Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 5 25-5, 2001, Pages

  Zhang, Haibo ^a,c   Porro, Giuliana ^a   Orzech, Neil ^a   Müllen, Brendan ^b   Liu, Mingyao ^c   Slutsky, Arthur S ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cytokine; Human neutrophil peptides; Inflammatory lung disease

Indexed keywords

CYTOCHROME C; DEFENSIN; ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL OXYGEN SATURATION; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; LUNG INJURY; LUNG LAVAGE; LYMPHOCYTE COUNT; LYMPHOCYTE MIGRATION; MALE; MEMBRANE PERMEABILITY; MOUSE; NEUTROPHIL; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 0035036995     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.5.l947     Document Type: Article

References (40)

1. Ashitani J, Mukae H, Ihiboshi H, Taniguchi H, Mashimoto H, Nakazato M, and Matsukura S. Defensin in plasma and in bronchoalveolar lavage fluid from patients with acute respiratory distress syndrome. Nippon Kyobu Shikkan Gakkai Zasshi 34: 1349-1353, 1996.
2. Baluk P, Thurston G, Murphy TJ, Bunnett NW, and McDonald NM. Neurogenic plasma leakage in mouse airways. Br J Pharmacol 126: 522-528, 1999.
3. Cavarra E, Martorana PA, de Santi M, Bartalesi B, Cortese S, Gambelli F, and Lungarella G. Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema. Am J Respir Cell Mol Biol 20: 264-269, 1999.
4. 1, or TNF-α exposure. Am J Physiol Lung Cell Mol Physiol 269: L248-L260, 1995.
5. Eisenhauer PB and Lehrer RI. Mouse neutrophils lack defensins. Infect Immun 60: 3446-3447, 1992.
6. Eisenhauer PB, Harwig SS, and Lehrer RI. Cryptdins: antimicrobial defensins of the murine small intestine. Infect Immun 60: 3556-3565, 1992.
7. Gabay JE and Almeida RP. Antibiotic peptides and serine protease homologs in human polymorphonuclear leukocytes: defensins and azurocidin. Curr Opin Immunol 5: 97-102, 1993.
8. Ganz T and Lehrer RI. Defensins. Curr Opin Immunol 6: 584-589, 1994.
9. Gehr P, Mwangi DK, Ammann A, Maloiy GMO, Taylor CR, and Weibel ER. Design of the mammalian respiratory system. V Scaling morphometric pulmonary diffusing capacity to body mass: wild and domestic mammals. Respir Physiol 44: 61-86, 1981.
10. Gunn MD, Nelken NA, Liao X, and Williams LT. Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. J Immunol 158: 376-383, 1997.
11. Harwig SS, Ganz T, and Lehere RI. Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol 236: 160-172, 1994.
12. Huttner KM, Selsted ME, and Ouellette AJ. Structure and diversity of the murine cryptdin gene family. Genomics 19: 448-453, 1994.
13. Ihi T, Nakazato M, Mukae H, and Matsukura S. Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections. Clin Infect Dis 25: 1134-1140, 1997.
14. Jones DE and Bevins CL. Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem 267: 23216-23225, 1992.
15. Jones ML, Mulligan MS, Flory CM, Ward PA, and Warren JS. Potential role of monocyte chemoattractant protein-1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat. J Immunol 149: 2147-2154, 1992.
16. Kaner RJ, Ladetto JV, Singh R, Fukuda N, Matthay MA, and Crystal RG. Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema. Am J Respir Cell Mol Biol 22: 657-664, 2000.
17. Kaplan SS, Heine RP, and Simmons RL. Defensins impair phagocytic killing by neutrophils in biomaterial-related infection. Infect Immun 67: 1640-1645, 1999.
18. Kawabata K, Hagio T, Matsumoto S, Nakao S, Orita S, Aze Y, and Ohno H. Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. Am J Respir Crit Care Med 161: 2013-2018, 2000.
19. Lehrer RI, Barton A, Daher KA, Harwig SSL, Ganz T, and Selsted ME. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest 84: 553-561, 1989.
20. Lehrer RI, Lichtenstein AK, and Ganz T. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol 11: 105-128, 1993.
21. Lichtenstein A, Ganz T, Selsted ME, and Lehrer RI. In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes. Blood 68: 1407-1410, 1986.
22. Lillard JW Jr, Boyaka PN, Chertov O, Oppenheim JJ, and McGhee JR. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc Natl Acad Sci USA 96: 651-656, 1999.
23. Maffei FA, Heine RP, Whalen MJ, Mortimer LF, and Carcillo JA. Levels of antimictobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis. Pediatrics 103: 987-992, 1999.
24. Mullin JM and Snock KV. Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res 50: 2172-2176, 1990.
25. Nygaard SD, Ganz T, and Peterson MW. Defensins reduce the barrier integrity of a cultured epithelial monolayer without cytotoxicity. Am J Respir Cell Mol Biol 8: 193-200, 1993.
26. Okrent DG, Lichtenstein AK, and Ganz T. Direct cytotoxicity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells. Am Rev Respir Dis 141: 179-185, 1990.
27. Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, and Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med 122: 202-207, 1993.
28. Paone G, Krein P, Rouhani F, and Brantly M. Human neutrophil peptides stimulate alveolar macrophage production of LTB4 and IL-8 (Abstract). Am J Respir Crit Care Med 159: A511, 1999.
29. Patterson CE, Rhoades RA, and Garcia JG. Evans blue dye as a marker of albumin clearance in cultured endothelial monolayer and isolated lung. J Appl Physiol 72: 865-873, 1992.
30. Peterson MW, Walter ME, and Nygaard SD. Effect of neutrophil mediators on epithelial permeability. Am J Respir Cell Mol Biol 13: 719-727, 1995.
31. Schwartz DA, Quinn TJ, Thorne PS, Sayeed S, Yi AK, and Krieg AM. CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract. J Clin Invest 100: 68-73, 1997.
32. Slutsky AS and Tremblay LN. Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 157: 1721-1725, 1998.
33. Soong LB, Ganz T, Ellison A, and Caughey GH. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res 46: 98-102, 1997.
34. Standiford TJ, Kunkel SL, Lukacs NW, Greenberger MJ, Danforth JM, Kunkel RG, and Strieter RM. Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia. J Immunol 155: 1515-1524, 1995.
35. Tal T and Aviram I. Defensin interferes with the activation of neutrophil NADPH oxidase in a cell-free system. Biochem Biophys Res Commun 196: 636-641, 1993.
36. Tal T, Sharabani M, Aviram I, Michaela S, and Irit A. Cationic proteins of neutrophil azurophilic granules: protein-protein interaction and blockade of NADPH oxidase activation. J Leukoc Biol 63: 305-311, 1998.
37. Van Wetering S, Mannesse-Lazeroms SPG, van Sterkenburg MAJA, Daha MR, Dijkman JH, and Hiemstra PS. Effect of defensins on interleukin-8 synthesis in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 272: L888-L896, 1997.
38. Ware LB and Matthay MA. The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349, 2000.
39. Weibel ER and Gil J. Electron microscopic demonstration of an extracullar duplex lining layer of alveoli. Respir Physiol 4: 42-57, 1968.
40. Welling MM, Hiemstra PS, van den Barselaar MT, Paulusma-Annema A, Nibbering PH, Pauwels EK, and Calame W. Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation. J Clin Invest 102: 1583-1590, 1998.