Elevated BALF concentrations of α- and β-defensins in patients with pulmonary alveolar proteinosis

Respiratory Medicine

Volumn 101, Issue 4, 2007, Pages 715-721

  Mukae, Hiroshi ^a   Ishimoto, Hiroshi ^a   Yanagi, Shigehisa ^b   Ishii, Hiroshi ^a   Nakayama, Seiko ^a   Ashitani, Jun ichi ^b   Nakazato, Masamitsu ^b   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

Author keywords

defensins; defensins; Interstitial lung diseases; Pulmonary alveolar proteinosis

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IDIOPATHIC DISEASE; INTERSTITIAL LUNG DISEASE; INTERSTITIAL PNEUMONIA; LUNG ALVEOLUS PROTEINOSIS; LUNG BIOPSY; LUNG FIBROSIS; LUNG LAVAGE; LUNG SARCOIDOSIS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; ORGANIZING PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; RADIOIMMUNOASSAY; RESPIRATORY TRACT INFECTION; STAPHYLOCOCCUS AUREUS;

ADULT; AGED; ALPHA-DEFENSINS; ANTI-INFECTIVE AGENTS; BETA-DEFENSINS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; COLONY COUNT, MICROBIAL; DEFENSINS; FEMALE; HUMANS; MALE; MIDDLE AGED; PULMONARY ALVEOLAR PROTEINOSIS;

EID: 33847285063     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2006.08.018     Document Type: Article

References (26)

1. Selsted M.E., and Ouellette A.J. Mammalian defensins in the antimicrobial immune response. Nat Immunol 6 (2005) 551-557
2. Oppenheim J.J., Biragyn A., Kwak L.W., and Yang D. Roles of antimicrobial peptides such as defensins in innate and adaptive immunity. Ann Rheum Dis 62 Suppl. II (2003) ii17-ii21
3. Ashitani J., Mukae H., Nakazato M., et al. Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis. Eur Respir J 11 (1998) 104-111
4. Soong L.B., Ganz T., Ellison A., and Caughey G.H. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res 46 (1997) 98-102
5. Ashitani J., Mukae H., Hiratsuka T., Nakazato M., Kumamoto K., and Matsukura S. Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellular infection. Chest 119 (2001) 1131-1137
6. Ashitani J., Mukae H., Hiratsuka T., Nakazato M., Kumamoto K., and Matsukura S. Elevated levels of α-defensins in plasma and BAL fluid of patients with active pulmonary tuberculosis. Chest 121 (2002) 519-526
7. Hiratsuka T., Mukae H., Iiboshi H., et al. Increased concentrations of human β-defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis. Thorax 58 (2003) 425-430
8. Zhang H., Porro G., Orzech N., Mullen B., Liu M., and Slutsky A.S. Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion. Am J Physiol Lung Cell Mol Physiol 280 (2001) L947-L954
9. Agerberth B., Grunewald J., Castanos-Velez E., et al. Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. Am J Respir Crit Care Med 160 (1999) 283-290
10. Mukae H., Iiboshi H., Nakazato M., et al. Raised plasma concentrations of α-defensins in patients with idiopathic pulmonary fibrosis. Thorax 57 (2002) 623-628
11. Ashitani J., Mukae H., Arimura Y., Sano A., Tokojima M., and Nakazato M. High concentrations of α-defensin in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Life Sci 75 (2004) 1123-1134
12. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment: international consensus statement. Am J Respir Crit Care Med 161 (2000) 646-664
13. Mukae H., Kohno S., Morikawa T., Kusano S., Kadota J., and Hara K. Two-color analysis of lymphocyte subsets of bronchoalveolar lavage fluid and peripheral blood in Japanese patients with sarcoidosis. Chest 105 (1994) 1474-1480
14. Shiomi K., Nakazato M., Ihi T., Kangawa K., Matsuo H., and Matsukura S. Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection. Biochem Biophys Res Commun 195 (1993) 1336-1344
15. Nakazato M., Shiomi K., Date Y., et al. Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils. Biochem Biophys Res Commun 211 (1995) 1053-1062
16. Hiratsuka T., Nakazato M., Ihi T., et al. Structural analysis of human beta-defensin 1 and its significance in urinary tract infection. Nephron 85 (2000) 34-40
17. Hiratsuka T., Nakazato M., Date Y., et al. Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun 249 (1998) 943-947
18. Harwig S.S., Ganz T., and Lehrer R.I. Neutrophil defensins: purification, characterization, and antimicrobial testing. Methods Enzymol 236 (1994) 160-172
19. Trapnell B.C., Whitsett J.A., and Nakata K. Pulmonary alveolar proteinosis. New Engl J Med 349 (2003) 2527-2539
20. Honda Y., Takahashi H., Shijubo N., et al. Surfactant protein-A concentration in bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis. Chest 103 (1993) 496-499
21. Duits L.A., Ravensbergen B., Rademaker M., et al. Expression of β-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 106 (2002) 517-525
22. Schnapp D., and Harris A. Antibacterial peptides in bronchoalveolar lavage fluid. Am J Respir Cell Mol Biol 19 (1998) 352-356
23. Wu H., Kuzmenko A., Wan S., et al. Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. J Clin Invest 111 (2003) 1589-1602
24. Takahashi T., Munakata M., Suzuki I., and Kawakami Y. Serum and bronchoalveolar fluid KL-6 levels in patients with pulmonary alveolar proteinosis. Am J Respir Crit Care Med 158 (1998) 1294-1298
25. Iyonaga K., Suga M., Yamamoto T., Ichiyasu H., Miyakawa H., and Ando M. Elevated bronchoalveolar concentrations of MCP-1 in patients with pulmonary alveolar proteinosis. Eur Respir J 14 (1999) 383-389
26. Ashitani J., Mukae H., Nakazato M., et al. Elevated pleural fluid levels of defensins in patients with empyema. Chest 113 (1998) 788-794