; 121: 181-185.
52. Brinkmann MM, Schulz TF. Regulation of intracellular signalling by the terminal membrane proteins of members of the gammaherpesvirinae. J Gen Virol 2006; 87: 1047-1074.
53. Alberter B, Ensser A. Histone modification pattern of the T-cellular herpesvirus saimiri genome in latency. J Virol 2007; 81: 2524-2530.
54. Muyrers JP, Zhang Y, Testa G, Stewart AF. Rapid modification of bacterial artificial chromosomes by ET-recombination. Nucleic Acids Res 1999; 27: 1555-1557.
55. Birnboim HC, Doly J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 1979; 7: 1513-1523.
56. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-2015.
57. Atha DH, Miller K, Sanow AD, Xu J, Hess JL, Wu OC et al. High-throughput analysis of telomerase by capillary electrophoresis. Electrophoresis 2003; 24: 109-114.