Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: Correlation with metabolic activation and toxicity

Chemical Research in Toxicology

Volumn 10, Issue 1, 1997, Pages 85-90

  Pelkonen, Päivi ^a,b   Lang, Matti A ^b   Negishi, Masahiko ^c   Wild, Christopher P ^d   Juvonen, Risto O ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; COUMARIN; CYTOCHROME P450 ISOENZYME; METHOXSALEN; METYRAPONE; PILOCARPINE; AMINO ACID; COUMARIN 7 HYDROXYLASE; COUMARIN 7-HYDROXYLASE; CYTOCHROME P450; FUNGAL DNA; MIXED FUNCTION OXIDASE; MUTAGENIC AGENT; RECOMBINANT PROTEIN; UNSPECIFIC MONOOXYGENASE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CYTOTOXICITY; EPOXIDATION; HYDROXYLATION; MICHAELIS CONSTANT; NONHUMAN; SACCHAROMYCES CEREVISIAE; DNA ADDUCT; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION;

AFLATOXIN B1; AMINO ACIDS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; DNA, FUNGAL; MIXED FUNCTION OXYGENASES; MUTAGENS; MUTATION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SUBSTRATE SPECIFICITY;

EID: 0030615123     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960078m     Document Type: Article

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