Up-regulation of telomerase activity in Herpesvirus saimiri immortalized human T-lymphocytes

Anticancer Research

Volumn 21, Issue 6 A, 2001, Pages 3969-3972

  Harnack, Ulf ^a   Lehmann, Christine ^a   Matthes, Eckart ^a   Pecher, Gabriele ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Herpesvirus saimiri (HVS); Immortalization; T cells; Telomerase

Indexed keywords

CD4 ANTIGEN; TELOMERASE;

ARTICLE; CELL IMMORTALIZATION; ENZYME ACTIVITY; ENZYME ASSAY; HERPES VIRUS SAIMIRI; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHOCYTE CLONE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

CD4-POSITIVE T-LYMPHOCYTES; CELL TRANSFORMATION, VIRAL; HERPESVIRUS 2, SAIMIRIINE; HL-60 CELLS; HUMANS; LEUKOCYTES, MONONUCLEAR; TELOMERASE; UP-REGULATION;

EID: 0035569039     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Telomerases
2. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
3. Telomere length, aging and somatic cell turnover
4. Specific association of human telomerase activity with immortal cells and cancer
5. The roles of telomeres and telomerase in cellular immortalization and the development of cancer
6. Telomerase activity in normal leukocytes and in hematologic malignancies
7. Regulated expression of telomerase activity in human T-lymphocyte development and activation
8. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
9. Telomerase regulation during entry into the cell cycle in normal human T-cells
10. Human naive and memory T-lymphocytes differ in telomeric length and replicative potential
11. Immortalization of human CD8+ T-cell clones by ectopic expression of telomerase reverse transcriptase
12. Ectopic human telomerase catalytic subunit-expression maintains telomere length but is not-sufficient for CD8+ T-lymphocyte immortalization
13. Herpesvirus saimiri and Herpesvirus ateles
14. Stable growth transformation of human T-lymphocytes by Herpesvirus saimiri
15. Functional phenotype of transformed human α/β and γ/σ T-cells determined by different subgroup C strains of Herpesvirus saimiri
16. Immortalization of human T-cells by Herpesvirus saimiri
17. Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri
18. STP and TIP are essential for herpesvirus saimiri oncogenicity
19. A role for herpesvirus saimiri orf 14 in transformation and persistent infection
20. Association of the viral oncoprotein STP-C 488 with cellular ras
21. Direct binding and activation of STAT-transcription factors by the herpesvirus saimiri protein tip
22. Human T-cell leukemia virus type II increases telomerase activity in uninfected CD34+ hematopoietic progenitor cells
23. Virus-induced CD8+ T-cell clonal expansion is associated with telomerase upregulation and telomere length preservation: A mechanism for rescue from replicative senescence
24. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
25. Telomerase activation by the E6 gene product of human papillomavirus type 16
26. Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process
27. Generation of an immortalized human CD4+ T-cell clone inhibiting tumor growth in mice
28. Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate NF-kB activity and interleukin-2 gene expression
29. Cytotoxicity of interleukin 2-activated lymphocytes for leukemia and lymphoma cells
30. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
31. Telomerase extends the lifespan of virus- transformed human cells without net telomere lengthening
32. The effects of telomerase inhibitiors on lymphocyte function
33. Telomerase protein rather than its RNA is the target of phosphorthioate-modified oligonucleotides