Neutrophil α-defensins cause lung injury by disrupting the capillary-epithelial barrier

American Journal of Respiratory and Critical Care Medicine

Volumn 181, Issue 9, 2010, Pages 935-946

  Bdeir, Khalil ^a   Higazi, Abd Al Roof ^a,b   Kulikovskaya, Irina ^a   Christofidou Solomidou, Melpo ^a   Vinogradov, Sergei A ^a   Allen, Timothy C ^c   Idell, Steven ^c   Linzmeier, Rose ^d   Ganz, Tomas ^d   Cines, Douglas B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

defensins; Acute lung injury; Capillary epithelial barrier; Low density lipoprotein related receptor; Receptor associated protein

Indexed keywords

ALPHA DEFENSIN; FIBRIN; LOW DENSITY LIPOPROTEIN RELATED RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG;

ACID ASPIRATION; ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG CAPILLARY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CAPILLARY; CHEMISTRY; EPITHELIUM CELL; GENE TRANSFER; LUNG LAVAGE; METABOLISM; NEUTROPHIL; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACUTE LUNG INJURY; ALPHA-DEFENSINS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARIES; CAPILLARY PERMEABILITY; EPITHELIAL CELLS; GENE TRANSFER TECHNIQUES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUTROPHILS;

EID: 77952310993     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.200907-1128OC     Document Type: Article

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