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Volumn 34, Issue 4, 2009, Pages 295-309

Genetic risk of breast cancer

Author keywords

Breast neoplasms; Gene expression profiling; Mutation; Risk factors

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; BRIP1 PROTEIN; CHECKPOINT KINASE 2; CYTOKERATIN 5; CYTOKERATIN 6; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PALB2 PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGESTERONE RECEPTOR; PROTEIN KINASE LKB1; PROTEIN P53; RAD50 PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN; TUMOR PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN; ANTINEOPLASTIC AGENT;

EID: 77952303881     PISSN: 03911977     EISSN: 18271634     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (4)

References (91)
  • 1
    • 0025277619 scopus 로고
    • Age at onset as an indicator of familial risk of breast cancer
    • Claus EB, Risch NJ, Thompson WD. Age at onset as an indicator of familial risk of breast cancer. Am J Epidemiol 1990;131:961-72.
    • (1990) Am J Epidemiol , vol.131 , pp. 961-972
    • Claus, E.B.1    Risch, N.J.2    Thompson, W.D.3
  • 3
    • 13344262707 scopus 로고    scopus 로고
    • Hereditary breast cancer: Pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage
    • Marcus JN, Watson P, Page DL, Narod SA, Lenoir GM, Tonin P et al. Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer 1996;77:697-709.
    • (1996) Cancer , vol.77 , pp. 697-709
    • Marcus, J.N.1    Watson, P.2    Page, D.L.3    Narod, S.A.4    Lenoir, G.M.5    Tonin, P.6
  • 5
    • 12944286550 scopus 로고    scopus 로고
    • The pathology of familial breast cancer: Histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2
    • Lakhani SR, Gusterson BA, Jacquemier J, Sloane JP, Anderson TJ, van de Vijver MJ et al. The pathology of familial breast cancer: histological features of cancers in families not attributable to mutations in BRCA1 or BRCA2. Clin Cancer Res 2000;6:782-9.
    • (2000) Clin Cancer Res , vol.6 , pp. 782-789
    • Lakhani, S.R.1    Gusterson, B.A.2    Jacquemier, J.3    Sloane, J.P.4    Anderson, T.J.5    Van De Vijver, M.J.6
  • 8
    • 33845953365 scopus 로고    scopus 로고
    • BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays
    • Bane AL, Beck JC, Bleiweiss I, Buys SS, Catalano E, Daly MB et al. BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays. Am J Surg Pathol 2007;31:121-8.
    • (2007) Am J Surg Pathol , vol.31 , pp. 121-128
    • Bane, A.L.1    Beck, J.C.2    Bleiweiss, I.3    Buys, S.S.4    Catalano, E.5    Daly, M.B.6
  • 9
    • 25144506227 scopus 로고    scopus 로고
    • The molecular pathology of hereditary breast cancer: Genetic testing and therapeutic implications
    • DOI 10.1038/modpathol.3800453, PII 3800453
    • Honrado E, Benitez J, Palacios J. The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications. Mod Pathol 2005;18:1305-20. (Pubitemid 41348649)
    • (2005) Modern Pathology , vol.18 , Issue.10 , pp. 1305-1320
    • Honrado, E.1    Benitez, J.2    Palacios, J.3
  • 10
    • 0035960431 scopus 로고    scopus 로고
    • Familial breast cancer: Collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease
    • Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 2001;358:1389-99.
    • (2001) Lancet , vol.358 , pp. 1389-1399
  • 11
    • 9144251028 scopus 로고    scopus 로고
    • The genetic epidemiology of breast cancer genes
    • DOI 10.1023/B:JOMG.0000048770.90334.3b, Chromosomal Instability and Breast Cancer Pathogenesis
    • Thompson D, Easton D. The genetic epidemiology of breast cancer genes. J Mammary Gland Biol Neoplasia 2004;9:221-36. (Pubitemid 39545740)
    • (2004) Journal of Mammary Gland Biology and Neoplasia , vol.9 , Issue.3 , pp. 221-236
    • Thompson, D.1    Easton, D.2
  • 12
    • 0033281609 scopus 로고    scopus 로고
    • The pathology of familial breast cancer: Morphological aspects
    • Lakhani SR. The pathology of familial breast cancer: morphological aspects. Breast Cancer Res 1999;1:31-5.
    • (1999) Breast Cancer Res , vol.1 , pp. 31-35
    • Lakhani, S.R.1
  • 13
    • 0032400785 scopus 로고    scopus 로고
    • The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: A population-based study
    • Armes JE, Egan AJ, Southey MC, Dite GS, McCredie MR, Giles GG et al. The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study. Cancer 1998;83:2335-45.
    • (1998) Cancer , vol.83 , pp. 2335-2345
    • Armes, J.E.1    Egan, A.J.2    Southey, M.C.3    Dite, G.S.4    McCredie, M.R.5    Giles, G.G.6
  • 15
    • 12444324167 scopus 로고    scopus 로고
    • Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: Differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers
    • Palacios J, Honrado E, Osorio A, Cazorla A, Sarrio D, Barroso A et al. Immunohistochemical characteristics defined by tissue microarray of hereditary breast cancer not attributable to BRCA1 or BRCA2 mutations: differences from breast carcinomas arising in BRCA1 and BRCA2 mutation carriers. Clin Cancer Res 2003;9(10 Pt 1):3606-14.
    • (2003) Clin Cancer Res , vol.9 , Issue.10 PART 1 , pp. 3606-3614
    • Palacios, J.1    Honrado, E.2    Osorio, A.3    Cazorla, A.4    Sarrio, D.5    Barroso, A.6
  • 16
    • 36248970130 scopus 로고    scopus 로고
    • Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families
    • Honrado E, Osorio A, Milne RL, Paz MF, Melchor L, Cascón A et al. Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families. Mod Pathol 2007;20:1298-306.
    • (2007) Mod Pathol , vol.20 , pp. 1298-1306
    • Honrado, E.1    Osorio, A.2    Milne, R.L.3    Paz, M.F.4    Melchor, L.5    Cascón, A.6
  • 17
    • 0036569877 scopus 로고    scopus 로고
    • The pathology of familial breast cancer: Predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2
    • DOI 10.1200/JCO.2002.09.023
    • Lakhani SR, Van De Vijver MJ, Jacquemier J, Anderson TJ, Osin PP, McGuffog L et al. The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. J Clin Oncol 2002;20:2310-8. (Pubitemid 34441658)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.9 , pp. 2310-2318
    • Lakhani, S.R.1    Van De Vijver, M.J.2    Jacquemier, J.3    Anderson, T.J.4    Osin, P.P.5    McGuffog, L.6    Easton, D.F.7
  • 18
    • 75149147887 scopus 로고    scopus 로고
    • Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue
    • Chen DT, Nasir A, Culhane A, Venkataramu C, Fulp W, Rubio R et al. Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res Treat 2009;22:22.
    • (2009) Breast Cancer Res Treat , vol.22 , pp. 22
    • Chen, D.T.1    Nasir, A.2    Culhane, A.3    Venkataramu, C.4    Fulp, W.5    Rubio, R.6
  • 22
    • 0028843102 scopus 로고
    • Breast and ovarian cancer incidence in BRCA1-mutation carriers
    • Breast Cancer Linkage Consortium
    • Easton DF, Ford D, Bishop DT. Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet 1995;56:265-71.
    • (1995) Am J Hum Genet , vol.56 , pp. 265-271
    • Easton, D.F.1    Ford, D.2    Bishop, D.T.3
  • 23
    • 17344365851 scopus 로고    scopus 로고
    • Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families
    • The Breast Cancer Linkage Consortium
    • Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet 1998;62:676-89.
    • (1998) Am J Hum Genet , vol.62 , pp. 676-689
    • Ford, D.1    Easton, D.F.2    Stratton, M.3    Narod, S.4    Goldgar, D.5    Devilee, P.6
  • 26
    • 0033281771 scopus 로고    scopus 로고
    • How many more breast cancer predisposition genes are there?
    • Easton DF. How many more breast cancer predisposition genes are there? Breast Cancer Res 1999;1:14-7.
    • (1999) Breast Cancer Res , vol.1 , pp. 14-17
    • Easton, D.F.1
  • 27
    • 0030044822 scopus 로고    scopus 로고
    • Cancer mortality in relatives of women with ovarian cancer: The OPCS Study
    • Office of Population Censuses and Surveys
    • Easton DF, Matthews FE, Ford D, Swerdlow AJ, Peto J. Cancer mortality in relatives of women with ovarian cancer: the OPCS Study. Office of Population Censuses and Surveys. Int J Cancer 1996;65:284-94.
    • (1996) Int J Cancer , vol.65 , pp. 284-294
    • Easton, D.F.1    Matthews, F.E.2    Ford, D.3    Swerdlow, A.J.4    Peto, J.5
  • 28
    • 0342940785 scopus 로고    scopus 로고
    • Pathology of familial breast cancer: Differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases
    • Breast Cancer Linkage Consortium
    • Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Breast Cancer Linkage Consortium. Lancet 1997;349:1505-10.
    • (1997) Lancet , vol.349 , pp. 1505-1510
  • 32
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • DOI 10.1038/nrc1819, PII N1819
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006;6:184-92. (Pubitemid 43292562)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.3 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 41
    • 0035211026 scopus 로고    scopus 로고
    • Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families
    • Pharoah PD, Guilford P, Caldas C. Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families. Gastroenterology 2001;121:1348-53. (Pubitemid 33140452)
    • (2001) Gastroenterology , vol.121 , Issue.6 , pp. 1348-1353
    • Pharoah, P.D.P.1    Guilford, P.2    Caldas, C.3
  • 43
    • 0032054770 scopus 로고    scopus 로고
    • Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer
    • Bignell GR, Barfoot R, Seal S, Collins N, Warren W, Stratton MR. Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res 1998;58:1384-6.
    • (1998) Cancer Res , vol.58 , pp. 1384-1386
    • Bignell, G.R.1    Barfoot, R.2    Seal, S.3    Collins, N.4    Warren, W.5    Stratton, M.R.6
  • 44
    • 0031613621 scopus 로고    scopus 로고
    • A study of the PTEN/MMAC1 gene in 136 breast cancer families
    • Chen J, Lindblom P, Lindblom A. A study of the PTEN/MMAC1 gene in 136 breast cancer families. Hum Genet 1998;102:124-5.
    • (1998) Hum Genet , vol.102 , pp. 124-125
    • Chen, J.1    Lindblom, P.2    Lindblom, A.3
  • 45
    • 35448967457 scopus 로고    scopus 로고
    • Germline mutations in the breast cancer susceptibility gene PTEN are rare in highrisk non-BRCA1/2 French Canadian breast cancer families
    • Guénard F, Labrie Y, Ouellette G, Beauparlant CJ, Bessette P, Chiquette J et al. Germline mutations in the breast cancer susceptibility gene PTEN are rare in highrisk non-BRCA1/2 French Canadian breast cancer families. Fam Cancer 2007;6:483-90.
    • (2007) Fam Cancer , vol.6 , pp. 483-490
    • Guénard, F.1    Labrie, Y.2    Ouellette, G.3    Beauparlant, C.J.4    Bessette, P.5    Chiquette, J.6
  • 46
    • 33846625493 scopus 로고    scopus 로고
    • PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
    • Rahman N, Seal S, Thompson D, Kelly P, Renwick A, Elliott A et al. PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat Genet 2007;39:165-7.
    • (2007) Nat Genet , vol.39 , pp. 165-167
    • Rahman, N.1    Seal, S.2    Thompson, D.3    Kelly, P.4    Renwick, A.5    Elliott, A.6
  • 48
    • 18544389716 scopus 로고    scopus 로고
    • Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations
    • M
    • M Meijers-Heijboer H, van den Ouweland A, Klijn J, Wasielewski M, de Snoo A, Oldenburg R et al Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Nat Genet 2002;31:55-9.
    • (2002) Nat Genet , vol.31 , pp. 55-59
    • Meijers-Heijboer, H.1    Van Den Ouweland, A.2    Klijn, J.3    Wasielewski, M.4    De Snoo, A.5    Oldenburg, R.6
  • 49
    • 0029057336 scopus 로고
    • A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    • Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L et al. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 1995;268:1749-53.
    • (1995) Science , vol.268 , pp. 1749-1753
    • Savitsky, K.1    Bar-Shira, A.2    Gilad, S.3    Rotman, G.4    Ziv, Y.5    Vanagaite, L.6
  • 50
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer
    • Lavin MF. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol 2008;9:759-69.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 51
  • 52
    • 0035877581 scopus 로고    scopus 로고
    • The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts
    • Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS. The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J Biol Chem 2001;276:21951-9.
    • (2001) J Biol Chem , vol.276 , pp. 21951-21959
    • Shackelford, R.E.1    Innes, C.L.2    Sieber, S.O.3    Heinloth, A.N.4    Leadon, S.A.5    Paules, R.S.6
  • 54
    • 0017238344 scopus 로고
    • Malignant neoplasms in the families of patients with ataxia- telangiectasia
    • Swift M, Sholman L, Perry M, Chase C. Malignant neoplasms in the families of patients with ataxia-telangiectasia. Cancer Res 1976;36:209-15.
    • (1976) Cancer Res , vol.36 , pp. 209-215
    • Swift, M.1    Sholman, L.2    Perry, M.3    Chase, C.4
  • 55
    • 0023244806 scopus 로고
    • Breast and other cancers in families with ataxia-telangiectasia
    • Swift M, Reitnauer PJ, Morrell D, Chase CL. Breast and other cancers in families with ataxia-telangiectasia. N Engl J Med 1987;316:1289-94.
    • (1987) N Engl J Med , vol.316 , pp. 1289-1294
    • Swift, M.1    Reitnauer, P.J.2    Morrell, D.3    Chase, C.L.4
  • 56
    • 56249103144 scopus 로고    scopus 로고
    • Inherited susceptibility to common cancers
    • Foulkes WD. Inherited susceptibility to common cancers. N Engl J Med 2008;359:2143-53.
    • (2008) N Engl J Med , vol.359 , pp. 2143-2153
    • Foulkes, W.D.1
  • 57
    • 55749109888 scopus 로고    scopus 로고
    • Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
    • Byrnes GB, Southey MC, Hopper JL. Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories? Breast Cancer Res 2008;10:208.
    • (2008) Breast Cancer Res , vol.10 , pp. 208
    • Byrnes, G.B.1    Southey, M.C.2    Hopper, J.L.3
  • 59
    • 34247612295 scopus 로고    scopus 로고
    • Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival
    • DOI 10.1002/cncr.22592
    • Ye C, Cai Q, Dai Q, Shu XO, Shin A, Gao YT et al. Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival. Cancer 2007;109:1729-35. (Pubitemid 46668533)
    • (2007) Cancer , vol.109 , Issue.9 , pp. 1729-1735
    • Ye, C.1    Cai, Q.2    Dai, Q.3    Shu, X.-O.4    Shin, A.5    Gao, Y.-T.6    Zheng, W.7
  • 60
    • 42049122030 scopus 로고    scopus 로고
    • The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer
    • Tommiska J, Bartkova J, Heinonen M, Hautala L, Kilpivaara O, Eerola H et al. The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer. Oncogene 2008;27:2501-6.
    • (2008) Oncogene , vol.27 , pp. 2501-2506
    • Tommiska, J.1    Bartkova, J.2    Heinonen, M.3    Hautala, L.4    Kilpivaara, O.5    Eerola, H.6
  • 61
    • 11244335534 scopus 로고    scopus 로고
    • The ATM gene is a target for epigenetic silencing in locally advanced breast cancer
    • DOI 10.1038/sj.onc.1208092
    • Vo QN, Kim WJ, Cvitanovic L, Boudreau DA, Ginzinger DG, Brown KD. The ATM gene is a target for epigenetic silencing in locally advanced breast cancer. Oncogene 2004;23:9432-7. (Pubitemid 40069676)
    • (2004) Oncogene , vol.23 , Issue.58 , pp. 9432-9437
    • Vo, Q.N.1    Kim, W.-J.2    Cvitanovic, L.3    Boudreau, D.A.4    Ginzinger, D.G.5    Brown, K.D.6
  • 62
    • 70350565471 scopus 로고    scopus 로고
    • p53 a Jack of all trades but master of none
    • Junttila MR, Evan GI. p53 a Jack of all trades but master of none. Nat Rev Cancer 2009;9:821-9.
    • (2009) Nat Rev Cancer , vol.9 , pp. 821-829
    • Junttila, M.R.1    Evan, G.I.2
  • 64
    • 0014587529 scopus 로고
    • Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome?
    • Li FP, Fraumeni JF Jr. Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 1969;71:747-52.
    • (1969) Ann Intern Med , vol.71 , pp. 747-752
    • Li, F.P.1    Fraumeni Jr., J.F.2
  • 65
    • 63049108452 scopus 로고    scopus 로고
    • Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment
    • Venkitaraman AR. Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment. Annu Rev Pathol 2009;4:461-87.
    • (2009) Annu Rev Pathol , vol.4 , pp. 461-487
    • Venkitaraman, A.R.1
  • 66
    • 0035907395 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
    • Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. J Biol Chem 2001;276:17276-80.
    • (2001) J Biol Chem , vol.276 , pp. 17276-17280
    • Gatei, M.1    Zhou, B.B.2    Hobson, K.3    Scott, S.4    Young, D.5    Khanna, K.K.6
  • 68
    • 0033527717 scopus 로고    scopus 로고
    • Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks
    • Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 1999;286:1162-6. (Pubitemid 129515811)
    • (1999) Science , vol.286 , Issue.5442 , pp. 1162-1166
    • Cortez, D.1    Wang, Y.2    Qin, J.3    Elledge, S.J.4
  • 69
    • 0033566082 scopus 로고    scopus 로고
    • Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
    • Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR et al. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 1999;18:4047-54.
    • (1999) Oncogene , vol.18 , pp. 4047-4054
    • Chaturvedi, P.1    Eng, W.K.2    Zhu, Y.3    Mattern, M.R.4    Mishra, R.5    Hurle, M.R.6
  • 70
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    • DOI 10.1126/science.280.5366.1089
    • Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 1998;280:1089-91. (Pubitemid 28234952)
    • (1998) Science , vol.280 , Issue.5366 , pp. 1089-1091
    • Herzog, K.-H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    McKinnon, P.J.5
  • 72
    • 33746491583 scopus 로고    scopus 로고
    • ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
    • Renwick A, Thompson D, Seal S, Kelly P, Chagtai T, Ahmed M et al. ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles. Nat Genet 2006;38:873-5.
    • (2006) Nat Genet , vol.38 , pp. 873-875
    • Renwick, A.1    Thompson, D.2    Seal, S.3    Kelly, P.4    Chagtai, T.5    Ahmed, M.6
  • 74
    • 33645728557 scopus 로고    scopus 로고
    • BACH1 is a DNA repair protein supporting BRCA1 damage response
    • Peng M, Litman R, Jin Z, Fong G, Cantor SB. BACH1 is a DNA repair protein supporting BRCA1 damage response. Oncogene 2006;25:2245-53.
    • (2006) Oncogene , vol.25 , pp. 2245-2253
    • Peng, M.1    Litman, R.2    Jin, Z.3    Fong, G.4    Cantor, S.B.5
  • 75
    • 33750465216 scopus 로고    scopus 로고
    • Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles
    • Seal S, Thompson D, Renwick A, Elliott A, Kelly P, Barfoot R et al. Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles. Nat Genet 2006;38:1239-41.
    • (2006) Nat Genet , vol.38 , pp. 1239-1241
    • Seal, S.1    Thompson, D.2    Renwick, A.3    Elliott, A.4    Kelly, P.5    Barfoot, R.6
  • 78
    • 24944575242 scopus 로고    scopus 로고
    • BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ
    • Litman R, Peng M, Jin Z, Zhang F, Zhang J, Powell S et al. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell 2005;8:255-65.
    • (2005) Cancer Cell , vol.8 , pp. 255-265
    • Litman, R.1    Peng, M.2    Jin, Z.3    Zhang, F.4    Zhang, J.5    Powell, S.6
  • 79
    • 33846569450 scopus 로고    scopus 로고
    • Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
    • Reid S, Schindler D, Hanenberg H, Barker K, Hanks S, Kalb R et al. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genet 2007;39:162-4.
    • (2007) Nat Genet , vol.39 , pp. 162-164
    • Reid, S.1    Schindler, D.2    Hanenberg, H.3    Barker, K.4    Hanks, S.5    Kalb, R.6
  • 81
    • 34547785606 scopus 로고    scopus 로고
    • Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: New lessons from old players
    • Rahman N, Scott RH. Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. Hum Mol Genet 2007;16(Spec No 1):R60-6.
    • (2007) Hum Mol Genet , vol.16 , Issue.SPEC NO 1
    • Rahman, N.1    Scott, R.H.2
  • 84
    • 34250001297 scopus 로고    scopus 로고
    • A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
    • Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 2007;39:870-4.
    • (2007) Nat Genet , vol.39 , pp. 870-874
    • Hunter, D.J.1    Kraft, P.2    Jacobs, K.B.3    Cox, D.G.4    Yeager, M.5    Hankinson, S.E.6
  • 85
    • 36749002743 scopus 로고    scopus 로고
    • RAD51 135G→C modifies breast cancer risk among BRCA2 mutation carriers: Results from a combined analysis of 19 studies
    • Antoniou AC, Sinilnikova OM, Simard J et al. RAD51 135G→C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. Am J Hum Genet 2007;81:1186-200.
    • (2007) Am J Hum Genet , vol.81 , pp. 1186-1200
    • Antoniou, A.C.1    Sinilnikova, O.M.2    Simard, J.3
  • 86
    • 41649097333 scopus 로고    scopus 로고
    • Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    • Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL et al. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 2008;82:937-48.
    • (2008) Am J Hum Genet , vol.82 , pp. 937-948
    • Antoniou, A.C.1    Sinilnikova, O.M.2    Simard, J.3    Léoné, M.4    Dumont, M.5    Neuhausen, S.L.6
  • 87
    • 0038501057 scopus 로고    scopus 로고
    • American Society of Clinical Oncology policy statement update: Genetic testing for cancer susceptibility
    • American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility. J Clin Oncol 2003;21:2397-406.
    • (2003) J Clin Oncol , vol.21 , pp. 2397-2406
  • 88
    • 0026677824 scopus 로고
    • Familial aggregation of a disease consequent upon correlation between relatives in a risk factor measured on a continuous scale
    • Hopper JL, Carlin JB. Familial aggregation of a disease consequent upon correlation between relatives in a risk factor measured on a continuous scale. Am J Epidemiol 1992;136:1138-47.
    • (1992) Am J Epidemiol , vol.136 , pp. 1138-1147
    • Hopper, J.L.1    Carlin, J.B.2
  • 90
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 91
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
    • McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res 2006;66:8109-15.
    • (2006) Cancer Res , vol.66 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3    Kluzek, K.4    Bialkowska, A.5    Swift, S.6


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