Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages

Gene Therapy

Volumn 17, Issue 5, 2010, Pages 662-671

  Van Strien, M E ^a   Mercier, D ^a,d   Drukarch, B ^a   Breve J J P ^a   Poole, S ^b   Binnekade, R ^a   Bol, J G J M ^a   Blits, B ^c   Verhaagen, J ^c   Van Dam, A M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^c NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^d Qiagen France   (France)

Author keywords

Inducible nitric oxide; Interleukin 6; Lentiviral vector; Multiple sclerosis; Neuro inflammation; Tumor necrosis factor a

Indexed keywords

GREEN FLUORESCENT PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; LENTIVIRUS VECTOR; LIPOPOLYSACCHARIDE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENCEPHALITIS; GENE OVEREXPRESSION; GLIA CELL; HYPOPHYSIS; IN VITRO STUDY; MACROPHAGE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ANIMALS; BRAIN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE THERAPY; GENETIC VECTORS; INFLAMMATION MEDIATORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-10; INTERLEUKIN-4; INTERLEUKIN-6; LENTIVIRUS; MACROPHAGES; MALE; NEUROGLIA; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; TRANSDUCTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 77952424239     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.8     Document Type: Article

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