Immunohistochemical localization of defensin in human coronary vessels

American Journal of Pathology

Volumn 150, Issue 3, 1997, Pages 1009-1020

  Barnathan, Elliot S ^a   Raghunath, P N ^a   Tomaszewski, John E ^a   Ganz, Tomas ^b   Cines, Douglas B ^a   Al Roof Higazi, Abd ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; CELL GRANULE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY BLOOD VESSEL; ENDOTHELIUM; ENDOTHELIUM CELL; FEMALE; HOST RESISTANCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEUKOCYTE ADHERENCE; MALE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SMOOTH MUSCLE FIBER;

ANTI-INFECTIVE AGENTS; ANTIBODIES; ARTERIOSCLEROSIS; BLOOD PROTEINS; CORONARY VESSELS; DEFENSINS; ENDOTHELIUM, VASCULAR; FEMALE; FIBRINOLYSIS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; REFERENCE VALUES; TUNICA INTIMA; TUNICA MEDIA;

EID: 0031052346     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Kagan B, Ganz T, Lehrer RI: Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 1994, 87:131-149
2. Harwig S, Ganz T, Lehrer RI: Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol 1994, 236:160-172
3. Levy O: Antibiotic proteins of polymorphonuclear leukocytes. Eur J Haematol 1996, 56:263-277
4. White S, Wimley W, Selsted M: Structure, function, and membrane integration of defensins. Curr Opin Struct Biol 1995, 5:521-527
5. Ganz T: Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun 1987, 55:568-571
6. Ganz T, Selsted M, Szklarek D, Harwig S, Daher K, Bainton D, Lehrer R: Defensins: natural peptide antibiotics of human neutrophils. J Clin Invest 1985, 75: 1427-1435
7. Panyutich A, Panyutich E, Krapivin V, Baturevich E, Ganz T: Plasma defensin concentrations are elevated in patients with sepsis or bacterial meningitis. J Lab Clin Med 1993, 122:202-207
8. Higazi A, Barghouti I, Abu-Much R: Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils. J Biol Chem 1995, 270:9472-9477
9. Higazi A, Ganz T, Kariko K, Cines D: Defensin modulates tPA and plasminogen binding to fibrin and endothelial cells. J Biol Chem 1996, 88:17650-17655
10. Raghunath P, Tomaszewski J, Brady S, Caron R, Okada S, Barnathan E: Plasminogen activator system in human coronary atherosclerosis. Arterioscler Thromb Vasc Biol 1995, 15:1432-1443
11. Panyutich A, Voitenok N, Lehrer R, Ganz T: An enzyme immunoassay for human defensin. J Immunol Methods 1991, 141:149-155
12. Yount N, Wang M, Yuan J, Oulette A, Selsted M: Rat neutrophil defensins: precursor structures and expression during neutrophilic myelopoiesis. J Immunol 1995, 155:4476-4484