Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 6012-6019

  Fickenscher, Helmut ^a   Biesinger, Brigitte ^a   Knappe, Andrea ^a   Wittmann, Sabine ^a   Fleckenstein, Bernhard ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN SPECIFICITY; ARTICLE; CEBIDAE; CELL SPECIFICITY; CELL TRANSFORMATION; EPISOME; GENE EXPRESSION; GENETIC REGULATION; HERPES VIRUS; HUMAN; HUMAN TISSUE; ONCOGENE; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; VIRUS GENE; VIRUS GENOME;

EID: 0029815220     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.6012-6019.1996     Document Type: Article

References (70)

1. Ahuja, S., and P. Murphy. 1993. Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri. J. Biol. Chem. 268:20691-20694.
2. Albrecht, J., and B. Fleckenstein. 1992. New member of the multigene family of complement control proteins in herpesvirus saimiri. J. Virol. 66:3937-3940.
3. Albrecht, J., J. Nicholas, D. Biller, K. Cameron, B. Biesinger, C. Newman, S. Wittmann, M. Craxton, H. Coleman, B. Fleckenstein, and R. Honess. 1992. Primary structure of the herpesvirus saimiri genome. J. Virol. 66:5047-5058.
4. Albrecht, J., J. Nicholas, K. Cameron, C. Newman, B. Fleckenstein, and R. Honess. 1992. Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59. Virology 190:527-530.
5. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1995. Current protocols in molecular biology. John Wiley & Sons, Inc., New York.
6. + cytotoxic T lymphocytes. J. Virol. 67:6317-6321.
7. Biesinger, B., I. Müller-Fleckenstein, B. Simmer, G. Lang, S. Wittmann. E. Platzer, R. Desrosiers, and B. Fleckenstein. 1992. Stable growth transformation of human T-lymphocytes by herpesvirus saimiri. Proc. Natl. Acad. Sci. USA 89:3116-3119.
8. Biesinger, B., J. Trimble, R. Desrosiers, and B. Fleckenstein. 1990. The divergence between two oncogenic herpesvirus saimiri strains in a genomic region related to the transforming phenotype. Virology 176:505-514.
9. Biesinger, B., A. Tsygankov, H. Fickenscher, F. Emmrich, B. Fleckenstein, J. Bolen, and B. Bröker. 1995. The product of the herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p561ck in transformed cells. J. Biol. Chem. 270:4729-2734.
10. Bodemer, W., H. Niller, N. Nitsche, B. Scholz, and B. Fleckenstein. 1986. Organization of the thymidylate synthase gene of herpesvirus saimiri. J. Virol. 60:114-123.
11. Broker, B., A. Tsygankov, H. Fickenseher, N. Chitaev, H. Schulze-Koops, I. Müller-Fleckenstein, B. Fleckenstein, J. Bolen, and F. Emmrich. 1994. Engagement of the CD4 receptor inhibits the interleukin-2 dependent proliferation of human T cells transformed by herpesvirus saimiri. Eur. J. Immunol. 24:843-850.
12. Bröker, B., A. Tsygankov, I. Müller-Fleckenstein, A. Guse, N. Chitaev, B. Biesinger, B. Fleckenstein, and F. Emmrich. 1993. Immortalization of human T cell clones by herpesvirus saimiri. Signal transduction analysis reveals functional CD3, CD4, and IL-2 receptors. J. Immunol. 51:1184-1192.
13. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
14. Daniel, M., D. Silva, and N. Ma. 1976. Establishment of owl monkey kidney 210 cell line for virological studies. In Vitro 12:290.
15. De Carli, M., S. Berthold, H. Fickenscher, I. Müller-Fleckenstein, M. D'Elios, Q. Gao, R. Biagiotti, M. Giudizi, J. Kalden, B. Fleckenstein, S. Romagnani, and G. Del Prete. 1993. Immortalization with herpesvirus saimiri modulates the cytokine secretion profile of established Th1 and Th2 human T cell clones. J. Immunol. 151:5022-5030.
16. Desrosiers, R., A. Bakker, J. Kamine, L. Falk, R. Hunt, and N. King. 1985. A region of the herpesvirus saimiri genome required for oncogenicity. Science 228:184-187.
17. Desrosiers, R., R. Burghoff, A. Bakker, and J. Kamine. 1984. Construction of replication-competent herpesvirus saimiri deletion mutants. J. Virol. 49:343-348.
18. Desrosiers, R., and L. Falk. 1982. Herpesvirus saimiri strain variability. J. Virol. 43:352-356.
19. Desrosiers, R., D. Silva, L. Waldron, and N. Letvin. 1986. Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization. J. Virol. 57:701-705.
20. Falk, L., L. Wolfe, and F. Marczynska. 1972. Characterization of lymphoid cell lines established from herpesvirus saimiri (HVS)-infected marmosets. Bacteriol. Proc. 38:191.
21. Feinberg, A., and B. Vogelstein. 1983. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
22. Fickenscher, H. Unpublished data.
23. Fickenscher, H., and B. Fleckenstein. 1994. Generation of human T-cell lines using lymphotropic herpesviruses. Methods Mol. Genet. 4:345-362.
24. Fickenscher, H., E. Meinl, A. Knappe, S. Wittmann, and B. Fleckenstein. 1996. TCR expression of herpesvirus saimiri immortalized human T cells. Immunologist 4:41-43.
25. Fleckenstein, B., and R. Desrosiers. 1982. Herpesvirus saimiri and herpesvirus ateles, p. 253-331. In B. Roizman (ed.), The herpesviruses, vol. 1. Plenum Press, New York.
26. Fodor, W., S. Rollins, S. Bianco-Caron, R. Rather, E. Guilmetle, W. Burton, J. Albrecht, B. Fleckenstein, and S. Squinto. 1995. The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity. J. Virol. 69:3889-3892.
27. Gardella, T., P. Medveczky, T. Sairenji, and C. Mulder. 1984. Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis. J. Virol. 50:248-254.
28. Geck, P., S. Whitaker, M. Medveczky, and P. Medveczky. 1990. Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri. J. Virol. 64: 3509-3515.
29. Huppes, W., H. Fickenscher, B. 'tHart, and B. Fleckenstein. 1994 Cytokine dependence of human to mouse graft-versus-host disease. Scand. J. Immunol. 40:26-36.
30. Irving, S., C. June, P. Zipfel, U. Siebenlist, and K. Kelly. 1989. Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation. Mol. Cell. Biol. 9:1034-1040.
31. Jung, J., and R. Desrosiers. 1991. Identification and characterization of the herpesvirus saimiri oncoprotein STP-C488. J. Virol. 65:6953-6960.
32. Jung, J., and R. Desrosiers. 1992. Herpesvirus saimiri oncogene STP-C488 encodes a phosphoprotein. J. Virol. 66:1777-1780.
33. Jung, J., and R. Desrosiers. 1994. Distinct functional domains of STP-C488 of herpesvirus saimiri. Virology 204:751-758.
34. Jung, J., and R. Desrosiers. 1995. Association of the viral oncoprotein Stp-C488 with cellular Ras. Mol. Cell. Biol. 15:6508-6512.
35. Jung, J., S. Lang, U. Friedrich, T. Jun, T. Roberts, R. Desrosiers, and B. Biesinger. 1995. Identification of Lck-binding elements in Tip of herpesvirus saimiri. J. Biol. Chem. 270:20660-20667.
36. Jung, J., S. Lang, T. Jun, T. Roberts, A. Veillette, and R. Desrosiers. 1995. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. J. Virol. 69:7814-7822.
37. Jung, J., M. Stager, and R. Desrosiers. 1994. Virus-encoded cyclin. Mol. Cell. Biol. 14:7235-7244.
38. Jung, J., J. Trimble, N. King, B. Biesinger, B. Fleckenstein, and R. Desrosiers. 1991. Identification of transforming genes of subgroup A and C strains of herpesvirus saimiri. Proc. Natl. Acad. Sci. USA 88:7051-7055.
39. Klein, J., H. Fickenscher, J. Holliday, B. Biesinger, and B. Fleckenstein. 1996. Herpesvirus saimiri immortalized γδ T cell line activated by IL-12. J. Immunol. 156:2754-2760.
40. Koomey, J., C. Mulder, R. Burghoff, B. Fleckenstein, and R. Desrosiers. 1984. Deletion of DNA sequences in a nononcogenic variant of herpesvirus saimiri. J. Virol. 50:662-665.
41. Lund, T., M. Medveczky, P. Geck, and P. Medveczky. 1995. A herpesvirus saimiri protein required for interleukin-2 independence is associated with membranes of transformed T cells. J. Virol. 69:4495-4499.
42. lck. J. Virol. 70:600-606.
43. Marczynska, B., L. Falk, L. Wolfe, and F. Deinhardt. 1973. Transplantation and cytogenetic studies of herpesvirus saimiri-induced disease in marmoset monkeys. J. Nat. Cancer Inst. 50:331-337.
44. Marth, J., D. Lewis, C. Wilson, M. Gearn, E. Krebs, and R. Perlmutter. 1987. Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J. 6:2727-2734.
45. Medveczky, M., P. Geck, J. Sullivan, D. Serbousek, J. Djeu, and P. Medveczky. 1993. IL-2 independent growth and cytotoxicity of herpesvirus saimiri infected human CD8 cells and involvement of two open reading frame sequences of the virus. Virology 196:402-412.
46. Medveczky, M., P. Geck, R. Vassallo, and P. Medveczky. 1993. Expression of the collagen-like putative oncoprotein of herpesvirus saimiri in transformed T cells. Virus Genes 7:349-365.
47. Medveczky, M., E. Szomolanyi, R. Hesselton, D. DeGrand, P. Geck, and P. Medveczky. 1989. Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand White rabbits. J. Virol. 63:3601-3611.
48. Medveczky, P., E. Szomolanyi, R. Desrosiers, and C. Mulder. 1984. Classification of herpesvirus saimiri into three groups based on extreme variation in a DNA region required far oncogenicity. J. Virol. 52:938-944.
49. Meinl, E. Unpublished data.
50. Meinl, E., R. Hohlfeld, H. Wekerle, and B. Fleckenstein. 1995. Immortalization of human T cells by herpesvirus saimiri. Immunol. Today 16:55-58.
51. Mittrücker, H., I. Müller-Fleckenstein, B. Fleckenstein, and B. Fleischer. 1992. GD2-mediated mutual stimulation of herpesvirus saimiri-transformed human T lymphocytes. J. Exp. Med. 176:909-913.
52. Mittrücker, H., I. Müller-Fleckenstein, B. Fleckenstein, and B. Fleischer. 1993. Herpesvirus saimiri-transformed human T lymphocytes: normal functional phenotype and preserved T cell receptor signalling. Int. Immunol. 5:985-990.
53. Murphy, C., C. Kretschmer, B. Biesinger, J. Beckers, J. Jung, R. Desrosiers, H. Müller-Hermelink, B. Fleckenstein, and U. Rüther. 1994. Epithelial tumors induced by a herpesvirus oncogene in transgenic mice. Oncogene 9:221-226.
54. Murthy, S., J. Trimble, and R. Desrosiers. 1989. Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation. J. Virol. 63:3307-3314.
55. Neubauer, R., W. Wallen, and H. Rabin. 1974. Stimulation of herpesvirus saimiri expression in the absence of evidence for type C virus activation in a marmoset lymphoid cell line. J. Virol. 14:745-750.
56. Nicholas, J., E. Smith, L. Coles, and R. Honess. 1990. Gene expression in cells infected with gammaherpesvirus saimiri: properties of transcripts from two immediate-early genes. Virology 179:189-200.
57. Nick, S., H. Fickenscher, B. Biesinger, G. Born, G. Jahn, and B. Fleckenstein. 1993. Herpesvirus saimiri transformed human T cell lines - a permissive system for human immunodeficiency viruses. Virology 194:875-877.
58. Rother, R., S. Rollins, W. Fodor, J. Albrecht, E. Setter, B. Fleckenstein, and S. Squinto. 1994. Inhibition of complement-mediated cytolysis by the terminal complement inhibitor of herpesvirus saimiri. J. Virol. 68:730-737.
59. Rouvier, E., M. Luciani, M. Mattei, F. Denizot, and P. Golstein. 1993. CTLA-8, cloned from an activated T cell, hearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J. Immunol. 150:5445-5456.
60. Schneider, U., H. Schwenk, and G. Bornkamm. 1977. Characterization of EBV-genome negative 'null' and T cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma. Int. J. Cancer 19:621-626.
61. Silva, D., and R. Desrosiers. Unpublished data.
62. Stamminger, T., H. Fickenscher, and B. Fleckenstein. 1990. Cell type-specific induction of the major immediate early enhancer of human cytomegalovirus by cyclic AMP. J. Gen. Virol. 71:105-113.
63. Trimble, J., S. Murthy, A. Bakker, R. Grassmann, and R. Desrosiers. 1988. A gene for dehydrofolate reductase in a herpesvirus. Science 239:1145-1147.
64. Troidl, B., B. Simmer, H. Fickenscher, I. Müller-Fleckenstein, F. Emmrich, B. Fleckenstein, and E. Gebhart. 1994. Karyotypic characterization of human T cell lines immortalized by herpesvirus saimiri. Int. J. Cancer 56:433-438.
65. Weber, F., E. Meinl, K. Drexler, A. Czlonkowska, S. Huber, H. Fickenscher, I. Müller-Fleckenstein, B. Fleckenstein, H. Wekerle, and R. Hohlfeld. 1993. Herpesvirus saimiri-transformed human T cell lines expressing functional receptor for myelin basic protein. Proc. Natl. Acad. Sci. USA 90:11049-11054.
66. Wiese, N., A. Tsygankov, U. Klauenberg, J. Bolen, B. Fleischer, and B. Bröker. 1996. Selective activation of T cell kinase p56lck by herpesvirus saimiri protein Tip. J. Biol. Chem. 271:847-852.
67. Yao, Z., W. Fanslow, M. Seidin, A. Rousseau, S. Painter, M. Comeau, J. Cohen, and M. Spriggs. 1995. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3:811-821.
68. Yasukawa, M., Y. Inoue, N. Kimura, and S. Fujita. 1995. Immortalization of human T cells expressing T-cell receptor γδ by herpesvirus saimiri. J. Virol. 69:8114-8117.
69. Zipfel, P., S. Irving, K. Kelly, and U. Siebenlist. 1989. Complexity of the primary genetic response to mitogenic activation of human T cells. Mol. Cell. Biol. 9:1041-1048.
70. Zur Hausen, H., F. O'Neill, U. Freese, and E. Hecker. 1978. Persisting oncogenic herpesvirus induced by the tumour promoter TPA. Nature (London) 272:373-375.