Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency

Toxicology

Volumn 252, Issue 1-3, 2008, Pages 9-16

  Lu, Yongke ^a   Gong, Pengfei ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

CYP2A5; CYP2E1; Free radicals; Nuclear factor erythroid 2 related factor 2 (Nrf2); Oxidative nitrosative stress; Pyrazole

Indexed keywords

ASCORBIC ACID; CYTOCHROME P450 2A5; CYTOCHROME P450 2E1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; PYRAZOLE; S ADENOSYLMETHIONINE; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIVER INJURY; MOUSE; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION;

7-ALKOXYCOUMARIN O-DEALKYLASE; ALANINE TRANSAMINASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; ASPARTATE AMINOTRANSFERASES; BLOTTING, WESTERN; CATALASE; CYTOCHROME P-450 CYP2E1; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEPATITIS, TOXIC; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INDICATORS AND REAGENTS; LIPID PEROXIDATION; LIVER; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PYRAZOLES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

MUS;

EID: 53249111242     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.07.058     Document Type: Article

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