Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival

Cancer

Volumn 109, Issue 9, 2007, Pages 1729-1735

  Ye, Chuanzhong ^a   Cai, Qiuyin ^a   Dai, Qi ^a   Shu, Xiao Ou ^a   Shin, Aesun ^a   Gao, Yu Tang ^b   Zheng, Wei ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b SHANGHAI CANCER INSTITUTE   (China)

Author keywords

ATM; Breast cancer; Chinese women; mRNA; Real time PCR; Survival

Indexed keywords

ATM PROTEIN; MESSENGER RNA;

ADULT; APOPTOSIS; ARTICLE; ATM GENE; BREAST CANCER; CANCER SURVIVAL; CELL CYCLE ARREST; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DNA REPAIR; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GENE;

EID: 34247612295     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.22592     Document Type: Article

References (36)

1. Lavin MF, Birrell G, Chen P, Kozlov S, Scott S, Gueven N. ATM signaling and genomic stability in response to DNA damage. Mutat Res. 2005;569:123-132.
2. Angele S, Treilleux I, Taniere P, et al. Abnormal expression of the ATM and TP53 genes in sporadic breast carcinomas. Clin Cancer Res. 2000;6:3536-3544.
3. Meyn MS. Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene. Clin Genet. 1999;55:289-304.
4. Khanna KK, Chenevix-Trench G. ATM and genome maintenance: defining its role in breast cancer susceptibility. J Mammary Gland Biol Neoplasia. 2004;9:247-262.
5. Szabo CI, Schutte M, Broeks A, et al. Are ATM mutations 7271T->G and 1VS10-6T->G really high-risk breast cancer-susceptibility alleles? Cancer Res. 2004;64:840-843.
6. Waha A, Sturne C, Kessler A, et al. Expression of the ATM gene is significantly reduced in sporadic breast carcinomas. Int J Cancer. 1998;78:306-309.
7. Hall J. The ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants. Cancer Lett. 2005;227:105-114.
8. Raptis S, Bapat B. Genetic instability in human tumors. EXS. 2006;96:303-320.
9. Thorstenson YR, Shen P, Tusher VG, et al. Global analysis of ATM polymorphism reveals significant functional constraint. Am J Hum Genet. 2001;69:396-412.
10. Angele S, Romestaing P, Moullan N, et al. ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity Cancer Res. 2003;63:8717-8725.
11. Gutierrez-Enriquez S, Fernet M, Dork T, et al. Functional consequences of ATM sequence variants for chromosomal radiosensitivity. Genes Chromosomes Cancer. 2004;40:109-119.
12. Kovalev S, Mateen A, Zaika AI, O'Hea BJ, Moll UM. Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines. Int J Oncol. 2000;16:825-831.
13. Brenner AJ, Aldaz CM. The genetics of sporadic breast cancer. Prog Clin Biol Res. 1997;396:63-82.
14. Shiloh Y, Kastan MB. ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res. 2001;83:209-254.
15. Charames GS, Bapat B. Genomic instability and cancer. Curr Mol Med. 2003;3:589-596.
16. Cuatrecasas M, Santamaria G, Velasco M, et al. ATM gene expression is associated with differentiation and angiogenesis in infiltrating breast carcinomas. Histol Histopathol. 2006;21:149-156.
17. Gao YT, Shu XO, Dai Q, et al. Association of menstrual and reproductive factors with breast cancer risk: results from the Shanghai Breast Cancer Study. Int J Cancer. 2000;87:295-300.
18. Shu XO, Gao YT, Cai Q, et al. Genetic polymorphisms in the TGF-beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer Study. Cancer Res. 2004;64:836-839.
19. Schnitt S, Connolly J.Pathology of benign breast disorders. In: Harris JR, Lippman ME, Morrow M, Osborne CK, eds. Diseases of the Breast. Philadelphia: Lippincott Williams & Wilkins; 1999:75-93.
20. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402-408.
21. Shao Z, Li J, Wu J. Clinical implication of apoptosis of breast cancer induced by preoperative chemotherapy [in Chinese]. Zhonghua Zhong Liu Za Zhi. 2000;22:295-297.
22. Shen ZZ, Zhang YW, Pan TX, Xia CJ. Multidisciplinary approach to the treatment of unresectable breast cancer. World J Surg. 1995;19:843-846.
23. Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol. 2000;25:169-193.
24. Chuanzhong Y, Ming G, Fanglin Z, et al. Real-time quantitative reverse transcription-PCR assay for renal cell carcinoma-associated antigen G250. Clin Chim Acta. 2002;318: 33-40.
25. Angele S, Treilleux I, Bremond A, Taniere P, Hall J. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Histopathology. 2003;43:347-353.
26. Vo QN, Kim WJ, Cvitanovic L, Boudreau DA, Ginzinger DG, Brown KD. The ATM gene is a target for epigenetic silencing in locally advanced breast cancer. Oncogene. 2004;23:9432-9437.
27. Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. ATM and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet. 1997;16:397-401.
28. Taylor AM, Byrd PJ. Molecular pathology of ataxia telangiectasia. J Clin Pathol. 2005;58:1009-1015.
29. Barlow C, Eckhaus MA, Schaffer AA, Wynshaw-Boris A. ATM haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice. Nat Genet. 1999;21:359-360.
30. Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG. Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression. Cancer Res. 2004;64:8526-8533.
31. Brew CT, Aronchik I, Hsu JC, et al. Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells. Int J Cancer. 2006;118:857-868.
32. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
33. Zhang CY, Feng YX, Yu Y, et al. The molecular mechanism of resistance to methotrexate in mouse methotrexate-resistant cells by cancer drug resistance and metabolism SuperArray. Basic Clin Pharmacol Toxicol. 2006;99:141-145.
34. Li W, Jian W, Xiaoping X, Yingfeng L, Tao X, Xiaoyan X. Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein. Int J Gynecol Cancer. 2006;16:1620-1630.
35. Barlow C, Ribaut-Barassin C, Zwingman TA, et al. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. Proc Natl Acad Sci U S A. 2000;97:871-876.
36. Chong MJ, Murray MR, Gosink EC, et al. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A. 2000;97:889-894.