메뉴 건너뛰기




Volumn 106, Issue 4, 2005, Pages 1355-1361

Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; ATP11A PROTEIN; BCR ABL PROTEIN; CYTOTOXIC AGENT; GGTI 298; IMATINIB; LONAFARNIB; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VINCRISTINE;

EID: 23744461504     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-09-3655     Document Type: Article
Times cited : (24)

References (48)
  • 1
    • 0344645722 scopus 로고    scopus 로고
    • BCR/ABL gene structure and BCR function
    • Carella AM, Daley GQ, Eaves CM, Goldman JM, Hehlman R, eds. Oxford, United Kingdom: Martin Dunitz Ltd
    • Heisterkamp N, Groffen J. BCR/ABL gene structure and BCR function. In: Carella AM, Daley GQ, Eaves CM, Goldman JM, Hehlman R, eds. Chronic Myeloid Leukemia: Biology and Treatment. Oxford, United Kingdom: Martin Dunitz Ltd; 2001:3-17.
    • (2001) Chronic Myeloid Leukemia: Biology and Treatment , pp. 3-17
    • Heisterkamp, N.1    Groffen, J.2
  • 2
    • 0141528828 scopus 로고    scopus 로고
    • Chronic myeloid leukemia: Advances in biology and new approaches to treatment
    • Goldman JM, Melo JV. Chronic myeloid leukemia: advances in biology and new approaches to treatment. N Engl J Med. 2003;349:1451-1464.
    • (2003) N Engl J Med , vol.349 , pp. 1451-1464
    • Goldman, J.M.1    Melo, J.V.2
  • 3
    • 0034611661 scopus 로고    scopus 로고
    • Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Arico M, Valsecchi MG, Camitta B, et al. Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia. N Engl J Med. 2000;342:998-1006.
    • (2000) N Engl J Med , vol.342 , pp. 998-1006
    • Arico, M.1    Valsecchi, M.G.2    Camitta, B.3
  • 4
    • 0036786909 scopus 로고    scopus 로고
    • Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia: Results of the prospective multicenter LALA-94 trial
    • Dombret H, Gabert J, Boiron JM, et al. Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 trial. Blood. 2002;100:2357-2366.
    • (2002) Blood , vol.100 , pp. 2357-2366
    • Dombret, H.1    Gabert, J.2    Boiron, J.M.3
  • 5
    • 0036341359 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive acute lymphoblastic leukemia: Current concepts and future perspectives
    • Faderl S, Garcia-Manero G, Thomas DA, Kantarjian HM. Philadelphia chromosome-positive acute lymphoblastic leukemia: current concepts and future perspectives. Rev Clin Exp Hematol. 2002;6:142-160.
    • (2002) Rev Clin Exp Hematol , vol.6 , pp. 142-160
    • Faderl, S.1    Garcia-Manero, G.2    Thomas, D.A.3    Kantarjian, H.M.4
  • 6
    • 0036814460 scopus 로고    scopus 로고
    • Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Hoelzer D, Gokbuget N, Ottmann OG. Targeted therapies in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Semin Hematol. 2002;39:32-37.
    • (2002) Semin Hematol , vol.39 , pp. 32-37
    • Hoelzer, D.1    Gokbuget, N.2    Ottmann, O.G.3
  • 7
    • 0037399322 scopus 로고    scopus 로고
    • Perspectives on the treatment of chronic phase and advanced phase CML and Philadelphia chromosome positive ALL
    • Schiffer CA, Hehlmann R, Larson R. Perspectives on the treatment of chronic phase and advanced phase CML and Philadelphia chromosome positive ALL. Leukemia. 2003;17:691-699.
    • (2003) Leukemia , vol.17 , pp. 691-699
    • Schiffer, C.A.1    Hehlmann, R.2    Larson, R.3
  • 8
    • 0037255947 scopus 로고    scopus 로고
    • Advanced-phase chronic myeloid leukemia
    • Cortes J, Kantarjian H. Advanced-phase chronic myeloid leukemia. Semin Hematol. 2003;40:79-86.
    • (2003) Semin Hematol , vol.40 , pp. 79-86
    • Cortes, J.1    Kantarjian, H.2
  • 9
    • 0842322903 scopus 로고    scopus 로고
    • Effect of imatinib mesylate on chronic myelogenous leukemia hematopoietic progenitor cells
    • Holtz MS, Bhatia R. Effect of imatinib mesylate on chronic myelogenous leukemia hematopoietic progenitor cells. Leuk Lymphoma. 2004;45:237-245.
    • (2004) Leuk Lymphoma , vol.45 , pp. 237-245
    • Holtz, M.S.1    Bhatia, R.2
  • 10
    • 4043063997 scopus 로고    scopus 로고
    • Efficacy of dual-specific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate
    • Tipping AJ, Baluch S, Barnes DJ, et al. Efficacy of dual-specific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate. Leukemia. 2004;18:1352-1356.
    • (2004) Leukemia , vol.18 , pp. 1352-1356
    • Tipping, A.J.1    Baluch, S.2    Barnes, D.J.3
  • 11
    • 0742306877 scopus 로고    scopus 로고
    • Treatment of advanced P190 Bcr/Abl positive leukemia with a farnesyltransferase inhibitor
    • Mishra S, Zhang B, Groffen J, Heisterkamp N. Treatment of advanced P190 Bcr/Abl positive leukemia with a farnesyltransferase inhibitor. Leukemia. 2004;18:23-28.
    • (2004) Leukemia , vol.18 , pp. 23-28
    • Mishra, S.1    Zhang, B.2    Groffen, J.3    Heisterkamp, N.4
  • 12
    • 0035282901 scopus 로고    scopus 로고
    • Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
    • Peters DG, Hoover RR, Gerlach MJ, et al. Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood. 2001;97:1404-1412.
    • (2001) Blood , vol.97 , pp. 1404-1412
    • Peters, D.G.1    Hoover, R.R.2    Gerlach, M.J.3
  • 13
    • 0035282735 scopus 로고    scopus 로고
    • Treatment of Bcr/Abl-positive ALL in P190 transgenic mice with the farnesyltransferase inhibitor SCH66336
    • Reichert A, Heisterkamp N, Daley GQ, Groffen J. Treatment of Bcr/Abl-positive ALL in P190 transgenic mice with the farnesyltransferase inhibitor SCH66336. Blood. 2001;97:399-1403.
    • (2001) Blood , vol.97 , pp. 399-1403
    • Reichert, A.1    Heisterkamp, N.2    Daley, G.Q.3    Groffen, J.4
  • 14
    • 0037369288 scopus 로고    scopus 로고
    • Apoptotic synergism between STI571 and the farnesyl transferase inhibitor SCH66336 on an imatinib-sensitive cell line
    • Brodsky AL. Apoptotic synergism between STI571 and the farnesyl transferase inhibitor SCH66336 on an imatinib-sensitive cell line. Blood. 2003;101:2070-2071.
    • (2003) Blood , vol.101 , pp. 2070-2071
    • Brodsky, A.L.1
  • 15
    • 0037762630 scopus 로고    scopus 로고
    • Towards combination target-directed chemotherapy for chronic myeloid leukemia: Role of farnesyl transferase inhibitors
    • Daley GQ. Towards combination target-directed chemotherapy for chronic myeloid leukemia: role of farnesyl transferase inhibitors. Semin Hematol. 2003;40:11-14.
    • (2003) Semin Hematol , vol.40 , pp. 11-14
    • Daley, G.Q.1
  • 16
    • 0036683409 scopus 로고    scopus 로고
    • Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336
    • Hoover RR, Mahon FX, MeIo JV, Daley GQ. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood. 2002;100:1068-1071.
    • (2002) Blood , vol.100 , pp. 1068-1071
    • Hoover, R.R.1    Mahon, F.X.2    Meio, J.V.3    Daley, G.Q.4
  • 17
    • 0344611212 scopus 로고    scopus 로고
    • Efficacy of SCH66336, a farnesyl transferase inhibitor, in conjunction with imatinib against BCR-ABL-positive cells
    • Nakajima A, Tauchi T, Sumi M, Bishop WR, Ohyashiki K. Efficacy of SCH66336, a farnesyl transferase inhibitor, in conjunction with imatinib against BCR-ABL-positive cells. Mol Cancer Ther. 2003;2:219-224.
    • (2003) Mol Cancer Ther , vol.2 , pp. 219-224
    • Nakajima, A.1    Tauchi, T.2    Sumi, M.3    Bishop, W.R.4    Ohyashiki, K.5
  • 18
    • 0348140591 scopus 로고    scopus 로고
    • Mechanisms and implications of imatinib resistance mutations in BCR-ABL
    • Nardi V, Azam M, Daley GQ. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol. 2004;11:35-43.
    • (2004) Curr Opin Hematol , vol.11 , pp. 35-43
    • Nardi, V.1    Azam, M.2    Daley, G.Q.3
  • 19
    • 0345600892 scopus 로고    scopus 로고
    • Resistance to Imatinib (Glivec): Update on clinical mechanisms
    • Weisbeg E, Griffin JD. Resistance to Imatinib (Glivec): update on clinical mechanisms. Drug Resist Update. 2003;6:231-238.
    • (2003) Drug Resist Update , vol.6 , pp. 231-238
    • Weisbeg, E.1    Griffin, J.D.2
  • 20
    • 8644219632 scopus 로고    scopus 로고
    • Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: Possible mechanisms of action
    • Jabbour E, Kantarjian H, Cortes J. Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: possible mechanisms of action. Leuk Lymphoma. 2004;45:2187-2195.
    • (2004) Leuk Lymphoma , vol.45 , pp. 2187-2195
    • Jabbour, E.1    Kantarjian, H.2    Cortes, J.3
  • 21
    • 3042676607 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors (FTIs) in myeloid malignancies
    • Karp JE, Lancet JE. Farnesyltransferase inhibitors (FTIs) in myeloid malignancies. Ann Hematol. 2004;83(suppl 1):S87-S88.
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Karp, J.E.1    Lancet, J.E.2
  • 23
    • 1642477902 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors as anticancer agents: Current status
    • Zhu K, Hamilton AD, Sebti SM. Farnesyltransferase inhibitors as anticancer agents: current status. Curr Opin Investig Drugs. 2003;12:1428-1435.
    • (2003) Curr Opin Investig Drugs , vol.12 , pp. 1428-1435
    • Zhu, K.1    Hamilton, A.D.2    Sebti, S.M.3
  • 27
    • 0029123812 scopus 로고
    • A simple procedure for gel electrophoresis and Northern blotting of RNA
    • Goda SK, Minton NP. A simple procedure for gel electrophoresis and Northern blotting of RNA. Nucl Acids Res. 1995;23:3357-3358.
    • (1995) Nucl Acids Res , vol.23 , pp. 3357-3358
    • Goda, S.K.1    Minton, N.P.2
  • 28
    • 0036915646 scopus 로고    scopus 로고
    • Rapid quantification of murine ABC mRNAs by real time reverse transcriptase-polymerase chain reaction
    • Su YR, Linton MF, Fazio SJ. Rapid quantification of murine ABC mRNAs by real time reverse transcriptase-polymerase chain reaction. Lipid Res. 2002;43:2180-2187.
    • (2002) Lipid Res , vol.43 , pp. 2180-2187
    • Su, Y.R.1    Linton, M.F.2    Fazio, S.J.3
  • 30
    • 0033578751 scopus 로고    scopus 로고
    • A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors
    • Del Villar K, Urano J, Guo L, Tamanoi F. A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors. J Biol Chem. 1999;274:27010-27017.
    • (1999) J Biol Chem , vol.274 , pp. 27010-27017
    • Del Villar, K.1    Urano, J.2    Guo, L.3    Tamanoi, F.4
  • 32
    • 0039948032 scopus 로고    scopus 로고
    • Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I
    • Del Villar K, Mitsuzawa H, Yang W, Sattler I, Tamanoi F. Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I. J Biol Chem. 1997;272:680-687.
    • (1997) J Biol Chem , vol.272 , pp. 680-687
    • Del Villar, K.1    Mitsuzawa, H.2    Yang, W.3    Sattler, I.4    Tamanoi, F.5
  • 33
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2002;2:48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 34
    • 0033547277 scopus 로고    scopus 로고
    • Differential expression of putative transbilayer amphipath transporters
    • Halleck MS, Lawler JF Jr, Blackshaw S, et al. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics. 1999;1:139-150.
    • (1999) Physiol Genomics , vol.1 , pp. 139-150
    • Halleck, M.S.1    Lawler Jr., J.F.2    Blackshaw, S.3
  • 35
    • 0034776102 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor SCH 66336 induces a G(2) -> M orG(1) pause in sensitive human tumor cell lines
    • Ashar HR, James L, Gray K, et al. The farnesyl transferase inhibitor SCH 66336 induces a G(2) -> M orG(1) pause in sensitive human tumor cell lines. Exp Cell Res. 2001;262:17-27.
    • (2001) Exp Cell Res , vol.262 , pp. 17-27
    • Ashar, H.R.1    James, L.2    Gray, K.3
  • 36
    • 7844233665 scopus 로고    scopus 로고
    • (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6] -cyclohepta[1,2-b]-pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl] -1-piperidinecarboxamide(SCH-66336): A very potent famesyl protein transferase inhibitor as a novel antitumor agent
    • Njoroge FG, Taveras AG, Kelly J, et al. (+)-4-[2-[4-(8-Chloro-3,10- dibromo-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]-pyridin-11(R)-yl) -1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide(SCH-66336): a very potent famesyl protein transferase inhibitor as a novel antitumor agent. J Med Chem. 1998;41:4890-4902.
    • (1998) J Med Chem , vol.41 , pp. 4890-4902
    • Njoroge, F.G.1    Taveras, A.G.2    Kelly, J.3
  • 37
    • 0037470819 scopus 로고    scopus 로고
    • Protein prenylation: A pivotal post-translational process
    • Roskoski R Jr. Protein prenylation: a pivotal post-translational process. Biochem Biophys Res Commun. 2003;303:1-7.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 1-7
    • Roskoski Jr., R.1
  • 38
    • 0043029517 scopus 로고    scopus 로고
    • Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors
    • Morgan MA, Wegner J, Aydilek E, Ganser A, Reuter CW. Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors. Leukemia. 2003;17:1508-1520.
    • (2003) Leukemia , vol.17 , pp. 1508-1520
    • Morgan, M.A.1    Wegner, J.2    Aydilek, E.3    Ganser, A.4    Reuter, C.W.5
  • 39
    • 0344629822 scopus 로고    scopus 로고
    • Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells
    • van de Donk NW, Schotte D, Kamphuis MM, et al. Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells. Clin Cancer Res. 2003;9:5735-5748.
    • (2003) Clin Cancer Res , vol.9 , pp. 5735-5748
    • Donk, N.W.1    Schotte, D.2    Kamphuis, M.M.3
  • 40
    • 0035733910 scopus 로고    scopus 로고
    • Remission induction therapy for childhood acute lymphoblastic leukaemia: Clinical and cellular pharmacology of vincristine, corticosteroids, L-asparaginase and anthracyclines
    • Ronghe M, Burke GA, Lowis SP, Estlin EJ. Remission induction therapy for childhood acute lymphoblastic leukaemia: clinical and cellular pharmacology of vincristine, corticosteroids, L-asparaginase and anthracyclines. Cancer Treat Rev. 2001;27:27-37.
    • (2001) Cancer Treat Rev , vol.27 , pp. 27-37
    • Ronghe, M.1    Burke, G.A.2    Lowis, S.P.3    Estlin, E.J.4
  • 41
    • 0036284741 scopus 로고    scopus 로고
    • Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line
    • Smith V, Rowlands MG, Barrie E, Workman P, Kelland LR. Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line. Clin Cancer Res. 2002;6:2002-2009.
    • (2002) Clin Cancer Res , vol.6 , pp. 2002-2009
    • Smith, V.1    Rowlands, M.G.2    Barrie, E.3    Workman, P.4    Kelland, L.R.5
  • 42
    • 0036687727 scopus 로고    scopus 로고
    • ATP binding cassette transporter A1: Key roles in cellular lipid transport and atherosclerosis
    • Srivastava N. ATP binding cassette transporter A1: key roles in cellular lipid transport and atherosclerosis. Mol Cell Biochem. 2002;237:155-164.
    • (2002) Mol Cell Biochem , vol.237 , pp. 155-164
    • Srivastava, N.1
  • 43
    • 0035966125 scopus 로고    scopus 로고
    • Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate
    • Gan X, Kaplan R, Menke JG, et al. Dual mechanisms of ABCA1 regulation by geranylgeranyl pyrophosphate. J Biol Chem. 2001;276:48702-48708.
    • (2001) J Biol Chem , vol.276 , pp. 48702-48708
    • Gan, X.1    Kaplan, R.2    Menke, J.G.3
  • 44
    • 0345735895 scopus 로고    scopus 로고
    • The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2
    • Wang EJ, Johnson WW. The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2. Chemotherapy. 2003;49:303-308.
    • (2003) Chemotherapy , vol.49 , pp. 303-308
    • Wang, E.J.1    Johnson, W.W.2
  • 45
    • 0037117313 scopus 로고    scopus 로고
    • Genetic defects in hepatobiliary transport
    • Oude Elferink R, Groen AK. Genetic defects in hepatobiliary transport. Biochim Biophys Acta. 2002;1586:129-145.
    • (2002) Biochim Biophys Acta , vol.1586 , pp. 129-145
    • Oude Elferink, R.1    Groen, A.K.2
  • 47
    • 0142061051 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes
    • Cortes J. Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes. Clin Lymphoma. 2003;4:S30-S35.
    • (2003) Clin Lymphoma , vol.4
    • Cortes, J.1
  • 48
    • 0037431539 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells
    • Smalley KS, Eisen TG. Farnesyltransferase inhibitor SCH66336 is cytostatic, pro-apoptotic and enhances chemosensitivity to cisplatin in melanoma cells. Int J Cancer. 2003;105:165-175.
    • (2003) Int J Cancer , vol.105 , pp. 165-175
    • Smalley, K.S.1    Eisen, T.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.