-
1
-
-
33749821755
-
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
-
Ahel I, Rass U, El-Khamisy SF, et al. 2006 The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature, 443:713-6.
-
(2006)
Nature
, vol.443
, pp. 713-716
-
-
Ahel, I.1
Rass, U.2
El-Khamisy, S.F.3
-
3
-
-
85047688311
-
Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival
-
Arber DA, Stein AS, Carter NH, et al. 2003. Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival. Am J Clin Pathol, 119:672-80.
-
(2003)
Am J Clin Pathol
, vol.119
, pp. 672-680
-
-
Arber, D.A.1
Stein, A.S.2
Carter, N.H.3
-
4
-
-
0033046551
-
Multicenter randomized phase II trial of idarubicin vs mitoxantrone, combined with VP16 and cytarabine for induction/consolidation therapy, followed by a feasibility study of autologous peripheral blood stem cell transplantation in elderly patients with acute myeloid leukemia
-
Archimbaud E, Jehn U, Thomas X, et al. 1999. Multicenter randomized phase II trial of idarubicin vs mitoxantrone, combined with VP16 and cytarabine for induction/consolidation therapy, followed by a feasibility study of autologous peripheral blood stem cell transplantation in elderly patients with acute myeloid leukemia. Leukemia, 13:843-9.
-
(1999)
Leukemia
, vol.13
, pp. 843-849
-
-
Archimbaud, E.1
Jehn, U.2
Thomas, X.3
-
6
-
-
4444314787
-
R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways
-
Beaupre DM, Cepero E, Obeng EA, et al. 2004. R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways. Mol Cancer Therap, 3:179-86.
-
(2004)
Mol Cancer Therap
, vol.3
, pp. 179-186
-
-
Beaupre, D.M.1
Cepero, E.2
Obeng, E.A.3
-
8
-
-
0037376717
-
Timed sequential therapy of acute myelogenous leukemia in adults: A phase II study of retinoids in combination with the sequential administration of cytosine arabinoside, idarubicin and etoposide
-
Bolanos-Meade J, Karp JE, Guo C, et al. 2003. Timed sequential therapy of acute myelogenous leukemia in adults: a phase II study of retinoids in combination with the sequential administration of cytosine arabinoside, idarubicin and etoposide. Leuk Res, 27:313-21.
-
(2003)
Leuk Res
, vol.27
, pp. 313-321
-
-
Bolanos-Meade, J.1
Karp, J.E.2
Guo, C.3
-
9
-
-
83455220636
-
A Phase I study of tipifarnib in combination with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia age 60 and over [abstract]
-
(abstract 899)
-
Brandwein JM, Leber BF, Howson-Jan K, et al. 2007. A Phase I study of tipifarnib in combination with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia age 60 and over [abstract]. Blood, 110:274a (abstract 899).
-
(2007)
Blood
, vol.110
-
-
Brandwein, J.M.1
Leber, B.F.2
Howson-Jan, K.3
-
10
-
-
20244361887
-
Prognostic index for adult patients with acute myeloid leukemia in first relapse
-
Breems DA, Van Putten WLJ, Huijgens PC, et al. 2005. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol, 23:1969-78.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1969-1978
-
-
Breems, D.A.1
van Putten, W.L.J.2
Huijgens, P.C.3
-
11
-
-
23044465584
-
Characterization of a human carcinoma cell line selected for resistance to farnesyltransferase inhibitors
-
Bruzek LM, Poynter JN, Kaufmann SH, et al. 2005. Characterization of a human carcinoma cell line selected for resistance to farnesyltransferase inhibitors. Mol Pharmacol, 68:477-86.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 477-486
-
-
Bruzek, L.M.1
Poynter, J.N.2
Kaufmann, S.H.3
-
12
-
-
33745003472
-
Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia
-
Buchner T, Berdel WE, Schoch C, et al. 2006. Double induction containing either two courses or one course of high-dose cytarabine plus mitoxantrone and postremission therapy by either autologous stem-cell transplantation or by prolonged maintenance for acute myeloid leukemia. J Clin Oncol, 24:2480-9.
-
(2006)
J Clin Oncol
, vol.24
, pp. 2480-2489
-
-
Buchner, T.1
Berdel, W.E.2
Schoch, C.3
-
13
-
-
16544369516
-
Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
-
Bullinger L, Dohner K, Bair E, et al. 2004. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. New Engl J Med, 350:1605-16.
-
(2004)
New Engl J Med
, vol.350
, pp. 1605-1616
-
-
Bullinger, L.1
Dohner, K.2
Bair, E.3
-
14
-
-
23844540638
-
Characterization of a R115777-resistant human multiple myeloma cell line with crossresistance to PS-341
-
Buzzeo R, Enkemann S, Nimmanapalli R, et al. 2005. Characterization of a R115777-resistant human multiple myeloma cell line with crossresistance to PS-341. Clin Cancer Res, 11:6057-64.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6057-6064
-
-
Buzzeo, R.1
Enkemann, S.2
Nimmanapalli, R.3
-
15
-
-
0026668478
-
Varying intensity of postremission therapy in acute myeloid leukemia
-
Cassileth PA, Lynch E, Hines JD, et al. 1992. Varying intensity of postremission therapy in acute myeloid leukemia. Blood, 79:1924-30.
-
(1992)
Blood
, vol.79
, pp. 1924-1930
-
-
Cassileth, P.A.1
Lynch, E.2
Hines, J.D.3
-
16
-
-
0041356888
-
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycinand farnesylation-dependent manner
-
Castro AF, Rebhun JF, Clark GJ, et al. 2003 Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycinand farnesylation-dependent manner. J Biol Chem, 278:32493-6.
-
(2003)
J Biol Chem
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.J.3
-
17
-
-
0037372488
-
Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
-
Cortes J, Albitar M, Thomas D, et al. 2003. Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood, 101:1692-7.
-
(2003)
Blood
, vol.101
, pp. 1692-1697
-
-
Cortes, J.1
Albitar, M.2
Thomas, D.3
-
18
-
-
77955710144
-
Final update of Phase I-II study of the farnesyltransferase inhibitor tipifarnib in combination with idarubicin and cytarabine for patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplasia [abstract]
-
(abstract 441)
-
Delmonte J, Kantarjian HM, Garcia-Manero G, et al. 2007. Final update of Phase I-II study of the farnesyltransferase inhibitor tipifarnib in combination with idarubicin and cytarabine for patients with newly diagnosed acute myeloid leukemia or high-risk myelodysplasia [abstract]. Blood, 110:136a (abstract 441).
-
(2007)
Blood
, vol.110
-
-
Delmonte, J.1
Kantarjian, H.M.2
Garcia-Manero, G.3
-
19
-
-
0033578751
-
A mutant form of protein farnesyltransferase exhibits increase resistance to farnesyltransferase inhibitors
-
Del Villar K, Urano J, Guo L, et al. 1999. A mutant form of protein farnesyltransferase exhibits increase resistance to farnesyltransferase inhibitors. J Biol Chem, 274:27010-17.
-
(1999)
J Biol Chem
, vol.274
, pp. 27010-27017
-
-
del Villar, K.1
Urano, J.2
Guo, L.3
-
20
-
-
0033375466
-
Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway
-
End DW. 1999. Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway. Invest New Drugs, 17:241-58.
-
(1999)
Invest New Drugs
, vol.17
, pp. 241-258
-
-
End, D.W.1
-
21
-
-
58349085978
-
Phase II studies of different schedules and doses of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra, NSC 702818) for patients of age 70 or older with previously untreated acute myeloid leukemia (AML): A North American Intergroup study (S0432) [abstract]
-
(abstract 440)
-
Erba HP, Kopecky KJ, Kirschbaum MH, et al. 2007. Phase II studies of different schedules and doses of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra, NSC 702818) for patients of age 70 or older with previously untreated acute myeloid leukemia (AML): A North American Intergroup study (S0432) [abstract]. Blood, 110:136a (abstract 440).
-
(2007)
Blood
, vol.110
-
-
Erba, H.P.1
Kopecky, K.J.2
Kirschbaum, M.H.3
-
22
-
-
34249810897
-
Acute myeloid leukemia and myelodysplastic syndromes in older patients
-
Estey E. 2007. Acute myeloid leukemia and myelodysplastic syndromes in older patients. J Clin Oncol, 25:1908-15.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1908-1915
-
-
Estey, E.1
-
23
-
-
0020427774
-
Remission induction in acute myeloid leukaemia with oral etoposide
-
Evans JPM, Prentice HG. 1982. Remission induction in acute myeloid leukaemia with oral etoposide. Lancet, 2(8311):1345-6.
-
(1982)
Lancet
, vol.2
, Issue.8311
, pp. 1345-1346
-
-
Evans, J.P.M.1
Prentice, H.G.2
-
24
-
-
0033539952
-
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects
-
Feldkamp MM, Lau N, Guha A. 1999. Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects. Oncogene, 18:7514-26.
-
(1999)
Oncogene
, vol.18
, pp. 7514-7526
-
-
Feldkamp, M.M.1
Lau, N.2
Guha, A.3
-
25
-
-
34248363673
-
A multicenter phase 2 study of the Farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
-
Fenaux P, Raza A, Mufti G, et al. 2007. A multicenter phase 2 study of the Farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome. Blood, 109:4158-63.
-
(2007)
Blood
, vol.109
, pp. 4158-4163
-
-
Fenaux, P.1
Raza, A.2
Mufti, G.3
-
26
-
-
15844363442
-
A phase I/II study of oral etoposide and idarubicin in elderly patients with high-risk acute myeloid leukemia unable to undergo intensive chemotherapy
-
Fiegl M. Buchner T, Hiddemann W, et al. 2005. A phase I/II study of oral etoposide and idarubicin in elderly patients with high-risk acute myeloid leukemia unable to undergo intensive chemotherapy. Ann Hematol, 84:227-31.
-
(2005)
Ann Hematol
, vol.84
, pp. 227-231
-
-
Fiegl, M.1
Buchner, T.2
Hiddemann, W.3
-
27
-
-
0025797361
-
Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin
-
Foisner R, Traub P, Wiche G. 1991. Protein kinase A- and protein kinase C-regulated interaction of plectin with lamin B and vimentin. Proc Natl Acad Sci USA, 88:3812-16.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 3812-3816
-
-
Foisner, R.1
Traub, P.2
Wiche, G.3
-
28
-
-
33645060977
-
A protein Farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
-
Fong LG, Frost D, Meta M, et al. 2006. A protein Farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science, 311:1621-3.
-
(2006)
Science
, vol.311
, pp. 1621-1623
-
-
Fong, L.G.1
Frost, D.2
Meta, M.3
-
29
-
-
27744475074
-
In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib: Identification of T-cell ALL and FAB M5 AML as the most sensitive subsets
-
Goemans BF, Zwaan CM, Harlow A, et al. 2005 In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib: identification of T-cell ALL and FAB M5 AML as the most sensitive subsets. Blood, 106:3532-7.
-
(2005)
Blood
, vol.106
, pp. 3532-3537
-
-
Goemans, B.F.1
Zwaan, C.M.2
Harlow, A.3
-
30
-
-
0035469856
-
Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: The results of the United Kingdom Medical Research Council AML 11 trial
-
Goldstone AH, Burnett AK, Wheatley K, et al. 2001. Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML 11 trial. Blood, 98:1302-11.
-
(2001)
Blood
, vol.98
, pp. 1302-1311
-
-
Goldstone, A.H.1
Burnett, A.K.2
Wheatley, K.3
-
31
-
-
21744460846
-
Farnesyltransferase inhibitor BMS-214662 induces apoptosis in myeloma cells through PUMA up-regulation, Bax and Bak activation, and Mcl-1 elimination
-
Gomez-Benito M, Marzo I, Anel A, et al. 2005. Farnesyltransferase inhibitor BMS-214662 induces apoptosis in myeloma cells through PUMA up-regulation, Bax and Bak activation, and Mcl-1 elimination. Mol Pharmacol, 67:1991-8.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1991-1998
-
-
Gomez-Benito, M.1
Marzo, I.2
Anel, A.3
-
32
-
-
0035469883
-
The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML 11 trial
-
Grimwade D, Walker H, Harrison G, et al. 2001. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML 11 trial. Blood, 98:1312-20.
-
(2001)
Blood
, vol.98
, pp. 1312-1320
-
-
Grimwade, D.1
Walker, H.2
Harrison, G.3
-
33
-
-
0032784783
-
World Health Organization classification of neoplastic diseases of the hematopoeitic and lymphoid tissues: Report of the clinical advisory committee meeting - Airlie House, Virginia, November
-
Harris NL, Jaffe ES, Diebold J, et al. 1997. World Health Organization classification of neoplastic diseases of the hematopoeitic and lymphoid tissues: report of the clinical advisory committee meeting - Airlie House, Virginia, November. J Clin Oncol, 17:3835-49.
-
(1997)
J Clin Oncol
, vol.17
, pp. 3835-3849
-
-
Harris, N.L.1
Jaffe, E.S.2
Diebold, J.3
-
34
-
-
34250006852
-
A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relasped acute myeloid leukemia
-
Harousseau J-L, Lancet JE, Reiffers J, et al. 2007a. A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relasped acute myeloid leukemia. Blood, 109:5151-6.
-
(2007)
Blood
, vol.109
, pp. 5151-5156
-
-
Harousseau, J.-L.1
Lancet, J.E.2
Reiffers, J.3
-
35
-
-
43449095098
-
A randomized Phase 3 study of tipifarnib compared to best supportive care (including hydroxyurea) in the treatment of newly diagnosed acute myeloid leukemia (AML) in patients 70 or older
-
(abstract 439)
-
Harousseau J-L, Martinelli G, Jedrejczak WW, et al. 2007b. A randomized Phase 3 study of tipifarnib compared to best supportive care (including hydroxyurea) in the treatment of newly diagnosed acute myeloid leukemia (AML) in patients 70 or older. Blood, 110:135a (abstract 439).
-
(2007)
Blood
, vol.110
-
-
Harousseau, J.-L.1
Martinelli, G.2
Jedrejczak, W.W.3
-
36
-
-
0030886609
-
The use of an all oral chemotherapy (idarubicin and etoposide) in the treatment of acute myeloid leukaemia in the elderly: A report of toxicity and efficacy
-
Jackson GH, Taylor PR, Iqbal A, et al. 1997. The use of an all oral chemotherapy (idarubicin and etoposide) in the treatment of acute myeloid leukaemia in the elderly: a report of toxicity and efficacy. Leukemia, 11:1193-6.
-
(1997)
Leukemia
, vol.11
, pp. 1193-1196
-
-
Jackson, G.H.1
Taylor, P.R.2
Iqbal, A.3
-
37
-
-
0033986790
-
The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis
-
Jiang K, Coppola D, Crespo NC, et al. 2000. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Mol Cell Biol, 20:139-48.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 139-148
-
-
Jiang, K.1
Coppola, D.2
Crespo, N.C.3
-
38
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase I clinical-laboratory correlative trial
-
Karp JE, Lancet JE, Kaufmann SH, et al. 2001. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase I clinical-laboratory correlative trial. Blood, 97:3361-9.
-
(2001)
Blood
, vol.97
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, S.H.3
-
39
-
-
38349063902
-
Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia (AML): Phase I trial of oral tipifarnib (T) combined with oral etoposide (E) for adults ≥age 70 who are not candidates for traditional cytotoxic chemotherapy
-
Karp JE, Feldman EJ, Morris LE, et al. 2006. Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia (AML): phase I trial of oral tipifarnib (T) combined with oral etoposide (E) for adults ≥age 70 who are not candidates for traditional cytotoxic chemotherapy. Blood, 108:130a.
-
(2006)
Blood
, vol.108
-
-
Karp, J.E.1
Feldman, E.J.2
Morris, L.E.3
-
40
-
-
34548815038
-
Development of farnesyltransferase inhibitors for clinical cancer therapy: Focus on hematologic malignancies
-
Karp JE, Lancet JE. 2007. Development of farnesyltransferase inhibitors for clinical cancer therapy: focus on hematologic malignancies. Cancer Investig, 25:484-94.
-
(2007)
Cancer Investig
, vol.25
, pp. 484-494
-
-
Karp, J.E.1
Lancet, J.E.2
-
41
-
-
77953465300
-
A Phase I study of the farnesyltransferase inhibitor tipifarnib in a week-on week-off dose schedule in acute myelogenous leukemia [abstract]
-
(abstract 891)
-
Kirschbaum MH, Selwyn Stein A, Tuscano J, et al. 2007. A Phase I study of the farnesyltransferase inhibitor tipifarnib in a week-on week-off dose schedule in acute myelogenous leukemia [abstract]. Blood, 110:182a (abstract 891).
-
(2007)
Blood
, vol.110
-
-
Kirschbaum, M.H.1
Selwyn, S.A.2
Tuscano, J.3
-
42
-
-
9444281436
-
The influence of farnesyl protein transferase inhibitor R115777 (Zarnestra) alone and in combination with purine nucleoside analogs on acute myeloid leukemia progenitors in vitro [abstract]
-
Korycka A, Smolewski P, Robak T. 2004. The influence of farnesyl protein transferase inhibitor R115777 (Zarnestra) alone and in combination with purine nucleoside analogs on acute myeloid leukemia progenitors in vitro [abstract]. Eur J Haematol, 73:418-26.
-
(2004)
Eur J Haematol
, vol.73
, pp. 418-426
-
-
Korycka, A.1
Smolewski, P.2
Robak, T.3
-
43
-
-
10744227474
-
Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: Clinical and biologic activities in the Phase 1 setting
-
Kurzrock R, Kantarjian HM, Cortes JE, et al. 2003. Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the Phase 1 setting. Blood, 102:4527-34.
-
(2003)
Blood
, vol.102
, pp. 4527-4534
-
-
Kurzrock, R.1
Kantarjian, H.M.2
Cortes, J.E.3
-
44
-
-
2142712474
-
Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome
-
Kurzrock R, Albitar M, Cortes JE, et al. 2004. Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome. J Clin Oncol, 22:1287-92.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1287-1292
-
-
Kurzrock, R.1
Albitar, M.2
Cortes, J.E.3
-
46
-
-
33847001315
-
A phase II study of the Farnesyltransferase inhibitor Tipifarnib in elderly patients with previously untreated poor-risk acute myelogenous leukemia
-
Lancet JE, Gojo I, Gotlib J, et al. 2007. A phase II study of the Farnesyltransferase inhibitor Tipifarnib in elderly patients with previously untreated poor-risk acute myelogenous leukemia. Blood, 109:1387-94.
-
(2007)
Blood
, vol.109
, pp. 1387-1394
-
-
Lancet, J.E.1
Gojo, I.2
Gotlib, J.3
-
47
-
-
0033179095
-
Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: A Southwest Oncology Group study
-
Leith CP, Kopecky KJ, Chen IM, et al. 1999. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group study. Blood, 94:1086-99.
-
(1999)
Blood
, vol.94
, pp. 1086-1099
-
-
Leith, C.P.1
Kopecky, K.J.2
Chen, I.M.3
-
48
-
-
0035029153
-
Tumor cell death induced by topoisomerase-targeting drugs
-
Li TK, Liu LF. 2001. Tumor cell death induced by topoisomerase-targeting drugs. Annu Rev Pharmacol Toxicol, 41:53-77.
-
(2001)
Annu Rev Pharmacol Toxicol
, vol.41
, pp. 53-77
-
-
Li, T.K.1
Liu, L.F.2
-
49
-
-
0343045296
-
Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy - the value of low-dose cyatarbine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: Final report of the Leukemia Cooperative Group of the European Organization for the Research and Treatment of Cancer
-
the Dutch-Belgian Hemato-Oncology Cooperative Hovon Group randomized phase III study AML-9
-
Lowenberg B, Suici S, Archimbaud E, et al. 1998. Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy - the value of low-dose cyatarbine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report of the Leukemia Cooperative Group of the European Organization for the Research and Treatment of Cancer and the Dutch-Belgian Hemato-Oncology Cooperative Hovon Group randomized phase III study AML-9. J Clin Oncol, 16:872-81.
-
(1998)
J Clin Oncol
, vol.16
, pp. 872-881
-
-
Lowenberg, B.1
Suici, S.2
Archimbaud, E.3
-
50
-
-
4644359707
-
Targeting the multidrug resistance-1 transporter in AML: Molecular regulation and therapeutic strategies
-
Mahadevan D, List AF. 2004. Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategies. Blood, 104:1940-51.
-
(2004)
Blood
, vol.104
, pp. 1940-1951
-
-
Mahadevan, D.1
List, A.F.2
-
52
-
-
33846230449
-
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
-
Mrozek K, Marcucci G, Paschka P, et al. 2007. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood, 109:431-48.
-
(2007)
Blood
, vol.109
, pp. 431-448
-
-
Mrozek, K.1
Marcucci, G.2
Paschka, P.3
-
53
-
-
33947361191
-
The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines
-
Medeiros BC, Landau HJ, Morrow M, et al. 2007. The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines. Leukemia, 21:739-46.
-
(2007)
Leukemia
, vol.21
, pp. 739-746
-
-
Medeiros, B.C.1
Landau, H.J.2
Morrow, M.3
-
54
-
-
34548136103
-
A Phase II trial of tipifarnib in myelofibrosis: Primary, post-polycythemia vera and post-essential thrombocythemia
-
Mesa RA, Camoriano JK, Geyer SM, et al. 2007. A Phase II trial of tipifarnib in myelofibrosis: primary, post-polycythemia vera and post-essential thrombocythemia. Leukemia, 21:1964-70.
-
(2007)
Leukemia
, vol.21
, pp. 1964-1970
-
-
Mesa, R.A.1
Camoriano, J.K.2
Geyer, S.M.3
-
55
-
-
31744448235
-
Molecularly targeted therapies in myelodysplastic syndromes and acute myeloid leukemias
-
Morgan MA, Reuter CW. 2006. Molecularly targeted therapies in myelodysplastic syndromes and acute myeloid leukemias. Ann Hematol, 85:139-63.
-
(2006)
Ann Hematol
, vol.85
, pp. 139-163
-
-
Morgan, M.A.1
Reuter, C.W.2
-
56
-
-
0037608688
-
Oral induction and consolidation chemotherapy with idarubicin and etoposide in elderly patients with acute myeloid leukemia
-
Oriol A, Ribera J-M, Brunet S, et al. 2003. Oral induction and consolidation chemotherapy with idarubicin and etoposide in elderly patients with acute myeloid leukemia. Haematologica, 88:229-30.
-
(2003)
Haematologica
, vol.88
, pp. 229-230
-
-
Oriol, A.1
Ribera, J.-M.2
Brunet, S.3
-
57
-
-
0029952467
-
Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyltransferase inhibitors
-
Prendergast GC, Davide JP, Lebowitz PF, et al. 1996. Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyltransferase inhibitors. Cancer Res, 56:2626-32.
-
(1996)
Cancer Res
, vol.56
, pp. 2626-2632
-
-
Prendergast, G.C.1
Davide, J.P.2
Lebowitz, P.F.3
-
58
-
-
33747420007
-
Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: A Cancer and Leukemia Croup B study
-
Radmacher MD, Marcucci G, Ruppert AS, et al. 2006. Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Croup B study. Blood, 108:1677-83.
-
(2006)
Blood
, vol.108
, pp. 1677-1683
-
-
Radmacher, M.D.1
Marcucci, G.2
Ruppert, A.S.3
-
59
-
-
13144296650
-
Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia
-
Raponi M, Belly RT, Karp JE, et al. 2004. Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia. BMC Cancer, 4:56.
-
(2004)
BMC Cancer
, vol.4
, pp. 56
-
-
Raponi, M.1
Belly, R.T.2
Karp, J.E.3
-
60
-
-
34247527215
-
Identification of molecular predictors of repsonse in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia
-
Raponi M, Harousseau JL, Lancet JE, et al. 2007. Identification of molecular predictors of repsonse in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia. Clin Cancer Res, 13:2254-60.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2254-2260
-
-
Raponi, M.1
Harousseau, J.L.2
Lancet, J.E.3
-
61
-
-
41949125894
-
A two-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia
-
Raponi M, Lancet JE, Fan H, et al. 2008. A two-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia. Blood, 111:2589-96.
-
(2008)
Blood
, vol.111
, pp. 2589-2596
-
-
Raponi, M.1
Lancet, J.E.2
Fan, H.3
-
62
-
-
34548845301
-
Resistance to the farnesyl transferase inhibitor SCH66336 (Lonafarnib) caused by mutations in the target protein farnesyl transferase beta
-
Raz T, Nardi V, Azam M, et al. 2007. Resistance to the farnesyl transferase inhibitor SCH66336 (Lonafarnib) caused by mutations in the target protein farnesyl transferase beta. Blood, 110:2102-9.
-
(2007)
Blood
, vol.110
, pp. 2102-2109
-
-
Raz, T.1
Nardi, V.2
Azam, M.3
-
63
-
-
0034284027
-
Targeting the Ras signaling pathway: A rational, mechanism-based treatment for hematologic malignancies?
-
Reuter CWM, Morgan MA, Bergmann L. 2000. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood, 96:1655-69.
-
(2000)
Blood
, vol.96
, pp. 1655-1669
-
-
Reuter, C.W.M.1
Morgan, M.A.2
Bergmann, L.3
-
64
-
-
1342331479
-
Searching for the elusive targets of Farnesyltransferase inhibitors
-
Sebti SM, Der CJ. 2003. Searching for the elusive targets of Farnesyltransferase inhibitors. Nat Rev, 3:945-51.
-
(2003)
Nat Rev
, vol.3
, pp. 945-951
-
-
Sebti, S.M.1
Der, C.J.2
-
65
-
-
1242273875
-
Farnesyltransferase inhibitors
-
Sebti SM, Adjei AA. 2004. Farnesyltransferase inhibitors. Semin Oncol, 31:28-39.
-
(2004)
Semin Oncol
, vol.31
, pp. 28-39
-
-
Sebti, S.M.1
Adjei, A.A.2
-
66
-
-
0036284741
-
Establishment and characterization of acquired resistance to farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line
-
Smith V, Rowlands MG, Barrie E, et al. 2002. Establishment and characterization of acquired resistance to farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line. Clin Cancer Res, 8:2002-9.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2002-2009
-
-
Smith, V.1
Rowlands, M.G.2
Barrie, E.3
-
67
-
-
0035437132
-
Postremission therapy in older patients with de novo acute myeloid leukemia: A randomized trial comparing mitoxantrone and intermediate-dose cytarabine with standard-dose cytarabine
-
Stone RM, Berg DT, George SL, et al. 2001. Postremission therapy in older patients with de novo acute myeloid leukemia: a randomized trial comparing mitoxantrone and intermediate-dose cytarabine with standard-dose cytarabine. Blood, 98:548-53.
-
(2001)
Blood
, vol.98
, pp. 548-553
-
-
Stone, R.M.1
Berg, D.T.2
George, S.L.3
-
68
-
-
0027972531
-
Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction proteins
-
Toksoz D, Williams DA. 1994. Novel human oncogene lbc detected by transfection with distinct homology regions to signal transduction proteins. Oncogene, 9:621-8.
-
(1994)
Oncogene
, vol.9
, pp. 621-628
-
-
Toksoz, D.1
Williams, D.A.2
-
69
-
-
33645472801
-
A mitotic lamin B matrix induced by RanGTP required for spindle assembly
-
Tsai MY, Wang S, Heidinger JM, et al. 2006. A mitotic lamin B matrix induced by RanGTP required for spindle assembly. Science, 311:1887-93.
-
(2006)
Science
, vol.311
, pp. 1887-1893
-
-
Tsai, M.Y.1
Wang, S.2
Heidinger, J.M.3
-
70
-
-
0036085460
-
Cellular roles of DNA topoisomerases: A molecular
-
Wang JC. 2002. Cellular roles of DNA topoisomerases: a molecular. Nat Rev Mol Cell Biol, 3:430-40.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 430-440
-
-
Wang, J.C.1
-
71
-
-
33745957993
-
Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction
-
Wilson CS, Davidson GS, Martin SB, et al. 2006. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood, 108:685-96.
-
(2006)
Blood
, vol.108
, pp. 685-696
-
-
Wilson, C.S.1
Davidson, G.S.2
Martin, S.B.3
-
72
-
-
33745909399
-
Inhibition of the phosphatidylinositol- 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies
-
Witzig TE, Kaufmann SH. 2006. Inhibition of the phosphatidylinositol- 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies. Curr Treat Options Oncol, 7:285-94.
-
(2006)
Curr Treat Options Oncol
, vol.7
, pp. 285-294
-
-
Witzig, T.E.1
Kaufmann, S.H.2
-
73
-
-
17444402847
-
Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: A single center experience
-
Yanada M, Suzuki M, Kawashima K, et al. 2005. Long-term outcomes for unselected patients with acute myeloid leukemia categorized according to the World Health Organization classification: a single center experience. Eur J Hematol,74:418-23.
-
(2005)
Eur J Hematol
, vol.74
, pp. 418-423
-
-
Yanada, M.1
Suzuki, M.2
Kawashima, K.3
-
74
-
-
31544482800
-
Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia
-
Yanamandra N, Colaco NM, Parquet NA, et al. 2006. Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia. Clin Cancer Res, 12:591-9.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 591-599
-
-
Yanamandra, N.1
Colaco, N.M.2
Parquet, N.A.3
-
75
-
-
23744461504
-
Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a
-
Zhang B, Groffen J, Heisterkamp N. 2005. Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a. Blood, 106:1355-61.
-
(2005)
Blood
, vol.106
, pp. 1355-1361
-
-
Zhang, B.1
Groffen, J.2
Heisterkamp, N.3
-
76
-
-
0028967665
-
Direct involvement of the small GTP-binding protein Rho in lbc oncogene function
-
Zheng Y, Olson MF, Hall A, et al. 1995. Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J Biol Chem, 270: 9031-4.
-
(1995)
J Biol Chem
, vol.270
, pp. 9031-9034
-
-
Zheng, Y.1
Olson, M.F.2
Hall, A.3
|