Oxygen distribution in murine tumors: Characterization using oxygen-dependent quenching of phosphorescence

Journal of Applied Physiology

Volumn 98, Issue 4, 2005, Pages 1503-1510

  Ziemer, Lisa S ^a,b   Lee, William M F ^b   Vinogradov, Sergei A ^a   Sehgal, Chandra ^a   Wilson, David F ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Hypoxia; Nitroimidazole; Oxygen measurement; Oxyphor G2; Tissue oxygenation

Indexed keywords

NITROIMIDAZOLE; OXYGEN; PHOSPHORUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HISTOGRAM; HISTOLOGY; HYPOXIA; KIDNEY CARCINOMA; LEWIS CARCINOMA; MELANOMA; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; OXYGEN TISSUE LEVEL; PHOSPHORESCENCE; PRIORITY JOURNAL; RELIABILITY; REPRODUCIBILITY; TISSUE OXYGENATION; TUMOR; TUMOR BLOOD FLOW; ULTRASOUND;

ANIMALS; CELL HYPOXIA; LUMINESCENT AGENTS; LUMINESCENT MEASUREMENTS; METALLOPORPHYRINS; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; OXYGEN; TISSUE DISTRIBUTION;

EID: 15444366529     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.01140.2004     Document Type: Article

References (47)

1. Brasch RC, Li KC, Husband JE, Keogan MT, Neeman M, Padhani AR, Shames D, and Turetschek K. In vivo monitoring of tumor angiogenesis with MR imaging. Acad Radiol 7: 812-823, 2000.
2. Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, and Dewhirst MW. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943, 1996.
3. Brizel DM, Sibley GS, Prosnitz LR, Scher RL, and Dewhirst MW. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 38: 285-289, 1997.
4. Bussink J, Kaanders JH, and van der Kogel AJ. Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother Oncol 67: 3-15, 2003.
5. Carmeliet P and Jain RK. Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
6. DeCampli WM, Schears G, Myung R, Schultz S, Creed J, Pastuszko A, and Wilson DF. Tissue oxygen tension during regional low flow perfusion in neonates. J Thorac Cardiovasc Surg 125: 472-480, 2003.
7. Dunphy I, Vinogradov SA, and Wilson DF. Oxyphor R2 and G2: phosphors for measuring oxygen by oxygen-dependent quenching of phosphorescence. Anal Biochem 310: 191-198, 2002.
8. Dvorak HF, Nagy JA, Feng D, Brown LF, and Dvorak AM. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol 237: 97-132, 1999.
9. Evans SM, Hahn S, Pook DR, Jenkins WT, Chalian AA, Zhang P, Stevens C, Weber R, Weinstein G, Benjamin I, Mirza N, Morgan M, Rubin S, McKenna WG, Lord EM, and Koch CJ. Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res 60: 2018-2024, 2000.
10. Evans SM, Hahn SM, Magarelli DP, and Koch CJ. Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation. Am J Clin Oncol 24: 467-472, 2001.
11. Evans SM, Judy KD, Dunphy I, Jenkins WT, Nelson PT, Collins R, Wileyto EP, Jenkins K, Hahn SM, Stevens CW, Judkins AR, Phillips P, Geoerger B, and Koch CJ. Comparative measurements of hypoxia in human brain tumors using needle electrodes and EF5 binding. Cancer Res 64: 1886-1892, 2004.
12. Ferrara KW, Merritt CR, Burns PN, Foster FS, Mattrey RF, and Wickline SA. Evaluation of tumor angiogenesis with US: imaging, Doppler, and contrast agents. Acad Radiol 7: 824-839, 2000.
13. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
14. Fournier LS, Cuenod CA, De Bazelaire C, Siauve N, Rosty C, Tran PL, Frija G, and Clement O. Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. Eur Radiol 14: 2125-2133, 2004.
15. Fyles AW, Milosevic M, Wong R, Kavanagh MC, Pintilie M, Sun A, Chapman W, Levin W, Manchul L, Keane TJ, and Hill RP. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 48: 149-156, 1998.
16. Gee MS, Koch CJ, Evans SM, Jenkins WT, Pletcher CH Jr, Moore JS, Koblish HK, Lee J, Lord EM, Trinchieri G, and Lee WM. Hypoxia-mediated apoptosis from angiogenesis inhibition underlies tumor control by recombinant interleukin 12. Cancer Res 59: 4882-4889, 1999.
17. Gee MS, Makonnen S, al-Kofahi K, Roysam B, Payvandi F, Man HW, Muller GW, and Lee WM. Selective cytokine inhibitory drugs with enhanced antiangiogenic activity control tumor growth through vascular inhibition. Cancer Res 63: 8073-8078, 2003.
18. Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, Jain RK, and McDonald DM. Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol 156: 1363-1380, 2000.
19. 2 histography as predictive assay in advanced cancer of the uterine cervix. Adv Exp Med Biol 345: 445-450, 1994.
20. Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, and Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515, 1996.
21. 2 in isolated skeletal muscle fibers. J Appl Physiol 86: 720-724, 1999.
22. Jain RK. Molecular regulation of vessel maturation. Nat Med 9: 685-693, 2003.
23. Kamotani Y, Lee WM, Arger PH, Cary TW, and Sehgal CM. Multigated contrast-enhanced power Doppler to measure blood flow in mice tumors. Ultrasound Med Biol 29: 977-984, 2003.
24. Kennedy AS, Raleigh JA, Perez GM, Calkins DP, Thrall DE, Novotny DB, and Varia MA. Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays. Int J Radiat Oncol Biol Phys 37: 897-905, 1997.
25. 2 uptake dynamics in isolated single skeletal myocytes. J Appl Physiol 94: 353-357, 2003.
26. 2-measurements as predictive assay in the treatment of carcinoma of the uterine cervix. Radiother Oncol 53: 99-104, 1999.
27. Koch CJ and Evans SM. Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles. Adv Exp Med Biol 510: 285-292, 2003.
28. Kripke ML. Speculations on the role of ultraviolet radiation in the development of malignant melanoma. J Natl Cancer Inst 63: 541-548, 1979.
29. Lord EM, Harwell L, and Koch CJ. Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res 53: 5721-5726, 1993.
30. Movsas B, Chapman JD, Horwitz EM, Pinover WH, Greenberg RE, Hanlon AL, Iyer R, and Hanks GE. Hypoxic regions exist in human prostate carcinoma. Urology 53: 11-18, 1999.
31. Murphy GP and Hrushesky WJ. A murine renal cell carcinoma. J Natl Cancer Inst 50: 1013-1025, 1973.
32. Nordsmark M, Loncaster J, Chou SC, Havsteen H, Lindegaard JC, Davidson SE, Varia M, West C, Hunter R, Overgaard J, and Raleigh JA. Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma. Int J Radiat Oncol Biol Phys 49: 581-586, 2001.
33. Nordsmark M, Overgaard M, and Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol 41: 31-39, 1996.
34. Padhani AR and Husband JE. Dynamic contrast-enhanced MRI studies in oncology with an emphasis on quantification, validation and human studies. Clin Radiol 56: 607-620, 2001.
35. Poole DC, Behnke BJ, McDonough P, McAllister RM, and Wilson DF. Measurement of muscle microvascular oxygen pressures: compartmentalization of phosphorescent probe. Microcirculation 11: 317-326, 2004.
36. Rietveld IB, Kim E, and Vinogradov SA. Dendrimers with tetrabenzoporphyrin cores: near infrared phosphors for in vivo oxygen imaging. Tetrahedron 59: 3821-3831, 2003.
37. Rumsey WL, Pawlowski M, Lejavardi N, and Wilson DF. Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic "border zone." Am J Physiol Heart Circ Physiol 266: H1676-H1680, 1994.
38. Stucker M, Esser M, Hoffmann M, Memmel U, Hirschmuller A, von Bormann C, Hoffmann K, and Altmeyer P. High-resolution laser Doppler perfusion imaging aids in differentiating between benign and malignant melanocytic skin tumours. Acta Derm Venereol 82: 25-29, 2002.
39. Urtasun RC, Parliament MB, McEwan AJ, Mercer JR, Mannan RH, Wiebe LI, Morin C, and Chapman JD. Measurement of hypoxia in human tumours by non-invasive spect imaging of iodoazomycin arabinoside. Br J Cancer Suppl 27: S209-S212, 1996.
40. Vanderkooi JM, Maniara G, Green TJ, and Wilson DF. An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J Biol Chem 262: 5476-5482, 1987.
41. Varia MA, Calkins-Adams DP, Rinker LH, Kennedy AS, Novotny DB, Fowler WC Jr, and Raleigh JA. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol 71: 270-277, 1998.
42. Vinogradov SA, Fernandez-Seara MA, Dupan BW, and Wilson DF. A method for measuring oxygen distributions in tissue using frequency domain phosphorometry. Comp Biochem Physiol A 132: 147-152, 2002.
43. Vinogradov SA, Fernandez-Seara MA, Dugan BW, and Wilson DF. Frequency domain instrument for measuring phosphorescence lifetime distributions in heterogeneous samples. Rev Sci Instrum 72: 3396-3406, 2001.
44. Wilson DF, Gomi S, Pastuszko A, and Greenberg JH. Microvascular damage in the cortex of cat brain from middle cerebral artery occlusion and reperfusion. J Appl Physiol 74: 580-589, 1993.
45. Wilson DF, Rumsey WL, Green TJ, and Vanderkooi JM. The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration. J Biol Chem 263: 2712-2718, 1988.
46. Wilson DF, Vinogradov SA, Dugan BW, Biruski D, Waldron L, and Evans SA. Measurement of tumor oxygenation using new frequency domain phosphorometers. Comp Biochem Physiol A 132: 153-159, 2002.
47. Ziemer LS, Evans SM, Kachur AV, Shuman AL, Cardi CA, Jenkins WT, Karp JS, Alavi A, Dolbier WR Jr, and Koch CJ. Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5. Eur J Nucl Med 30: 259-266, 2003.