Interleukin-10: A complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug

Critical Care Medicine

Volumn 30, Issue 1 SUPPL. B, 2002, Pages

  Oberholzer, Andreas ^a   Oberholzer, Caroline ^a   Moldawer, Lyle L ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Apoptosis; Dendritic cells; Immunosuppression; Inflammation; Macrophage

Indexed keywords

ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; INTERFERON; INTERLEUKIN 10; NUCLEAR FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; CONFERENCE PAPER; CYTOKINE PRODUCTION; DENDRITIC CELL; ENDOTOXEMIA; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; T LYMPHOCYTE; THERMAL INJURY;

EID: 0036164902     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200201001-00008     Document Type: Conference Paper

References (47)

1. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
2. Interleukin-10
3. IL-10-mediated suppression of TNF-alpha production is independent of its ability to inhibit NF kappa B activity
4. In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13
5. Interleukin-10 production during septicaemia
6. High levels of interleukin 10 in serum are associated with fatality in meningococcal disease
7. Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock
8. Interleukin-10 and the monocyte/macrophage-induced inflammatory response in septic shock
9. Blood interleukin 10 levels parallel the severity of septic shock
10. Relationship of interleukin-10 plasma levels to severity of injury and clinical outcome in injured patients
11. Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees
12. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
13. The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome
14. Biological properties of interleukin 10
15. Interleukin 10 protects mice from lethal endotoxemia
16. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia
17. Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia
18. Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia
19. Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: Effect of timing of recombinant human IL-10 administration
20. Animal models of sepsis and shock: A review and lessons learned
21. Multiple organ failure, multiple organ dysfunction syndrome, and systemic inflammatory response syndrome: Why no magic bullets?
22. Balance of inflammatory cytokines related to severity and mortality of murine sepsis
23. Endogenous IL-10 protects mice from death during septic peritonitis
24. Exogenous interleukin-10 fails to decrease the mortality or morbidity of sepsis
25. IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense
26. Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection
27. Interleukin-10 impairs host defense in murine pneumococcal pneumonia
28. Effect of interleukin-10 on gut-derived sepsis caused by Pseudomonas aeruginosa in mice
29. Interleukin-10 protects neonatal mice from lethal group B streptococcal infection
30. Carbon: Microbiological and inflammatory effects of murine recombinant interleukin-10 in two models of polymicrobial peritonitis in rats
31. Anti-interleukin-10 antibody restores burn-induced defects in T-cell function
32. What is the role of interleukin 10 in polymicrobial sepsis: Anti-inflammatory agent or immunosuppressant?
33. Caspase-3-dependent organ apoptosis early after burn injury
34. Circulating mediators in serum of injured patients with complications inhibit neutrophil apoptosis up-regulation of protein-tyrosine phosphorylation
35. Therapeutic implications of interleukin-10 in surgical disease
36. Foxwell: Interleukin-10 rescues T cells from apoptotic cell death: Association with an up-regulation of Bcl-2
37. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein
38. Sir Isaac Newton, sepsis,SIRS, and CARS
39. Adenoviral delivery of human and viral IL-10 in murine sepsis
40. Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis
41. The dendritic cell system and its role in immunogenicity
42. Dendritic cells and the control of immunity
43. Interleukin-10 does not affect phagocytosis of particulate antigen by bone marrow-derived dendritic cells but does impair antigen presentation
44. Effect of interleukin-10 on dendritic cell maturation and function
45. Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells
46. Mammalian and viral IL-10 enhance C-Cc chemokine receptor 5 but down-regulate C-C chemokine receptor 7 expression by myeloid dendritic cells: Impact on chemotactic responses and in vivo homing ability
47. Interleukin-10 and the interleukin-10 receptor