-
1
-
-
15944404601
-
The development of imatinib as a therapeutic agent for chronic myeloid leukemia
-
Deininger M, Buchdunger E, Druker BJ. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood. 2005;105:2640-2653.
-
(2005)
Blood
, vol.105
, pp. 2640-2653
-
-
Deininger, M.1
Buchdunger, E.2
Druker, B.J.3
-
2
-
-
31344441164
-
Looking beyond imatinib next line of targeted drugs for CML shows promise
-
Hampton T. Looking beyond imatinib next line of targeted drugs for CML shows promise. JAMA. 2006;295:369-370.
-
(2006)
JAMA
, vol.295
, pp. 369-370
-
-
Hampton, T.1
-
3
-
-
0027248872
-
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
-
Kohl NE, Mosser SD, deSolms SJ, et al. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science. 1993;260:1934-1937.
-
(1993)
Science
, vol.260
, pp. 1934-1937
-
-
Kohl, N.E.1
Mosser, S.D.2
deSolms, S.J.3
-
4
-
-
0041356888
-
Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin-and farnesylation-dependent manner
-
Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin-and farnesylation-dependent manner. J Biol Chem. 2003;278:32493-32496.
-
(2003)
J Biol Chem
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.J.3
Quilliam, L.A.4
-
5
-
-
0034730625
-
Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules
-
Ashar HR, James L, Gray K, et al. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J Biol Chem. 2000;275:30451-30457.
-
(2000)
J Biol Chem
, vol.275
, pp. 30451-30457
-
-
Ashar, H.R.1
James, L.2
Gray, K.3
-
6
-
-
0029664317
-
Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells
-
James G, Goldstein JL, Brown MS. Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells. Proc Natl Acad Sci U S A. 1996;93:4454-4458.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 4454-4458
-
-
James, G.1
Goldstein, J.L.2
Brown, M.S.3
-
7
-
-
0030923192
-
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
Whyte DB, Kirschmeier P, Hockenberry TN, et al. K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J Biol Chem. 1997;272:14459-14464.
-
(1997)
J Biol Chem
, vol.272
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
-
8
-
-
30844467746
-
Thematic review series: Lipid posttranslational modifications: farnesyl transferase inhibitors
-
Basso AD, Kirschmeier P, Bishop WR. Thematic review series: lipid posttranslational modifications: farnesyl transferase inhibitors. J Lipid Res. 2006;47:15-31.
-
(2006)
J Lipid Res
, vol.47
, pp. 15-31
-
-
Basso, A.D.1
Kirschmeier, P.2
Bishop, W.R.3
-
9
-
-
33847001315
-
A phase II study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
-
Lancet JE, Gojo I, Gotlib J, et al. A phase II study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia. Blood. 2006;109:1387-1394.
-
(2006)
Blood
, vol.109
, pp. 1387-1394
-
-
Lancet, J.E.1
Gojo, I.2
Gotlib, J.3
-
10
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
-
Karp JE, Lancet JE, Kaufmann SH, et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood. 2001;97:3361-3369.
-
(2001)
Blood
, vol.97
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, S.H.3
-
11
-
-
0034071688
-
A phase I trial of the farnesyl transferase inhibitor SCH66336: Evidence for biological and clinical activity
-
Adjei AA, Erlichman C, Davis JN, et al. A phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity. Cancer Res. 2000;60:1871-1877.
-
(2000)
Cancer Res
, vol.60
, pp. 1871-1877
-
-
Adjei, A.A.1
Erlichman, C.2
Davis, J.N.3
-
12
-
-
0035865305
-
Phase I and pharmacokinetic study of the oral farnesyl transferase inhibitor SCH 66336 given twice daily to patients with advanced solid tumors
-
Eskens FA, Awada A, Cutler DL, et al. Phase I and pharmacokinetic study of the oral farnesyl transferase inhibitor SCH 66336 given twice daily to patients with advanced solid tumors. J Clin Oncol. 2001;19:1167-1175.
-
(2001)
J Clin Oncol
, vol.19
, pp. 1167-1175
-
-
Eskens, F.A.1
Awada, A.2
Cutler, D.L.3
-
13
-
-
28844500739
-
The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT
-
David E, Sun SY, Waller EK, Chen J, Khuri FR, Lonial S. The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT. Blood. 2005;106:4322-4329.
-
(2005)
Blood
, vol.106
, pp. 4322-4329
-
-
David, E.1
Sun, S.Y.2
Waller, E.K.3
Chen, J.4
Khuri, F.R.5
Lonial, S.6
-
14
-
-
21744457612
-
Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro
-
Jorgensen HG, Allan EK, Graham SM, et al. Lonafarnib reduces the resistance of primitive quiescent CML cells to imatinib mesylate in vitro. Leukemia. 2005;19:1184-1191.
-
(2005)
Leukemia
, vol.19
, pp. 1184-1191
-
-
Jorgensen, H.G.1
Allan, E.K.2
Graham, S.M.3
-
15
-
-
0034905234
-
Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines
-
Adjei AA, Davis JN, Bruzek LM, Erlichman C, Kaufmann SH. Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines. Clin Cancer Res. 2001;7:1438-1445.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1438-1445
-
-
Adjei, A.A.1
Davis, J.N.2
Bruzek, L.M.3
Erlichman, C.4
Kaufmann, S.H.5
-
16
-
-
0036683409
-
Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336
-
Hoover RR, Mahon FX, Melo JV, Daley GQ. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood. 2002;100:1068-1071.
-
(2002)
Blood
, vol.100
, pp. 1068-1071
-
-
Hoover, R.R.1
Mahon, F.X.2
Melo, J.V.3
Daley, G.Q.4
-
17
-
-
8644219632
-
Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: Possible mechanisms of action
-
Jabbour E, Kantarjian H, Cortes J. Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: possible mechanisms of action. Leuk Lymphoma. 2004;45:2187-2195.
-
(2004)
Leuk Lymphoma
, vol.45
, pp. 2187-2195
-
-
Jabbour, E.1
Kantarjian, H.2
Cortes, J.3
-
18
-
-
23344435930
-
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis
-
Buckner FS, Eastman RT, Yokoyama K, Gelb MH, Van Voorhis WC. Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis. Curr Opin Investig Drugs. 2005;6:791-797.
-
(2005)
Curr Opin Investig Drugs
, vol.6
, pp. 791-797
-
-
Buckner, F.S.1
Eastman, R.T.2
Yokoyama, K.3
Gelb, M.H.4
Van Voorhis, W.C.5
-
19
-
-
33645060977
-
A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
-
Fong LG, Frost D, Meta M, et al. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science. 2006;311:1621-1623.
-
(2006)
Science
, vol.311
, pp. 1621-1623
-
-
Fong, L.G.1
Frost, D.2
Meta, M.3
-
20
-
-
33746715642
-
A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
-
Yang SH, Meta M, Qiao X, et al. A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest. 2006;116:2115-2121.
-
(2006)
J Clin Invest
, vol.116
, pp. 2115-2121
-
-
Yang, S.H.1
Meta, M.2
Qiao, X.3
-
21
-
-
0036284741
-
Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line
-
Smith V, Rowlands MG, Barrie E, Workman P, Kelland LR. Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line. Clin Cancer Res. 2002;8:2002-2009.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2002-2009
-
-
Smith, V.1
Rowlands, M.G.2
Barrie, E.3
Workman, P.4
Kelland, L.R.5
-
22
-
-
23844540638
-
Characterization of a R115777-resistant human multiple myeloma cell line with cross-resistance to PS-341
-
Buzzeo R, Enkemann S, Nimmanapalli R, et al. Characterization of a R115777-resistant human multiple myeloma cell line with cross-resistance to PS-341. Clin Cancer Res. 2005;11:6057-6064.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6057-6064
-
-
Buzzeo, R.1
Enkemann, S.2
Nimmanapalli, R.3
-
23
-
-
23744461504
-
Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a
-
Zhang B, Groffen J, Heisterkamp N. Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a. Blood. 2005;106:1355-1361.
-
(2005)
Blood
, vol.106
, pp. 1355-1361
-
-
Zhang, B.1
Groffen, J.2
Heisterkamp, N.3
-
24
-
-
23044465584
-
Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)- cyclohepta(1,2- b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1- piperidinecarboxamide (SCH66336)
-
Bruzek LM, Poynter JN, Kaufmann SH, Adjei AA. Characterization of a human carcinoma cell line selected for resistance to the farnesyl transferase inhibitor 4-(2-(4-(8-chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)- cyclohepta(1,2- b)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1- piperidinecarboxamide (SCH66336). Mol Pharmacol. 2005;68:477-486.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 477-486
-
-
Bruzek, L.M.1
Poynter, J.N.2
Kaufmann, S.H.3
Adjei, A.A.4
-
25
-
-
0033578751
-
A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors
-
Del Villar K, Urano J, Guo L, Tamanoi F. A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors. J Biol Chem. 1999;274:27010-27017.
-
(1999)
J Biol Chem
, vol.274
, pp. 27010-27017
-
-
Del Villar, K.1
Urano, J.2
Guo, L.3
Tamanoi, F.4
-
26
-
-
20244388655
-
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum
-
Eastman RT, White J, Hucke O, et al. Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum. J Biol Chem. 2005;280:13554-13559.
-
(2005)
J Biol Chem
, vol.280
, pp. 13554-13559
-
-
Eastman, R.T.1
White, J.2
Hucke, O.3
-
27
-
-
33846197423
-
Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase
-
Eastman RT, White J, Hucke O, et al. Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase. Mol Biochem Parasitol. 2007;152:66-71.
-
(2007)
Mol Biochem Parasitol
, vol.152
, pp. 66-71
-
-
Eastman, R.T.1
White, J.2
Hucke, O.3
-
28
-
-
30144432781
-
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain
-
Heidel F, Solem FK, Breitenbuecher F, et al. Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain. Blood. 2006;107:293-300.
-
(2006)
Blood
, vol.107
, pp. 293-300
-
-
Heidel, F.1
Solem, F.K.2
Breitenbuecher, F.3
-
29
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005;352:786-792.
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
30
-
-
18244371651
-
-
Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;2:e73:225-235.
-
Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005;2:e73:225-235.
-
-
-
-
31
-
-
0037114239
-
-
Koh EY, Chen T, Daley GQ. Novel retroviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res. 2002;30:e142:1-7.
-
Koh EY, Chen T, Daley GQ. Novel retroviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res. 2002;30:e142:1-7.
-
-
-
-
32
-
-
0025352187
-
Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
-
Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 1990;18:3587-3596.
-
(1990)
Nucleic Acids Res
, vol.18
, pp. 3587-3596
-
-
Morgenstern, J.P.1
Land, H.2
-
33
-
-
0028385758
-
Versatile retroviral vectors for potential use in gene therapy
-
Hawley RG, Lieu FH, Fong AZ, Hawley TS. Versatile retroviral vectors for potential use in gene therapy. Gene Ther. 1994;1:136-138.
-
(1994)
Gene Ther
, vol.1
, pp. 136-138
-
-
Hawley, R.G.1
Lieu, F.H.2
Fong, A.Z.3
Hawley, T.S.4
-
34
-
-
0346670259
-
A screen to identify drug resistant variants to target-directed anti-cancer agents
-
Azam M, Raz T, Nardi V, Opitz SL, Daley GQ. A screen to identify drug resistant variants to target-directed anti-cancer agents. Biol Proced Online. 2003;5:204-210.
-
(2003)
Biol Proced Online
, vol.5
, pp. 204-210
-
-
Azam, M.1
Raz, T.2
Nardi, V.3
Opitz, S.L.4
Daley, G.Q.5
-
35
-
-
0029955714
-
The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses
-
Naviaux RK, Costanzi E, Haas M, Verma IM. The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol. 1996;70:5701-5705.
-
(1996)
J Virol
, vol.70
, pp. 5701-5705
-
-
Naviaux, R.K.1
Costanzi, E.2
Haas, M.3
Verma, I.M.4
-
36
-
-
34548833716
-
-
Rasband WS. ImageJ, U.S. Bethesda, MD: National Institutes of Health; 1997-2006.
-
Rasband WS. ImageJ, U.S. Bethesda, MD: National Institutes of Health; 1997-2006.
-
-
-
-
38
-
-
0037459344
-
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
-
Azam M, Latek RR, Daley GQ. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell. 2003;112:831-843.
-
(2003)
Cell
, vol.112
, pp. 831-843
-
-
Azam, M.1
Latek, R.R.2
Daley, G.Q.3
-
39
-
-
33644838556
-
Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas
-
Widemann BC, Salzer WL, Arceci RJ, et al. Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas. J Clin Oncol. 2006;24:507-516.
-
(2006)
J Clin Oncol
, vol.24
, pp. 507-516
-
-
Widemann, B.C.1
Salzer, W.L.2
Arceci, R.J.3
-
40
-
-
21144440538
-
A multinomial phase II study of lonafarnib (SCH 66336) in patients with refractory urothelial cancer
-
Winquist E, Moore MJ, Chi KN, et al. A multinomial phase II study of lonafarnib (SCH 66336) in patients with refractory urothelial cancer. Urol Oncol. 2005;23:143-149.
-
(2005)
Urol Oncol
, vol.23
, pp. 143-149
-
-
Winquist, E.1
Moore, M.J.2
Chi, K.N.3
-
41
-
-
0034084316
-
Comparison of potential markers of farnesyltransferase inhibition
-
Adjei AA, Davis JN, Erlichman C, Svingen PA, Kaufmann SH. Comparison of potential markers of farnesyltransferase inhibition. Clin Cancer Res. 2000;6:2318-2325.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2318-2325
-
-
Adjei, A.A.1
Davis, J.N.2
Erlichman, C.3
Svingen, P.A.4
Kaufmann, S.H.5
-
42
-
-
0033578085
-
Tricyclic farnesyl protein transferase inhibitors: Crystallographic and calorimetric studies of structure-activity relationships
-
Strickland CL, Weber PC, Windsor WT, et al. Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships. J Med Chem. 1999;42:2125-2135.
-
(1999)
J Med Chem
, vol.42
, pp. 2125-2135
-
-
Strickland, C.L.1
Weber, P.C.2
Windsor, W.T.3
-
43
-
-
0030909826
-
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
-
Park HW, Boduluri SR, Moomaw JF, Casey PJ, Beese LS. Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. Science. 1997;275:1800-1804.
-
(1997)
Science
, vol.275
, pp. 1800-1804
-
-
Park, H.W.1
Boduluri, S.R.2
Moomaw, J.F.3
Casey, P.J.4
Beese, L.S.5
-
44
-
-
0347065351
-
Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand
-
Pickett JS, Bowers KE, Fierke CA. Mutagenesis studies of protein farnesyltransferase implicate aspartate beta 352 as a magnesium ligand. J Biol Chem. 2003;278:51243-51250.
-
(2003)
J Biol Chem
, vol.278
, pp. 51243-51250
-
-
Pickett, J.S.1
Bowers, K.E.2
Fierke, C.A.3
-
45
-
-
0039948032
-
Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I
-
Del Villar K, Mitsuzawa H, Yang W, Sattler I, Tamanoi F. Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I. J Biol Chem. 1997;272:680-687.
-
(1997)
J Biol Chem
, vol.272
, pp. 680-687
-
-
Del Villar, K.1
Mitsuzawa, H.2
Yang, W.3
Sattler, I.4
Tamanoi, F.5
|