Liver injury and expression of cytochromes p450: Evidence that regulation of CYP2A5 is different from that of other major xenobiotic metabolizing CYP enzymes

Toxicology and Applied Pharmacology

Volumn 138, Issue 1, 1996, Pages 140-148

  Camus Randon, Anne Marie ^a   Raffalli, Françoise ^a   Béréziat, Jean Claude ^a   McGregor, Douglas ^a   Konstandi, Maria ^a,b   Lang, Matti A ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b UNIVERSITY OF IOANNINA   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROFORM; CYTOCHROME P450 ISOENZYME; DRUG METABOLIZING ENZYME; THIOACETAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME REGULATION; HISTOLOGY; HISTOPATHOLOGY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER INJURY; MALE; MOUSE; NONHUMAN; XENOBIOTIC METABOLISM;

ANIMALIA;

EID: 0030014639     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0107     Document Type: Article

References (43)

1. Aida, K., and Negishi, M. (1991). Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole. Biochemistry 30, 8041-8045.
2. Aitio, A. (1978). A simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal. Biochem. 85, 488-491.
3. Arvela, P., Kraul, H., Stenback, F., and Pelkonen, O. (1991). The ceriuminduced liver injury and oxidative drug metabolism in DBA/2 and C57BL/6 mice. Toxicology 69, 1-9.
4. Burke, M. D., Prough, R. A., and Mayer, R. T. (1977). Characteristics of a microsomal cytochrome P-448-mediated reaction: Ethoxyresorufin Ode-ethylation. Drug Metab. Dispos. Biol. Fate Chem. 5, 1-8.
5. Burke, M. D., Thompson, S., Elcombe, C. R., Halpert, J., Haaparanta, T., and Mayer, R. T. (1985). Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450. Biochem. Pharmacol. 34, 3337-3345.
6. Camus, A. M., Geneste, O., Honkakoski, P., Bereziat, J. C., Henderson, C. J., Wolf, C. R., Bartsch, H., and Lang, M. A. (1993). High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans. Mol. Carcinog. 7, 268-275.
7. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem, 162, 156-159.
8. Docks, E. L., and Krishna, G. (1976). The role of glutathione in chloroform-induced hepatotoxicity. Exp. Mol. Pathol. 24, 13-22.
9. Duescher, R. J., and Elfarra, A. A. (1994). Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: Evidence for major roles by cytochromes P450 2A6 and 2E1. Arch. Biochem, Biophys. 311, 342-349.
10. Guengerich, F. P., Kim, D. H., and Iwasaki, M. (1991). Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem, Res. Toxicol. 4, 168-179.
11. Hahnemann, B., Kuhn, B., Heubel, F., and Legrum, W. (1989). Selective induction of the coumarin hydroxylase by N-containing heteroaromatic compounds. Arch. Toxicol. Suppl. 13, 297-301.
12. Hahnemann, B., Salonpää, P., Pasanen, M., Mäenpää, J., Honkakoski, P., Juvonen, R., Lang, M. A., Pelkonen, O., and Raunio, H. (1992). Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. Biochem, J. 286, 289-294.
13. Honkakoski, P., and Lang, M. A. (1989). Mouse liver phenobarbital-inducible P450 system: Purification, characterization, and differential inducibility of four cytochrome P450 isozymes from D2 mouse. Arch. Biochem. Biophys. 273, 42-57.
14. Honkakoski, P., Auriola, S., and Lang, M. A. (1992). Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isoenzymes. Biochem. Pharmacol. 43, 2121-2128.
15. Juvonen, R. O., Kaipainen, P. K., and Lang, M. A. (1985). Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice. Eur. J. Biochem. 152, 3-8.
16. Juvonen, R. O., Autio, S., and Lang, M. A. (1987). Pyrazole as a modifier of liver microsomal monooxygenase in DBA/2N and AKR/J mice. Biochem. Pharmacol. 36, 3993-3997.
17. Kim, S. G., Williams, D. E., Schuetz, E. G., Guzelian, P. S., and Novak, R. F. (1988). Pyridine induction of cytochrome P-450 in the rat: Role of P-450j (alcohol-inducible form) in pyridine N-oxidation. J. Pharmacol. Exp. Ther. 246, 1175-1182.
18. Kirby, G. M., Chemin, I., Montesano, R., Chisari, F. V., Lang, M. A., and Wild, C. P. (1994a). Induction of specific cytochrome P450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice. Mol. Carcinog. 11, 74-80.
19. Kirby, G. M., Pelkonen, P., Vatanasapt, V., Camus, A. M., Wild, C. P., and Lang, M. A. (1994b). Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver. Mol. Carcinog. 11, 81-89.
20. Kocer, Z., Raunio, H., and Pasanen, M. (1990). Comparison between cobalt and pyrazole in the increased expression of coumarin 7-hydroxylase in mouse liver. Biochem. Pharmacol. 41, 462-465.
21. Kojo, A., Heiskanen, R., Rytkonen, A. L., Honkakoski, P., Juvonen, R., and Lang, M. (1991). Inducibility of P450Coh by pyrazole and its derivatives. Biochem. Pharmacol. 42, 1751-1759.
22. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
23. Lang, M. A., Juvonen, R., Jarvinen, P., Honkakoski, P., and Raunio, H. (1989). Mouse liver P450Coh: Genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes. Arch. Biochem. Biophys. 271, 139-148.
24. Ledda Columbano, G. M., Coni, P., Curto, M., Giacomini, L., Faa, G., Oliverio, S., Piacentini, M., and Columbano, A. (1991). Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide. Am. J. Pathol. 139, 1099-1109.
25. Legrum, W., and Netter, K. J. (1980). Characteristics of coumarin metabolism by liver microsomes from cobalt-pretreated mice. Xenobiotica 10, 271-279.
26. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, F. J. (1951). Protein measurement with the folin phenol reagent. Anal. Biochem. 193, 265-275.
27. Mangoura, S. A., Strack, A., Legrum, W., and Netter, K. J. (1989). Indium selectively increases the cytochrome P-450 dependent O-dealkylation of coumarin derivatives in male mice. Naunyn. Schmiedebergs Arch. Pharmacol. 339, 596-602.
28. Matsuura, Y., Fukuda, T., Yoshida, T., and Kuroiwa, Y. (1988). Inhibitory effect of zinc-protoporphyrin on the induction of heme oxygenase and the associated decrease in cytochrome P-450 content in rats. Toxicology 50, 169-180.
29. Matsuura, Y., Takizawa, Y., Fukuda, T., Yoshida, T., and Kuroiwa, Y. (1983). Induction of heme oxygenase and inhibition of delta-aminolevulinic acid synthetase of rat liver by thioacetamide and thioacetamide-S-oxide. J. Pharmacobiodyn. 6, 340-345.
30. Muller, D., Sommer, M., Kretzschmar, M., Zimmermann, T., Buko, V. U., Lukivskaya, O., and Dargel, R. (1991). Lipid peroxidation in thioacetamide-induced macronodular rat liver cirrhosis. Arch. Toxicol. 65, 199-203.
31. Munoz Torres, F., Paz Bouza, J. I., Lopez Bravo, A., Abad Hernandez, M. M., and Carrascal Marino, E. (1991). Experimental thioacetamide-induced cirrhosis of the liver. Histol. Histopathol. 6, 95 -100.
32. Negishi, M., Lindberg, R., Burkhart, B., Ichikawa, T., Honkakoski, P., and Lang, M. (1989). Mouse steroid 15 alpha-hydroxylase gene family: Identification of type II P-450(15)alpha as coumarin 7-hydroxylase. Biochemistry 28, 4169-4172.
33. Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., Gunsalus, I. C., Gotoh, O., Okuda, K., and Nebert, D. W. (1993). The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12, 1-51.
34. Omura, T., and Sato, R. (1964). The carbon monoxide binding pigment of liver microsomes. II. Solubilization, purification and properties. J. Biol. Chem. 239, 2379-2385.
35. Pellinen, P., Stenback, F., Rautio, A., Pelkonen, O., Lang, M., and Pasanen, M. (1993). Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: Dependence on strain and agent and comparison to other monooxygenases. Naunyn. Schmiedebergs Arch. Pharmacol. 348, 435-443.
36. Pohl, L. R., Bhooshan, B., Whittaker, N. F., and Krishna, G. (1977). Phosgene: A metabolite of chloroform. Biochem. Biophys. Res. Commun. 79, 684-691.
37. Raunio, H., Kojo, A., Juvonen, R., Honkakoski, P., Jarvinen, P., Lang, M. A., Vahakangas, K., Gelboin, H. V., Park, S. S., and Pelkonen, O. (1988). Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital. Biochem. Pharmacol. 37, 4141-4147.
38. Salonpää, P., Iscan, M., Pasanen, M., Arvela, P., Pelkonen, O., and Raunio, H. (1992). Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice. Biochem. Pharmacol. 44, 1269-1274.
39. Sambrook et al. (1989). Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
40. Satarug, S., Lang, M., and Yongvanit, P. (1994). Enhanced coumarin 7-hydroxylation and possibly nitrosamine metabolism during liver fluke infection. In Proceedings, Fourteenth International Symposium on Cancer: The Sapporo Cancer Seminar on Genetic Polymorphism and Cancer Susceptibility, July 6-9, 1994, Sapporo, Japan.
41. Towbin, H., Staehelin, T., and Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
42. Waxman, D. J., Ko, A., and Walsh, C. (1983). Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. J. Biol. Chem. 258, 11937-11947.
43. Wood, A. W., and Conney, A. H. (1974). Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus). Science 185, 612-614.