Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Journal of Pharmacology and Experimental Therapeutics

Volumn 311, Issue 3, 2004, Pages 874-884

  Sakai, Hiromi ^a   Masada, Yohei ^a   Horinouchi, Hirohisa ^b   Ikeda, Eiji ^b   Sou, Keitaro ^a   Takeoka, Shinji ^a   Suematsu, Makoto ^b   Takaori, Masuhiko ^c   Kobayashi, Koichi ^b   Tsuchida, Eishun ^a  

^a WASEDA UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c Higashi Takarazuka Satoh Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; HEME OXYGENASE 1; HEMOGLOBIN; HEMOSIDERIN; IRON; LIPOSOME;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD TRANSFUSION; BLOOD VOLUME; BODY WEIGHT; CELL AGING; CONTROLLED STUDY; DEGRADATION; DETOXIFICATION; DOSE RESPONSE; DRUG INFUSION; ENCAPSULATION; ENZYME REGULATION; ERYTHROCYTE; HEPATOSPLENOMEGALY; IRON BLOOD LEVEL; LIPID COMPOSITION; LIPID VESICLE; LIVER PARENCHYMA; MALE; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL SYSTEM; SPLEEN; SURVIVAL; SUSPENSION; SYMPTOMATOLOGY;

ANIMALS; BLOOD CHEMICAL ANALYSIS; BLOOD COAGULATION; BLOOD GAS ANALYSIS; BLOOD GLUCOSE; DRUG CARRIERS; FIBRINOGEN; HEME; HEMODYNAMIC PROCESSES; HEMOGLOBINS; INFUSIONS, INTRAVENOUS; LIPOSOMES; ORGAN SIZE; RATS; RATS, WISTAR; RETICULOENDOTHELIAL SYSTEM; SUSPENSIONS; URINALYSIS; WEIGHT GAIN;

EID: 10044298332     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.073049     Document Type: Article

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