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Volumn 104, Issue 6, 1999, Pages 1131-1138

Defensins: Key players or bystanders in infection, injury, and repair in the lung?

Author keywords

Antimicrobial peptides; Defensins; Epithelial cells; Host defense; Immune response; Infection; Inflammatory lung disease; Innate immunity; Neutrophils

Indexed keywords

CHEMOKINE; DEFENSIN; HISTAMINE; ISOPROTEIN;

EID: 0033452745     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(99)70004-7     Document Type: Review
Times cited : (154)

References (57)
  • 1
    • 0027474382 scopus 로고
    • Defensins: Antimicrobial and cytotoxic peptides of mammalian cells
    • 1. Lehrer RI, Lichtenstein AK, Ganz T. Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol 1993;11:105-28.
    • (1993) Annu Rev Immunol , vol.11 , pp. 105-128
    • Lehrer, R.I.1    Lichtenstein, A.K.2    Ganz, T.3
  • 2
    • 0029051685 scopus 로고
    • Defensins and other endogenous peptide antibiotics of vertebrates
    • 2. Martin E, Ganz T, Lehrer RI. Defensins and other endogenous peptide antibiotics of vertebrates. J Leukoc Biol 1995;58:128-36.
    • (1995) J Leukoc Biol , vol.58 , pp. 128-136
    • Martin, E.1    Ganz, T.2    Lehrer, R.I.3
  • 3
    • 0031898688 scopus 로고    scopus 로고
    • Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract
    • 3. Quayle AJ, Porter EM, Nussbaum AA, Wang YM, Brabec C, Yip KP, et al. Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 1998;152:1247-58.
    • (1998) Am J Pathol , vol.152 , pp. 1247-1258
    • Quayle, A.J.1    Porter, E.M.2    Nussbaum, A.A.3    Wang, Y.M.4    Brabec, C.5    Yip, K.P.6
  • 4
    • 0032168228 scopus 로고    scopus 로고
    • β-defensins: Endogenous antibiotics of the innate host defense response
    • 4. Diamond G, Bevins CL. β-Defensins: endogenous antibiotics of the innate host defense response. Clin Immunol Immunopathol 1998;88:221-5.
    • (1998) Clin Immunol Immunopathol , vol.88 , pp. 221-225
    • Diamond, G.1    Bevins, C.L.2
  • 5
    • 0029877550 scopus 로고    scopus 로고
    • Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha
    • 5. Russell JP, Diamond G, Tarver AP, Scanlin TF, Bevins CL. Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun 1996;64:1565-8.
    • (1996) Infect Immun , vol.64 , pp. 1565-1568
    • Russell, J.P.1    Diamond, G.2    Tarver, A.P.3    Scanlin, T.F.4    Bevins, C.L.5
  • 7
    • 0030949875 scopus 로고    scopus 로고
    • Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis
    • 7. Goldman MJ, Anderson GM, Stolzenberg ED, Kari UP, Zasloff M, Wilson JM. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 1997;88:553-60.
    • (1997) Cell , vol.88 , pp. 553-560
    • Goldman, M.J.1    Anderson, G.M.2    Stolzenberg, E.D.3    Kari, U.P.4    Zasloff, M.5    Wilson, J.M.6
  • 10
    • 0027409134 scopus 로고
    • The gene encoding the human corticostatin hp-4 precursor contains a recent 86-base duplication and is located on chromosome 8
    • 10. Palfree RG, Sadro LC, Solomon S. The gene encoding the human corticostatin HP-4 precursor contains a recent 86-base duplication and is located on chromosome 8. Mol Endocrinol 1993;7:199-205.
    • (1993) Mol Endocrinol , vol.7 , pp. 199-205
    • Palfree, R.G.1    Sadro, L.C.2    Solomon, S.3
  • 11
  • 13
    • 0024370068 scopus 로고
    • Purification and characterization of human neutrophil peptide 4, a novel member of the defensins family
    • 13. Wilde CG, Griffith JE, Marra MN, Snable JL, Scott RW. Purification and characterization of human neutrophil peptide 4, a novel member of the defensins family. J Biol Chem 1989;264:11200-3.
    • (1989) J Biol Chem , vol.264 , pp. 11200-11203
    • Wilde, C.G.1    Griffith, J.E.2    Marra, M.N.3    Snable, J.L.4    Scott, R.W.5
  • 14
    • 0029978338 scopus 로고    scopus 로고
    • Intramolecular inhibition of human defensin hnp-1 by its propiece
    • 14. Valore EV, Martin E, Harwig SSL, Ganz T. Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest 1996;97:1624-9.
    • (1996) J Clin Invest , vol.97 , pp. 1624-1629
    • Valore, E.V.1    Martin, E.2    Harwig, S.S.L.3    Ganz, T.4
  • 15
    • 0031213832 scopus 로고    scopus 로고
    • The human β-defensin-1 and α-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry
    • 15. Liu L, Zhao C, Heng HH, Ganz T. The human β-defensin-1 and α-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 1997;43:316-20.
    • (1997) Genomics , vol.43 , pp. 316-320
    • Liu, L.1    Zhao, C.2    Heng, H.H.3    Ganz, T.4
  • 16
    • 0032548181 scopus 로고    scopus 로고
    • Structure and mapping of the human β-defensin hbd-2 gene and its expression at sites of inflammation
    • 16. Liu L, Wang L, Zhao C, Heng HHQ, Schutte BC, McCray PB Jr, et al. Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation. Gene 1998;222:237-44.
    • (1998) Gene , vol.222 , pp. 237-244
    • Liu, L.1    Wang, L.2    Zhao, C.3    Heng, H.H.Q.4    Schutte, B.C.5    McCray P.B., Jr.6
  • 18
    • 0032575664 scopus 로고    scopus 로고
    • Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia
    • 18. Hiratsuka T, Nakazato M, Date Y, Ashitani J, Minematsu T, Chino N, et al. Identification of human β-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Bioehem Biophys Res Commun 1998;249:943-7.
    • (1998) Bioehem Biophys Res Commun , vol.249 , pp. 943-947
    • Hiratsuka, T.1    Nakazato, M.2    Date, Y.3    Ashitani, J.4    Minematsu, T.5    Chino, N.6
  • 20
    • 0001422023 scopus 로고    scopus 로고
    • A human β-defensin is produced by urogenital epithelia
    • 20. Valore EV. Quayle AJ, Robbins A, Ganz T. A human β-defensin is produced by urogenital epithelia [abstract]. J Invest Med 1996;44:268.
    • (1996) J Invest Med , vol.44 , pp. 268
    • Valore, E.V.1    Quayle, A.J.2    Robbins, A.3    Ganz, T.4
  • 21
    • 0001548678 scopus 로고    scopus 로고
    • Human α-and β-defensins evolved from a common pre-mammalian ancestor peptide
    • 21. Liu L, Heng HH, Zhao C, Ganz T. Human α-and β-defensins evolved from a common pre-mammalian ancestor peptide [abstract]. J Invest Med 1996;44:294.
    • (1996) J Invest Med , vol.44 , pp. 294
    • Liu, L.1    Heng, H.H.2    Zhao, C.3    Ganz, T.4
  • 22
    • 0030569343 scopus 로고    scopus 로고
    • Widespread expression of β-defensin hbd-1 in human secretory glands and epithelial cells
    • 22. Zhao C, Wang I, Lehrer RI. Widespread expression of β-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996;396:319-22.
    • (1996) FEBS Lett , vol.396 , pp. 319-322
    • Zhao, C.1    Wang, I.2    Lehrer, R.I.3
  • 23
    • 0025903814 scopus 로고
    • Crystal structure of defensin hnp-3, an amphiphilic dimer: Mechanisms of membrane permeabilization
    • 23. Hill CP, Yee J, Selsted ME, Eisenberg SP. Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science 1991;251:1481-5.
    • (1991) Science , vol.251 , pp. 1481-1485
    • Hill, C.P.1    Yee, J.2    Selsted, M.E.3    Eisenberg, S.P.4
  • 24
    • 0025021992 scopus 로고
    • Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes
    • 24. Kagan BL, Selsted ME, Ganz T, Lehrer RI. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci USA 1990;87:210-4.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 210-214
    • Kagan, B.L.1    Selsted, M.E.2    Ganz, T.3    Lehrer, R.I.4
  • 25
    • 0032169557 scopus 로고    scopus 로고
    • Human β-defensin2 is a salt sensitive peptide antiobiotic expressed in human lung
    • 25. Bals R, Wang X, Wu Z, Freeman T, Zasloff M, Wilson JM. Human β-defensin2 is a salt sensitive peptide antiobiotic expressed in human lung. J Clin Invest 1998;102:874-80.
    • (1998) J Clin Invest , vol.102 , pp. 874-880
    • Bals, R.1    Wang, X.2    Wu, Z.3    Freeman, T.4    Zasloff, M.5    Wilson, J.M.6
  • 26
    • 0027237329 scopus 로고
    • Plasma defensin concentrations are elevated in patients with septicemia and bacterial meningitis
    • 26. Panyutich AV, Panyutich EA, Krapivin A, Baturevich EA, Ganz T. Plasma defensin concentrations are elevated in patients with septicemia and bacterial meningitis. J Lab Clin Med 1993;122:202-7.
    • (1993) J Lab Clin Med , vol.122 , pp. 202-207
    • Panyutich, A.V.1    Panyutich, E.A.2    Krapivin, A.3    Baturevich, E.A.4    Ganz, T.5
  • 27
    • 0031889912 scopus 로고    scopus 로고
    • Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis
    • 27. Ashitani JMH, Nakazato M, Ihi T, Mason GR, Kagan BL, Koike K, et al. Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis. Eur Respir J 1998;11:104-11.
    • (1998) Eur Respir J , vol.11 , pp. 104-111
    • Ashitani, J.M.H.1    Nakazato, M.2    Ihi, T.3    Mason, G.R.4    Kagan, B.L.5    Koike, K.6
  • 28
    • 0030942221 scopus 로고    scopus 로고
    • Purification and characterization of defensins from cystic fibrosis sputum
    • 28. Soong LB, Ganz T, Ellison A, Caughey GH. Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res 1997;46:98-102.
    • (1997) Inflamm Res , vol.46 , pp. 98-102
    • Soong, L.B.1    Ganz, T.2    Ellison, A.3    Caughey, G.H.4
  • 30
    • 0000504888 scopus 로고    scopus 로고
    • Potential role of human neutrophil defensins in lung destruction of individuals with α-1-antitrypsin deficiency
    • 30. Paone G, Rouhani F, Brantley M. Potential role of human neutrophil defensins in lung destruction of individuals with α-1-antitrypsin deficiency [abstract]. Am J Respir Crit Care Med 1997;155:853.
    • (1997) Am J Respir Crit Care Med , vol.155 , pp. 853
    • Paone, G.1    Rouhani, F.2    Brantley, M.3
  • 33
    • 0008973994 scopus 로고    scopus 로고
    • Human neutrophil peptides stimulate alveolar macrophage production of ltb4 and il-8
    • 33. Paone G, Krein P, Rouhani F, Brantly ML. Human neutrophil peptides stimulate alveolar macrophage production of LTB4 and IL-8 [abstract]. Am J Respir Crit Care Med 1999;159:511.
    • (1999) Am J Respir Crit Care Med , vol.159 , pp. 511
    • Paone, G.1    Krein, P.2    Rouhani, F.3    Brantly, M.L.4
  • 34
    • 0024797674 scopus 로고
    • Monocyte-chemotactic activity of defensins from human neutrophils
    • 34. Territo MC, Ganz T, Selsted ME, Lehrer RI. Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest 1989;84:2017-20.
    • (1989) J Clin Invest , vol.84 , pp. 2017-2020
    • Territo, M.C.1    Ganz, T.2    Selsted, M.E.3    Lehrer, R.I.4
  • 35
    • 0030038197 scopus 로고    scopus 로고
    • Identification of defensin-1, defensin-2 and cap37/azurocidin as t-cell chemoattractant proteins released from interleukin-8 stimulated neutrophils
    • 35. Chertov O, Michiel DF, Xu L, Wang JM, Tani K, Murphy WJ, et al. Identification of defensin-1, defensin-2 and cap37/azurocidin as T-cell chemoattractant proteins released from interleukin-8 stimulated neutrophils. J Biol Chem 1996;271:2935-40.
    • (1996) J Biol Chem , vol.271 , pp. 2935-2940
    • Chertov, O.1    Michiel, D.F.2    Xu, L.3    Wang, J.M.4    Tani, K.5    Murphy, W.J.6
  • 36
    • 0032532679 scopus 로고    scopus 로고
    • Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation
    • 36. Welling MM, Hiemstra PS, van den Barselaar MTh, Paulusma-Annema A, Nibbering PH, Pauwels EKJ, et al. Antibacterial activity of human neutrophil defensins in experimental infections in mice is accompanied by increased leukocyte accumulation. J Clin Invest 1998;102:1583-90.
    • (1998) J Clin Invest , vol.102 , pp. 1583-1590
    • Welling, M.M.1    Hiemstra, P.S.2    Van Den Barselaar, M.Th.3    Paulusma-Annema, A.4    Nibbering, P.H.5    Pauwels, E.K.J.6
  • 39
    • 0022672452 scopus 로고
    • 99mtc-dpta aerosol deposition and clearance in copd, interstitial disease, and smokers
    • 99mTc-DPTA aerosol deposition and clearance in COPD, interstitial disease, and smokers. J Thorac Imaging 1986;1:54-60.
    • (1986) J Thorac Imaging , vol.1 , pp. 54-60
    • Effros, R.M.1    Mason, G.R.2    Mena, I.3
  • 40
    • 0030775610 scopus 로고    scopus 로고
    • Effect of neutrophil serine proteinases and defensins on lung epithelial cells: Modulation of cytotoxicity and il-8 production
    • 40. van Wetering S, Mannesse-Lazeroms SPG, Dijkman JH, Hiemstra PS. Effect of neutrophil serine proteinases and defensins on lung epithelial cells: modulation of cytotoxicity and IL-8 production. J Leukoc Biol 1997;62:217-26.
    • (1997) J Leukoc Biol , vol.62 , pp. 217-226
    • Van Wetering, S.1    Mannesse-Lazeroms, S.P.G.2    Dijkman, J.H.3    Hiemstra, P.S.4
  • 41
    • 0008971362 scopus 로고    scopus 로고
    • Effects of neutrophil defensins and elastase on the production of antileukoprotease (alp) by primary bronchial epithelial cells in vitro: Modulation by a1-proteinase inhibitor
    • 41. van Wetering S, van der Linden AC, van Sterkenburg MAJA, Hiemstra PS. Effects of neutrophil defensins and elastase on the production of antileukoprotease (ALP) by primary bronchial epithelial cells in vitro: modulation by a1-proteinase inhibitor [abstract]. Am J Respir Crit Care Med 1998;157:570.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 570
    • Van Wetering, S.1    Van Der Linden, A.C.2    Van Maja, S.3    Hiemstra, P.S.4
  • 42
    • 0023147734 scopus 로고
    • Lung lavage fluid from patients with a α1-proteinase inhibitor deficiency or chronic obstructive bronchitis: Anti-elastase function and cell profile
    • 42. Morrison HM, Kramps JA, Burnett D, Stockley RA. Lung lavage fluid from patients with a α1-proteinase inhibitor deficiency or chronic obstructive bronchitis: anti-elastase function and cell profile. Clin Sci 1987;72:373-81.
    • (1987) Clin Sci , vol.72 , pp. 373-381
    • Morrison, H.M.1    Kramps, J.A.2    Burnett, D.3    Stockley, R.A.4
  • 43
    • 0026503152 scopus 로고
    • α1 -proteinase inhibitor and mucus proteinase inhibitor in human lung emphysema
    • 43. Trefz G, Schließer J, Heck B, Schulz V, Eby GA. α1 -Proteinase inhibitor and mucus proteinase inhibitor in human lung emphysema. Clin Invest 1992;70:269-76.
    • (1992) Clin Invest , vol.70 , pp. 269-276
    • Trefz, G.1    Schließer, J.2    Heck, B.3    Schulz, V.4    Eby, G.A.5
  • 44
    • 4243236679 scopus 로고    scopus 로고
    • Role of intracellular glutathione in neutrophil defensin-induced il-8 synthesis and cytotoxicity in airway epithelial cells
    • 44. van Wetering S, Rahman I, Hiemstra PS, MacNee W. Role of intracellular glutathione in neutrophil defensin-induced IL-8 synthesis and cytotoxicity in airway epithelial cells. Eur Respir J 1998;12:420s.
    • (1998) Eur Respir J , vol.12
    • Wetering, S.1    Rahman, I.2    Hiemstra, P.S.3    MacNee, W.4
  • 45
    • 0023924993 scopus 로고
    • Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins
    • 45. Lichtenstein AK, Ganz T, Selsted ME, Lehrer RI. Synergistic cytolysis mediated by hydrogen peroxide combined with peptide defensins. Cell Immunol 1988;114:104-16.
    • (1988) Cell Immunol , vol.114 , pp. 104-116
    • Lichtenstein, A.K.1    Ganz, T.2    Selsted, M.E.3    Lehrer, R.I.4
  • 47
    • 0029147217 scopus 로고
    • Gluthathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress
    • 47. Rahman I, Li XY, Donaldson K, Harrison DJ, MacNee W. Gluthathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. Am J Physiol 1995;269:L28592.
    • (1995) Am J Physiol , vol.269
    • Rahman, I.1    Li, X.Y.2    Donaldson, K.3    Harrison, D.J.4    MacNee, W.5
  • 48
    • 0031662738 scopus 로고    scopus 로고
    • Stimulation of adherence of haemophilus influenzae to human lung epithelial cells by antimicrobial neutrophil defensins
    • 48. Gorter A. Eijk PP, van Wetering S, Hiemstra PS, Dankert J, van Alphen L. Stimulation of adherence of Haemophilus influenzae to human lung epithelial cells by antimicrobial neutrophil defensins. J Infect Dis 1998;178:1067-74.
    • (1998) J Infect Dis , vol.178 , pp. 1067-1074
    • Gorter, A.1    Eijk, P.P.2    Van Wetering, S.3    Hiemstra, P.S.4    Dankert, J.5    Van Alphen, L.6
  • 50
    • 0029278910 scopus 로고
    • Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation
    • 50. Fahy JV, Kim KW, Liu J, Boushey HA. Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. J Allergy Clin Immunol 1995;95:843-52.
    • (1995) J Allergy Clin Immunol , vol.95 , pp. 843-852
    • Fahy, J.V.1    Kim, K.W.2    Liu, J.3    Boushey, H.A.4
  • 55
    • 0028925198 scopus 로고
    • Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils
    • 55. Higazi AA, Barghouti II, Abu-Much R. Identification of an inhibitor of tissue-type plasminogen activator-mediated fibrinolysis in human neutrophils. A role for defensin. J Biol Chem 1995;270:9472-7.
    • (1995) A Role for Defensin. J Biol Chem , vol.270 , pp. 9472-9477
    • Higazi, A.A.1    Barghouti, I.I.2    Abu-Much, R.3
  • 57
    • 0029870085 scopus 로고    scopus 로고
    • Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
    • 57. Smith JJ, Travis SM, Greenberg EP, Welsh MJ. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 1996;85:229-36. airway wall remodeling. (J Allergy Clin Immunol 1999;104:1139-46.)
    • (1996) Cell , vol.85 , pp. 229-236
    • Smith, J.J.1    Travis, S.M.2    Greenberg, E.P.3    Welsh, M.J.4


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